• 15 Innovation Walk, 75

    3800 Clayton

1985 …2021

Research output per year

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Research Output

Contribution of stromal cells to the migration, function and retention of plasma cells in human spleen: potential roles of CXCL12, IL-6 and CD54

Ellyard, J. I., Avery, D. T., Mackay, C. R. & Tangye, S. G., 2005, In : European Journal of Immunology. 35, 3, p. 699 - 708 10 p.

Research output: Contribution to journalArticleResearchpeer-review

47 Citations (Scopus)

CXCR3(+)CCR5(+) T cells and autoimmune diseases: guilty as charged?

Mackay, C. R., 2014, In : Journal of Clinical Investigation. 124, 9, p. 3682 - 3684 3 p.

Research output: Contribution to journalArticleOther

13 Citations (Scopus)

CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses

Chevalier, N., Jarrossay, D., Ho, E., Avery, D. T., Ma, C. S., Yu, D., Sallusto, F., Tangye, S. G. & Mackay, C. R., 2011, In : Journal of Immunology. 186, 10, p. 5556 - 5568 13 p.

Research output: Contribution to journalArticleResearchpeer-review

203 Citations (Scopus)

Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2K(d) -specific CD8+ T cells

Rahir, G., Wathelet, N., Hanoteau, A., Henin, C., Oldenhove, G., Galuppo, A., Lanaya, H., Colau, D., Mackay, C. R., Van den Eynde, B. J. & Moser, M., 2014, In : International Journal of Cancer. 134, 12, p. 2841 - 2852 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Das Vorkommen von CD44 und seinen Isoformen unter orthologischen und pathologischen Bedingungen.

Translated title of the contribution: Occurrence of CD44 and its isoforms under orthological and pathological conditionsTerpe, A., Franke, F., Stark, H., Gustmann, C., Mackay, C., Marston, W. & Günthert, U., 1 Jan 1993, In : Verhandlungen der Deutschen Gesellschaft für Pathologie. 77, p. 276-281 6 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

Hu, M., Eviston, D., Hsu, P., Mariño, E., Chidgey, A., Santner-Nanan, B., Wong, K., Richards, J. L., Yap, Y. A., Collier, F., Quinton, A., Joung, S., Peek, M., Benzie, R., Macia, L., Wilson, D., Ponsonby, A. L., Tang, M. L. K., O’Hely, M., Daly, N. L. & 5 others, Mackay, C. R., Dahlstrom, J. E., The BIS Investigator Group, Vuillermin, P. & Nanan, R., 10 Jul 2019, In : Nature Communications. 10, 1, 13 p., 3031.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Development and uses for monoclonal antibodies to chemoattractant receptors

Mackay, C. R., May 2012, In : Current Immunology Reviews. 8, 2, p. 149-153 5 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Development of autoimmune nephritis in genetically asplenic and splenectomized BAFF transgenic mice

Fletcher, C., Groom, J., Woehl, B., Leung, H., Mackay, C. & Mackay-Fisson, F., 2011, In : Journal of Autoimmunity. 36, 2, p. 125 - 134 10 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Diet, gut microbiota and immune responses

Maslowski, K. M. & Mackay, C. R., 2011, In : Nature Immunology. 12, 1, p. 5 - 9 5 p.

Research output: Contribution to journalArticleResearchpeer-review

617 Citations (Scopus)

Diet, metabolites, and "Western-lifestyle" inflammatory diseases

Thorburn, A. N., Macia, L. & Mackay, C. R., 2014, In : Immunity. 40, 6, p. 833 - 842 10 p.

Research output: Contribution to journalArticleResearchpeer-review

325 Citations (Scopus)

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

Tan, J., McKenzie, C., Vuillermin, P. J., Goverse, G., Vinuesa, C. G., Mebius, R. E., Macia, L. & Mackay, C. R., 21 Jun 2016, In : Cell Reports. 15, 12, p. 2809-2824 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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149 Citations (Scopus)

Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice

Vieira, A. T., Galvão, I., Macia, L. M., Sernaglia, E. M., Vinolo, M. A. R., Garcia, C. C., Tavares, L. P., Amaral, F. A., Sousa, L. P., Martins, F. S., Mackay, C. R. & Teixeira, M. M., 1 Jan 2017, In : Journal of leukocyte biology. 101, 1, p. 275-284 10 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases

Richards, J. L., Yap, Y. A., McLeod, K., Mackay, C. R. & Marino Moreno, E., 4 Apr 2016, In : Clinical and Translational Immunology. 5, 5, 8 p.

Research output: Contribution to journalScientific ReviewOtherpeer-review

Open Access
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Diet-derived short chain fatty acids stimulate intestinal epithelial cells to induce mucosal tolerogenic dendritic cells

Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M. N., Konijn, T., Knippenberg, M., Cook, E. C. L., Hanekamp, D., Veldhoen, M., Hartog, A., Roeselers, G., MacKay, C. R. & Mebius, R. E., 1 Mar 2017, In : Journal of Immunology. 198, 5, p. 2172-2181 10 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2

Jones, S. A., Wolf, M., Qin, S., Mackay, C. R. & Baggiolini, M., 26 Jul 1996, In : Proceedings of the National Academy of Sciences of the United States of America. 93, 13, p. 6682-6686 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
200 Citations (Scopus)

Differential expression of homing molecules on recirculating lymphocytes from sheep gut, peripheral, and lung lymph

Abitorabi, M. A., Mackay, C. R., Jerome, E. H., Osorio, O., Butcher, E. C. & Erle, D. J., 1 May 1996, In : Journal of Immunology. 156, 9, p. 3111-3117 7 p.

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)

Discrete steps in binding and signaling of interleukin-8 with its receptor

Wu, L., Ruffing, N., Shi, X., Newman, W., Soler, D., Mackay, C. R. & Qin, S., 17 Dec 1996, In : Journal of Biological Chemistry. 271, 49, p. 31202-31209 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
83 Citations (Scopus)

Discussion

Mackay, C., Cyster, J., Goodnow, C. C., Lam, K. P., Vinuesa, C., Malissen, B., Gros, P., Turner, S., Kaufman, J. & Hume, D., 1 Dec 2007, Decoding the Genomic Control of Immune Reactions. p. 61-64 4 p. (Novartis Foundation Symposium; vol. 281).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Discussion

Britton, W. J., Casanova, J. L., Foote, S., Goodnow, C. C., Gros, P., Hume, D., Karupiah, G., Mackay, C., Morahan, G., Turner, S. & Young, D., 1 Dec 2007, Decoding the Genomic Control of Immune Reactions. p. 177-180 4 p. (Novartis Foundation Symposium; vol. 281).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Discussion

Alexander, W. S., Belz, G., Britton, W. J., Cook, M., Cyster, J., Goodnow, C. C., Hume, D., Kaufman, J., Mackay, C., Stacker, S. & Turner, S., 1 Dec 2007, Decoding the Genomic Control of Immune Reactions. p. 44-49 6 p. (Novartis Foundation Symposium; vol. 281).

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7

Sierro, F., Biben, C., Martinez-Munoz, L., Mellado, M., Ransohoff, R. M., Li, M., Woehl, B., Leung, H., Groom, J., Batten, M., Harvey, R. P., Matinez-A, C., Mackay, C. R. & Mackay-Fisson, F., 2007, In : Proceedings of the National Academy of Sciences. 104, 37, p. 14759 - 14764 6 p.

Research output: Contribution to journalArticleResearchpeer-review

419 Citations (Scopus)

Dual personality of memory T cells

Mackay, C. R., 14 Oct 1999, In : Nature. 401, 6754, p. 659-660 2 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

53 Citations (Scopus)

Effect of Dietary Fibre Intake and the Gut Microbiota in a Model of Heart Failure

Coelho Marques, F., Nelson, E. M., Chu, P. Y., Horlock, D., Fiedler, A., Ziemann, M. D., Tan, J., Kuruppu, D. M. S., Rajapakse, N., El-Osta, A., Mackay, C. R. & Kaye, D. M., 11 Nov 2016. 1 p.

Research output: Contribution to conferenceAbstract

Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells

Ying, S., Robinson, D. S., Meng, Q., Rottman, J., Kennedy, R., Ringler, D. J., Mackay, C. R., Daugherty, B. L., Springer, M. S., Durham, S. R., Williams, T. J. & Kay, A. B., 1 Dec 1997, In : European Journal of Immunology. 27, 12, p. 3507-3516 10 p.

Research output: Contribution to journalArticleResearchpeer-review

369 Citations (Scopus)

Enhanced levels of functional HIV-1 co-receptors on human mucosal T cells demonstrated using intestinal biopsy tissue

Anton, P. A., Elliott, J., Poles, M. A., McGowan, I. M., Matud, J., Hultin, L. E., Grovit-Ferbas, K., Mackay, C. R., Chen, I. S. Y. & Giorgi, J. V., 26 Sep 2000, In : AIDS. 14, 12, p. 1761-1765 5 p.

Research output: Contribution to journalArticleResearchpeer-review

134 Citations (Scopus)

Epitopes of the T19 lymphocyte surface antigen are extensively conserved in ruminants

Hein, W. R., Dudler, L., Beya, M. F. & Mackay, C. R., 1 Jan 1991, In : Veterinary Immunology and Immunopathology. 27, 1-3, p. 173-181 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Erratum: B-Cell cross-presentation of autologous antigen precipitates diabetes (Diabetes( 2012) 61 (2893-2905))

Mariño, E., Tan, B., Binge, L., Mackay, C. R. & Grey, S. T., Feb 2013, In : Diabetes. 62, 2, p. 662 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

Essential role for CCR6 in certain inflammatory diseases demonstrated using specific antagonist and knockin mice

Robert, R., Ang, C., Sun, G., Juglair, L., Lim, E. X., Mason, L. J., Payne, N. L., Bernard, C. C. A. & Mackay, C. R., 3 Aug 2017, In : JCI Insight. 2, 15, 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

Thorburn, A. N., McKenzie, C., Shen, S. S., Stanley, D., Macia, L., Mason, L. J., Roberts, L. K., Wong, C. H. Y., Shim, R., Robert, R., Chevalier, N., Tan, J. K., Marino, E. M., Moore, R. J., Wong, L. H. H., McConville, M. J., Tull, D. L., Wood, L., Murphy, V., Mattes, J. & 3 others, Gibson, P. G., Wood, L. G. & Mackay, C. R., 2015, In : Nature Communications. 6, 7320, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
255 Citations (Scopus)

Expression and modulation of CD44 variant isoforms in humans

Mackay, C. R., Terpe, H. J., Stauder, R., Marston, W. L., Stark, H. & Günthert, U., 1 Jan 1994, In : Journal of Cell Biology. 124, 1-2, p. 71-82 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
383 Citations (Scopus)

Expression of CD44 molecules and CD44 ligands during human thymic fetal development: Expression of CD44 isoforms is developmentally regulated

Patel, D. D., Hale, L. P., Whichard, L. P., Radcliff, G., Mackay, C. R. & Haynes, B. F., 1 Feb 1995, In : International Immunology. 7, 2, p. 277-286 10 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Expression of Human CD4 in Transgenic Mice Does Not Confer Sensitivity to Human Immunodeficiency Virus Infection

Lorès, P., Boucher, V., Mackay, C., Pla, M., Von Boehmer, H., Jami, J., Barré-Sinoussi, F. & Weill, J. C., 1 Jan 1992, In : AIDS Research and Human Retroviruses. 8, 12, p. 2063-2071 9 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Expression of monocyte chemoattractant protein-1 and interleukin-8 receptors on subsets of T cells: Correlation with transendothelial chemotactic potential

Qin, S., LaRosa, G., Campbell, J. J., Smith-Heath, H., Kassam, N., Shi, X., Zeng, L., Butcher, E. C. & Mackay, C. R., 1 Mar 1996, In : European Journal of Immunology. 26, 3, p. 640-647 8 p.

Research output: Contribution to journalArticleResearchpeer-review

151 Citations (Scopus)

Expression of the "T19" and "null cell" markers on γδT cells of the sheep

Mackay, C. R., Marston, W. L., Dudler, L. & Hein, W. R., 1 Jan 1991, In : Veterinary Immunology and Immunopathology. 27, 1-3, p. 183-188 6 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

Brooks, L., Viardot, A., Tsakmaki, A., Stolarczyk, E., Howard, J. K., Cani, P. D., Everard, A., Sleeth, M. L., Psichas, A., Anastasovskaj, J., Bell, J. D., Bell-Anderson, K., Mackay, C. R., Ghatei, M. A., Bloom, S. R., Frost, G. & Bewick, G. A., 1 Jan 2017, In : Molecular Metabolism. 6, 1, p. 48-60 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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68 Citations (Scopus)

Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes

Sallusto, F., Lenig, D., Mackay, C. R. & Lanzavecchia, A., 16 Mar 1998, In : The Journal of Experimental Medicine. 187, 6, p. 875-883 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1309 Citations (Scopus)

Follicular B helper T cells in antibody responses and autoimmunity

Vinuesa, C. G., Tangye, S. G., Moser, B. & Mackay, C. R., 1 Nov 2005, In : Nature Reviews Immunology. 5, 11, p. 853-865 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

442 Citations (Scopus)

Follicular homing T helper (Th) cells and the Th1/Th2 paradigm

Mackay, C. R., 4 Dec 2000, In : The Journal of Experimental Medicine. 192, 11

Research output: Contribution to journalComment / DebateOtherpeer-review

Open Access
53 Citations (Scopus)

Four antigens expressed on most ovine cell types

Maddox, J. F., Mackay, C. R. & Brandon, M. R., 1 Dec 1986, In : Immunology. 59, 4, p. 631-632 2 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Functional expression of the eotaxin receptor CCR3 in T lymphocytes co-localizing with eosinophils

Gerber, B. O., Zanni, M. P., Uguccioni, M., Loetscher, M., Mackay, C. R., Pichler, W. J., Yawalkar, N., Baggiolini, M. & Moser, B., 1 Nov 1997, In : Current Biology. 7, 11, p. 836-843 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
235 Citations (Scopus)

Functional roles for C5a receptors in sepsis

Rittirsch, D., Flierl, M. A., Nadeau, B. A., Day, D. E., Huber-Lang, M., Mackay, C. R., Zetoune, F. S., Gerard, N. P., Cianglone, K., Kohl, J., Gerard, C., Sarma, J. V. & Ward, P. A., 2008, In : Nature Medicine. 14, 5, p. 551 - 557 7 p.

Research output: Contribution to journalArticleResearchpeer-review

247 Citations (Scopus)

Function and evolutionary conservation of distinct epitopes on the leukocyte adhesion molecule-1 (TQ-1, Leu-8) that regulate leukocyte migration

Spertini, O., Kansas, G. S., Reimann, K. A., Mackay, C. R. & Tedder, T. F., 1 Aug 1991, In : Journal of Immunology. 147, 3, p. 942-949 8 p.

Research output: Contribution to journalArticleResearchpeer-review

103 Citations (Scopus)

Gene microarrays reveal extensive differential gene expression in both CD4+ and CD8+ type 1 and type 2 T cells

Chtanova, T., Kemp, R. A., Sutherland, A. P. R., Ronchese, F. & Mackay, C. R., 15 Sep 2001, In : Journal of Immunology. 167, 6, p. 3057-3063 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
116 Citations (Scopus)

Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody

Lutgens, E., Faber, B., Schapira, K., Evelo, C. TA., van Haaften, R., Heeneman, S., Cleutjens, K. BJM., Bijnens, A. P., Beckers, L., Porter, J. G., Mackay, C. R., Rennert, P., Bailly, V., Jarpe, M., Dolinski, B., Koteliansky, V., de Fougerolles, T. & Daemen, M. JAP., 2005, In : Circulation. 111, 25, p. 3443 - 3452 10 p.

Research output: Contribution to journalArticleResearchpeer-review

81 Citations (Scopus)

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

Lassen, K. G., McKenzie, C. I., Mari, M., Murano, T., Begun, J., Baxt, L. A., Goel, G., Villablanca, E. J., Kuo, S. Y., Huang, H., Macia, L., Bhan, A. K., Batten, M., Daly, M. J., Reggiori, F., Mackay, C. R. & Xavier, R. J., 21 Jun 2016, In : Immunity. 44, 6, p. 1392-1405 14 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Genetic subtype-independent inhibition of human immunodeficiency virus type 1 replication by CC and CXC chemokines

Trkola, A., Paxton, W. A., Monard, S. P., Hoxie, J. A., Siani, M. A., Thompson, D. A., Wu, L., Mackay, C. R., Horuk, R. & Moore, J. P., 1 Jan 1998, In : Journal of Virology. 72, 1, p. 396-404 9 p.

Research output: Contribution to journalArticleResearchpeer-review

112 Citations (Scopus)

GPR43 - a prototypic metabolite sensor linking metabolic and inflammatory diseases

McKenzie, C., Mackay, C. R. & Macia, L., Oct 2015, In : Trends in Endocrinology and Metabolism. 26, 10, p. 511-512 2 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

16 Citations (Scopus)

G protein-coupled receptor 43 modulates neutrophil recruitment during acute inflammation

Kamp, M. E., Shim, R., Nicholls, A. J., Oliveira, A. C., Mason, L. J., Binge, L., Mackay, C. R. & Wong, C. H. Y., 22 Sep 2016, In : PLoS ONE. 11, 9, 15 p., e0163750.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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22 Citations (Scopus)

Granulocyte-macrophage colony-stimulating factor is required for bronchial eosinophilia in a murine model of allergic airway inflammation

Su, Y-C., Rolph, M. S., Hansbro, N. G., Mackay, C. R. & Sewell, W. A., 2008, In : Journal of Immunology. 180, 4, p. 2600 - 2607 8 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses

Gatto, D., Paus, D., Basten, A., Mackay, C. R. & Brink, R., 2009, In : Immunity. 31, 2, p. 259 - 269 11 p.

Research output: Contribution to journalArticleResearchpeer-review

164 Citations (Scopus)