• 15 Innovation Walk, 75

    3800 Clayton

1985 …2021
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Research Output 1985 2019

2019
2 Citations (Scopus)

Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

Hu, M., Eviston, D., Hsu, P., Mariño, E., Chidgey, A., Santner-Nanan, B., Wong, K., Richards, J. L., Yap, Y. A., Collier, F., Quinton, A., Joung, S., Peek, M., Benzie, R., Macia, L., Wilson, D., Ponsonby, A. L., Tang, M. L. K., O’Hely, M., Daly, N. L. & 5 others, Mackay, C. R., Dahlstrom, J. E., The BIS Investigator Group, Vuillermin, P. & Nanan, R., 10 Jul 2019, In : Nature Communications. 10, 1, 13 p., 3031.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Guidelines for Transparency on Gut Microbiome Studies in Essential and Experimental Hypertension

Marques, F. Z., Jama, H. A., Tsyganov, K., Gill, P. A., Rhys-Jones, D., Muralitharan, R. R., Muir, J., Holmes, A. & Mackay, C. R., Dec 2019, In : Hypertension. 74, 6, p. 1279-1293 15 p.

Research output: Contribution to journalArticleOtherpeer-review

Gut microbial metabolite butyrate protects against proteinuric kidney disease through epigenetic- and GPR109a-mediated mechanisms

Felizardo, R. J. F., de Almeida, D. C., Pereira, R. L., Watanabe, I. K. M., Doimo, N. T. S., Ribeiro, W. R., Cenedeze, M. A., Hiyane, M. I., Amano, M. T., Braga, T. T., Ferreira, C. M., Parmigiani, R. B., Andrade-Oliveira, V., Volpini, R. A., Vinolo, M. A. R., Mariño, E., Robert, R., Mackay, C. R. & Camara, N. O. S., Nov 2019, (Accepted/In press) In : FASEB Journal. 33, 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Intergenerational Prevention Of Heart Failure Through Maternal Intake Of High Fibre

Jama, H. A., Shihata, W., Ziemann, M. D., Donner, D. G., Kiriazis, H., Du, X-J., El-Osta, A., Mackay, C. R., Kaye, D. M. & Coelho Marques, F., Feb 2019. 1 p.

Research output: Contribution to conferenceAbstractOther

1 Citation (Scopus)

Short-chain fatty acids and FFAR2 as suppressors of bone resorption

Montalvany-Antonucci, C. C., Duffles, L. F., de Arruda, J. A. A., Zicker, M. C., de Oliveira, S., Macari, S., Garlet, G. P., Madeira, M. F. M., Fukada, S. Y., Andrade, I., Teixeira, M. M., Mackay, C., Vieira, A. T., Vinolo, M. A. & Silva, T. A., 1 Aug 2019, In : Bone. 125, p. 112-121 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2018
57 Citations (Scopus)

Beyond gut feelings: How the gut microbiota regulates blood pressure

Marques, F. Z., Mackay, C. R. & Kaye, D. M., 1 Jan 2018, In : Nature Reviews Cardiology. 15, 1, p. 20-32 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

8 Citations (Scopus)

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis

Dick, J., Gan, P. Y., Ford, S. L., Odobasic, D., Alikhan, M. A., Loosen, S. H., Hall, P., Westhorpe, C. L., Li, A., Ooi, J. D., Woodruff, T. M., Mackay, C. R., Kitching, A. R., Hickey, M. J. & Holdsworth, S. R., 1 Mar 2018, In : Kidney International. 93, 3, p. 615-625 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Gαs-coupled GPCRs GPR65 and GPR174. Downers for immune responses

Robert, R. & Mackay, C. R., 1 Apr 2018, In : Immunology and Cell Biology. 96, 4, p. 341-343 3 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
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7 Citations (Scopus)

The metabolic sensor GPR43 receptor plays a role in the control of Klebsiella pneumoniae infection in the lung

Galvão, I., Tavares, L. P., Corrêa, R. O., Fachi, J. L., Rocha, V. M., Rungue, M., Garcia, C. C., Cassali, G., Ferreira, C. M., Martins, F. S., Oliveira, S. C., Mackay, C. R., Teixeira, M. M., Vinolo, M. A. R. & Vieira, A. T., 20 Feb 2018, In : Frontiers in Immunology. 9, 11 p., 142.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017
9 Citations (Scopus)

A fully humanized IgG-like bispecific antibody for effective dual targeting of CXCR3 and CCR6

Robert, R., Juglair, L., Lim, E. X., Ang, C., Wang, C. J. H., Ebert, G., Dolezal, O. & Mackay, C. R., 5 Sep 2017, In : PLoS ONE. 12, 9, 18 p., e0184278.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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18 Citations (Scopus)

c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses

Piovesan, D., Tempany, J., Di Pietro, A., Baas, I., Yiannis, C., O'Donnell, K., Chen, Y., Peperzak, V., Belz, G. T., Mackay, C. R., Smyth, G. K., Groom, J. R., Tarlinton, D. M. & Good-Jacobson, K. L., 18 Apr 2017, In : Cell Reports. 19, 3, p. 461-470 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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26 Citations (Scopus)

Dietary fiber and the short-chain fatty acid acetate promote resolution of neutrophilic inflammation in a model of gout in mice

Vieira, A. T., Galvão, I., Macia, L. M., Sernaglia, E. M., Vinolo, M. A. R., Garcia, C. C., Tavares, L. P., Amaral, F. A., Sousa, L. P., Martins, F. S., Mackay, C. R. & Teixeira, M. M., 1 Jan 2017, In : Journal of leukocyte biology. 101, 1, p. 275-284 10 p.

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Diet-derived short chain fatty acids stimulate intestinal epithelial cells to induce mucosal tolerogenic dendritic cells

Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M. N., Konijn, T., Knippenberg, M., Cook, E. C. L., Hanekamp, D., Veldhoen, M., Hartog, A., Roeselers, G., MacKay, C. R. & Mebius, R. E., 1 Mar 2017, In : Journal of Immunology. 198, 5, p. 2172-2181 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Essential role for CCR6 in certain inflammatory diseases demonstrated using specific antagonist and knockin mice

Robert, R., Ang, C., Sun, G., Juglair, L., Lim, E. X., Mason, L. J., Payne, N. L., Bernard, C. C. A. & Mackay, C. R., 3 Aug 2017, In : JCI Insight. 2, 15, 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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59 Citations (Scopus)

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

Brooks, L., Viardot, A., Tsakmaki, A., Stolarczyk, E., Howard, J. K., Cani, P. D., Everard, A., Sleeth, M. L., Psichas, A., Anastasovskaj, J., Bell, J. D., Bell-Anderson, K., Mackay, C. R., Ghatei, M. A., Bloom, S. R., Frost, G. & Bewick, G. A., 1 Jan 2017, In : Molecular Metabolism. 6, 1, p. 48-60 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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146 Citations (Scopus)

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Marino, E., Richards, J. L., McLeod, K. H., Stanley, D., Yap, Y. A., Knight, J., McKenzie, C., Kranich, J., Oliveira, A. C., Rossello, F. J., Krishnamurthy, B., Nefzger, C. M., Macia, L., Thorburn, A., Baxter, A. G., Morahan, G., Wong, L. H., Polo, J. M., Moore, R. J., Lockett, T. J. & 4 others, Clarke, J. M., Topping, D. L., Harrison, L. C. & Mackay, C. R., May 2017, In : Nature Immunology. 18, 5, p. 552-562 13 p.

Research output: Contribution to journalArticleResearchpeer-review

137 Citations (Scopus)

High Fibre Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in DOCA-Salt Hypertensive Mice

Marques, F. Z., Nelson, E., Chu, P. Y., Horlock, D., Fiedler, A., Ziemann, M., Tan, J. K., Kuruppu, S., Rajapakse, N. W., El-Osta, A., Mackay, C. R. & Kaye, D. M., 7 Mar 2017, In : Circulation. 135, 10, p. 964-977 14 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Metabolite-sensing G protein-coupled receptors-facilitators of diet-related immune regulation

Tan, J. K., McKenzie, C., Mariño, E., Macia, L. & Mackay, C. R., 26 Apr 2017, In : Annual Review of Immunology. 35, p. 371-402 32 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

56 Citations (Scopus)

The nutrition-gut microbiome-physiology axis and allergic diseases

McKenzie, C., Tan, J., Macia, L. & Mackay, C. R., 1 Jul 2017, In : Immunological Reviews. 278, 1, p. 277-295 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2016
2 Citations (Scopus)

Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges

Chevalier, N., Tan, J. K., Mason, L. J., Robert, R., McKenzie, C. I., Lim, F., Wong, C. H., Macia, L., Thorburn, A. N., Russ, B. E., Masters, S. L. & Mackay, C. R., 1 Sep 2016, In : Journal of Autoimmunity. 73, p. 120-129 10 p.

Research output: Contribution to journalArticleResearchpeer-review

137 Citations (Scopus)

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways

Tan, J., McKenzie, C., Vuillermin, P. J., Goverse, G., Vinuesa, C. G., Mebius, R. E., Macia, L. & Mackay, C. R., 21 Jun 2016, In : Cell Reports. 15, 12, p. 2809-2824 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases

Richards, J. L., Yap, Y. A., McLeod, K., Mackay, C. R. & Marino Moreno, E., 4 Apr 2016, In : Clinical and Translational Immunology. 5, 5, 8 p.

Research output: Contribution to journalScientific ReviewOtherpeer-review

Open Access
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Effect of Dietary Fibre Intake and the Gut Microbiota in a Model of Heart Failure

Coelho Marques, F., Nelson, E. M., Chu, P. Y., Horlock, D., Fiedler, A., Ziemann, M. D., Tan, J., Kuruppu, D. M. S., Rajapakse, N., El-Osta, A., Mackay, C. R. & Kaye, D. M., 11 Nov 2016. 1 p.

Research output: Contribution to conferenceAbstractOther

27 Citations (Scopus)

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

Lassen, K. G., McKenzie, C. I., Mari, M., Murano, T., Begun, J., Baxt, L. A., Goel, G., Villablanca, E. J., Kuo, S. Y., Huang, H., Macia, L., Bhan, A. K., Batten, M., Daly, M. J., Reggiori, F., Mackay, C. R. & Xavier, R. J., 21 Jun 2016, In : Immunity. 44, 6, p. 1392-1405 14 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

G protein-coupled receptor 43 modulates neutrophil recruitment during acute inflammation

Kamp, M. E., Shim, R., Nicholls, A. J., Oliveira, A. C., Mason, L. J., Binge, L., Mackay, C. R. & Wong, C. H. Y., 22 Sep 2016, In : PLoS ONE. 11, 9, 15 p., e0163750.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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15 Citations (Scopus)

The role of follicular helper T cell molecules and environmental influences in autoantibody production and progression to inflammatory arthritis in mice

Chevalier, N., Macia, L., Tan, J. K., Mason, L. J., Robert, R., Thorburn, A. N., Wong, C. H. Y., Tsai, L. M., Bourne, K., Brink, R., Yu, D. & Mackay, C. R., 4 Apr 2016, In : Arthritis and Rheumatology. 68, 4, p. 1026-1038 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015
48 Citations (Scopus)

An acetate-specific GPCR, FFAR2, regulates insulin secretion

Priyadarshini, M., Villa, S. R., Fuller, M., Wicksteed, B., Mackay, C. R., Alquier, T., Poitout, V., Mancebo, H., Mirmira, R. G., Gilchrist, A. & Layden, B. T., 2015, In : Molecular Endocrinology. 29, 7, p. 1055 - 1066 12 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

A role for gut microbiota and the metabolite-sensing receptor GPR43 in a murine model of gout

Vieira, A. T., Macia, L., Galvao, I., Martins, F. S., Canesso, M. C. C., Amaral, F. A., Garcia, C. C. O., Maslowski, K. M., De Leon, E., Shim, D. S. C., Nicoli, J. R., Harper, J. L., Teixeira, M. M. & Mackay, C. R., 2015, In : Arthritis and Rheumatology. 67, 6, p. 1646 - 1656 11 p.

Research output: Contribution to journalArticleResearchpeer-review

238 Citations (Scopus)

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

Thorburn, A. N., McKenzie, C., Shen, S. S., Stanley, D., Macia, L., Mason, L. J., Roberts, L. K., Wong, C. H. Y., Shim, R., Robert, R., Chevalier, N., Tan, J. K., Marino, E. M., Moore, R. J., Wong, L. H. H., McConville, M. J., Tull, D. L., Wood, L., Murphy, V., Mattes, J. & 3 others, Gibson, P. G., Wood, L. G. & Mackay, C. R., 2015, In : Nature Communications. 6, 7320, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)

GPR43 - a prototypic metabolite sensor linking metabolic and inflammatory diseases

McKenzie, C., Mackay, C. R. & Macia, L., Oct 2015, In : Trends in Endocrinology and Metabolism. 26, 10, p. 511-512 2 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

292 Citations (Scopus)

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., McKenzie, C., Hijikata, A., Wong, C. H. Y., Binge, L. C., Thorburn, A. N., Chevalier, N., Ang Kim Lian, C., Marino Moreno, E., Robert, R., Offermanns, S., Teixeira, M. M., Moore, R. J., Flavell, R. A. & 2 others, Fagarasan, S. & Mackay, C. R., 2015, In : Nature Communications. 6, (Art. No: 7734), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
8 Citations (Scopus)

Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model

Atkinson, S. M., Nansen, A., Usher, P. A., Sondergaard, B. C., Mackay, C. R., Friedrichsen, B. N., Chang, C-C., Tang, R., Skov, S., Haase, C. G. & Hornum, L., 2015, In : Autoimmunity. 48, 7, p. 460 - 470 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Adhesion molecules and chemoattractants in autoimmunity

Mackay, C. R. & von Andrian, U. H., 2014, The Autoimmune Diseases. Rose, N. R. & Mackay, I. R. (eds.). 5th ed. USA: Elsevier, p. 297-308 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

12 Citations (Scopus)

BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice

Marino Moreno, E., Walters, S. N., Villanueva, J. E., Richards, J. L., Mackay, C. R. & Grey, S. T., 2014, In : European Journal of Immunology. 44, 4, p. 983 - 993 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

CXCR3(+)CCR5(+) T cells and autoimmune diseases: guilty as charged?

Mackay, C. R., 2014, In : Journal of Clinical Investigation. 124, 9, p. 3682 - 3684 3 p.

Research output: Contribution to journalArticleOther

7 Citations (Scopus)

Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2K(d) -specific CD8+ T cells

Rahir, G., Wathelet, N., Hanoteau, A., Henin, C., Oldenhove, G., Galuppo, A., Lanaya, H., Colau, D., Mackay, C. R., Van den Eynde, B. J. & Moser, M., 2014, In : International Journal of Cancer. 134, 12, p. 2841 - 2852 12 p.

Research output: Contribution to journalArticleResearchpeer-review

306 Citations (Scopus)

Diet, metabolites, and "Western-lifestyle" inflammatory diseases

Thorburn, A. N., Macia, L. & Mackay, C. R., 2014, In : Immunity. 40, 6, p. 833 - 842 10 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Inflammation and Lymphopenia Trigger Autoimmunity by Suppression of IL-2-Controlled Regulatory T Cell and Increase of IL-21-Mediated Effector T Cell Expansion

Chevalier, N., Thorburn, A. N., Macia, L., Tan, J., Juglair, L., Yagita, H., Yu, D., Hansbro, P. M. & Mackay, C. R., 2014, In : Journal of Immunology. 193, 10, p. 4845 - 4858 14 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Rapid-onset clinical and mechanistic effects of anti-C5aR treatment in the mouse collagen-induced arthritis model

Andersson, C. T., Wenander, C. S., Usher, P. A., Hebsgaard, J. B., Sondergaard, B. C., Rono, B., Mackay, C. R., Friedrichsen, B. N., Chang, C., Tang, R. & Hornum, L., 2014, In : Clinical and Experimental Immunology. 177, 1, p. 219 - 233 15 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice

Chtanova, T., Hampton, H. R., Waterhouse, L. A., Wood, K., Tomura, M., Miwa, Y., Mackay, C. R., Brink, R. & Phan, T. G., 2014, In : Journal of Biophotonics. 7, 6, p. 425 - 433 9 p.

Research output: Contribution to journalArticleResearchpeer-review

395 Citations (Scopus)

The role of short-chain fatty acids in health and disease

Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R. & Macia, L., 2014, In : Advances in Immunology. 121, p. 91 - 119 29 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
295 Citations (Scopus)

Circulating precursor CCR7(lo)PD-1(hi) CXCR5(+) CD4(+) T cells indicate Tfh cell activity and promote antibody responses upon antigen reexposure

He, J., Tsai, L. M., Leong, Y. A., Hu, X. J., Ma, C. S., Chevalier, N., Sun, X., Vandenberg, K., Rockman, S., Ding, Y., Zhu, L., Wei, W., Wang, C., Karnowski, A., Belz, G. T., Ghali, J. R., Cook, M. C., Riminton, S., Veillette, A., Schwartzberg, P. L. & 7 others, Mackay, F., Brink, R., Tangye, S. G., Vinuesa, C. G., Mackay, C. R., Li, Z. G. & Yu, D., 2013, In : Immunity. 39, p. 770 - 781 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Erratum: B-Cell cross-presentation of autologous antigen precipitates diabetes (Diabetes( 2012) 61 (2893-2905))

Mariño, E., Tan, B., Binge, L., Mackay, C. R. & Grey, S. T., Feb 2013, In : Diabetes. 62, 2, p. 662 1 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

2012
50 Citations (Scopus)

B-cell cross-presentation of autologous antigen precipitates diabetes

Marino, E., Tan, B., Binge, L. C., Mackay, C. R. & Grey, S. T., 2012, In : Diabetes. 61, 11, p. 2893 - 2905 13 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice

Starkey, M. R., Kim, R. Y., Beckett, E. L., Schilter, H. C., Shim, D. SC., Essilfie, A-T., Nguyen, D. H., Beagley, K. W., Mattes, J., Mackay, C. R., Horvat, J. C. & Hansbro, P. M., 2012, In : PLoS ONE. 7, 8, 7 p., e42588.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Development and uses for monoclonal antibodies to chemoattractant receptors

Mackay, C. R., May 2012, In : Current Immunology Reviews. 8, 2, p. 149-153 5 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

51 Citations (Scopus)

IL-21 enhances the potential of human {gamma delta} T cells to provide B-cell help

Bansal, R. R., Mackay, C. R., Moser, B. & Eberl, M., 2012, In : European Journal of Immunology. 42, 1, p. 110 - 119 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling

Gunton, J. E., Sisavanh, M., Stokes, R. A., Satin, J., Satin, L. S., Zhang, M., Liu, S. M., Cai, W., Cheng, K., Cooney, G. J., Laybutt, D. R., So, T., Molero, J-C., Grey, S. T., Andres, D. A., Rolph, M. S. & Mackay, C. R., 2012, In : PLoS ONE. 7, 6, 9 p., e39462.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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112 Citations (Scopus)

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases

Macia, L., Thorburn, A. N., Binge, L. C., Marino Moreno, E., Rogers, K. E., Maslowski, K. M., Vieira, A. T., Kranich, J. & Mackay, C. R., 2012, In : Immunological Reviews. 245, 1, p. 164 - 176 13 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Protection against Nippostrongylus brasiliensis infection in mice is independent of GM-CSF

Shim, D. SC., Schilter, H. C., Knott, M. L., Almeida, R. A., Short, R. P., Mackay, C. R., Dent, L. A. & Sewell, W. A., 2012, In : Immunology and Cell Biology. 90, 5, p. 553 - 558 6 p.

Research output: Contribution to journalArticleResearchpeer-review