Projects per year
Personal profile
Biography
Dr Charbel Darido graduated with a Master in Endocrinology and a Master in Physiology before completing his PhD studies on colon cancer at the University of Montpellier in France. He then moved to Australia to conduct post-doctoral studies at the Royal Melbourne Hospital and the University of Melbourne. Here he initiated a cancer project that led to the identification of a critical tumour suppressor gene against squamous cell carcinoma (SCC) of skin and head & neck tissues.
Following his first post-doc, he relocated to Monash University to lead the cancer program in the “epidermal development laboratory” at the School of Translational Medicine (The Alfred Centre). More recently, Dr Darido was appointed a Group Leader position within the Cancer Therapeutic Program at Peter Mac to establish a vibrant research program on head and neck cancer. The main focus of his lab is to develop model systems for the investigation of head & neck SCC with an emphasis on studying the initiating lesions and identifying the cell of origin of these cancers.
His research group studies the molecular basis of cancer, with emphasis on basic mechanisms of tumour suppression and signal transduction and their dysregulation in skin and head and neck squamous cell carcinogenesis. He is recognised for his pioneering research aimed at unravelling the complexity of the intracellular signalling circuitries by which loss of transcription factors promote oncogenic addiction, thereby leading to malignant transformation and cancer cell proliferation.
Dr Darido’s current investigations are made possible through the use of genetically engineered mouse models and carcinogenic protocols, orthotopic SCC xenografts and cultured cancer-derived cell lines. His ultimate goal is to translate molecular insights into new strategies of preventing and treating this disease, which causes significant mortality and morbidity worldwide.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Squamous cell carcinoma
- Head and neck cancer
- Cancer
Collaborations and top research areas from the last five years
Projects
- 2 Finished
-
Charactereization of two therapeutic strategies for squamous cell carcinoma of the skin in mice and human
1/01/12 → 31/12/13
Project: Research
-
YBX1 integration of oncogenic PI3K/mTOR signalling regulates the fitness of malignant epithelial cells
Bai, Y., Gotz, C., Chincarini, G., Zhao, Z., Slaney, C., Boath, J., Furic, L., Angel, C., Jane, S. M., Phillips, W. A., Stacker, S. A., Farah, C. S. & Darido, C., 22 Mar 2023, In: Nature Communications. 14, 1, 16 p., 1591.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Citations (Scopus) -
EHF is essential for epidermal and colonic epithelial homeostasis, and suppresses Apc-initiated colonic tumorigenesis
Reehorst, C. M., Nightingale, R., Luk, I. Y., Jenkins, L., Koentgen, F., Williams, D. S., Darido, C., Tan, F., Anderton, H., Chopin, M., Schoffer, K., Eissmann, M. F., Buchert, M., Mouradov, D., Sieber, O. M., Ernst, M., Dhillon, A. S. & Mariadason, J. M., Jun 2021, In: Development. 148, 12, 10 p., dev199542.Research output: Contribution to journal › Article › Research › peer-review
Open Access14 Citations (Scopus) -
Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure
Carpinelli, M. R., De Vries, M. E., Auden, A., Butt, T., Deng, Z., Partridge, D. D., Miles, L. B., Georgy, S. R., Haigh, J. J., Darido, C., Brabletz, S., Brabletz, T., Stemmler, M. P., Dworkin, S. & Jane, S. M., 1 Mar 2020, In: Disease Models & Mechanisms. 13, 3, 14 p., dmm042218.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile23 Citations (Scopus) -
Loss of GRHL3 leads to TARC/CCL17-mediated keratinocyte proliferation in the epidermis
Goldie, S. J., Cottle, D. L., Tan, F. H., Roslan, S., Srivastava, S., Brady, R., Partridge, D. D., Auden, A., Smyth, I. M., Jane, S. M., Dworkin, S. & Darido, C., 19 Oct 2018, In: Cell Death & Disease. 9, 11, 12 p., 1072.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile29 Citations (Scopus) -
Stage-dependent therapeutic efficacy in PI3K/mTOR-driven squamous cell carcinoma of the skin
Darido, C., Georgy, S. R., Cullinane, C., Partridge, D. D., Walker, R., Srivastava, S., Roslan, S., Carpinelli, M. R., Dworkin, S., Pearson, R. B. & Jane, S. M., 1 Jun 2018, In: Cell Death and Differentiation. 25, 6, p. 1146-1159 14 p.Research output: Contribution to journal › Article › Research › peer-review
36 Citations (Scopus)