Personal profile
Biography
Position
Post-doctoral Fellow
Faculty of Pharmacy and Pharmaceutical Sciences
Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences
Research area keywords
- GPCRs
- Allostery
- muscarinic receptor
- Neurocognitive Processes
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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Development of novel allosteric modulators for the treatment of chronic pain
Imlach, W. (Primary Chief Investigator (PCI)), Scammells, P. (Chief Investigator (CI)), Valant, C. (Chief Investigator (CI)), Christopoulos, A. (Chief Investigator (CI)), Spanswick, D. (Chief Investigator (CI)), Miller, S. (Chief Investigator (CI)), Malik, R. (Associate Investigator (AI)), Taverner, M. (Associate Investigator (AI)) & Tung Ng, K. (Associate Investigator (AI))
1/12/25 → 30/11/27
Project: Research
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Better Treatments for Neurological Disorders: Clinical Potential of Bitopic Ligands
Valant, C. (Primary Chief Investigator (PCI)), Scammells, P. (Chief Investigator (CI)), Thal, D. (Chief Investigator (CI)) & Choy, C. (Chief Investigator (CI))
17/11/25 → 31/12/26
Project: Research
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Harnessing Endogenous Opioids to Treat Gut Motility Disorders and Pain
Poole, D. (Primary Chief Investigator (PCI)), Valant, C. (Chief Investigator (CI)), Carbone, S. (Chief Investigator (CI)), Mobbs, J. (Chief Investigator (CI)), Thal, D. (Associate Investigator (AI)), Scammells, P. (Associate Investigator (AI)), King, S. K. (Associate Investigator (AI)), Imlach, W. (Associate Investigator (AI)), Hamilton, J. (Associate Investigator (AI)) & Veldhuis, N. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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Modulation of the M4 muscarinic receptor for the treatment of schizophrenia
Valant, C. (Primary Chief Investigator (PCI)), Capuano, B. (Chief Investigator (CI)), Choy, C. (Chief Investigator (CI)), Thal, D. (Associate Investigator (AI)), Miao, Y. (Associate Investigator (AI)), Christopoulos, A. (Associate Investigator (AI)), Felder, C. (Associate Investigator (AI)) & Pantellis, C. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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NAMs of Gq-coupled muscarinic acetylcholine receptors
Valant, C. (Primary Chief Investigator (PCI)) & Christopoulos, A. (Chief Investigator (CI))
Department of Defence (Australia)
20/09/21 → 28/02/23
Project: Research
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The Prosperity and Adversity of M4 Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders
Liu, B., Christopoulos, A., Thal, D. M., Capuano, B., Valant, C. & Scammells, P. J., 16 Apr 2025, In: Journal of Medicinal Chemistry. 68, 8, p. 7932–7954 23 p.Research output: Contribution to journal › Review Article › Research › peer-review
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Brain region-specific alterations in gene expression trajectories in the offspring born from influenza A virus infected mice
Liong, S., Choy, K. H. C., De Luca, S. N., Liong, F., Coward-Smith, M., Oseghale, O., Miles, M. A., Vlahos, R., Valant, C., Nithianantharajah, J., Pantelis, C., Christopoulos, A. & Selemidis, S., Aug 2024, In: Brain, Behavior, and Immunity. 120, p. 488-498 11 p.Research output: Contribution to journal › Article › Research › peer-review
1 Link opens in a new tab Citation (Scopus) -
Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders
Liu, B., Thompson, G., Jörg, M., Barnes, N., Thal, D. M., Christopoulos, A., Capuano, B., Valant, C. & Scammells, P. J., 18 Jul 2024, In: Journal of Medicinal Chemistry. 67, 15, p. 13286–13304 19 p.Research output: Contribution to journal › Article › Research › peer-review
1 Link opens in a new tab Citation (Scopus) -
Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor
Jiang, Y., Yeasmin, M., Gondin, A. B., Christopoulos, A., Valant, C., Burger, W. A. C. & Thal, D. M., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2338-2350 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access10 Link opens in a new tab Citations (Scopus) -
Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges
Kaoullas, M. G., Thal, D. M., Christopoulos, A. & Valant, C., 1 Nov 2024, In: Neuropharmacology. 258, 9 p., 110092.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access16 Link opens in a new tab Citations (Scopus)
Prizes
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Denis Wade Johnson & Johnson New Investigator Award 2012
Valant, C. (Recipient), Dec 2012
Prize: Prize (including medals and awards)
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Outstanding New Investigator Award 2012
Valant, C. (Recipient), Dec 2012
Prize: Prize (including medals and awards)
Activities
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World Congress of Neuropsychopharmacology 2025
Choy, C. (Invited speaker), Li, J. C. (Speaker), Jones, N. (Speaker), Pantelis, C. (Speaker), Christopoulos, A. (Speaker) & Valant, C. (Speaker)
Jun 2025Activity: Participating in or organising an event types › Contribution to conference
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ASCEPT 2018
Valant, C. (Invited speaker)
26 Nov 2018 → 30 Nov 2018Activity: Participating in or organising an event types › Contribution to conference
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Introduction to advanced receptor pharmacology
Valant, C. (Organiser)
14 Oct 2018 → 19 Oct 2018Activity: Participating in or organising an event types › Contribution to workshop, seminar, course
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MP-GPCR 2018
Valant, C. (Organiser)
2 Dec 2018 → 4 Dec 2018Activity: Participating in or organising an event types › Contribution to conference
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MP-GPCR 2018
Valant, C. (Invited speaker)
2 Dec 2018 → 4 Dec 2018Activity: Participating in or organising an event types › Contribution to conference