Projects per year
Personal profile
Biography
Dr Cedric Tremblay completed his PhD in Molecular and Cellular Biology (Medicine) at Laval University, Quebec City, Canada in 2008. He was awarded a national Health Research Fund of Quebec (FRSQ) postgraduate scholarship (2004-2008) and training award from the Foundation for Research into Children’s Diseases (2007-2008) at the Laval University Hospital Research Centre (2004-2007) which used animal models to study DNA repair in hematopoiesis. Cedric Tremblay was awarded the prestigious Excellence prize in Pediatric Research, which is annually attributed to recognize the unique contribution of scientists working for the improvement of children health, at the 26th Ball of Stars of the Foundation of Stars in 2008.
He was later awarded a Terry Fox Foundation fellowship from the Canadian Cancer Society for postdoctoral studies in the laboratory of Dr Trang Hoang at the Institute for Research in Immunology and Cancer – University of Montreal, Canada (2008-2011) to study the role of the oncogenes SCL, LMO1 and NOTCH1 in hematopoiesis and T-cell Acute Lymphoblastic Leukemia (T-ALL). In 2011, Cedric Tremblay relocated to the Australian Centre for Blood Diseases (ACBD) to complete a research program on the molecular mechanisms involved in the development of malignant stem cells, within the Stem Cell Research Group under the direction of Prof Professor David Curtis. Over the last 10 years, Cedric Tremblay has established superior and complex mouse models to study the 'stem cell-like' properties of relapse-inducing cells in leukemia.
In 2014, Cedric Tremblay was appointed as a research fellow at the ACBD and awarded a research Grant-in Aid from the Leukaemia Foundation of Australia to establish a translational research program based upon the rationale that the eradication of cancer stem cells (CSCs) is essential for achieving long-term remission in patients. His specific areas of expertise include: the regulation of growth factor-induced signalling pathways and endocytosis in hematopoietic cells; the role of transcription factors and cell cycle regulators to control the fate of normal and malignant hematopoietic stem cells; and the molecular mechanisms of treatment-resistance in leukemia. Although investigating the mechanisms by which malignant stem cells develop, clonally evolve and escape high-dose therapy in acute leukemia remains the primary focus of his research program, his future findings will have important translational implications beyond hematological malignancies.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Anemia
- Biological Sciences
- Blood Diseases
- Bone Marrow
- Gene Regulation
- Immunology
- Leukemia
- Transgenic Animals
Network
Projects
- 3 Finished
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Targeted therapies for chemo-resistant leukaemia cells
National Health and Medical Research Council (NHMRC) (Australia)
1/01/19 → 31/12/21
Project: Research
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Targeting IL-7 signaling pathway in T-cell Acute Lymphoblastic Leukaemia
1/01/14 → 31/12/14
Project: Research
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Mechanism of oncogene collaboration in T cell leukemia
Canadian Cancer Society Research Institute
16/12/11 → 30/06/12
Project: Research
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Author Correction: Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells (Nature Communications, (2020), 11, 1, (6211), 10.1038/s41467-020-20091-6)
Tremblay, C. S., Chiu, S. K., Saw, J., McCalmont, H., Litalien, V., Boyle, J., Sonderegger, S. E., Chau, N., Evans, K., Cerruti, L., Salmon, J. M., McCluskey, A., Lock, R. B., Robinson, P. J., Jane, S. M. & Curtis, D. J., Dec 2021, In: Nature Communications. 12, 1, 1288.Research output: Contribution to journal › Comment / Debate › Other › peer-review
Open Access -
Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation
Fischer, K. C., Daunt, C. P., Tremblay, C. S., Dias, S., Vince, J. E. & Jabbour, A. M., Jan 2021, In: Cell Death & Disease. 12, 1, 16 p., 28.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Shutting the gate: targeting endocytosis in acute leukemia
Tremblay, C. S., Ting, S. B., McCluskey, A., Robinson, P. J. & Curtis, D. J., Dec 2021, In: Experimental Hematology. 104, p. 17-31 15 p.Research output: Contribution to journal › Review Article › Other › peer-review
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Single-cell lineage tracing approaches in hematology research: technical considerations
Carrelha, J., Lin, D. S., Rodriguez-Fraticelli, A. E., Luis, T. C., Wilkinson, A. C., Cabezas-Wallscheid, N., Tremblay, C. S. & Haas, S., Sep 2020, In: Experimental Hematology. 89, p. 26-36 11 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Small molecule inhibition of Dynamin-dependent endocytosis targets multiple niche signals and impairs leukemia stem cells
Tremblay, C. S., Chiu, S. K., Saw, J., McCalmont, H., Litalien, V., Boyle, J. A., Sonderegger, S. E., Chau, N., Evans, K., Cerruti, L., Salmon, J. M., McCluskey, A., Lock, R. B., Robinson, P. J., Jane, S. M. & Curtis, D. J., Dec 2020, In: Nature Communications. 11, 1, 18 p., 6211.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus)
Prizes
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2018 AMREP EMCR Collaborative Seed Grant
Borger, Jessica (Recipient) & Tremblay, Cedric (Recipient), Jan 2018
Prize: Prize (including medals and awards)