Research output per year
Research output per year
Personal profile
Biography
Dr Giannangelo uses state-of-the-art systems biology techniques (metabolomics and proteomics) to understand the complex biology of the malaria parasite, Plasmodium falciparum, and to elucidate the mechanisms of action and resistance for novel malaria therapeutics. The goal of his research is to improve existing, and discovery new, medicines for the treatment of malaria.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Malaria
- Parasitology
- Metabolomics
- Proteomics
- Systems Pharmacology
- Drug Discovery
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Promising antimalarial hits from phenotypic screens: a review of recently-described multi-stage actives and their modes of action
Luo, A. P., Giannangelo, C., Siddiqui, G. & Creek, D. J., 15 Dec 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 12 p., 1308193.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access2 Citations (Scopus) -
Dimeric Artesunate Glycerophosphocholine Conjugate Nano- Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance
Du, Y., Giannangelo, C., He, W., Shami, G. J., Zhou, W., Yang, T., Creek, D. J., Dogovski, C., Li, X. & Tilley, L., May 2022, In: Antimicrobial Agents and Chemotherapy. 66, 5, 13 p., aac.02065-21.Research output: Contribution to journal › Article › Research › peer-review
Open Access12 Citations (Scopus) -
Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells
Siddiqui, G., Giannangelo, C., De Paoli, A., Schuh, A. K., Heimsch, K. C., Anderson, D., Brown, T. G., Macraild, C. A., Wu, J., Wang, X., Dong, Y., Vennerstrom, J. L., Becker, K. & Creek, D. J., 14 Jan 2022, In: ACS Infectious Diseases. 8, 1, p. 210-226 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access24 Citations (Scopus) -
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy
Xie, S. C., Metcalfe, R. D., Dunn, E., Morton, C. J., Huang, S. C., Puhalovich, T., Du, Y., Wittlin, S., Nie, S., Luth, M. R., Ma, L., Kim, M. S., Pasaje, C. F. A., Kumpornsin, K., Giannangelo, C., Houghton, F. J., Churchyard, A., Famodimu, M. T., Barry, D. C., Gillett, D. L., & 17 others, 3 Jun 2022, In: Science. 376, 6597, p. 1074-1079 6 p.Research output: Contribution to journal › Article › Research › peer-review
32 Citations (Scopus) -
System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion
Giannangelo, C., Siddiqui, G., de Paoli, A., Anderson, B. M., Edgington-Mitchell, L. E., Charman, S. A. & Creek, D. J., 26 Jun 2020, In: PLoS Pathogens. 16, 6, 32 p., e1008485.Research output: Contribution to journal › Article › Research › peer-review
Open Access19 Citations (Scopus)