Projects per year
Personal profile
Biography
Dr Giannangelo uses state-of-the-art systems biology techniques (metabolomics and proteomics) to understand the complex biology of the malaria parasite, Plasmodium falciparum, and to elucidate the mechanisms of action and resistance for novel malaria therapeutics. The goal of his research is to improve existing, and discovery new, medicines for the treatment of malaria.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Bachelor of Pharmacy, University of Queensland
Award Date: 31 Oct 2008
Research area keywords
- Malaria
- Parasitology
- Metabolomics
- Proteomics
- Systems Pharmacology
- Drug Discovery
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Projects
- 1 Active
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Discovery of New Antimalarials with a Novel Mechanism of Action and Irresistible Target
Giannangelo, C. (Primary Chief Investigator (PCI)), Dillon, A. (Chief Investigator (CI)), Shackleford, D. (Chief Investigator (CI)), Edstein, M. (Chief Investigator (CI)), Creek, D. (Associate Investigator (AI)), Charman, S. (Associate Investigator (AI)), Burrows, J. N. (Associate Investigator (AI)), Stupple, P. (Associate Investigator (AI)), Gilson, P. (Associate Investigator (AI)), Niles, J. (Associate Investigator (AI)), Delves, M. (Associate Investigator (AI)) & Wittlin, S. (Associate Investigator (AI))
1/01/25 → 31/12/27
Project: Research
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Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4
Ashton, T. D., Calic, P. P. S., Dans, M. G., Ooi, Z. K., Zhou, Q., Palandri, J., Loi, K., Jarman, K. E., Qiu, D., Lehane, A. M., Maity, B. C., De, N., Giannangelo, C., MacRaild, C. A., Creek, D. J., Mao, E. Y., Gancheva, M. R., Wilson, D. W., Chowdury, M. & de Koning-Ward, T. F. & 9 others, , 22 Aug 2024, In: Journal of Medicinal Chemistry. 67, 16, p. 14493-14523 31 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy
Giannangelo, C., Challis, M. P., Siddiqui, G., Edgar, R., Malcolm, T. R., Webb, C. T., Drinkwater, N., Vinh, N., Macraild, C., Counihan, N., Duffy, S., Wittlin, S., Devine, S. M., Avery, V. M., De Koning-Ward, T., Scammells, P., McGowan, S. & Creek, D. J., 8 Jul 2024, In: eLife. 13, 32 p., RP92990.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity
Edgar, R. C. S., Malcolm, T. R., Siddiqui, G., Giannangelo, C., Counihan, N. A., Challis, M., Duffy, S., Chowdhury, M., Marfurt, J., Dans, M., Wirjanata, G., Noviyanti, R., Daware, K., Suraweera, C. D., Price, R. N., Wittlin, S., Avery, V. M., Drinkwater, N., Charman, S. A. & Creek, D. J. & 3 others, , 12 Jun 2024, In: mBio. 15, 6, 27 p., e0096624.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Promising antimalarial hits from phenotypic screens: a review of recently-described multi-stage actives and their modes of action
Luo, A. P., Giannangelo, C., Siddiqui, G. & Creek, D. J., 15 Dec 2023, In: Frontiers in Cellular and Infection Microbiology. 13, 12 p., 1308193.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access2 Citations (Scopus) -
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy
Xie, S. C., Metcalfe, R. D., Dunn, E., Morton, C. J., Huang, S. C., Puhalovich, T., Du, Y., Wittlin, S., Nie, S., Luth, M. R., Ma, L., Kim, M. S., Pasaje, C. F. A., Kumpornsin, K., Giannangelo, C., Houghton, F. J., Churchyard, A., Famodimu, M. T., Barry, D. C. & Gillett, D. L. & 17 others, , 3 Jun 2022, In: Science. 376, 6597, p. 1074-1079 6 p.Research output: Contribution to journal › Article › Research › peer-review
38 Citations (Scopus)
Prizes
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ANZMN Travel Award
Giannangelo, C. (Recipient), 17 Jul 2015
Prize: Prize (including medals and awards)
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Australian Society for Parasitology Student Travel Grant
Giannangelo, C. (Recipient), 13 Jul 2016
Prize: Prize (including medals and awards)
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D4 Early Career Researcher Travel Award
Giannangelo, C. (Recipient), 20 Jun 2023
Prize: Prize (including medals and awards)
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Postgraduate Publications Award
Giannangelo, C. (Recipient), 1 May 2018
Prize: Prize (including medals and awards)
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RSTMH Early Career Grant
Giannangelo, C. (Recipient), 5 Oct 2022
Prize: Prize (including medals and awards)
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Malaria in Melbourne 2025
Giannangelo, C. (Organiser)
1 Jan 2025 → …Activity: Participating in or organising an event types › Contribution to conference
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Frontiers in Malaria (Journal)
Giannangelo, C. (Associate editor)
16 Dec 2024 → …Activity: Publication peer-review and editorial work types › Editorial responsibility
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Melbourne Malaria Seminar Series 2023
Giannangelo, C. (Member of programme committee)
1 Jan 2023 → …Activity: Participating in or organising an event types › Contribution to conference
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Malaria in Melbourne 2023
Giannangelo, C. (Member of programme committee)
1 Jan 2023 → …Activity: Participating in or organising an event types › Contribution to conference
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EMCR Committee
Giannangelo, C. (Fellow)
2022 → …Activity: External Academic Engagement › Committees and working groups