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2020

Connexin-Dependent Transfer of cGAMP to Phagocytes Modulates Antiviral Responses

Pépin, G., De Nardo, D., Rootes, C. L., Ullah, T. R., Al-Asmari, S. S., Balka, K. R., Li, H-M., Quinn, K. M., Moghaddas, F., Chappaz, S., Kile, B. T., Morand, E. F., Masters, S. L., Stewart, C. R., Williams, B. R. G. & Gantier, M. P., 28 Jan 2020, In : mBio. 11, 1, 6 p., e03187-19.

Research output: Contribution to journalArticleResearchpeer-review

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2018

(−)-Epigallocatechin-3-gallate and EZH2 inhibitor GSK343 have similar inhibitory effects and mechanisms of action on colorectal cancer cells

Ying, L., Yan, F., Williams, B. R. G., Xu, P., Li, X., Zhao, Y., Hu, Y., Wang, Y., Xu, D. & Dai, J., 1 Jan 2018, In : Clinical and Experimental Pharmacology and Physiology. 45, 1, p. 58-67 10 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Meeting summary: 2nd Aegean Conference on Cytokine Signaling in Cancer

Ilangumaran, S., Williams, B. R. G. & Kalvakolanu, D. V., Aug 2018, In : Cytokine. 108, p. 225-231 7 p.

Research output: Contribution to journalArticleOtherpeer-review

PD-L1 expression is a prognostic factor in subgroups of gastric cancer patients stratified according to their levels of CD8 and FOXP3 immune markers

Ying, L., Yan, F., Meng, Q., Yu, L., Yuan, X., Gantier, M. P., Williams, B. R. G., Chan, D. W., Shi, L., Tu, Y., Ni, P., Wang, X., Chen, W., Zang, X., Xu, D. & Hu, Y., 20 Feb 2018, In : OncoImmunology. 7, 6, 11 p., e1433520.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2017

(-)-Epigallocatechin-3-gallate and atorvastatin treatment down-regulates liver fibrosis-related genes in non-alcoholic fatty liver disease

Ying, L., Yan, F., Zhao, Y., Gao, H., Williams, B. R. G., Hu, Y., Li, X., Tian, R., Xu, P. & Wang, Y., 1 Dec 2017, In : Clinical and Experimental Pharmacology and Physiology. 44, 12, p. 1180-1191 12 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Activation of cGAS-dependent antiviral responses by DNA intercalating agents

Pepin, G., Nejad, C., Thomas, B. J., Ferrand, J., McArthur, K., Bardin, P. G., Williams, B. R. G. & Gantier, M. P., 9 Jan 2017, In : Nucleic Acids Research. 45, 1, p. 198-205 8 p.

Research output: Contribution to journalArticleResearchpeer-review

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9 Citations (Scopus)

An emergence framework of carcinogenesis

Sigston, E. A. W. & Williams, B. R. G., 14 Sep 2017, In : Frontiers in Oncology. 7, SEP, 14 p., 198.

Research output: Contribution to journalArticleResearchpeer-review

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5 Citations (Scopus)

A non-canonical function of Ezh2 preserves immune homeostasis

Vasanthakumar, A., Xu, D., Lun, A. T. L., Kueh, A. J., van Gisbergen, K. P. J. M., Iannarella, N., Li, X., Yu, L., Wang, D., Williams, B. RG., Lee, S. C. W., Majewski, I. J., Godfrey, D. I., Smyth, G. K., Alexander, W. S., Herold, M. J., Kallies, A., Nutt, S. L. & Allan, R. S., 1 Apr 2017, In : EMBO Reports. 18, 4, p. 619-631 13 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

ATF3 repression of BCL-XL determines apoptotic sensitivity to HDAC inhibitors across tumor types

Chüeh, A. C., Tse, J. W. T., Dickinson, M., Ioannidis, P., Jenkins, L., Togel, L., Tan, B. S., Luk, I., Davalos-Salas, M., Nightingale, R., Thompson, M. R., Williams, B. R. G., Lessene, G., Lee, E. F., Fairlie, W. D., Dhillon, A. S. & Mariadason, J. M., 15 Sep 2017, In : Clinical Cancer Research. 23, 18, p. 5573-5584 12 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Auto-phosphorylation represses protein kinase R activity

Wang, D., De Weerd, N. A., Willard, B., Polekhina, G., Williams, B. R. G. & Sadler, A. J., 10 Mar 2017, In : Scientific Reports. 7, 15 p., 44340.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Identification of a histone family gene signature for predicting the prognosis of cervical cancer patients

Li, X., Tian, R., Gao, H., Yang, Y., Williams, B. R. G., Gantier, M. P., McMillan, N. A. J., Xu, D., Hu, Y. & Gao, YE., 1 Dec 2017, In : Scientific Reports. 7, 1, 13 p., 16495.

Research output: Contribution to journalArticleResearchpeer-review

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10 Citations (Scopus)

Integrin-linked kinase expression in myeloid cells promotes inflammatory signaling during experimental colitis

Ahmed, A. U., Yim, H. C. H., Alorro, M. G., Ernst, M. & Williams, B. R. G., 15 Sep 2017, In : Journal of Immunology. 199, 6, p. 2128-2139 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation

Dou, Y., Yim, H. C. H., Kirkwood, C. D., Williams, B. R. G. & Sadler, A. J., 15 Sep 2017, In : EMBO Journal. 36, 18, p. 2742-2757 16 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Topoisomerase 1 inhibition promotes cyclic GMP-AMP synthase-dependent antiviral responses

Pépin, G., Nejad, C., Ferrand, J., Thomas, B. J., Stunden, H. J., Sanij, E., Foo, C. H., Stewart, C. R., Cain, J. E., Bardin, P. G., Williams, B. R. G. & Gantier, M. P., 1 Sep 2017, In : mBio. 8, 5, 9 p., e01611-17.

Research output: Contribution to journalArticleResearchpeer-review

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3 Citations (Scopus)

Understanding immune phenotypes in human gastric disease tissues by multiplexed immunohistochemistry

Ying, L., Yan, F., Meng, Q., Yuan, X., Yu, L., Williams, B. R. G., Chan, D. W., Shi, L., Tu, Y., Ni, P., Wang, X., Xu, D. & Hu, Y., 12 Oct 2017, In : Journal of Translational Medicine. 15, 1, 11 p., 206.

Research output: Contribution to journalArticleResearchpeer-review

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4 Citations (Scopus)
2016

Activating transcription factor 3 expression as a marker of response to the histone deacetylase inhibitor pracinostat

Sooraj, D., Xu, D., Cain, J. E., Gold, D. P. & Williams, B. R. G., 1 Jul 2016, In : Molecular Cancer Therapeutics. 15, 7, p. 1726-1739 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Cre-dependent DNA recombination activates a STING-dependent innate immune response

Pépin, G., Ferrand, J., Höning, K., Jayasekara, W. S. N., Cain, J. E., Behlke, M. A., Gough, D. J., Williams, B. R. G., Hornung, V. & Gantier, M. P., 20 Jun 2016, In : Nucleic Acids Research. 44, 11, p. 5356-5364 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

Surgical margins in head and neck squamous cell carcinoma: Effect of heat artifact on immunohistochemistry as a future tool for assessment

Sigston, E. A. W., Longano, A., Strzelecki, A. T. & Williams, B. R. G., Sep 2016, In : Head & Neck. 38, 9, p. 1401-1406 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

The kinase activity of PKR represses inflammasome activity

Yim, H. C. H., Wang, D., Yu, L., White, C. L., Faber, P. W., Williams, B. R. G. & Sadler, A. J., 1 Mar 2016, In : Cell Research. 26, 3, p. 367-379 13 p.

Research output: Contribution to journalArticleResearchpeer-review

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15 Citations (Scopus)
2015

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

Sadler, A. J., Rossello, F. J., Yu, L., Deane, J. A., Yuan, X-L., Wang, D., Irving, A. T., Liaskos, M., Gantier, M. P. M., Ying, H., Yim, H. C. H., Hartland, E. L., Notini, A. J., De Boer, C. M., White, S., Mansell, A. S., Liu, J-P., Watkins, D. N., Gerondakis, S. D., Williams, B. R. G. & 1 others, Xu, D., 2015, In : Proceedings of the National Academy of Sciences. 112, 5, p. 1535 - 1540 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
34 Citations (Scopus)

IL-10 regulates Aicda expression through miR-155

Fairfax, K., Gantier, M. P. M., Mackay-Fisson, F., Williams, B. R. G. & McCoy, C., 2015, In : Journal of leukocyte biology. 97, 1, p. 71 - 78 8 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Sequence-dependent off-target inhibition of TLR7/8 sensing by synthetic microRNA inhibitors

Sarvestani, S., Stunden, H. J., Behlke, M. A., Forster, S., McCoy, C., Tate, M., Ferrand, J. F. P., Lennox, K. A., Latz, E., Williams, B. R. G. & Gantier, M. P. M., 30 Jan 2015, In : Nucleic Acids Research. 43, 2, p. 1177-1188 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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23 Citations (Scopus)

Telomerase deficiency causes alveolar stem cell senescence-associated low-grade inflammation in lungs

Chen, R., Zhang, K., Chen, H., Zhao, X., Wang, J., Li, L., Cong, Y-S., Ju, Z., Xu, D., Williams, B. R. G., Jia, J. & Liu, J-P., 2015, In : Journal of Biological Chemistry. 290, 52, p. 30813 - 30829 17 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The acetyltransferase HAT1 moderates the NF-?B response by regulating the transcription factor PLZF

Sadler, A. J., Suliman, B. A., Yu, L., Yuan, X-L., Wang, D., Irving, A. T., Sarvestani, S., Banerjee, A., Mansell, A. S., Liu, J-P., Gerondakis, S. D., Williams, B. R. G. & Xu, D., 2015, In : Nature Communications. 6, 13 (Art. ID: 6795), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
28 Citations (Scopus)

The protein activator of protein kinase R, PACT/RAX, negatively regulates protein kinase R during mouse anterior pituitary development

Dickerman, B. K., White, C. L., Kessler, P. M., Sadler, A. J., Williams, B. R. G. & Sen, G. C., 2015, In : FEBS Journal. 282, 24, p. 4766 - 4781 16 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)
2014

High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

De Nardo, D. F., Labzin, L. I., Kono, H., Seki, R., Schmidt, S. V., Beyer, M., Xu, D., Zimmer, S., Lahrmann, C., Schildberg, F. A., Vogelhuber, J., Kraut, M., Ulas, T., Kerksiek, A., Krebs, W., Bode, N., Grebe, A., Fitzgerald, M. L., Hernandez, N. J., Williams, B. R. G. & 7 others, Knolle, P. A., Kneilling, M., Rocken, M., Lutjohann, D., Wright, S. D., Schultze, J. L. & Latz, E., 2014, In : Nature Immunology. 15, 2, p. 152 - 160 9 p.

Research output: Contribution to journalArticleResearchpeer-review

180 Citations (Scopus)

Inosine-mediated modulation of RNA sensing by Toll-like receptor 7 (TLR7) and TLR8

Sarvestani, S., Tate, M., Moffat, J. M., Jacobi, A. M., Behlke, M. A., Miller, A., Beckham, S. A., McCoy, C., Chen, W., Mintern, J., O'Keeffe, M., John, M., Williams, B. R. G. & Gantier, M. P. M., 2014, In : Journal of Virology. 88, 2, p. 799 - 810 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)

Molecular dynamics reveal a novel kinase-substrate interface that regulates protein translation

Liu, M. S., Wang, D., Morimoto, H., Yim, H. C. H., Irving, A. T., Williams, B. R. G. & Sadler, A. J., 2014, In : Journal of Molecular Cell Biology. 6, 6, p. 473 - 485 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Protein kinase R and the inflammasome

Yim, H. C. H. & Williams, B. R. G., 2014, In : Journal of Interferon and Cytokine Research. 34, 6, p. 447 - 454 8 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

The role of Ets2 transcription factor in the induction of microRNA-155 (miR-155) by lipopolysaccharide and its targeting by interleukin-10

Quinn, S. R., Mangan, N., Caffrey, B. E., Gantier, M. P. M., Williams, B. R. G., Hertzog, P. J., McCoy, C. & O'Neill, L. A. J., 2014, In : Journal of Biological Chemistry. 289, 7, p. 4316 - 4325 10 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)
2013

Activating transcription factor 3 contributes to Toll-like receptor-mediated macrophage survival via repression of Bax and Bak

Thompson, M., Xu, D. & Williams, B. R. G., 2013, In : Journal of Interferon and Cytokine Research. 33, 11, p. 682 - 693 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

ATF3 suppresses metastasis of bladder cancer by regulating gelsolin-mediated remodeling of the actin cytoskeleton

Yuan, X., Yu, L., Li, J., Xie, G., Rong, T., Zhang, L., Chen, J., Meng, Q., Irving, A. T., Wang, D., Williams, E., Liu, J-P., Sadler, A. J., Williams, B. R. G., Shen, L. & Xu, D., 2013, In : Cancer Research. 73, 12, p. 3625 - 3637 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
60 Citations (Scopus)

Conformational rearrangements of RIG-I receptor on formation of a multiprotein:dsRNA assembly

Beckham, S. A., Brouwer, J. M., Roth, A., Wang, D., Sadler, A. J., John, M., Jahn-Hofmann, K., Williams, B. R. G., Wilce, J. A. & Wilce, M. C. J., 2013, In : Nucleic Acids Research. 41, 5, p. 3436 - 3445 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
20 Citations (Scopus)

Fine tuning type I interferon responses

Hertzog, P. J. & Williams, B. R. G., 2013, In : Cytokine and Growth Factor Reviews. 24, 3, p. 217 - 225 9 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

The use of miRNA microarrays for the analysis of cancer samples with global miRNA decrease

Wu, D., Hu, Y., Tong, S., Williams, B. R. G., Smyth, G. K. & Gantier, M. P. M., 2013, In : Rna-A Publication of the Rna Society. 19, 7, p. 876 - 888 13 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)
2012

A miR-19 regulon that controls NF-{kappa}B signaling

Gantier, M. P. M., Stunden, H. J., McCoy, C., Behlke, M. A., Wang, D., Liaskos, M., Sarvestani, S., Yang, Y. H., Xu, D., Corr, S. C., Morand, E. F. & Williams, B. R. G., 2012, In : Nucleic Acids Research. 40, 16, p. 8048 - 8058 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
117 Citations (Scopus)

HDACi: molecular mechanisms and therapeutic implications in the innate immune system

Suliman, B., Xu, D. & Williams, B., 2012, In : Immunology and Cell Biology. 90, 1, p. 23 - 32 10 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Human Toll-like receptor 8 can be cool too: implications for foreign RNA sensing

Sarvestani, S., Williams, B. R. G. & Gantier, M. P. M., 2012, In : Journal of Interferon and Cytokine Research. 32, 8, p. 350 - 361 12 p.

Research output: Contribution to journalArticleResearchpeer-review

21 Citations (Scopus)

Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense

Irving, A., Wang, D., Vasilevski, O., Latchoumanin, O., Kozer, N., Clayton, A., Szczepny, A., Morimoto, H., Xu, D., Williams, B. & Sadler, A., 2012, In : Immunity. 36, 5, p. 795 - 806 12 p.

Research output: Contribution to journalArticleResearchpeer-review

28 Citations (Scopus)
2 Citations (Scopus)

siRNA-induced immunostimulation through TLR7 promotes antitumoral activity against HPV-driven tumors in vivo

Khairuddin, N., Gantier, M., Blake, S., Wu, S., Behlke, M., Williams, B. & McMillan, N., 2012, In : Immunology and Cell Biology. 90, 2, p. 187 - 196 10 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

The promyelocytic leukemia zinc finger protein: two decades of molecular oncology

Suliman, B. A., Xu, D. & Williams, B. R. G., 2012, In : Frontiers in Oncology. 2, 74, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
56 Citations (Scopus)
2011

Analysis of microRNA turnover in mammalian cells following Dicer1 ablation

Gantier, M., McCoy, C., Rusinova, I., Saulep, D., Wang, D., Xu, D., Irving, A., Behlke, M., Hertzog, P., Mackay-Fisson, F. & Williams, B., 2011, In : Nucleic Acids Research. 39, 13, p. 5692 - 5703 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
245 Citations (Scopus)

Different modes of interaction by TIAR and HuR with target RNA and DNA

Kim, H. S., Wilce, M. C. J., Yoga, Y., Pendini, N. R., Gunzburg, M. J., Cowieson, N., Wilson, G. M., Williams, B., Gorospe, M. & Wilce, J. A., 2011, In : Nucleic Acids Research. 39, 3, p. 1117 - 1130 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
44 Citations (Scopus)
2010

Genetic modulation of TLR8 response following bacterial phagocytosis

Gantier, M. P. M., Irving, A. T., Liaskos, M., Xu, D., Evans, V., Cameron, P. U., Bourne, J. A., Ferrero, R. L., John, M., Behlke, M. A. & Williams, B. R. G., 2010, In : Human Mutation. 31, 9, p. 1069 - 1079 11 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Rational design of immunostimulatory siRNAs

Gantier, M. P. M., Tong, S., Behlke, M. A., Irving, A. T., Lappas, M., Nilsson, U. W., Latz, E., McMillan, N. A. J. & Williams, B. R. G., 2010, In : Molecular Therapy. 18, 4, p. 785 - 795 11 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Role of PKR and Type I IFNs in viral control during primary and secondary infection

Nakayama, Y., Plisch, E. H., Sullivan, J., Thomas, C., Czuprynski, C. J., Williams, B. R. G. & Suresh, M., 2010, In : PLoS Pathogens. 6, 6 (e1000966), p. 1 - 19 19 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Tumor cell response to synchrotron microbeam radiation therapy differs markedly from cells in normal tissues

Crosbie, J., Anderson, R., Rothkamm, K., Restall, C., Cann, L. M., Ruwanpura, S. M., Meachem, S. J., Yagi, N., Svalbe, I. D., Lewis, R., Williams, B. R. G. & Rogers, P. A. W., 2010, In : International Journal of Radiation Oncology Biology Physics. 77, 3, p. 886 - 894 9 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

Viral apoptosis is induced by IRF-3-mediated activation of Bax

Chattopadhyay, S., Marques, J. T., Yamashita, M., Peters, K. L., Smith, K., Desai, A., Williams, B. R. G. & Sen, G. C., 2010, In : EMBO Journal. 29, 10, p. 1762 - 1773 12 p.

Research output: Contribution to journalArticleResearchpeer-review

143 Citations (Scopus)