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2020

Systemic treatment with human amnion epithelial cells after experimental traumatic brain injury

Kim, H. A., Semple, B. D., Dill, L. K., Pham, L., Dworkin, S., Zhang, S. R., Lim, R., Sobey, C. G. & McDonald, S. J., May 2020, In : Brain, Behavior, and Immunity. 5, 8 p., 100072.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model

Zamani, A., Powell, K. L., May, A. & Semple, B. D., 1 Mar 2020, In : Brain Research Bulletin. 156, p. 43-49 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice

Webster, K. M., Sun, M., Crack, P. J., O'Brien, T. J., Shultz, S. R. & Semple, B. D., 15 Apr 2019, In : The Journal of Comparative Neurology. 527, 6, p. 1102-1117 16 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

Munji, R. N., Soung, A. L., Weiner, G. A., Sohet, F., Semple, B., Trivedi, A., Gimlin, K., Kotoda, M., Korai, M., Aydin, S., Batugal, A., Cabangcala, A. C., Schupp, P. G., Oldham, M. C., Hashimoto, T., Noble-Haeusslein, L. J. & Daneman, R., 14 Oct 2019, In : Nature Neuroscience. 22, 11, p. 1892–1902 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

Webster, K. M., Shultz, S. R., Ozturk, E., Dill, L. K., Sun, M., Casillas-Espinosa, P., Jones, N. C., Crack, P. J., O'Brien, T. J. & Semple, B. D., 1 Oct 2019, In : Experimental Neurology. 320, 14 p., 112979.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
2018

A concomitant muscle injury does not worsen traumatic brain injury outcomes in mice

Sun, M., Brady, R. D., Poel, C. V. D., Apted, D., Semple, B. D., Church, J. E., O'Brien, T. J., McDonald, S. J. & Shultz, S. R., 11 Dec 2018, In : Frontiers in Neurology. 9, 11 p., 1089.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mild traumatic brain injury in adolescent mice alters skull bone properties to influence a subsequent brain impact at adulthood: A pilot study

McColl, T. J., Brady, R. D., Shultz, S. R., Lovick, L., Webster, K. M., Sun, M., McDonald, S. J., O'Brien, T. J. & Semple, B. D., 25 May 2018, In : Frontiers in Neurology. 9, 15 p., 372.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Oculomotor Cognitive Control Abnormalities in Australian Rules Football Players with a History of Concussion

Clough, M., Mutimer, S., Wright, D. K., Tsang, A., Costello, D. M., Gardner, A. J., Stanwell, P., Mychasiuk, R., Sun, M., Brady, R. D., McDonald, S. J., Webster, K. M., Johnstone, M. R., Semple, B. D., Agoston, D. V., White, O. B., Frayne, R., Fielding, J., O'Brien, T. J. & Shultz, S. R., 1 Mar 2018, In : Journal of Neurotrauma. 35, 5, p. 730-738 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)
2017

Interleukin-1 receptor in seizure susceptibility after traumatic injury to the pediatric brain

Semple, B. D., O’Brien, T. J., Gimlin, K., Wright, D. K., Kim, S. E., Casillas-Espinosa, P. M., Webster, K. M., Petrou, S. & Noble-Haeusslein, L. J., 16 Aug 2017, In : Journal of Neuroscience. 37, 33, p. 7864-7877 14 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Sex-dependent changes in neuronal morphology and psychosocial behaviors after pediatric brain injury

Semple, B. D., Dixit, S., Shultz, S. R., Boon, W. C. & O'Brien, T. J., 15 Feb 2017, In : Behavioural Brain Research. 319, p. 48-62 15 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury

Woodcock, T. M., Frugier, T., Nguyen, T. T., Semple, B. D., Bye, N., Massara, M., Savino, B., Besio, R., Sobacchi, C., Locati, M. & Morganti-Kossmann, M. C., 1 Nov 2017, In : PLoS ONE. 12, 11, 21 p., e0188305.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Sun, M., Brady, R. D., Wright, D. K., Kim, H. A., Zhang, S. R., Sobey, C. G., Johnstone, M. R., O'Brien, T. J., Semple, B. D., McDonald, S. J. & Shultz, S. R., Nov 2017, In : Brain, Behavior, and Immunity. 66, p. 359-371 13 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)
2016

Behavioral, blood, and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury

Wright, D. K., Trezise, J., Kamnaksh, A., Bekdash, R., Johnston, L. A., Ordidge, R., Semple, B. D., Gardner, A. J., Stanwell, P., O'Brien, T. J., Agoston, D. V. & Shultz, S. R., 28 Jun 2016, In : Scientific Reports. 6, 16 p., 28713.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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32 Citations (Scopus)

Challenging the dogma that ‘rest is best’ after concussion (Commentary on Mychasiuk et al.)

Semple, B. D., 1 Oct 2016, In : European Journal of Neuroscience. 44, 7, p. 2405-2406 2 p.

Research output: Contribution to journalArticleOtherpeer-review

Long-Term Anesthetic-Dependent Hypoactivity after Repetitive Mild Traumatic Brain Injuries in Adolescent Mice

Semple, B. D., Sadjadi, R., Carlson, J., Chen, Y., Xu, D., Ferriero, D. M. & Noble-Haeusslein, L. J., 1 Oct 2016, In : Developmental Neuroscience. 38, 3, p. 220-238 19 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Mild concussion, but not moderate traumatic brain injury, is associated with long-term depression-like phenotype in mice

Bajwa, N. M., Halavi, S., Hamer, M., Semple, B. D., Noble-Haeusslein, L. J., Baghchechi, M., Hiroto, A., Hartman, R. E. & Obenaus, A., 1 Jan 2016, In : PLoS ONE. 11, 1, 19 p., e0146886.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)
2015

Early gelatinase activity is not a determinant of long-term recovery after traumatic brain injury in the immature mouse

Semple, B. D., Noble-Haeusslein, L. J., Gooyit, M., Tercovich, K. G., Peng, Z., Nguyen, T. T., Schroeder, V. A., Suckow, M. A., Chang, M., Raber, J. & Trivedi, A., 1 Nov 2015, In : PLoS ONE. 10, 11, 25 p., e0143386.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain

Semple, B. D., Trivedi, A., Gimlin, K. & Noble-Haeusslein, L. J., 1 Feb 2015, In : Neurobiology of Disease. 74, p. 263-280 18 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)
Open Access
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67 Citations (Scopus)
2014

Granulocyte-macrophage colony-stimulating factor is neuroprotective in experimental traumatic brain injury

Shultz, S. R., Tan, X. L., Wright, D. K., Liu, S. J., Semple, B. D., Johnston, L., Jones, N. C., Cook, A. D., Hamilton, J. A. & O'Brien, T. J., 15 May 2014, In : Journal of Neurotrauma. 31, 10, p. 976-983 8 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Sociosexual and communication deficits after traumatic injury to the developing murine brain

Semple, B. D., Noble-Haeusslein, L. J., Kwon, Y. J., Sam, P. N., Gibson, A. M., Grissom, S., Brown, S., Adahman, Z., Hollingsworth, C. A., Kwakye, A., Gimlin, K., Wilde, E. A., Hanten, G., Levin, H. S. & Schenk, A. K., 8 Aug 2014, In : PLoS ONE. 9, 8, 18 p., e103386.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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20 Citations (Scopus)
2013

Traumatic injury to the immature frontal lobe: A new murine model of long-term motor impairment in the absence of psychosocial or cognitive deficits

Chen, C. Y., Noble-Haeusslein, L. J., Ferriero, D. & Semple, B. D., Dec 2013, In : Developmental Neuroscience. 35, 6, p. 474-490 17 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2012

Attenuation of microglial activation with minocycline is not associated with changes in neurogenesis after focal traumatic brain injury in adult mice

Ng, S. Y., Semple, B. D., Morganti-Kossmann, M. C. & Bye, N., 2012, In : Journal of Neurotrauma. 29, 7, p. 1410 - 1425 16 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Deficits in social behavior emerge during development after pediatric traumatic brain injury in mice

Semple, B. D., Canchola, S. A. & Noble-Haeusslein, L. J., 20 Nov 2012, In : Journal of Neurotrauma. 29, 17, p. 2672-2683 12 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)
2011

Attenuated neurological deficit, cell death and lesion volume in Fas-mutant mice is associated with altered neuroinflammation following traumatic brain injury

Ziebell, J., Bye, N., Semple, B. D., Kossmann, T. K. & Morganti-Kossmann, M., 2011, In : Brain Research. 1414, p. 94 - 105 12 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)
2010

CCL2 modulates cytokine production in cultured mouse astrocytes

Semple, B., Frugier, T. J. & Morganti-Kossmann, M. C., 2010, In : Journal of Neuroinflammation. 7, 67, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Deficiency of the chemokine receptor CXCR2 attenuates neutrophil infiltration and cortical damage following closed head injury

Semple, B. D., Bye, N., Ziebell, J. M. & Morganti-Kossmann, M. C., 2010, In : Neurobiology of Disease. 40, 2, p. 394 - 403 10 p.

Research output: Contribution to journalArticleResearchpeer-review

75 Citations (Scopus)

Role of CCL2 (MCP-1) in traumatic brain injury (TBI): Evidence from severe TBI patients and CCL2-/- mice

Semple, B., Bye, N., Rancan, M., Ziebell, J. M. & Morganti-Kossmann, M. C., 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 4, p. 769 - 782 14 p.

Research output: Contribution to journalArticleResearchpeer-review

201 Citations (Scopus)

Role of chemokines in CNS health and pathology: A focus on the CCL2/CCR2 and CXCL8/CXCR2 networks

Semple, B. D., Kossmann, T. K. & Morganti-Kossmann, M. C., 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 3, p. 459 - 473 15 p.

Research output: Contribution to journalArticleResearchpeer-review

236 Citations (Scopus)