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Research Output

2020

Immune challenges and seizures: How do early life insults influence epileptogenesis?

Semple, B. D., Dill, L. K. & O'Brien, T. J., 1 Jan 2020, In : Frontiers in Pharmacology. 11, 14 p., 00002.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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Potential Neuroprotective Effect of the HMGB1 Inhibitor Glycyrrhizin in Neurological Disorders

Paudel, Y. N., Angelopoulou, E., Semple, B., Piperi, C., Othman, I. & Shaikh, M. F., 19 Feb 2020, In : ACS Chemical Neuroscience. 11, 4, p. 485-500 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Systemic treatment with human amnion epithelial cells after experimental traumatic brain injury

Kim, H. A., Semple, B. D., Dill, L. K., Pham, L., Dworkin, S., Zhang, S. R., Lim, R., Sobey, C. G. & McDonald, S. J., May 2020, In : Brain, Behavior, and Immunity. 5, 8 p., 100072.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model

Zamani, A., Powell, K. L., May, A. & Semple, B. D., 1 Mar 2020, In : Brain Research Bulletin. 156, p. 43-49 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

Semple, B. D., Zamani, A., Rayner, G., Shultz, S. R. & Jones, N. C., 1 Mar 2019, In : Neurobiology of Disease. 123, p. 27-41 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

14 Citations (Scopus)

Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice

Webster, K. M., Sun, M., Crack, P. J., O'Brien, T. J., Shultz, S. R. & Semple, B. D., 15 Apr 2019, In : The Journal of Comparative Neurology. 527, 6, p. 1102-1117 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

An animal model of genetic predisposition to develop acquired epileptogenesis: The FAST and SLOW rats

Leung, W. L., Casillas-Espinosa, P., Sharma, P., Perucca, P., Powell, K., O'Brien, T. J. & Semple, B. D., Oct 2019, In : Epilepsia. 60, 10, p. 2023-2036 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

1 Citation (Scopus)

Determinants of social behavior deficits and recovery after pediatric traumatic brain injury

Zamani, A., Mychasiuk, R. & Semple, B. D., 1 Apr 2019, In : Experimental Neurology. 314, p. 34-45 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

4 Citations (Scopus)

High mobility group box 1 (HMGB1) as a novel frontier in epileptogenesis: from pathogenesis to therapeutic approaches

Paudel, Y. N., Semple, B. D., Jones, N. C., Othman, I. & Shaikh, M. F., Dec 2019, In : Journal of Neurochemistry. 151, 5, p. 542-557 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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14 Citations (Scopus)

Infections after a traumatic brain injury: The complex interplay between the immune and neurological systems

Sharma, R., Shultz, S. R., Robinson, M. J., Belli, A., Hibbs, M. L., O'Brien, T. J. & Semple, B. D., Jul 2019, In : Brain, Behavior, and Immunity. 79, p. 63-74 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

6 Citations (Scopus)

In search of antiepileptogenic treatments for post-traumatic epilepsy

Saletti, P. G., Ali, I., Casillas-Espinosa, P. M., Semple, B. D., Lisgaras, C. P., Moshé, S. L. & Galanopoulou, A. S., Mar 2019, In : Neurobiology of Disease. 123, p. 86-99 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

16 Citations (Scopus)

Neuroinflammation in post-traumatic epilepsy: Pathophysiology and tractable therapeutic targets

Sharma, R., Leung, W. L., Zamani, A., O’brien, T. J., Espinosa, P. M. C. & Semple, B. D., 1 Nov 2019, In : Brain Sciences. 9, 11, 25 p., 318.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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1 Citation (Scopus)

Profiling the mouse brain endothelial transcriptome in health and disease models reveals a core blood–brain barrier dysfunction module

Munji, R. N., Soung, A. L., Weiner, G. A., Sohet, F., Semple, B., Trivedi, A., Gimlin, K., Kotoda, M., Korai, M., Aydin, S., Batugal, A., Cabangcala, A. C., Schupp, P. G., Oldham, M. C., Hashimoto, T., Noble-Haeusslein, L. J. & Daneman, R., 14 Oct 2019, In : Nature Neuroscience. 22, 11, p. 1892–1902 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting high-mobility group box protein 1 (HMGB1) in pediatric traumatic brain injury: Chronic neuroinflammatory, behavioral, and epileptogenic consequences

Webster, K. M., Shultz, S. R., Ozturk, E., Dill, L. K., Sun, M., Casillas-Espinosa, P., Jones, N. C., Crack, P. J., O'Brien, T. J. & Semple, B. D., 1 Oct 2019, In : Experimental Neurology. 320, 14 p., 112979.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The Clinical Relevance of Behavior Testing in Animal Models of Traumatic Brain Injur

Shultz, S. R., McDonald, S., Corrigan, F., Semple, B., Salberg, S., Zamani, A., Jones, N. & Mychasiuk, R., 24 May 2019, (Accepted/In press) In : Journal of Neurotrauma. 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2018

A concomitant muscle injury does not worsen traumatic brain injury outcomes in mice

Sun, M., Brady, R. D., Poel, C. V. D., Apted, D., Semple, B. D., Church, J. E., O'Brien, T. J., McDonald, S. J. & Shultz, S. R., 11 Dec 2018, In : Frontiers in Neurology. 9, 11 p., 1089.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Mild traumatic brain injury in adolescent mice alters skull bone properties to influence a subsequent brain impact at adulthood: A pilot study

McColl, T. J., Brady, R. D., Shultz, S. R., Lovick, L., Webster, K. M., Sun, M., McDonald, S. J., O'Brien, T. J. & Semple, B. D., 25 May 2018, In : Frontiers in Neurology. 9, 15 p., 372.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

Modelling traumatic brain injury and posttraumatic epilepsy in rodents

Brady, R. D., Casillas-Espinosa, P. M., Agoston, D. V., Bertram, E. H., Kamnaksh, A., Semple, B. D. & Shultz, S. R., 1 Mar 2018, In : Neurobiology of Disease. 123, p. 8-19 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)

Oculomotor Cognitive Control Abnormalities in Australian Rules Football Players with a History of Concussion

Clough, M., Mutimer, S., Wright, D. K., Tsang, A., Costello, D. M., Gardner, A. J., Stanwell, P., Mychasiuk, R., Sun, M., Brady, R. D., McDonald, S. J., Webster, K. M., Johnstone, M. R., Semple, B. D., Agoston, D. V., White, O. B., Frayne, R., Fielding, J., O'Brien, T. J. & Shultz, S. R., 1 Mar 2018, In : Journal of Neurotrauma. 35, 5, p. 730-738 9 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments

Morganti-Kossmann, M. C., Semple, B. D., Hellewell, S. C., Bye, N. & Ziebell, J. M., 1 May 2018, In : Acta Neuropathologica. 137, 5, p. 731-755 25 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

20 Citations (Scopus)
2017

Inflammation in epileptogenesis after traumatic brain injury

Webster, K. M., Sun, M., Crack, P., O'Brien, T. J., Shultz, S. R. & Semple, B. D., 13 Jan 2017, In : Journal of Neuroinflammation. 14, 1, 17 p., 10.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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64 Citations (Scopus)

Interleukin-1 receptor in seizure susceptibility after traumatic injury to the pediatric brain

Semple, B. D., O’Brien, T. J., Gimlin, K., Wright, D. K., Kim, S. E., Casillas-Espinosa, P. M., Webster, K. M., Petrou, S. & Noble-Haeusslein, L. J., 16 Aug 2017, In : Journal of Neuroscience. 37, 33, p. 7864-7877 14 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Sex-dependent changes in neuronal morphology and psychosocial behaviors after pediatric brain injury

Semple, B. D., Dixit, S., Shultz, S. R., Boon, W. C. & O'Brien, T. J., 15 Feb 2017, In : Behavioural Brain Research. 319, p. 48-62 15 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

The scavenging chemokine receptor ACKR2 has a significant impact on acute mortality rate and early lesion development after traumatic brain injury

Woodcock, T. M., Frugier, T., Nguyen, T. T., Semple, B. D., Bye, N., Massara, M., Savino, B., Besio, R., Sobacchi, C., Locati, M. & Morganti-Kossmann, M. C., 1 Nov 2017, In : PLoS ONE. 12, 11, 21 p., e0188305.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma

Sun, M., Brady, R. D., Wright, D. K., Kim, H. A., Zhang, S. R., Sobey, C. G., Johnstone, M. R., O'Brien, T. J., Semple, B. D., McDonald, S. J. & Shultz, S. R., Nov 2017, In : Brain, Behavior, and Immunity. 66, p. 359-371 13 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)
2016

Behavioral, blood, and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury

Wright, D. K., Trezise, J., Kamnaksh, A., Bekdash, R., Johnston, L. A., Ordidge, R., Semple, B. D., Gardner, A. J., Stanwell, P., O'Brien, T. J., Agoston, D. V. & Shultz, S. R., 28 Jun 2016, In : Scientific Reports. 6, 16 p., 28713.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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32 Citations (Scopus)

Behavioral testing after experimental traumatic brain injury

Semple, B. D. & Noble-Haeusslein, L. J., 6 Apr 2016, Cellular Therapy for Neurological Injury. Cox, C. S. (ed.). Boca Raton: CRC Press, p. 167-191 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Challenging the dogma that ‘rest is best’ after concussion (Commentary on Mychasiuk et al.)

Semple, B. D., 1 Oct 2016, In : European Journal of Neuroscience. 44, 7, p. 2405-2406 2 p.

Research output: Contribution to journalArticleOtherpeer-review

Long-Term Anesthetic-Dependent Hypoactivity after Repetitive Mild Traumatic Brain Injuries in Adolescent Mice

Semple, B. D., Sadjadi, R., Carlson, J., Chen, Y., Xu, D., Ferriero, D. M. & Noble-Haeusslein, L. J., 1 Oct 2016, In : Developmental Neuroscience. 38, 3, p. 220-238 19 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Mild concussion, but not moderate traumatic brain injury, is associated with long-term depression-like phenotype in mice

Bajwa, N. M., Halavi, S., Hamer, M., Semple, B. D., Noble-Haeusslein, L. J., Baghchechi, M., Hiroto, A., Hartman, R. E. & Obenaus, A., 1 Jan 2016, In : PLoS ONE. 11, 1, 19 p., e0146886.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

Pediatric rodent models of traumatic brain injury

Semple, B. D., Carlson, J. & Noble-Haeusslein, L. J., 2016, Methods in Molecular Biology. Kobeissy, F., Dixon, C. E., Hayes, R. L. & Mondello, S. (eds.). New York NY USA: Humana Press, Vol. 1462. p. 325-343 19 p. (Methods in Molecular Biology; vol. 1462).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

11 Citations (Scopus)

Social dysfunction after pediatric traumatic brain injury: A translational perspective

Ryan, N. P., Catroppa, C., Godfrey, C., Noble-Haeusslein, L. J., Shultz, S. R., O'Brien, T. J., Anderson, V. & Semple, B. D., 1 May 2016, In : Neuroscience and Biobehavioral Reviews. 64, p. 196-214 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

29 Citations (Scopus)

Therapies negating neuroinflammation after brain trauma

Hellewell, S., Semple, B. D. & Morganti-Kossmann, M. C., 2016, In : Brain Research. 1640, p. 36-56 21 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

46 Citations (Scopus)
2015

Early gelatinase activity is not a determinant of long-term recovery after traumatic brain injury in the immature mouse

Semple, B. D., Noble-Haeusslein, L. J., Gooyit, M., Tercovich, K. G., Peng, Z., Nguyen, T. T., Schroeder, V. A., Suckow, M. A., Chang, M., Raber, J. & Trivedi, A., 1 Nov 2015, In : PLoS ONE. 10, 11, 25 p., e0143386.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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12 Citations (Scopus)

Found in translation: Understanding the biology and behavior of experimental traumatic brain injury

Bondi, C. O., Semple, B. D., Noble-Haeusslein, L. J., Osier, N. D., Carlson, S. W., Dixon, C. E., Giza, C. C. & Kline, A. E., 1 Nov 2015, In : Neuroscience and Biobehavioral Reviews. 58, p. 123-146 24 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

47 Citations (Scopus)

Neutrophil elastase mediates acute pathogenesis and is a determinant of long-term behavioral recovery after traumatic injury to the immature brain

Semple, B. D., Trivedi, A., Gimlin, K. & Noble-Haeusslein, L. J., 1 Feb 2015, In : Neurobiology of Disease. 74, p. 263-280 18 p.

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)
Open Access
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66 Citations (Scopus)

Repetitive concussions in adolescent athletes - Translating clinical and experimental research into perspectives on rehabilitation strategies

Semple, B. D., Lee, S., Sadjadi, R., Fritz, N., Carlson, J., Griep, C., Ho, V., Jang, P., Lamb, A., Popolizio, B., Saini, S., Bazarian, J. J., Prins, M. L., Ferriero, D. M., Michele Basso, D. & Noble-Haeusslein, L. J., 2015, In : Frontiers in Neurology. 6, APR, 00069.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
15 Citations (Scopus)
2014

Early preservation of mitochondrial bioenergetics supports both structural and functional recovery after neurotrauma

Semple, B. D., 2014, In : Experimental Neurology. 261, p. 291-297 7 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

16 Citations (Scopus)

Granulocyte-macrophage colony-stimulating factor is neuroprotective in experimental traumatic brain injury

Shultz, S. R., Tan, X. L., Wright, D. K., Liu, S. J., Semple, B. D., Johnston, L., Jones, N. C., Cook, A. D., Hamilton, J. A. & O'Brien, T. J., 15 May 2014, In : Journal of Neurotrauma. 31, 10, p. 976-983 8 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Sociosexual and communication deficits after traumatic injury to the developing murine brain

Semple, B. D., Noble-Haeusslein, L. J., Kwon, Y. J., Sam, P. N., Gibson, A. M., Grissom, S., Brown, S., Adahman, Z., Hollingsworth, C. A., Kwakye, A., Gimlin, K., Wilde, E. A., Hanten, G., Levin, H. S. & Schenk, A. K., 8 Aug 2014, In : PLoS ONE. 9, 8, 18 p., e103386.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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20 Citations (Scopus)
2013

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

Semple, B. D., Blomgren, K., Gimlin, K., Ferriero, D. M. & Noble-Haeusslein, L. J., Jul 2013, In : Progress in Neurobiology. 106-107, p. 1-16 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

614 Citations (Scopus)

Traumatic injury to the immature frontal lobe: A new murine model of long-term motor impairment in the absence of psychosocial or cognitive deficits

Chen, C. Y., Noble-Haeusslein, L. J., Ferriero, D. & Semple, B. D., Dec 2013, In : Developmental Neuroscience. 35, 6, p. 474-490 17 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)
2012

Attenuation of microglial activation with minocycline is not associated with changes in neurogenesis after focal traumatic brain injury in adult mice

Ng, S. Y., Semple, B. D., Morganti-Kossmann, M. C. & Bye, N., 2012, In : Journal of Neurotrauma. 29, 7, p. 1410 - 1425 16 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Cerebral inflammation after traumatic injury: regulation of secondary damage, repair or both?

Semple, B. D. & Morganti-Kossmann, M. C., 2012, Traumatic Brain and Spinal Cord Injury: Challenges and Developments. Morganti-Kossmann, C., Raghupathi, R. & Maas, A. (eds.). New York, USA: Cambridge University Press, p. 155 - 168 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Deficits in social behavior emerge during development after pediatric traumatic brain injury in mice

Semple, B. D., Canchola, S. A. & Noble-Haeusslein, L. J., 20 Nov 2012, In : Journal of Neurotrauma. 29, 17, p. 2672-2683 12 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)
2011

Attenuated neurological deficit, cell death and lesion volume in Fas-mutant mice is associated with altered neuroinflammation following traumatic brain injury

Ziebell, J., Bye, N., Semple, B. D., Kossmann, T. K. & Morganti-Kossmann, M., 2011, In : Brain Research. 1414, p. 94 - 105 12 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Broad-spectrum neuroprotection against traumatic brain injury by agonism of peroxisome proliferator-activated receptors

Semple, B. D. & Noble-Haeusslein, L. J., Jun 2011, In : Experimental Neurology. 229, 2, p. 195-197 3 p.

Research output: Contribution to journalComment / DebateOtherpeer-review

14 Citations (Scopus)
2010

CCL2 modulates cytokine production in cultured mouse astrocytes

Semple, B., Frugier, T. J. & Morganti-Kossmann, M. C., 2010, In : Journal of Neuroinflammation. 7, 67, p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)