Projects per year
Personal profile
Biography
A/Prof. Semple has an established national and international reputation for excellence in neurotrauma research. Based on the Department of Neuroscience at Monash University’s School of Translational Medicine, she led the productive Paediatric Neurotrauma Group between 2018 and 2024, before scaling back the experimental work to allow for other activities. Her research program has focused on the fundamental neurobiology of traumatic brain injuries across the lifespan.
A/Prof. Semple has received substantial competitive fellowship and grant funding, totalling <$4.5M, from the NHMRC, US Department of Defense, Veski, American Australian Association, Rebecca L Cooper Medical Research Foundation, Monash University and Capstone Editing. She has a prolific publication track record in the fields of neurotrauma, epilepsy, social behaviour, and neuroinflammation, and she has sat on several journal editorial boards including Experimental Neurology and Neurotrauma Reports.
A/Prof. Semple has been active and engaged with the research community globally. She has served on the Executive Board for the International Neurotrauma Society, and was elected to the Council for the US National Neurotrauma Society (Vice-President-Elect 2022-23; past-Secretary, 2021-22). She was also a coordinating member of the Australasian Neurotrauma Workshop annual scientific conference and associated seminar series in 2022. In 2022, she was awarded the inaugural Mid-Career Excellence in Leadership Award from Monash University’s School of Translational Medicine Gender, Equity, Diversity and Inclusion (GEDI) committee; and in 2023, she was awarded the Rosalind Franklin Award from the US National Neurotrauma Society for excellence in research, education and mentoring.
Education/Academic qualification
Neuroscience, PhD, Monash University
Feb 2007 → Jun 2010
External positions
Honorary Research Fellow, University of Melbourne
1 Jan 2018 → …
Research area keywords
- neuroinflammation
- paediatric
- traumatic brain injury
- neurotrauma
- animal models
- epilepsy
- social behaviour
- Brain injury
- seizures
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
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SDG 3 Good Health and Well-being
Collaborations and top research areas from the last five years
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Developing a Preclinical Model of Neonatal Inflicted Head Trauma to Improve Outcomes for Survivors
Salberg, S. (Primary Chief Investigator (PCI)), Mychasiuk, R. (Chief Investigator (CI)) & Semple, B. (Chief Investigator (CI))
Project: Research
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Chronic outcomes after early life brain injury: mechanisms, manifestation and modification
Semple, B. (Primary Chief Investigator (PCI))
Victorian Endowment for Science, Knowledge and Innovation, Monash University – Internal School Contribution
1/07/22 → 30/06/23
Project: Research
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An informatics approach to predict outcomes and monitor intervention efficacy following moderate to severe traumatic brain injury
Fitzgerald, M. (Primary Chief Investigator (PCI)), Gabbe, B. (Chief Investigator (CI)), Lannin, N. (Chief Investigator (CI)), Vallmuur, K. (Chief Investigator (CI)), Curtis, K. A. (Chief Investigator (CI)), Harrison, J. E. (Chief Investigator (CI)), Young, J. T. (Chief Investigator (CI)), Menon, D. K. (Chief Investigator (CI)), Cullen, J. C. (Chief Investigator (CI)), Armstrong, E. (Chief Investigator (CI)), Eades, S. (Chief Investigator (CI)), Cameron, P. (Chief Investigator (CI)), Cooper, J. (Chief Investigator (CI)), Fitzgerald, M. (Chief Investigator (CI)), Balogh, Z. (Chief Investigator (CI)), Fatovich, D. (Chief Investigator (CI)), Honeybul, S. (Chief Investigator (CI)), Jeffree, R. L. (Chief Investigator (CI)), McNamara, R. (Chief Investigator (CI)), Mitchell, G. J. (Chief Investigator (CI)), Delaney, A. (Chief Investigator (CI)), Reade, M. (Chief Investigator (CI)), Wells, A. (Chief Investigator (CI)), Williams, J. K. (Chief Investigator (CI)), Ponsford, J. (Chief Investigator (CI)), McDonald, S. (Chief Investigator (CI)), Kendall, E. (Chief Investigator (CI)), Ownsworth , T. (Chief Investigator (CI)), Simpson, G. (Chief Investigator (CI)), Togher, L. (Chief Investigator (CI)), Hassett, L. (Chief Investigator (CI)), Fleming, J. (Chief Investigator (CI)), Williams, G. P. (Chief Investigator (CI)), Collins-Praino, L. (Chief Investigator (CI)), Reeder, S. (Chief Investigator (CI)), Mobbs, R. (Chief Investigator (CI)), Vickers, J. C. (Chief Investigator (CI)), Anderson, V. A. (Chief Investigator (CI)), Barlow, K. (Chief Investigator (CI)), Holland, A. J. A. (Chief Investigator (CI)), Scheinberg, A. (Chief Investigator (CI)), Semple, B. (Chief Investigator (CI)), Parizel, P. M. (Chief Investigator (CI)), O'Brien, T. (Chief Investigator (CI)), Law, M. (Chief Investigator (CI)), Rose, S. (Chief Investigator (CI)), Varma, D. (Chief Investigator (CI)), Nasrallah, F. (Chief Investigator (CI)), Shultz, S. (Chief Investigator (CI)), Hellewell, S. C. (Chief Investigator (CI)), Bosio, E. (Associate Investigator (AI)), King, K. (Associate Investigator (AI)), Parr, M. (Associate Investigator (AI)), Udy, A. (Associate Investigator (AI)), Hill, A. F. (Associate Investigator (AI)), Olver, J. (Associate Investigator (AI)), Teague, W. (Associate Investigator (AI)), Egan, G. (Associate Investigator (AI)), Fisher, M. (Associate Investigator (AI)), York, L. (Associate Investigator (AI)), Bynevelt, M. (Associate Investigator (AI)), Maas, A. I. R. (Chief Investigator (CI)), O'Reilly, G. (Associate Investigator (AI)), McDonald, S. (Associate Investigator (AI)), Capell, J. (Associate Investigator (AI)), Gilroy, J. (Associate Investigator (AI)), Walsham, J. (Associate Investigator (AI)), Newcombe, V. (Associate Investigator (AI)), Geraghty, T. J. (Associate Investigator (AI)), Joyce, C. J. (Associate Investigator (AI)), Rosenfeld, J. (Associate Investigator (AI)), Elcock, M. (Associate Investigator (AI)), Ross, J. (Associate Investigator (AI)), Bragge, P. (Associate Investigator (AI)), Meka, S. (Associate Investigator (AI)), Chai, K. (Associate Investigator (AI)), Cowen, G. (Associate Investigator (AI)), Hasseler, L. (Associate Investigator (AI)), Ercole, A. (Associate Investigator (AI)), Wagland , J. (Associate Investigator (AI)), Alexander, T. (Associate Investigator (AI)), Babl, F. (Associate Investigator (AI)), Bidargaddi, N. (Associate Investigator (AI)), Mahoney, A. J. (Associate Investigator (AI)), Wright, D. (Associate Investigator (AI)), Crowe, L. M. (Associate Investigator (AI)), Robinson, S. M. (Associate Investigator (AI)), Rushworth, N. (Associate Investigator (AI)), Hansen, M. (Associate Investigator (AI)), Ellis, D. (Associate Investigator (AI)), Zeeman, H. (Associate Investigator (AI)), Francis, R. J. (Associate Investigator (AI)), Whiley, L. (Associate Investigator (AI)) & Reid, C. (Associate Investigator (AI))
1/07/21 → 30/06/23
Project: Research
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Infections promote post-traumatic epilepsy and poor outcomes after traumatic brain injury
Semple, B. (Primary Chief Investigator (PCI)), O'Brien, T. (Chief Investigator (CI)) & Li, J. (Chief Investigator (CI))
United States Department of Defense (DOD)
4/01/21 → 29/09/24
Project: Research
File -
Polarization of immune cells by novel compounds
Ali, I. (Primary Chief Investigator (PCI)), Jones, N. (Chief Investigator (CI)), Monif, M. (Chief Investigator (CI)) & Semple, B. (Chief Investigator (CI))
Katholieke Universiteit Leuven (KU Leuven) (Catholic University of Leuven)
13/07/20 → 12/09/21
Project: Research
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A companion to the preclinical common data elements for rodent genetic epilepsy models. A report of the TASK3-WG1B: Paediatric and genetic models working group of the ILAE/AES joint translational TASK force
Mantegazza, M., Auvin, S., Barker-Haliski, M., Katsarou, A. M., Kubova, H., Galanopoulou, A. S., Semple, B. & Reid, C. A., Aug 2025, In: Epilepsia Open. 10, S1, p. S40-S52 13 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access10 Link opens in a new tab Citations (Scopus) -
A companion to the preclinical common data elements for rodent models of pediatric acquired epilepsy: A report of the TASK3-WG1B, Pediatric and Genetic Models Working Group of the ILAE/AES Joint Translational Task Force
Katsarou, A.-M., Kubova, H., Auvin, S., Mantegazza, M., Barker-Haliski, M., Galanopoulou, A. S., Reid, C. A. & Semple, B. D., Aug 2025, In: Epilepsia Open. 10, S1, p. S53-S86 34 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access6 Link opens in a new tab Citations (Scopus) -
A post-injury immune challenge with lipopolysaccharide following adult traumatic brain injury alters neuroinflammation and the gut microbiome acutely, but has little effect on chronic outcomes
Rewell, S. S. J., Shad, A., Chen, L., Macowan, M., Chu, E., Gandasasmita, N., Casillas-Espinosa, P. M., Li, J., O'Brien, T. J. & Semple, B. D., Apr 2025, In: Experimental Neurology. 386, 16 p., 115150.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Link opens in a new tab Citations (Scopus) -
Chronic outcomes after mild-moderate traumatic brain injury in adult seizure-prone (FAST) and seizure-resistant (SLOW) rats: A model for understanding genetic contributions to acquired epileptogenesis?
Leung, W. L., Shad, A., Perucca, P., O'Brien, T. J., Semple, B. D. & Casillas-Espinosa, P. M., May 2025, In: Epilepsy & Behavior. 166, 14 p., 110347.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Link opens in a new tab Citation (Scopus) -
Clioquinol as a new therapy in epilepsy: From preclinical evidence to a proof-of-concept clinical study
Thevissen, K., Ny, A., Copmans, D., Tits, J., Kamata, K., Gielis, E., Longin, K., Sourbron, J., Thergarajan, P., Tan, T. H. L., Ali, I., Jones, N. C., O'Brien, T. J., Monif, M., Semple, B. D., Germeys, C., Frizzi, B., Minniti, V., Perrone, S. & Linster, C. L. & 6 others, , Oct 2025, In: Epilepsia. 66, 10, p. 3769-3784 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Link opens in a new tab Citations (Scopus)
Prizes
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Abstract Finalist, National Neurotrauma Society meeting, Nashville, TN
Semple, B. (Recipient), 2013
Prize: Prize (including medals and awards)
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Advancing Women's Research Success Grant
Semple, B. (Recipient), 2018
Prize: Prize (including medals and awards)
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Best Oral Presentation (Non-Medical), Australian and New Zealand Trauma Society (ANZTS) annual meeting, Brisbane, QLD
Semple, B. (Recipient), 2022
Prize: Prize (including medals and awards)
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Best Poster Prize, Melbourne Brain Centre at the Royal Melbourne Hospital Annual Symposium in Melbourne
Semple, B. (Recipient), 2016
Prize: Prize (including medals and awards)
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Carer Equity Travel Support Grant from the Faculty of Medicine, Nursing and Health Sciences, Monash University, to attend the Australasian Neuroscience Meeting
Semple, B. (Recipient), 2020
Prize: Prize (including medals and awards)
Activities
- 5 Committees and working groups
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Council (Elected)
Semple, B. (Member)
2022 → …Activity: External Academic Engagement › Committees and working groups
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Co-Chair, Publication Committee
Semple, B. (Chair/ Co-Chair)
2022 → …Activity: External Academic Engagement › Committees and working groups
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Invited Member
Semple, B. (Member)
2022 → …Activity: External Academic Engagement › Committees and working groups
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Executive Board
Semple, B. (Member)
2021 → …Activity: External Academic Engagement › Committees and working groups
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Secretary
Semple, B. (Member)
2018 → …Activity: External Academic Engagement › Committees and working groups