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Personal profile


Dr. Semple is an NHMRC R.D. Wright Biomedical Career Development Fellowship recipient and Head of the Paediatric Neurotrauma Group in the Department of Neuroscience, Monash University, Central Clinical School. Her research focuses on the acute and chronic neuropathology after traumatic injury to both the adult and pediatric brain, with a particular interest in neuroinflammation and behavioural outcomes. After obtaining her PhD at Monash University in 2010, Dr. Semple completed postdoctoral training at the University of California San Francisco, USA. Returning to Australia in 2015, she established a preclinical laboratory team at the University of Melbourne, before coming full circle back to Monash in January 2018.


External positions

Honorary Research Fellow, University of Melbourne

1 Jan 2018 → …

Research area keywords

  • neuroinflammation
  • paediatric
  • traumatic brain injury
  • neurotrauma
  • animal models
  • epilepsy
  • social behaviour
  • Brain injury
  • seizures

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Research Output

Immune challenges and seizures: How do early life insults influence epileptogenesis?

Semple, B. D., Dill, L. K. & O'Brien, T. J., 1 Jan 2020, In : Frontiers in Pharmacology. 11, 14 p., 00002.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access

Potential Neuroprotective Effect of the HMGB1 Inhibitor Glycyrrhizin in Neurological Disorders

Paudel, Y. N., Angelopoulou, E., Semple, B., Piperi, C., Othman, I. & Shaikh, M. F., 19 Feb 2020, In : ACS Chemical Neuroscience. 11, 4, p. 485-500 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Validation of reference genes for gene expression analysis following experimental traumatic brain injury in a pediatric mouse model

Zamani, A., Powell, K. L., May, A. & Semple, B. D., 1 Mar 2020, In : Brain Research Bulletin. 156, p. 43-49 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

Semple, B. D., Zamani, A., Rayner, G., Shultz, S. R. & Jones, N. C., 1 Mar 2019, In : Neurobiology of Disease. 123, p. 27-41 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

10 Citations (Scopus)

Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice

Webster, K. M., Sun, M., Crack, P. J., O'Brien, T. J., Shultz, S. R. & Semple, B. D., 15 Apr 2019, In : Journal of Comparative Neurology. 527, 6, p. 1102-1117 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)


Advancing Women's Research Success Grant

Bridgette Semple (Recipient), 2018

Prize: Prize (including medals and awards)