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Personal profile


Dr. Semple is an NHMRC R.D. Wright Biomedical Career Development Fellowship recipient and Head of the Paediatric Neurotrauma Group in the Department of Neuroscience, Monash University, Central Clinical School. Her research focuses on the acute and chronic neuropathology after traumatic injury to both the adult and pediatric brain, with a particular interest in neuroinflammation and behavioural outcomes. After obtaining her PhD at Monash University in 2010, Dr. Semple completed postdoctoral training at the University of California San Francisco, USA. Returning to Australia in 2015, she established a small laboratory team at the University of Melbourne, before coming full circle back to Monash in January 2018.


External positions

Honorary Research Fellow, The University of Melbourne

1 Jan 2018 → …


  • neuroinflammation
  • paediatric
  • traumatic brain injury
  • neurotrauma
  • animal models
  • epilepsy
  • social behaviour
  • Brain injury
  • seizures

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Projects 2018 2021

Research Output 2010 2019

Affective, neurocognitive and psychosocial disorders associated with traumatic brain injury and post-traumatic epilepsy

Semple, B. D., Zamani, A., Rayner, G., Shultz, S. R. & Jones, N. C., 1 Mar 2019, In : Neurobiology of Disease. 123, p. 27-41 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Age-dependent release of high-mobility group box protein-1 and cellular neuroinflammation after traumatic brain injury in mice

Webster, K. M., Sun, M., Crack, P. J., O'Brien, T. J., Shultz, S. R. & Semple, B. D., 15 Apr 2019, In : Journal of Comparative Neurology. 527, 6, p. 1102-1117 16 p.

Research output: Contribution to journalArticleResearchpeer-review

An animal model of genetic predisposition to develop acquired epileptogenesis: The FAST and SLOW rats

Leung, W. L., Casillas-Espinosa, P., Sharma, P., Perucca, P., Powell, K., O'Brien, T. J. & Semple, B. D., 29 Aug 2019, (Accepted/In press) In : Epilepsia.

Research output: Contribution to journalReview ArticleResearchpeer-review

Determinants of social behavior deficits and recovery after pediatric traumatic brain injury

Zamani, A., Mychasiuk, R. & Semple, B. D., 1 Apr 2019, In : Experimental Neurology. 314, p. 34-45 12 p.

Research output: Contribution to journalReview ArticleResearchpeer-review