Research output per year
Research output per year
Personal profile
Biography
Brendon is passionate about translating innovative research discoveries into potential new therapies and has extensive experience leading collaborative multidisciplinary drug discovery programs. Prior to joining MIPS as the Director of MedChem Australia, Brendon was the Chief Scientific Officer of Canthera Discovery, formerly the Cancer Therapeutics CRC (CTx), a leading Australian small molecule drug discovery organisation whose research partners included Monash University, CSIRO, WEHI, Peter MacCallum Cancer Centre, Children’s Cancer Institute and Griffith University.
Brendon has a molecular biology background with research experience in drug discovery, cancer biology, gene regulation and epigenetics. Brendon has contributed to many successfully licensed drug discovery programs across epigenetic, kinase, RNA modulation, and immuno-oncology targets, with two assets currently in active clinical trials.
Brendon was the project leader of the lysine acetyltransferase projects licensed to Pfizer in a deal worth $20M upfront, ~$650M in potential milestone payments, plus royalties.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Drug discovery
- Biomedical Research, Multidisciplinary
- Translational Medical Research
- Collaborative translation
- Cancer therapeutics
- Therapeutic Development
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Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer
Sharma, S., Chung, C. Y., Uryu, S., Petrovic, J., Cao, J., Rickard, A., Nady, N., Greasley, S., Johnson, E., Brodsky, O., Khan, S., Wang, H., Wang, Z., Zhang, Y., Tsaparikos, K., Chen, L., Mazurek, A., Lapek, J., Kung, P. P., Sutton, S., & 59 others, 19 Oct 2023, In: Cell Chemical Biology. 30, 10, p. 1191-1210 40 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access16 Citations (Scopus) -
Loss of TIP60 (KAT5) abolishes H2AZ lysine 7 acetylation and causes p53, INK4A, and ARF-independent cell cycle arrest
Wichmann, J., Pitt, C., Eccles, S., Garnham, A. L., Li-Wai-Suen, C. S. N., May, R., Allan, E., Wilcox, S., Herold, M. J., Smyth, G. K., Monahan, B. J., Thomas, T. & Voss, A. K., 20 Jul 2022, In: Cell Death & Disease. 13, 7, 13 p., 627.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
Adaptation to industrial stressors through genomic and transcriptional plasticity in a bioethanol producing fission yeast isolate
Vassiliadis, D., Wong, K. H., Blinco, J., Dumsday, G., Andrianopoulos, A. & Monahan, B., 1 Apr 2020, In: G3: Genes, Genomes, Genetics. 10, 4, p. 1375-1391 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Crystal structures of human ENPP1 in apo and bound forms
Dennis, M. L., Newman, J., Dolezal, O., Hattarki, M., Surjadi, R. N., Nuttall, S. D., Pham, T., Nebl, T., Camerino, M., Khoo, P. S., Monahan, B. J. & Peat, T. S., Sept 2020, In: Acta Crystallographica Section D: Structural Biology. 76, 9, p. 889-898 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access24 Citations (Scopus) -
Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents
Priebbenow, D. L., Leaver, D. J., Nguyen, N., Cleary, B., Lagiakos, H. R., Sanchez, J., Xue, L., Huang, F., Sun, Y., Mujumdar, P., Mudududdla, R., Varghese, S., Teguh, S., Charman, S. A., White, K. L., Shackleford, D. M., Katneni, K., Cuellar, M., Strasser, J. M., Dahlin, J. L., & 13 others, 14 May 2020, In: Journal of Medicinal Chemistry. 63, 9, p. 4655-4684 30 p.Research output: Contribution to journal › Article › Research › peer-review
10 Citations (Scopus)