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Research Output 1998 2019

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2019

ADAM17: An emerging therapeutic target for lung cancer

Saad, M. I., Rose-John, S. & Jenkins, B. J., 21 Aug 2019, In : Cancers. 11, 9, 28 p., 1218.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., Tang, K., Jarde, T., Smith, J. A., Prodanovic, Z., Tate, M. D., Balic, J. J., Watkins, D. N., Cain, J. E., Bozinovski, S., Algar, E., Kohmoto, T., Ebi, H., Ferlin, W., Garbers, C. & 4 others, Ruwanpura, S., Sagi, I., Rose-John, S. & Jenkins, B. J., Apr 2019, In : EMBO Molecular Medicine. 11, 4, 19 p., e9976.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice

Han, T. S., Voon, D. C. C., Oshima, H., Nakayama, M., Echizen, K., Sakai, E., Yong, Z. W. E., Murakami, K., Yu, L., Minamoto, T., Ock, C. Y., Jenkins, B. J., Kim, S. J., Yang, H. K. & Oshima, M., 1 Mar 2019, In : Gastroenterology. 156, 4, p. 1140-1155.e4 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Toll-like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2

Liu, Y. D., Yu, L., Ying, L., Balic, J., Gao, H., Deng, N. T., West, A., Yan, F., Ji, C. B., Gough, D., Tan, P., Jenkins, B. J. & Li, J. K., 15 Jun 2019, In : International Journal of Cancer. 144, 12, p. 3056-3069 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2018

Clinical utility of a STAT3-regulated miRNA-200 family signature with prognostic potential in early gastric cancer

Yu, L., Wu, D., Gao, H., Balic, J. J., Tsykin, A., Han, T. S., Liu, Y. D., Kennedy, C. L., Li, J. K., Mao, J. Q., Tan, P., Oshima, M., Goodall, G. J. & Jenkins, B. J., 15 Mar 2018, In : Clinical Cancer Research. 24, 6, p. 1459-1472 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Helicobacter pylori type IV secretion system and its adhesin subunit, CagL, mediate potent inflammatory responses in primary human endothelial cells

Tafreshi, M., Guan, J., Gorrell, R. J., Chew, N., Xin, V., Deswaerte, V., Rohde, M., Daly, R. J., Peek Jr, R. M., Jenkins, B. J., Davies, E. M. & Kwok, T., 6 Feb 2018, In : Frontiers in Cellular and Infection Microbiology. 8, FEB, 15 p., 22.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development

Hill, D. G., Yu, L., Gao, H., Balic, J. J., West, A., Oshima, H., McLeod, L., Oshima, M., Gallimore, A., D'Costa, K., Bhathal, P. S., Sievert, W., Ferrero, R. L., Jenkins, B. J. & Jones, G. W., 1 Jul 2018, In : International Journal of Cancer. 143, 1, p. 167-178 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Inflammasome adaptor ASC suppresses apoptosis of gastric cancer cells by an IL18-mediated inflammation-independent mechanism

Deswaerte, V., Nguyen, P., West, A., Browning, A. F., Yu, L., Ruwanpura, S. M., Balic, J., Livis, T., Girard, C., Preaudet, A., Oshima, H., Fung, K. Y., Tye, H., Najdovska, M., Ernst, M., Oshima, M., Gabay, C., Putoczki, T. & Jenkins, B. J., 1 Mar 2018, In : Cancer Research. 78, 5, p. 1293-1307 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma

Miller, A., McLeod, L., Alhayyani, S., Szczepny, A., Watkins, D. N., Chen, W., Enriori, P., Ferlin, W., Ruwanpura, S. & Jenkins, B. J., 25 May 2017, In : Oncogene. 36, 21, p. 3059-3066 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Endoscopic ultrasound-guided fine-needle aspirate-derived preclinical pancreatic cancer models reveal panitumumab sensitivity in KRAS wild-type tumors

Berry, W., Algar, E., Kumar, B., Desmond, C., Swan, M., Jenkins, B. J. & Croagh, D., 15 May 2017, In : International Journal of Cancer. 140, 10, p. 2331-2343 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer

West, AC., Tang, K., Tye, H., Yu, L., Deng, N., Najdovska, M., Lin, S. J., Balic, JJ., Okochi-Takada, E., McGuirk, P., Keogh, B., McCormack, W., Bhathal, P. S., Reilly, M., Oshima, M., Ushijima, T., Tan, P. & Jenkins, B. J., 7 Sep 2017, In : Oncogene. 36, 36, p. 5134-5144 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling

Balic, J. J., Garbers, C., Rose-John, S., Yu, L. & Jenkins, B. J., 1 Apr 2017, In : Cytokine. 92, p. 118-123 6 p.

Research output: Contribution to journalArticleResearchpeer-review

In vivo evidence that RBM5 is a tumour suppressor in the lung

Jamsai, D., Watkins, D. N., O'Connor, A. E., Merriner, D. J., Gursoy, S., Bird, A. D., Kumar, B., Miller, A., Cole, T. J., Jenkins, B. J. & O'Bryan, M. K., 1 Dec 2017, In : Scientific Reports. 7, 1, 8 p., 15874.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

IL6 trans-signaling promotes KRAS-driven lung carcinogenesis

Brooks, G. D., McLeod, L., Alhayyani, S., Miller, A., Russell, P. A., Ferlin, W., Rose-John, S., Ruwanpura, S. & Jenkins, B. J., 15 Feb 2016, In : Cancer Research. 76, 4, p. 866-876 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Murine oncostatin m acts via leukemia inhibitory factor receptor to phosphorylate signal transducer and activator of transcription 3 (STAT3) but not STAT1, an effect that protects bone mass

Walker, E. C., Johnson, R. W., Hu, Y., Brennan, H. J., Poulton, I. J., Zhang, J. G., Jenkins, B. J., Smyth, G. K., Nicola, N. A. & Sims, N. A., 7 Oct 2016, In : Journal of Biological Chemistry. 291, 41, p. 21703-21716 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Myeloid differentiation factor 88 signaling in bone marrow-derived cells promotes gastric tumorigenesis by generation of inflammatory microenvironment

Maeda, Y., Echizen, K., Oshima, H., Yu, L., Sakulsak, N., Hirose, O., Yamada, Y., Taniguchi, T., Jenkins, B. J., Saya, H. & Oshima, M., 1 Mar 2016, In : Cancer Prevention Research. 9, 3, p. 253-263 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Therapeutic targeting of the IL-6 trans-signaling/mechanistic target of rapamycin complex 1 axis in pulmonary emphysema

Ruwanpura, S. M., McLeod, L., Dousha, L. F., Seow, H. J., Alhayyani, S., Tate, M. D., Deswaerte, V., Brooks, G. D., Bozinovski, S., MacDonald, M., Garbers, C., King, P. T., Bardin, P. G., Vlahos, R., Rose-John, S., Anderson, G. P. & Jenkins, B. J., 15 Dec 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 12, p. 1494-1505 12 p.

Research output: Contribution to journalArticleResearchpeer-review

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2015

Differential involvement of gp130 signalling pathways in modulating tobacco carcinogen-induced lung tumourigenesis

Miller, A., Brooks, G. D. C., McLeod, L., Ruwanpura, S. M. & Jenkins, B. J., 19 Mar 2015, In : Oncogene. 34, 12, p. 1510 - 1519 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis

Jones, G. W., McLeod, L., Kennedy, C. L., Bozinovski, S., Najdovska, M. & Jenkins, B. J., 2015, In : Atherosclerosis. 238, 2, p. 321 - 328 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Inflammatory and non-inflammatory roles for toll-like receptors in gastrointestinal cancer

West, A. C. & Jenkins, B. J., 2015, In : Current Pharmaceutical Design. 21, 21, p. 2968 - 2977 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice

Bozinovski, S., Seow, H. J., Chan, S. P. J., Anthony, D. A., McQualter, J. L., Hansen, M. J., Jenkins, B. J., Anderson, G. & Vlahos, R., 2015, In : Clinical Science. 129, 9, p. 785 - 796 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis

Jones, G. W., Bombardieri, M., Greenhill, C. J., McLeod, L., Nerviani, A., Rocher-Ros, V., Cardus, A., Williams, A. S., Pitzalis, C., Jenkins, B. J. & Jones, S. A., 2015, In : Journal of Experimental Medicine. 212, 11, p. 1793 - 1802 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis

Kennedy, C. L., Najdovska, M., Tye, Y. M. H., McLeod, L., Yu, L., Jarnicki, A. G., Bhathal, P. S., Putoczki, T. L., Ernst, M. R. & Jenkins, B. J., 2014, In : Oncogene. 33, 19, p. 2540 - 2546 7 p.

Research output: Contribution to journalArticleResearchpeer-review

IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice

Ruwanpura, S. M., McLeod, L., Brooks, G. D. C., Bozinovski, S., Vlahos, R., Longano, A., Bardin, P. G., Anderson, G. & Jenkins, B. J., 2014, In : Respirology. 19, 3, p. 419 - 427 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Inflammation and gastrointestinal cancer: an overview

Marusawa, H. & Jenkins, B. J., 2014, In : Cancer Letters. 345, 2, p. 153 - 156 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin-6 signaling drives fibrosis in unresolved inflammation

Fielding, C. A., Jones, G. W., McLoughlin, R. M., McLeod, L., Hammond, V. J., Uceda, J., Williams, A. S., Lambie, M., Foster, T. L., Liao, C-T., Rice, C. M., Greenhill, C. J., Colmont, C. S., Hams, E., Coles, B., Kift-Morgan, A., Newton, Z., Craig, K. J., Williams, J. D., Williams, G. T. & 7 others, Davies, S. J., Humphreys, I. R., O'Donnell, V. B., Taylor, P. R., Jenkins, B. J., Topley, N. & Jones, S. A., 2014, In : Immunity. 40, 1, p. 40 - 50 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Rab8a interacts directly with PI3Kgamma to modulate TLR4-driven PI3K and mTOR signalling

Luo, L., Wall, A. A., Yeo, J. C., Condon, N. D., Norwood, S. J., Schoenwaelder, S. M., Chen, K. W., Jackson, S., Jenkins, B. J., Hartland, E. L., Schroder, K., Collins, B. M., Sweet, M. J. & Stow, J. L., 2014, In : Nature Communications. 5, (Art. No.:4407), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

STAT1 plays a role in TLR signal transduction and inflammatory responses

Luu, K., Greenhill, C. J., Majoros, A., Decker, T., Jenkins, B. J. & Mansell, A. S., 2014, In : Immunology and Cell Biology. 92, 9, p. 761 - 769 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis

Carow, B., Reuschl, A-K., Gavier-Widen, D., Jenkins, B. J., Ernst, M. R., Yoshimura, A., Chambers, B. J. & Rottenberg, M. E., 2013, In : PLoS Pathogens. 9, 7, 20 p., e1003442.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A

Jones, G., Greenhill, C. J., Williams, J. O., Nowell, M. A., Williams, A. S., Jenkins, B. J. & Jones, S. A., 2013, In : Annals of the Rheumatic Diseases. 72, 10, p. 1738 - 1742 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice

Ruwanpura, S. M., McLeod, L., Lilja, A., Brooks, G. D. C., Dousha, L., Seow, H. J., Bozinovski, S., Vlahos, R., Hertzog, P. J., Anderson, G. & Jenkins, B. J., 2013, In : PLoS ONE. 8, 10, 9 p., e78095.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Nucleotide oligomerization domain 1 enhances IFN-gamma signaling in gastric epithelial cells during Helicobacter pylori infection and exacerbates disease severity

Allison, C. C., Ferrand, J. F. P., McLeod, L., Hassan, M., Kaparakis-Liaskos, M., Grubman, A., Bhathal, P. S., Dev, A. T., Sievert, W., Jenkins, B. J. & Ferrero, R. L., 2013, In : Journal of Immunology. 190, 7, p. 3706-3715 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Tying the knot between cytokine and toll-like receptor signaling in gastrointestinal tract cancers

Tye, Y. M. H. & Jenkins, B. J., 2013, In : Cancer Science. 104, 9, p. 1139 - 1145 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice

Ruwanpura, S., McLeod, L., Miller, A., Jones, J., Vlahos, R., Ramm, G., Longano, A., Bardin, P., Bozinovski, S., Anderson, G. & Jenkins, B., 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 32, 7, p. L627 - L639 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling

Greenhill, C. J., Gould, J. A., Ernst, M. R., Jarnicki, A. G., Hertzog, P. J., Mansell, A. S. & Jenkins, B. J., 2012, In : Immunology and Cell Biology. 90, 5, p. 559 - 563 5 p.

Research output: Contribution to journalArticleResearchpeer-review

STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation

Tye, Y. M. H., Kennedy, C. L., Najdovska, M., McLeod, L., McCormack, W., Hughes, N. R., Dev, A. T., Sievert, W., Ooi, C. H., Ishikawa, T., Oshima, H., Bhathal, P. S., Parker, A. E., Oshima, M., Tan, P. & Jenkins, B. J., 2012, In : Cancer Cell. 22, 4, p. 466 - 478 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3

Greenhill, C. J., Rose-John, S., Lissilaa, R., Ferlin, W., Ernst, M., Hertzog, P. J., Mansell, A. S. & Jenkins, B. J., 2011, In : Journal of Immunology. 186, 2, p. 1199 - 1208 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice

Ruwanpura, S., McLeod, L., Miller, A., Jones, J., Bozinovski, S., Vlahos, R., Ernst, M., Armes, J., Bardin, P., Anderson, G. & Jenkins, B., 2011, In : American Journal of Respiratory Cell and Molecular Biology. 45, 4, p. 720 - 730 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation

Jones, G., Stumhofer, J., Foster, T., Twohig, J., Hertzog, P. J., Topley, N., Williams, A. S., Hunter, C., Jenkins, B. J., Wang, E. & Jones, S. A., 2011, In : FASEB Journal. 25, 1, p. 409 - 419 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17

Kennedy, C., Najdovska, M., Jones, G., McLeod, L., Hughes, N., Allison, C., Ooi, C. H., Tan, P., Ferrero, R., Jones, S., Dev, A., Sievert, W., Bhathal, P. S. & Jenkins, B., 2011, In : Journal of Pathology. 225, 2, p. 255 - 264 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors

Mejias-Luque, R., Linden, S., Garrido, M., Tye, Y., Najdovska, M., Jenkins, B. J., Iglesias, M., Ernst, M. & de Bolos, C., 2010, In : Oncogene. 29, 12, p. 1753 - 1762 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis

Nowell, M., Williams, A. S., Carty, S., Scheller, J., Hayes, A., Jones, G., Richards, P., Slinn, S., Ernst, M., Jenkins, B. J., Topley, N., Rose-John, S. & Jones, S. A., 2009, In : Journal of Immunology. 182, 1, p. 613 - 622 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

IL-6 regulates neutrophil trafficking during acute inflammation via STAT3

Fielding, C. A., McLoughlin, R. M., McLeod, L., Colmont, C., Najdovska, M., Grail, D., Ernst, M., Jones, S. A., Topley, N. & Jenkins, B. J., 2008, In : Journal of Immunology. 181, 3, p. 2189 - 2195 7 p.

Research output: Contribution to journalArticleResearchpeer-review

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice

Ernst, M. R., Najdovska, M., Grail, D., Lundgren-May, T., Buchert, M., Tye, Y. M. H., Matthews, V. B., Armes, J. E., Bhathal, P. S., Hughes, N. R., Marcusson, E. G., Karras, J. G., Na, S., Sedgwick, J. D., Hertzog, P. J. & Jenkins, B. J., 2008, In : Journal of Clinical Investigation. 118, 5, p. 1727 - 1738 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis

Jenkins, B. J., Roberts, A. W., Greenhill, C. J., Najdovska, M., Lundgren-May, T., Robb, L. M., Grail, D. & Ernst, M. R., 2007, In : Blood. 109, 6, p. 2380 - 2388 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27

Brender, C., Tannahill, G. M., Jenkins, B. J., Fletcher, J., Columbus, R., Saris, C. JM., Ernst, M. R., Nicola, N. A., Hilton, D. J., Alexander, W. S. & Starr, R. J., 2007, In : Blood. 110, 7, p. 2528 - 2536 9 p.

Research output: Contribution to journalArticleResearchpeer-review