If you made any changes in Pure these will be visible here soon.

Research Output 1998 2019

2011
37 Citations (Scopus)

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation

Jones, G., Stumhofer, J., Foster, T., Twohig, J., Hertzog, P. J., Topley, N., Williams, A. S., Hunter, C., Jenkins, B. J., Wang, E. & Jones, S. A., 2011, In : FASEB Journal. 25, 1, p. 409 - 419 11 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17

Kennedy, C., Najdovska, M., Jones, G., McLeod, L., Hughes, N., Allison, C., Ooi, C. H., Tan, P., Ferrero, R., Jones, S., Dev, A., Sievert, W., Bhathal, P. S. & Jenkins, B., 2011, In : Journal of Pathology. 225, 2, p. 255 - 264 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
43 Citations (Scopus)

Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors

Mejias-Luque, R., Linden, S., Garrido, M., Tye, Y., Najdovska, M., Jenkins, B. J., Iglesias, M., Ernst, M. & de Bolos, C., 2010, In : Oncogene. 29, 12, p. 1753 - 1762 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
132 Citations (Scopus)

Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis

Nowell, M., Williams, A. S., Carty, S., Scheller, J., Hayes, A., Jones, G., Richards, P., Slinn, S., Ernst, M., Jenkins, B. J., Topley, N., Rose-John, S. & Jones, S. A., 2009, In : Journal of Immunology. 182, 1, p. 613 - 622 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
171 Citations (Scopus)

IL-6 regulates neutrophil trafficking during acute inflammation via STAT3

Fielding, C. A., McLoughlin, R. M., McLeod, L., Colmont, C., Najdovska, M., Grail, D., Ernst, M., Jones, S. A., Topley, N. & Jenkins, B. J., 2008, In : Journal of Immunology. 181, 3, p. 2189 - 2195 7 p.

Research output: Contribution to journalArticleResearchpeer-review

226 Citations (Scopus)

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice

Ernst, M. R., Najdovska, M., Grail, D., Lundgren-May, T., Buchert, M., Tye, Y. M. H., Matthews, V. B., Armes, J. E., Bhathal, P. S., Hughes, N. R., Marcusson, E. G., Karras, J. G., Na, S., Sedgwick, J. D., Hertzog, P. J. & Jenkins, B. J., 2008, In : Journal of Clinical Investigation. 118, 5, p. 1727 - 1738 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
44 Citations (Scopus)

Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis

Jenkins, B. J., Roberts, A. W., Greenhill, C. J., Najdovska, M., Lundgren-May, T., Robb, L. M., Grail, D. & Ernst, M. R., 2007, In : Blood. 109, 6, p. 2380 - 2388 9 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27

Brender, C., Tannahill, G. M., Jenkins, B. J., Fletcher, J., Columbus, R., Saris, C. JM., Ernst, M. R., Nicola, N. A., Hilton, D. J., Alexander, W. S. & Starr, R. J., 2007, In : Blood. 110, 7, p. 2528 - 2536 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
97 Citations (Scopus)

STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis

Judd, L., Bredin, K., Kalantzis, A., Jenkins, B., Ernst, M. & Giraud, A., 2006, In : Gastroenterology. 131, 4, p. 1073 - 1085 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
51 Citations (Scopus)

Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130

Howlett, M., Judd, L., Jenkins, B., La Gruta, N. L., Grail, D., Ernst, M. & Giraud, A., 2005, In : Gastroenterology. 129, 3, p. 1005 - 1018 14 p.

Research output: Contribution to journalArticleResearchpeer-review

213 Citations (Scopus)

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling

Jenkins, B. J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R. M., Jones, S. A., Topley, N., Baumann, H., Judd, L. M., Giraud, A. S., Boussioutas, A., Zhu, H-J. & Ernst, M. R., 2005, In : Nature Medicine. 11, p. 845 - 852 8 p.

Research output: Contribution to journalArticleResearchpeer-review

180 Citations (Scopus)

IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation

McLoughlin, R. M., Jenkins, B. J., Grail, D., Williams, A. S., Fielding, C. A., Parker, C. R., Ernst, M. R., Topley, N. & Jones, S. A., 2005, In : Proceedings of the National Academy of Sciences. 102, 27, p. 9589 - 9594 6 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

Interleukin-11 receptor signaling is required for normal bone remodeling

Sims, N., Jenkins, B., Nakamura, A., Quinn, J. M. W., Li, R., Gillespie, M., Ernst, M., Robb, L. & Martin, T., 2005, In : Journal of Bone and Mineral Research. 20, 7, p. 1093 - 1102 10 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis

Jenkins, B. J., Roberts, A. W., Najdovska, M., Grail, D. & Ernst, M. R., 2005, In : Blood. 105, 9, p. 3512 - 3520 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
221 Citations (Scopus)

Acquiring signalling specificity from the cytokine receptor gp130

Ernst, M. & Jenkins, B., 2004, In : Trends in Genetics. 20, 1, p. 23 - 32 10 p.

Research output: Contribution to journalArticleResearchpeer-review

141 Citations (Scopus)

Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130

Judd, L., Alderman, B., Howlett, M., Shulkes, A., Dow, C., Moverley, J., Grail, D., Jenkins, B., Ernst, M. & Giraud, A., 2004, In : Gastroenterology. 126, 1, p. 196 - 207 12 p.

Research output: Contribution to journalArticleResearchpeer-review

133 Citations (Scopus)

Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

Sims, N. A., Jenkins, B. J., Quinn, J. M. W., Nakamura, A., Glatt, M., Gillespie, M. T., Ernst, M. & Martin, T. J., 1 Jan 2004, In : Journal of Clinical Investigation. 113, 3, p. 379-389 11 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression

Jenkins, B. J., Grail, D., Inglese, M., Quilici, C., Bozinovksi, S., Wong, P. & Ernst, M. R., 2004, In : Molecular and Cellular Biology. 24, 4, p. 1453 - 1463 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
23 Citations (Scopus)

Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling

Jenkins, B. J., Quilici, C., Roberts, A. W., Grail, D., Dunn, A. R. & Ernst, M., 1 Nov 2002, In : Experimental Hematology. 30, 11, p. 1248-1256 9 p.

Research output: Contribution to journalArticleResearchpeer-review

354 Citations (Scopus)

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

Tebbutt, N. C., Giraud, A. S., Inglese, M., Jenkins, B. J., Waring, P., Clay, F. J., Malki, S., Grail, D., Hollande, F., Heath, J. K. & Ernst, M. R., 2002, In : Nature Medicine. 8, 10, p. 1089 - 1097 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

Activated mutants of the human gm-csf receptor β subunit cause myeloproliferative disorders and leukaemia in mice

McCormack, M. P., Jenkins, B. J. & Gonda, T. J., 1 Dec 1998, In : Experimental Hematology. 26, 8, 1 p.

Research output: Contribution to journalArticleResearchpeer-review