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Research Output 1998 2019

Article
221 Citations (Scopus)

Acquiring signalling specificity from the cytokine receptor gp130

Ernst, M. & Jenkins, B., 2004, In : Trends in Genetics. 20, 1, p. 23 - 32 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Activated mutants of the human gm-csf receptor β subunit cause myeloproliferative disorders and leukaemia in mice

McCormack, M. P., Jenkins, B. J. & Gonda, T. J., 1 Dec 1998, In : Experimental Hematology. 26, 8, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

ADAM17: An emerging therapeutic target for lung cancer

Saad, M. I., Rose-John, S. & Jenkins, B. J., 21 Aug 2019, In : Cancers. 11, 9, 28 p., 1218.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2 Citations (Scopus)

ADAM17 selectively activates the IL-6 trans-signaling/ERK MAPK axis in KRAS-addicted lung cancer

Saad, M. I., Alhayyani, S., McLeod, L., Yu, L., Alanazi, M., Deswaerte, V., Tang, K., Jarde, T., Smith, J. A., Prodanovic, Z., Tate, M. D., Balic, J. J., Watkins, D. N., Cain, J. E., Bozinovski, S., Algar, E., Kohmoto, T., Ebi, H., Ferlin, W., Garbers, C. & 4 others, Ruwanpura, S., Sagi, I., Rose-John, S. & Jenkins, B. J., Apr 2019, In : EMBO Molecular Medicine. 11, 4, 19 p., e9976.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

Blockade of the IL-6 trans-signalling/STAT3 axis suppresses cachexia in Kras-induced lung adenocarcinoma

Miller, A., McLeod, L., Alhayyani, S., Szczepny, A., Watkins, D. N., Chen, W., Enriori, P., Ferlin, W., Ruwanpura, S. & Jenkins, B. J., 25 May 2017, In : Oncogene. 36, 21, p. 3059-3066 8 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Clinical utility of a STAT3-regulated miRNA-200 family signature with prognostic potential in early gastric cancer

Yu, L., Wu, D., Gao, H., Balic, J. J., Tsykin, A., Han, T. S., Liu, Y. D., Kennedy, C. L., Li, J. K., Mao, J. Q., Tan, P., Oshima, M., Goodall, G. J. & Jenkins, B. J., 15 Mar 2018, In : Clinical Cancer Research. 24, 6, p. 1459-1472 14 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis

Carow, B., Reuschl, A-K., Gavier-Widen, D., Jenkins, B. J., Ernst, M. R., Yoshimura, A., Chambers, B. J. & Rottenberg, M. E., 2013, In : PLoS Pathogens. 9, 7, 20 p., e1003442.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)
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23 Citations (Scopus)

Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice

Ruwanpura, S., McLeod, L., Miller, A., Jones, J., Vlahos, R., Ramm, G., Longano, A., Bardin, P., Bozinovski, S., Anderson, G. & Jenkins, B., 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 32, 7, p. L627 - L639 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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8 Citations (Scopus)

Differential involvement of gp130 signalling pathways in modulating tobacco carcinogen-induced lung tumourigenesis

Miller, A., Brooks, G. D. C., McLeod, L., Ruwanpura, S. M. & Jenkins, B. J., 19 Mar 2015, In : Oncogene. 34, 12, p. 1510 - 1519 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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51 Citations (Scopus)

Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130

Howlett, M., Judd, L., Jenkins, B., La Gruta, N. L., Grail, D., Ernst, M. & Giraud, A., 2005, In : Gastroenterology. 129, 3, p. 1005 - 1018 14 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis

Kennedy, C. L., Najdovska, M., Tye, Y. M. H., McLeod, L., Yu, L., Jarnicki, A. G., Bhathal, P. S., Putoczki, T. L., Ernst, M. R. & Jenkins, B. J., 2014, In : Oncogene. 33, 19, p. 2540 - 2546 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Endoscopic ultrasound-guided fine-needle aspirate-derived preclinical pancreatic cancer models reveal panitumumab sensitivity in KRAS wild-type tumors

Berry, W., Algar, E., Kumar, B., Desmond, C., Swan, M., Jenkins, B. J. & Croagh, D., 15 May 2017, In : International Journal of Cancer. 140, 10, p. 2331-2343 13 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A

Jones, G., Greenhill, C. J., Williams, J. O., Nowell, M. A., Williams, A. S., Jenkins, B. J. & Jones, S. A., 2013, In : Annals of the Rheumatic Diseases. 72, 10, p. 1738 - 1742 5 p.

Research output: Contribution to journalArticleResearchpeer-review

141 Citations (Scopus)

Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130

Judd, L., Alderman, B., Howlett, M., Shulkes, A., Dow, C., Moverley, J., Grail, D., Jenkins, B., Ernst, M. & Giraud, A., 2004, In : Gastroenterology. 126, 1, p. 196 - 207 12 p.

Research output: Contribution to journalArticleResearchpeer-review

133 Citations (Scopus)

Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

Sims, N. A., Jenkins, B. J., Quinn, J. M. W., Nakamura, A., Glatt, M., Gillespie, M. T., Ernst, M. & Martin, T. J., 1 Jan 2004, In : Journal of Clinical Investigation. 113, 3, p. 379-389 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Helicobacter pylori type IV secretion system and its adhesin subunit, CagL, mediate potent inflammatory responses in primary human endothelial cells

Tafreshi, M., Guan, J., Gorrell, R. J., Chew, N., Xin, V., Deswaerte, V., Rohde, M., Daly, R. J., Peek Jr, R. M., Jenkins, B. J., Davies, E. M. & Kwok, T., 6 Feb 2018, In : Frontiers in Cellular and Infection Microbiology. 8, FEB, 15 p., 22.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling

Jenkins, B. J., Quilici, C., Roberts, A. W., Grail, D., Dunn, A. R. & Ernst, M., 1 Nov 2002, In : Experimental Hematology. 30, 11, p. 1248-1256 9 p.

Research output: Contribution to journalArticleResearchpeer-review

213 Citations (Scopus)

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling

Jenkins, B. J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R. M., Jones, S. A., Topley, N., Baumann, H., Judd, L. M., Giraud, A. S., Boussioutas, A., Zhu, H-J. & Ernst, M. R., 2005, In : Nature Medicine. 11, p. 845 - 852 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Hyperactive gp130/STAT3-driven gastric tumourigenesis promotes submucosal tertiary lymphoid structure development

Hill, D. G., Yu, L., Gao, H., Balic, J. J., West, A., Oshima, H., McLeod, L., Oshima, M., Gallimore, A., D'Costa, K., Bhathal, P. S., Sievert, W., Ferrero, R. L., Jenkins, B. J. & Jones, G. W., 1 Jul 2018, In : International Journal of Cancer. 143, 1, p. 167-178 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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11 Citations (Scopus)

Identification of a TLR2-regulated gene signature associated with tumor cell growth in gastric cancer

West, AC., Tang, K., Tye, H., Yu, L., Deng, N., Najdovska, M., Lin, S. J., Balic, JJ., Okochi-Takada, E., McGuirk, P., Keogh, B., McCormack, W., Bhathal, P. S., Reilly, M., Oshima, M., Ushijima, T., Tan, P. & Jenkins, B. J., 7 Sep 2017, In : Oncogene. 36, 36, p. 5134-5144 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice

Ruwanpura, S. M., McLeod, L., Brooks, G. D. C., Bozinovski, S., Vlahos, R., Longano, A., Bardin, P. G., Anderson, G. & Jenkins, B. J., 2014, In : Respirology. 19, 3, p. 419 - 427 9 p.

Research output: Contribution to journalArticleResearchpeer-review

171 Citations (Scopus)

IL-6 regulates neutrophil trafficking during acute inflammation via STAT3

Fielding, C. A., McLoughlin, R. M., McLeod, L., Colmont, C., Najdovska, M., Grail, D., Ernst, M., Jones, S. A., Topley, N. & Jenkins, B. J., 2008, In : Journal of Immunology. 181, 3, p. 2189 - 2195 7 p.

Research output: Contribution to journalArticleResearchpeer-review

126 Citations (Scopus)

IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3

Greenhill, C. J., Rose-John, S., Lissilaa, R., Ferlin, W., Ernst, M., Hertzog, P. J., Mansell, A. S. & Jenkins, B. J., 2011, In : Journal of Immunology. 186, 2, p. 1199 - 1208 10 p.

Research output: Contribution to journalArticleResearchpeer-review

40 Citations (Scopus)

IL6 trans-signaling promotes KRAS-driven lung carcinogenesis

Brooks, G. D., McLeod, L., Alhayyani, S., Miller, A., Russell, P. A., Ferlin, W., Rose-John, S., Ruwanpura, S. & Jenkins, B. J., 15 Feb 2016, In : Cancer Research. 76, 4, p. 866-876 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
180 Citations (Scopus)

IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation

McLoughlin, R. M., Jenkins, B. J., Grail, D., Williams, A. S., Fielding, C. A., Parker, C. R., Ernst, M. R., Topley, N. & Jones, S. A., 2005, In : Proceedings of the National Academy of Sciences. 102, 27, p. 9589 - 9594 6 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression

Jenkins, B. J., Grail, D., Inglese, M., Quilici, C., Bozinovksi, S., Wong, P. & Ernst, M. R., 2004, In : Molecular and Cellular Biology. 24, 4, p. 1453 - 1463 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis

Jones, G. W., McLeod, L., Kennedy, C. L., Bozinovski, S., Najdovska, M. & Jenkins, B. J., 2015, In : Atherosclerosis. 238, 2, p. 321 - 328 8 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Inflammasome adaptor ASC suppresses apoptosis of gastric cancer cells by an IL18-mediated inflammation-independent mechanism

Deswaerte, V., Nguyen, P., West, A., Browning, A. F., Yu, L., Ruwanpura, S. M., Balic, J., Livis, T., Girard, C., Preaudet, A., Oshima, H., Fung, K. Y., Tye, H., Najdovska, M., Ernst, M., Oshima, M., Gabay, C., Putoczki, T. & Jenkins, B. J., 1 Mar 2018, In : Cancer Research. 78, 5, p. 1293-1307 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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25 Citations (Scopus)

Inflammation and gastrointestinal cancer: an overview

Marusawa, H. & Jenkins, B. J., 2014, In : Cancer Letters. 345, 2, p. 153 - 156 4 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors

Mejias-Luque, R., Linden, S., Garrido, M., Tye, Y., Najdovska, M., Jenkins, B. J., Iglesias, M., Ernst, M. & de Bolos, C., 2010, In : Oncogene. 29, 12, p. 1753 - 1762 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Inflammatory and non-inflammatory roles for toll-like receptors in gastrointestinal cancer

West, A. C. & Jenkins, B. J., 2015, In : Current Pharmaceutical Design. 21, 21, p. 2968 - 2977 10 p.

Research output: Contribution to journalArticleResearchpeer-review

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29 Citations (Scopus)

Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice

Bozinovski, S., Seow, H. J., Chan, S. P. J., Anthony, D. A., McQualter, J. L., Hansen, M. J., Jenkins, B. J., Anderson, G. & Vlahos, R., 2015, In : Clinical Science. 129, 9, p. 785 - 796 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling

Balic, J. J., Garbers, C., Rose-John, S., Yu, L. & Jenkins, B. J., 1 Apr 2017, In : Cytokine. 92, p. 118-123 6 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

Interleukin-11 receptor signaling is required for normal bone remodeling

Sims, N., Jenkins, B., Nakamura, A., Quinn, J. M. W., Li, R., Gillespie, M., Ernst, M., Robb, L. & Martin, T., 2005, In : Journal of Bone and Mineral Research. 20, 7, p. 1093 - 1102 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Interleukin 1 Up-regulates MicroRNA 135b to Promote Inflammation-Associated Gastric Carcinogenesis in Mice

Han, T. S., Voon, D. C. C., Oshima, H., Nakayama, M., Echizen, K., Sakai, E., Yong, Z. W. E., Murakami, K., Yu, L., Minamoto, T., Ock, C. Y., Jenkins, B. J., Kim, S. J., Yang, H. K. & Oshima, M., 1 Mar 2019, In : Gastroenterology. 156, 4, p. 1140-1155.e4 20 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis

Jones, G. W., Bombardieri, M., Greenhill, C. J., McLeod, L., Nerviani, A., Rocher-Ros, V., Cardus, A., Williams, A. S., Pitzalis, C., Jenkins, B. J. & Jones, S. A., 2015, In : Journal of Experimental Medicine. 212, 11, p. 1793 - 1802 10 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice

Ruwanpura, S., McLeod, L., Miller, A., Jones, J., Bozinovski, S., Vlahos, R., Ernst, M., Armes, J., Bardin, P., Anderson, G. & Jenkins, B., 2011, In : American Journal of Respiratory Cell and Molecular Biology. 45, 4, p. 720 - 730 11 p.

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)

Interleukin-6 signaling drives fibrosis in unresolved inflammation

Fielding, C. A., Jones, G. W., McLoughlin, R. M., McLeod, L., Hammond, V. J., Uceda, J., Williams, A. S., Lambie, M., Foster, T. L., Liao, C-T., Rice, C. M., Greenhill, C. J., Colmont, C. S., Hams, E., Coles, B., Kift-Morgan, A., Newton, Z., Craig, K. J., Williams, J. D., Williams, G. T. & 7 others, Davies, S. J., Humphreys, I. R., O'Donnell, V. B., Taylor, P. R., Jenkins, B. J., Topley, N. & Jones, S. A., 2014, In : Immunity. 40, 1, p. 40 - 50 11 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

In vivo evidence that RBM5 is a tumour suppressor in the lung

Jamsai, D., Watkins, D. N., O'Connor, A. E., Merriner, D. J., Gursoy, S., Bird, A. D., Kumar, B., Miller, A., Cole, T. J., Jenkins, B. J. & O'Bryan, M. K., 1 Dec 2017, In : Scientific Reports. 7, 1, 8 p., 15874.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling

Greenhill, C. J., Gould, J. A., Ernst, M. R., Jarnicki, A. G., Hertzog, P. J., Mansell, A. S. & Jenkins, B. J., 2012, In : Immunology and Cell Biology. 90, 5, p. 559 - 563 5 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Murine oncostatin m acts via leukemia inhibitory factor receptor to phosphorylate signal transducer and activator of transcription 3 (STAT3) but not STAT1, an effect that protects bone mass

Walker, E. C., Johnson, R. W., Hu, Y., Brennan, H. J., Poulton, I. J., Zhang, J. G., Jenkins, B. J., Smyth, G. K., Nicola, N. A. & Sims, N. A., 7 Oct 2016, In : Journal of Biological Chemistry. 291, 41, p. 21703-21716 14 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Myeloid differentiation factor 88 signaling in bone marrow-derived cells promotes gastric tumorigenesis by generation of inflammatory microenvironment

Maeda, Y., Echizen, K., Oshima, H., Yu, L., Sakulsak, N., Hirose, O., Yamada, Y., Taniguchi, T., Jenkins, B. J., Saya, H. & Oshima, M., 1 Mar 2016, In : Cancer Prevention Research. 9, 3, p. 253-263 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
37 Citations (Scopus)

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation

Jones, G., Stumhofer, J., Foster, T., Twohig, J., Hertzog, P. J., Topley, N., Williams, A. S., Hunter, C., Jenkins, B. J., Wang, E. & Jones, S. A., 2011, In : FASEB Journal. 25, 1, p. 409 - 419 11 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice

Ruwanpura, S. M., McLeod, L., Lilja, A., Brooks, G. D. C., Dousha, L., Seow, H. J., Bozinovski, S., Vlahos, R., Hertzog, P. J., Anderson, G. & Jenkins, B. J., 2013, In : PLoS ONE. 8, 10, 9 p., e78095.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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30 Citations (Scopus)

Nucleotide oligomerization domain 1 enhances IFN-gamma signaling in gastric epithelial cells during Helicobacter pylori infection and exacerbates disease severity

Allison, C. C., Ferrand, J. F. P., McLeod, L., Hassan, M., Kaparakis-Liaskos, M., Grubman, A., Bhathal, P. S., Dev, A. T., Sievert, W., Jenkins, B. J. & Ferrero, R. L., 2013, In : Journal of Immunology. 190, 7, p. 3706-3715 10 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis

Jenkins, B. J., Roberts, A. W., Greenhill, C. J., Najdovska, M., Lundgren-May, T., Robb, L. M., Grail, D. & Ernst, M. R., 2007, In : Blood. 109, 6, p. 2380 - 2388 9 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Rab8a interacts directly with PI3Kgamma to modulate TLR4-driven PI3K and mTOR signalling

Luo, L., Wall, A. A., Yeo, J. C., Condon, N. D., Norwood, S. J., Schoenwaelder, S. M., Chen, K. W., Jackson, S., Jenkins, B. J., Hartland, E. L., Schroder, K., Collins, B. M., Sweet, M. J. & Stow, J. L., 2014, In : Nature Communications. 5, (Art. No.:4407), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
354 Citations (Scopus)

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

Tebbutt, N. C., Giraud, A. S., Inglese, M., Jenkins, B. J., Waring, P., Clay, F. J., Malki, S., Grail, D., Hollande, F., Heath, J. K. & Ernst, M. R., 2002, In : Nature Medicine. 8, 10, p. 1089 - 1097 9 p.

Research output: Contribution to journalArticleResearchpeer-review

57 Citations (Scopus)

STAT1 plays a role in TLR signal transduction and inflammatory responses

Luu, K., Greenhill, C. J., Majoros, A., Decker, T., Jenkins, B. J. & Mansell, A. S., 2014, In : Immunology and Cell Biology. 92, 9, p. 761 - 769 9 p.

Research output: Contribution to journalArticleResearchpeer-review