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Research Output 1998 2019

1998

Activated mutants of the human gm-csf receptor β subunit cause myeloproliferative disorders and leukaemia in mice

McCormack, M. P., Jenkins, B. J. & Gonda, T. J., 1 Dec 1998, In : Experimental Hematology. 26, 8, 1 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
23 Citations (Scopus)

Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling

Jenkins, B. J., Quilici, C., Roberts, A. W., Grail, D., Dunn, A. R. & Ernst, M., 1 Nov 2002, In : Experimental Hematology. 30, 11, p. 1248-1256 9 p.

Research output: Contribution to journalArticleResearchpeer-review

354 Citations (Scopus)

Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice

Tebbutt, N. C., Giraud, A. S., Inglese, M., Jenkins, B. J., Waring, P., Clay, F. J., Malki, S., Grail, D., Hollande, F., Heath, J. K. & Ernst, M. R., 2002, In : Nature Medicine. 8, 10, p. 1089 - 1097 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
221 Citations (Scopus)

Acquiring signalling specificity from the cytokine receptor gp130

Ernst, M. & Jenkins, B., 2004, In : Trends in Genetics. 20, 1, p. 23 - 32 10 p.

Research output: Contribution to journalArticleResearchpeer-review

141 Citations (Scopus)

Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130

Judd, L., Alderman, B., Howlett, M., Shulkes, A., Dow, C., Moverley, J., Grail, D., Jenkins, B., Ernst, M. & Giraud, A., 2004, In : Gastroenterology. 126, 1, p. 196 - 207 12 p.

Research output: Contribution to journalArticleResearchpeer-review

133 Citations (Scopus)

Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways

Sims, N. A., Jenkins, B. J., Quinn, J. M. W., Nakamura, A., Glatt, M., Gillespie, M. T., Ernst, M. & Martin, T. J., 1 Jan 2004, In : Journal of Clinical Investigation. 113, 3, p. 379-389 11 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression

Jenkins, B. J., Grail, D., Inglese, M., Quilici, C., Bozinovksi, S., Wong, P. & Ernst, M. R., 2004, In : Molecular and Cellular Biology. 24, 4, p. 1453 - 1463 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
51 Citations (Scopus)

Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130

Howlett, M., Judd, L., Jenkins, B., La Gruta, N. L., Grail, D., Ernst, M. & Giraud, A., 2005, In : Gastroenterology. 129, 3, p. 1005 - 1018 14 p.

Research output: Contribution to journalArticleResearchpeer-review

213 Citations (Scopus)

Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling

Jenkins, B. J., Grail, D., Nheu, T., Najdovska, M., Wang, B., Waring, P., Inglese, M., McLoughlin, R. M., Jones, S. A., Topley, N., Baumann, H., Judd, L. M., Giraud, A. S., Boussioutas, A., Zhu, H-J. & Ernst, M. R., 2005, In : Nature Medicine. 11, p. 845 - 852 8 p.

Research output: Contribution to journalArticleResearchpeer-review

180 Citations (Scopus)

IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation

McLoughlin, R. M., Jenkins, B. J., Grail, D., Williams, A. S., Fielding, C. A., Parker, C. R., Ernst, M. R., Topley, N. & Jones, S. A., 2005, In : Proceedings of the National Academy of Sciences. 102, 27, p. 9589 - 9594 6 p.

Research output: Contribution to journalArticleResearchpeer-review

92 Citations (Scopus)

Interleukin-11 receptor signaling is required for normal bone remodeling

Sims, N., Jenkins, B., Nakamura, A., Quinn, J. M. W., Li, R., Gillespie, M., Ernst, M., Robb, L. & Martin, T., 2005, In : Journal of Bone and Mineral Research. 20, 7, p. 1093 - 1102 10 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis

Jenkins, B. J., Roberts, A. W., Najdovska, M., Grail, D. & Ernst, M. R., 2005, In : Blood. 105, 9, p. 3512 - 3520 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
97 Citations (Scopus)

STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis

Judd, L., Bredin, K., Kalantzis, A., Jenkins, B., Ernst, M. & Giraud, A., 2006, In : Gastroenterology. 131, 4, p. 1073 - 1085 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
44 Citations (Scopus)

Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis

Jenkins, B. J., Roberts, A. W., Greenhill, C. J., Najdovska, M., Lundgren-May, T., Robb, L. M., Grail, D. & Ernst, M. R., 2007, In : Blood. 109, 6, p. 2380 - 2388 9 p.

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27

Brender, C., Tannahill, G. M., Jenkins, B. J., Fletcher, J., Columbus, R., Saris, C. JM., Ernst, M. R., Nicola, N. A., Hilton, D. J., Alexander, W. S. & Starr, R. J., 2007, In : Blood. 110, 7, p. 2528 - 2536 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
171 Citations (Scopus)

IL-6 regulates neutrophil trafficking during acute inflammation via STAT3

Fielding, C. A., McLoughlin, R. M., McLeod, L., Colmont, C., Najdovska, M., Grail, D., Ernst, M., Jones, S. A., Topley, N. & Jenkins, B. J., 2008, In : Journal of Immunology. 181, 3, p. 2189 - 2195 7 p.

Research output: Contribution to journalArticleResearchpeer-review

226 Citations (Scopus)

STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice

Ernst, M. R., Najdovska, M., Grail, D., Lundgren-May, T., Buchert, M., Tye, Y. M. H., Matthews, V. B., Armes, J. E., Bhathal, P. S., Hughes, N. R., Marcusson, E. G., Karras, J. G., Na, S., Sedgwick, J. D., Hertzog, P. J. & Jenkins, B. J., 2008, In : Journal of Clinical Investigation. 118, 5, p. 1727 - 1738 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
132 Citations (Scopus)

Therapeutic targeting of IL-6 trans signaling counteracts STAT3 control of experimental inflammatory arthritis

Nowell, M., Williams, A. S., Carty, S., Scheller, J., Hayes, A., Jones, G., Richards, P., Slinn, S., Ernst, M., Jenkins, B. J., Topley, N., Rose-John, S. & Jones, S. A., 2009, In : Journal of Immunology. 182, 1, p. 613 - 622 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
43 Citations (Scopus)

Inflammation modulates the expression of the intestinal mucins MUC2 and MUC4 in gastric tumors

Mejias-Luque, R., Linden, S., Garrido, M., Tye, Y., Najdovska, M., Jenkins, B. J., Iglesias, M., Ernst, M. & de Bolos, C., 2010, In : Oncogene. 29, 12, p. 1753 - 1762 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
126 Citations (Scopus)

IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3

Greenhill, C. J., Rose-John, S., Lissilaa, R., Ferlin, W., Ernst, M., Hertzog, P. J., Mansell, A. S. & Jenkins, B. J., 2011, In : Journal of Immunology. 186, 2, p. 1199 - 1208 10 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Interleukin-6 promotes pulmonary emphysema associated with apoptosis in mice

Ruwanpura, S., McLeod, L., Miller, A., Jones, J., Bozinovski, S., Vlahos, R., Ernst, M., Armes, J., Bardin, P., Anderson, G. & Jenkins, B., 2011, In : American Journal of Respiratory Cell and Molecular Biology. 45, 4, p. 720 - 730 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Naive and activated T cells display differential responsiveness to TL1A that affects Th17 generation, maintenance, and proliferation

Jones, G., Stumhofer, J., Foster, T., Twohig, J., Hertzog, P. J., Topley, N., Williams, A. S., Hunter, C., Jenkins, B. J., Wang, E. & Jones, S. A., 2011, In : FASEB Journal. 25, 1, p. 409 - 419 11 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17

Kennedy, C., Najdovska, M., Jones, G., McLeod, L., Hughes, N., Allison, C., Ooi, C. H., Tan, P., Ferrero, R., Jones, S., Dev, A., Sievert, W., Bhathal, P. S. & Jenkins, B., 2011, In : Journal of Pathology. 225, 2, p. 255 - 264 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
23 Citations (Scopus)

Deregulated Stat3 signaling dissociates pulmonary inflammation from emphysema in gp130 mutant mice

Ruwanpura, S., McLeod, L., Miller, A., Jones, J., Vlahos, R., Ramm, G., Longano, A., Bardin, P., Bozinovski, S., Anderson, G. & Jenkins, B., 2012, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 32, 7, p. L627 - L639 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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6 Citations (Scopus)

LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling

Greenhill, C. J., Gould, J. A., Ernst, M. R., Jarnicki, A. G., Hertzog, P. J., Mansell, A. S. & Jenkins, B. J., 2012, In : Immunology and Cell Biology. 90, 5, p. 559 - 563 5 p.

Research output: Contribution to journalArticleResearchpeer-review

153 Citations (Scopus)

STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation

Tye, Y. M. H., Kennedy, C. L., Najdovska, M., McLeod, L., McCormack, W., Hughes, N. R., Dev, A. T., Sievert, W., Ooi, C. H., Ishikawa, T., Oshima, H., Bhathal, P. S., Parker, A. E., Oshima, M., Tan, P. & Jenkins, B. J., 2012, In : Cancer Cell. 22, 4, p. 466 - 478 13 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Toll-like receptor 2: therapeutic target for gastric carcinogenesis

McCormack, W., Oshima, M., Tan, P. & Jenkins, B. J., 2012, In : Oncotarget. 3, 11, p. 1260 - 1261 2 p.

Research output: Contribution to journalLetterOther

Open Access
File
2013
25 Citations (Scopus)

Critical and independent role for SOCS3 in either myeloid or T cells in resistance to Mycobacterium tuberculosis

Carow, B., Reuschl, A-K., Gavier-Widen, D., Jenkins, B. J., Ernst, M. R., Yoshimura, A., Chambers, B. J. & Rottenberg, M. E., 2013, In : PLoS Pathogens. 9, 7, 20 p., e1003442.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)
File
12 Citations (Scopus)

Exacerbated inflammatory arthritis in response to hyperactive gp130 signalling is independent of IL-17A

Jones, G., Greenhill, C. J., Williams, J. O., Nowell, M. A., Williams, A. S., Jenkins, B. J. & Jones, S. A., 2013, In : Annals of the Rheumatic Diseases. 72, 10, p. 1738 - 1742 5 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Non-essential role for TLR2 and its signaling adaptor Mal/TIRAP in preserving normal lung architecture in mice

Ruwanpura, S. M., McLeod, L., Lilja, A., Brooks, G. D. C., Dousha, L., Seow, H. J., Bozinovski, S., Vlahos, R., Hertzog, P. J., Anderson, G. & Jenkins, B. J., 2013, In : PLoS ONE. 8, 10, 9 p., e78095.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
30 Citations (Scopus)

Nucleotide oligomerization domain 1 enhances IFN-gamma signaling in gastric epithelial cells during Helicobacter pylori infection and exacerbates disease severity

Allison, C. C., Ferrand, J. F. P., McLeod, L., Hassan, M., Kaparakis-Liaskos, M., Grubman, A., Bhathal, P. S., Dev, A. T., Sievert, W., Jenkins, B. J. & Ferrero, R. L., 2013, In : Journal of Immunology. 190, 7, p. 3706-3715 10 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Tying the knot between cytokine and toll-like receptor signaling in gastrointestinal tract cancers

Tye, Y. M. H. & Jenkins, B. J., 2013, In : Cancer Science. 104, 9, p. 1139 - 1145 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
24 Citations (Scopus)

Differential role of MyD88 and Mal/TIRAP in TLR2-mediated gastric tumourigenesis

Kennedy, C. L., Najdovska, M., Tye, Y. M. H., McLeod, L., Yu, L., Jarnicki, A. G., Bhathal, P. S., Putoczki, T. L., Ernst, M. R. & Jenkins, B. J., 2014, In : Oncogene. 33, 19, p. 2540 - 2546 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

IL-6/Stat3-driven pulmonary inflammation, but not emphysema, is dependent on interleukin-17A in mice

Ruwanpura, S. M., McLeod, L., Brooks, G. D. C., Bozinovski, S., Vlahos, R., Longano, A., Bardin, P. G., Anderson, G. & Jenkins, B. J., 2014, In : Respirology. 19, 3, p. 419 - 427 9 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Inflammation and gastrointestinal cancer: an overview

Marusawa, H. & Jenkins, B. J., 2014, In : Cancer Letters. 345, 2, p. 153 - 156 4 p.

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)

Interleukin-6 signaling drives fibrosis in unresolved inflammation

Fielding, C. A., Jones, G. W., McLoughlin, R. M., McLeod, L., Hammond, V. J., Uceda, J., Williams, A. S., Lambie, M., Foster, T. L., Liao, C-T., Rice, C. M., Greenhill, C. J., Colmont, C. S., Hams, E., Coles, B., Kift-Morgan, A., Newton, Z., Craig, K. J., Williams, J. D., Williams, G. T. & 7 others, Davies, S. J., Humphreys, I. R., O'Donnell, V. B., Taylor, P. R., Jenkins, B. J., Topley, N. & Jones, S. A., 2014, In : Immunity. 40, 1, p. 40 - 50 11 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Rab8a interacts directly with PI3Kgamma to modulate TLR4-driven PI3K and mTOR signalling

Luo, L., Wall, A. A., Yeo, J. C., Condon, N. D., Norwood, S. J., Schoenwaelder, S. M., Chen, K. W., Jackson, S., Jenkins, B. J., Hartland, E. L., Schroder, K., Collins, B. M., Sweet, M. J. & Stow, J. L., 2014, In : Nature Communications. 5, (Art. No.:4407), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
57 Citations (Scopus)

STAT1 plays a role in TLR signal transduction and inflammatory responses

Luu, K., Greenhill, C. J., Majoros, A., Decker, T., Jenkins, B. J. & Mansell, A. S., 2014, In : Immunology and Cell Biology. 92, 9, p. 761 - 769 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2015

Cytokine Receptors and Their Ligands

Dhagat, U., Nero, T. L., Kan, W. L., Hercus, T. R., Broughton, S. E., De Weerd, N. A., Jenkins, B. J., Mansell, A., Guthridge, M. A., Hertzog, P. J., Lopez, A. F. & Parker, M. W., 1 Jan 2015, Encyclopedia of Cell Biology: Functional Cell Biology. Bradshaw, R. A. & Stahl, P. D. (eds.). Waltham MA USA: Elsevier, Vol. 3. p. 22-36 15 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

8 Citations (Scopus)

Differential involvement of gp130 signalling pathways in modulating tobacco carcinogen-induced lung tumourigenesis

Miller, A., Brooks, G. D. C., McLeod, L., Ruwanpura, S. M. & Jenkins, B. J., 19 Mar 2015, In : Oncogene. 34, 12, p. 1510 - 1519 10 p.

Research output: Contribution to journalArticleResearchpeer-review

File
8 Citations (Scopus)

Imbalanced gp130 signalling in ApoE-deficient mice protects against atherosclerosis

Jones, G. W., McLeod, L., Kennedy, C. L., Bozinovski, S., Najdovska, M. & Jenkins, B. J., 2015, In : Atherosclerosis. 238, 2, p. 321 - 328 8 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Inflammatory and non-inflammatory roles for toll-like receptors in gastrointestinal cancer

West, A. C. & Jenkins, B. J., 2015, In : Current Pharmaceutical Design. 21, 21, p. 2968 - 2977 10 p.

Research output: Contribution to journalArticleResearchpeer-review

File
29 Citations (Scopus)

Innate cellular sources of interleukin-17A regulate macrophage accumulation in cigarette- smoke-induced lung inflammation in mice

Bozinovski, S., Seow, H. J., Chan, S. P. J., Anthony, D. A., McQualter, J. L., Hansen, M. J., Jenkins, B. J., Anderson, G. & Vlahos, R., 2015, In : Clinical Science. 129, 9, p. 785 - 796 12 p.

Research output: Contribution to journalArticleResearchpeer-review

51 Citations (Scopus)

Interleukin-27 inhibits ectopic lymphoid-like structure development in early inflammatory arthritis

Jones, G. W., Bombardieri, M., Greenhill, C. J., McLeod, L., Nerviani, A., Rocher-Ros, V., Cardus, A., Williams, A. S., Pitzalis, C., Jenkins, B. J. & Jones, S. A., 2015, In : Journal of Experimental Medicine. 212, 11, p. 1793 - 1802 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2016
40 Citations (Scopus)

IL6 trans-signaling promotes KRAS-driven lung carcinogenesis

Brooks, G. D., McLeod, L., Alhayyani, S., Miller, A., Russell, P. A., Ferlin, W., Rose-John, S., Ruwanpura, S. & Jenkins, B. J., 15 Feb 2016, In : Cancer Research. 76, 4, p. 866-876 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2 Citations (Scopus)

Investigating the role of Toll-like receptors in mouse models of gastric cancer

West, A. C. & Jenkins, B. J., 2016, Methods in Molecular Biology. Humana Press, Vol. 1390. p. 427-449 23 p. (Methods in Molecular Biology; vol. 1390).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Multifaceted Role of IRAK-M in the Promotion of Colon Carcinogenesis via Barrier Dysfunction and STAT3 Oncoprotein Stabilization in Tumors

Jenkins, B. J., 9 May 2016, In : Cancer Cell. 29, 5, p. 615-617 3 p.

Research output: Contribution to journalShort SurveyOtherpeer-review

13 Citations (Scopus)

Murine oncostatin m acts via leukemia inhibitory factor receptor to phosphorylate signal transducer and activator of transcription 3 (STAT3) but not STAT1, an effect that protects bone mass

Walker, E. C., Johnson, R. W., Hu, Y., Brennan, H. J., Poulton, I. J., Zhang, J. G., Jenkins, B. J., Smyth, G. K., Nicola, N. A. & Sims, N. A., 7 Oct 2016, In : Journal of Biological Chemistry. 291, 41, p. 21703-21716 14 p.

Research output: Contribution to journalArticleResearchpeer-review