Projects per year
Personal profile
Biography
Professor Brendan Jenkins
Head - Cancer and Immune Signalling Laboratory
Centre for Innate Immunity and Infectious Diseases
NHMRC Senior Research Fellow
Brendan is Head of the Cancer and Immune Signalling Laboratory in the Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, and currently holds a prestigious NHMRC Senior Research Fellowship. His research laboratory has a strong focus on cancer (stomach, lung, pancreatic) and immune-related diseases (emphysema/COPD, arthritis, peritonitis).
Prof Brendan Jenkins is a current NHMRC Senior Research Fellow and prior to this he was holder of an NHMRC RD Wright Postdoctoral Research Fellowship, a Monash University Fellowship, and most recently a prestigious Sylvia and Charles Viertel Senior Medical Research Fellowship.
Over the last 15 years he has been at the forefront of research to examine the roles cytokines play in human disease, in particular cancer of the stomach (gastric cancer) which is the second most lethal cancer world-wide, and chronic inflammation. Since being recruited to the Hudson Institute, he further expanded his research to also include cancers of the lung (most common and lethal cancer in the world) and pancreas (worst survival rates worldwide), as well as the debilitating lung disease emphysema/chronic obstructive pulmonary disease (COPD). Collectively, his research programs incorporate long standing collaborations with basic scientific researchers, industry and clinicians both nationwide and overseas (UK, Japan, Singapore, Europe). Amongst his scientific achievements are publications in the highest ranking science and medical research journals including Cancer Cell, Nature, Nature Medicine, Immunity, Journal of Clinical Investigation, Journal of Experimental Medicine, Cancer Research, Oncogene, and Journal of Immunology.
In recognition of his group's research achievements, he has received numerous national and international awards, including the Australian Institute for Policy and Science Tall Poppy Award. He is a holder of multiple project grants within Australia (NHMRC, Cancer Council) and overseas (Association for International Cancer Research), and is a regular invited speaker at local and international scientific meetings.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, PhD, University of Adelaide
Research area keywords
- Animal Disease Models
- Cancer
- Cytokine Signal Transduction
- Emphysema
- Gastric (Stomach) Cancer
- Inflammation
- Inflammatory diseases
- Interleukin (Il)-6 Family Cytokines
- Lung Cancer
- Pattern Recognition Receptors
- Pancreatic Cancer
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Targeting Innate Immune Inflammasomes as Key Drivers of Microbial-Associated Pancreatic Cancer and Therapy Resistance
Jenkins, B., Croagh, D., Forster, S., Pajic, M., Zavros, Y., Kumar, B. & Schmidt, F.
1/09/22 → 31/08/25
Project: Research
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Innate immune cytosolic DNA sensors as novel pro-tumorigenic drivers in stomach cancer
Jenkins, B., Ferrero, R., Zavros, Y., Thomas, P. & Kumar, B.
1/07/22 → 30/06/25
Project: Research
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Accelerating the uptake of precision medicine in pancreatic cancer using endoscopic ultrasound biopsy.
Croagh, D., Goldstein, D., Jenkins, B., Nguyen, N., Devereaux, B., Kaffes, A., Ragunath, K., Lundy, J., Fanning, S., Rathi, V. & Gao, H. Y.
28/07/21 → 30/06/23
Project: Research
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Uncovering the broad clinical utility of the innate immune pattern recognition receptor, Toll-like receptor 2, in pancreatic cancer
Jenkins, B., Croagh, D., Pajic, M. & Zavros, Y.
1/01/21 → 31/12/23
Project: Research
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Targeting key regulators of innate immunity in inflammation-associated cancer
1/01/19 → 31/12/23
Project: Research
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Blockade of the protease ADAM17 ameliorates experimental pancreatitis
Saad, M. I., Weng, T., Lundy, J., Gearing, L. J., West, A. C., Harpur, C. M., Alanazi, M., Hodges, C., Croagh, D., Kumar, B., Sagi, I., Rose-John, S. & Jenkins, B. J., 18 Oct 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 42, 12 p., e2213744119.Research output: Contribution to journal › Article › Research › peer-review
3 Citations (Scopus) -
Complete loss of miR-200 family induces EMT associated cellular senescence in gastric cancer
Yu, L., Cao, C., Li, X., Zhang, M., Gu, Q., Gao, H., Balic, J. J., Xu, D., Zhang, L., Ying, L., Xu, D., Yang, Y., Wu, D., He, B., Jenkins, B. J., Liu, Y. & Li, J., 3 Jan 2022, In: Oncogene. 41, 1, p. 26-36 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus) -
Context-dependent functions of pattern recognition receptors in cancer
Man, S. M. & Jenkins, B. J., Jul 2022, In: Nature Reviews Cancer. 22, 7, p. 397-413 17 p.Research output: Contribution to journal › Review Article › Research › peer-review
13 Citations (Scopus) -
Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema
Ruwanpura, S. M., McLeod, L., Dousha, L. F., Seow, H. J., West, A. C., West, A. J., Weng, T., Alanazi, M., MacDonald, M., King, P. T., Bardin, P. G., Gabay, C., Klinman, D. M., Bozinovski, S., Vlahos, R., Anderson, G. P., Rose-John, S., Saad, M. I. & Jenkins, B. J., 6 Sep 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 36, 12 p., e2201494119.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
IL-6 family cytokines: An updated perspective on their broad pathophysiology
Jenkins, B. J., Apr 2022, In: Cytokine. 152, 1 p., 155822.Research output: Contribution to journal › Editorial › Other › peer-review
Open Access1 Citation (Scopus)