Projects per year
Personal profile
Biography
Professor Brendan Jenkins
Head - Cancer and Immune Signalling Laboratory
Centre for Innate Immunity and Infectious Diseases
NHMRC Senior Research Fellow
Brendan is Head of the Cancer and Immune Signalling Laboratory in the Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, and currently holds a prestigious NHMRC Senior Research Fellowship. His research laboratory has a strong focus on cancer (stomach, lung, pancreatic) and immune-related diseases (emphysema/COPD, arthritis, peritonitis).
Prof Brendan Jenkins is a current NHMRC Senior Research Fellow and prior to this he was holder of an NHMRC RD Wright Postdoctoral Research Fellowship, a Monash University Fellowship, and most recently a prestigious Sylvia and Charles Viertel Senior Medical Research Fellowship.
Over the last 15 years he has been at the forefront of research to examine the roles cytokines play in human disease, in particular cancer of the stomach (gastric cancer) which is the second most lethal cancer world-wide, and chronic inflammation. Since being recruited to the Hudson Institute, he further expanded his research to also include cancers of the lung (most common and lethal cancer in the world) and pancreas (worst survival rates worldwide), as well as the debilitating lung disease emphysema/chronic obstructive pulmonary disease (COPD). Collectively, his research programs incorporate long standing collaborations with basic scientific researchers, industry and clinicians both nationwide and overseas (UK, Japan, Singapore, Europe). Amongst his scientific achievements are publications in the highest ranking science and medical research journals including Cancer Cell, Nature, Nature Medicine, Immunity, Journal of Clinical Investigation, Journal of Experimental Medicine, Cancer Research, Oncogene, and Journal of Immunology.
In recognition of his group's research achievements, he has received numerous national and international awards, including the Australian Institute for Policy and Science Tall Poppy Award. He is a holder of multiple project grants within Australia (NHMRC, Cancer Council) and overseas (Association for International Cancer Research), and is a regular invited speaker at local and international scientific meetings.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Medicine, PhD, University of Adelaide
Research area keywords
- Animal Disease Models
- Cancer
- Cytokine Signal Transduction
- Emphysema
- Gastric (Stomach) Cancer
- Inflammation
- Inflammatory diseases
- Interleukin (Il)-6 Family Cytokines
- Lung Cancer
- Pattern Recognition Receptors
- Pancreatic Cancer
Collaborations and top research areas from the last five years
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Innate immune cytosolic DNA sensors as novel pro-tumorigenic drivers in stomach cancer
Jenkins, B. (Primary Chief Investigator (PCI)), Ferrero, R. (Chief Investigator (CI)), Zavros, Y. (Chief Investigator (CI)), Thomas, P. (Chief Investigator (CI)) & Kumar, B. (Chief Investigator (CI))
1/07/22 → 30/06/25
Project: Research
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Therapeutic targeting of JAK-STAT pathway in a novel mouse model for gastro-intestinal cancers
Jenkins, B. (Primary Chief Investigator (PCI)), Ernst, M. R. W. (Chief Investigator (CI)), Segal, D. H. (Chief Investigator (CI)) & Sievert, W. (Chief Investigator (CI))
Project: Research
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Targeting Innate Immune Inflammasomes as Key Drivers of Microbial-Associated Pancreatic Cancer and Therapy Resistance
Jenkins, B. (Primary Chief Investigator (PCI)), Croagh, D. (Chief Investigator (CI)), Forster, S. (Chief Investigator (CI)), Pajic, M. (Chief Investigator (CI)), Zavros, Y. (Chief Investigator (CI)), Kumar, B. (Chief Investigator (CI)) & Schmidt, F. (Chief Investigator (CI))
1/09/22 → 24/02/24
Project: Research
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SII small animal optical imaging system AmiHTX
Hartland, E., Hertzog, P. & Jenkins, B.
1/10/21 → 31/12/22
Project: Research
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Accelerating the uptake of precision medicine in pancreatic cancer using endoscopic ultrasound biopsy.
Croagh, D. (Primary Chief Investigator (PCI)), Goldstein, D. P. (Chief Investigator (CI)), Jenkins, B. (Chief Investigator (CI)), Nguyen, N. (Chief Investigator (CI)), Devereaux, B. (Chief Investigator (CI)), Kaffes, A. (Chief Investigator (CI)), Ragunath, K. (Chief Investigator (CI)), Lundy, J. (Chief Investigator (CI)), Fanning, S. (Chief Investigator (CI)), Rathi, V. (Chief Investigator (CI)) & Gao, H. Y. (Chief Investigator (CI))
28/07/21 → 1/06/25
Project: Research
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Cytosolic DNA sensor AIM2 promotes KRAS-driven lung cancer independent of inflammasomes
Alanazi, M., Weng, T., McLeod, L., Gearing, L. J., Smith, J. A., Kumar, B., Saad, M. I. & Jenkins, B. J., Jun 2024, In: Cancer Science. 115, 6, p. 1834-1850 17 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
The protease ADAM17 at the crossroads of disease: revisiting its significance in inflammation, cancer, and beyond
Saad, M. I. & Jenkins, B. J., Jan 2024, In: The FEBS Journal. 291, 1, p. 10-24 15 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access17 Citations (Scopus) -
An In Vitro Model for Assessing Acute Lung Injury During Pancreatitis Development Using Primary Mouse Cell Co-cultures
Saad, M. I. & Jenkins, B. J., 2023, Inflammation and Cancer: Methods and Protocols. Jenkins, B. J. (ed.). 2nd ed. New York NY USA: Humana Press, p. 71-80 10 p. (Methods in Molecular Biology; vol. 2691).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
1 Citation (Scopus) -
Circulating Tumor DNA Is an Accurate Diagnostic Tool and Strong Prognostic Marker in Pancreatic Cancer
Sellahewa, R., Moghaddam, S. M., Lundy, J., Jenkins, B. J. & Croagh, D., 1 Mar 2023, In: Pancreas. 52, 3, p. E188-E195 8 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
The cytosolic DNA sensor AIM2 promotes Helicobacter-induced gastric pathology via the inflammasome
Dawson, R. E., Deswaerte, V., West, A. C., Sun, E., Wray-McCann, G., Livis, T., Kumar, B., Rodriguez, E., Gabay, C., Ferrero, R. L. & Jenkins, B. J., May 2023, In: Immunology and Cell Biology. 101, 5, p. 444-457 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus)