Bradley Doak

Dr

20092022

Research output per year

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Research Output

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A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Application of fragment-based screening to the design of inhibitors of Escherichia coli DsbA

Adams, L. A., Sharma, P., Mohanty, B., Ilyichova, O., Mulcair, M., Williams, M., Gleeson, E., Torsika, M., Doak, B. C., Dias de Gouveia Caria, S. M., Rimmer, K., Horne, H. J., Shouldice, S. R., Vazirani, M., Headey, S. J., Plumb, B. R., Martin, J., Heras, B., Simpson, J. S. & Scanlon, M., 2015, In : Angewandte Chemie - International Edition. 54, 7, p. 2179-2184 6 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Cell permeability beyond the rule of 5

Matsson, P., Doak, B. C., Over, B. & Kihlberg, J., 1 Jun 2016, In : Advanced Drug Delivery Reviews. 101, p. 42-61 20 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Design and evaluation of the performance of an NMR screening fragment library

Doak, B. C., Morton, C. J., Simpson, J. S. & Scanlon, M., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1465-1472 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

Determination of ligand binding modes in weak protein–ligand complexes using sparse NMR data

Mohanty, B., Williams, M., Doak, B. C., Vazirani, M., Ilyichova, O., Wang, G., Bermel, W., Simpson, J. S., Chalmers, D. K., King, G. F., Mobli, M. & Scanlon, M. J., Nov 2016, In : Journal of Biomolecular NMR. 66, 3, p. 195-208 14 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Drug discovery beyond the rule of 5 - opportunities and challenges

Doak, B. C. & Kihlberg, J., 2017, In : Expert Opinion on Drug Discovery. 12, 2, p. 115-119 5 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs beyond the Rule of 5

Rossi Sebastiano, M., Doak, B. C., Backlund, M., Poongavanam, V., Over, B., Ermondi, G., Caron, G., Matsson, P. & Kihlberg, J., 10 May 2018, In : Journal of Medicinal Chemistry. 61, 9, p. 4189-4202 14 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens

Smith, R. P., Mohanty, B., Mowlaboccus, S., Paxman, J. J., Williams, M. L., Headey, S. J., Wang, G., Subedi, P., Doak, B. C., Kahler, C. M., Scanlon, M. J. & Heras, B., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 43, p. 16559-16571 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

Structural and conformational determinants of macrocycle cell permeability

Over, B., Matsson, P., Tyrchan, C., Artursson, P., Doak, B. C., Foley, M. A., Hilgendorf, C., Johnston, S. E., Lee IV, M. D., Lewis, R. J., McCarren, P., Muncipinto, G., Norinder, U., Perry, M. W. D., Duvall, J. R. & Kihlberg, J., Dec 2016, In : Nature Chemical Biology. 12, 12, p. 1065-1074 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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61 Citations (Scopus)

Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis

Vivian, J., Scoullar, J., Rimmer, K., Bushell, S. R., Beddoe, T. C., Wilce, M. C. J., Byres, E., Boyle, T. P., Doak, B. C., Simpson, J. S., Graham, B., Heras, B., Kahler, C. M., Rossjohn, J. & Scanlon, M., 2009, In : Journal of Molecular Biology. 394, 5, p. 931 - 943 13 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Synthesis of unsymmetrical 1,1 '-disubstituted Bis(1,2,3-triazole)s using monosilylbutadiynes

Doak, B., Scanlon, M. & Simpson, J., 2011, In : Organic Letters. 13, 3, p. 537 - 539 3 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

The ways and means of fragment-based drug design

Doak, B. C., Norton, R. S. & Scanlon, M. J., 1 Nov 2016, In : Pharmacology and Therapeutics. 167, p. 28-37 10 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)