Bradley Doak

Dr

20092019
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Research Output 2009 2019

A ligand-induced structural change in fatty acid-binding protein 1 is associated with potentiation of peroxisome proliferator-activated receptor α agonists

Patil, R., Mohanty, B., Liu, B., Chandrashekaran, I. R., Headey, S. J., Williams, M. L., Clements, C. S., Ilyichova, O., Doak, B. C., Genissel, P., Weaver, R., Vuillard, L., Halls, M. L., Porter, C. J. H. & Scanlon, M. J., 8 Mar 2019, In : Journal of Biological Chemistry. 294, 10, p. 3720-3734 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Impact of Dynamically Exposed Polarity on Permeability and Solubility of Chameleonic Drugs beyond the Rule of 5

Rossi Sebastiano, M., Doak, B. C., Backlund, M., Poongavanam, V., Over, B., Ermondi, G., Caron, G., Matsson, P. & Kihlberg, J., 10 May 2018, In : Journal of Medicinal Chemistry. 61, 9, p. 4189-4202 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Opportunities and guidelines for discovery of orally absorbed drugs in beyond rule of 5 space

Poongavanam, V., Doak, B. C. & Kihlberg, J., 1 Jun 2018, In : Current Opinion in Chemical Biology. 44, p. 23-29 7 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Structural and biochemical insights into the disulfide reductase mechanism of DsbD, an essential enzyme for neisserial pathogens

Smith, R. P., Mohanty, B., Mowlaboccus, S., Paxman, J. J., Williams, M. L., Headey, S. J., Wang, G., Subedi, P., Doak, B. C., Kahler, C. M., Scanlon, M. J. & Heras, B., 1 Jan 2018, In : Journal of Biological Chemistry. 293, 43, p. 16559-16571 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Drug discovery beyond the rule of 5 - opportunities and challenges

Doak, B. C. & Kihlberg, J., 2017, In : Expert Opinion on Drug Discovery. 12, 2, p. 115-119 5 p.

Research output: Contribution to journalArticleResearchpeer-review