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Research Output 2002 2019

2019

Self-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke

Hong, A., Aguilar, M-I., Del Borgo, M. P., Sobey, C. G., Broughton, B. R. S. & Forsythe, J. S., 2019, In : Journal of Materials Chemistry B. 7, 25, p. 3927-3943 17 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

2018

Actin polymerization contributes to enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia

Weise-Cross, L., Sands, M. A., Sheak, J. R., Broughton, B. R. S., Snow, J. B., Gonzalez Bosc, L. V., Jernigan, N. L., Walker, B. R. & Resta, T. C., May 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 314, 5, p. H1011-H1021 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke

Evans, M. A., Lim, R., Kim, H. A., Chu, H. X., Gardiner-Mann, C. V., Taylor, K. W. E., Chan, C. T., Brait, V. H., Lee, S., Dinh, Q. N., Vinh, A., Phan, T. G., Srikanth, V. K., Ma, H., Arumugam, T. V., Fann, D. Y., Poh, L., Hunt, C. P. J., Pouton, C. W., Haynes, J. M. & 12 othersSelemidis, S., Kwan, W., Teo, L., Bourne, J. A., Neumann, S., Young, S., Gowing, E. K., Drummond, G. R., Clarkson, A. N., Wallace, E. M., Sobey, C. G. & Broughton, B. R. S., 1 Mar 2018, In : Stroke. 49, 3, p. 700-709 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Amnion epithelial cells - A novel therapy for ischemic stroke?

Evans, M. A., Broughton, B. R. S., Drummond, G. R., Ma, H., Phan, T. G., Wallace, E. M., Lim, R. & Sobey, C. G., 1 Aug 2018, In : Neural Regeneration Research. 13, 8, p. 1346-1349 4 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

Diet-induced vitamin D deficiency has no effect on acute post-stroke outcomes in young male mice

Evans, M. A., Kim, H. A., De Silva, T. M., Arumugam, T. V., Clarkson, A. N., Drummond, G. R., Zosky, G. R., Broughton, B. R. S. & Sobey, C. G., 1 Nov 2018, In : Journal of Cerebral Blood Flow and Metabolism. 38, 11, p. 1968-1978 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology

Alexander, S. P. H., Roberts, R. E., Broughton, B. R. S., Sobey, C. G., George, C. H., Stanford, S. C., Cirino, G., Docherty, J. R., Giembycz, M. A., Hoyer, D., Insel, P. A., Izzo, A. A., Ji, Y., MacEwan, D. J., Mangum, J., Wonnacott, S. & Ahluwalia, A., 1 Feb 2018, In : British Journal of Pharmacology. 175, 3, p. 407-411 5 p.

Research output: Contribution to journalEditorialOtherpeer-review

Open Access
File

IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke

Zhang, S. R., Piepke, M., Chu, H. X., Broughton, B. R. S., Shim, R., Wong, C. H. Y., Lee, S., Evans, M. A., Vinh, A., Sakkal, S., Arumugam, T. V., Magnus, T., Huber, S., Gelderblom, M., Drummond, G. R., Sobey, C. G. & Kim, H. A., 20 Sep 2018, In : JCI Insight. 3, 18, 16 p., e121560.

Research output: Contribution to journalArticleResearchpeer-review

Vitamin D3 Supplementation Reduces Subsequent Brain Injury and Inflammation Associated with Ischemic Stroke

Evans, M. A., Kim, H. A., Ling, Y. H., Uong, S., Vinh, A., De Silva, T. M., Arumugam, T. V., Clarkson, A. N., Zosky, G. R., Drummond, G. R., Broughton, B. R. S. & Sobey, C. G., 1 Mar 2018, In : NeuroMolecular Medicine. 20, 1, p. 147-159 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Endosomal NOX2 oxidase exacerbates virus pathogenicity and is a target for antiviral therapy

To, E. E., Vlahos, R., Luong, R., Halls, M. L., Reading, P. C., King, P. T., Chan, C., Drummond, G. R., Sobey, C. G., Broughton, B. R. S., Starkey, M. R., van der Sluis, R., Lewin, S. R., Bozinovski, S., O'Neill, L. A. J., Quach, T., Porter, C. J. H., Brooks, D. A., O'Leary, J. & Selemidis, S., 1 Dec 2017, In : Nature Communications. 8, 1, 17 p., 69.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2016

Evidence of CCR2-independent transmigration of Ly6Chi monocytes into the brain after permanent cerebral ischemia in mice

Chu, H. X., Kim, H. A., Lee, S., Broughton, B. R. S., Drummond, G. R. & Sobey, C. G., 15 Apr 2016, In : Brain Research. 1637, p. 118-127 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Evidence that Ly6C(hi) monocytes are protective in acute ischemic stroke by promoting M2 macrophage polarization

Chu, H. X., Broughton, B. R. S., Kim, H. H. A., Lee, S. S., Drummond, G. R. & Sobey, C. G., 2015, In : Stroke. 46, 7, p. 1929 - 1937 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Nontypeable Haemophilus influenzae induces sustained lung oxidative stress and protease expression

King, P. T., Sharma, R., O'Sullivan, K., Selemidis, S., Lim, S., Radhakrishna, N., Lo, C. Y-W., Prasad, J., Callaghan, J. M., McLaughlin, P., Farmer, M., Steinfort, D. P., Jennings, B. R., Ngui, J., Broughton, B. R. S., Thomas, B., Essilfie, A-T., Hickey, M. J., Holmes, P., Hansbro, P. M. & 2 othersBardin, P. G. & Holdsworth, S. R., 2015, In : PLoS ONE. 10, 3 (Art. No.: e0120371), p. 1 - 17 17 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

Immune cell infiltration in malignant middle cerebral artery infarction: comparison with transient cerebral ischemia

Chu, H. X., Huynh, K., Lee, S. S., Moore, J. P., Chan, C. T. L., Vinh, A., Gelderblom, M., Arumugam, T., Broughton, B. R. S., Drummond, G. R. & Sobey, C. G., 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 3, p. 450 - 459 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Influenza A virus and TLR7 activation potentiate NOX2 oxidase-dependent ROS production in macrophages

To, E., Broughton, B. R. S., Hendricks, K. S., Vlahos, R. & Selemidis, S., 2014, In : Free Radical Research. 48, 8, p. 940 - 947 8 p.

Research output: Contribution to journalArticleResearchpeer-review

PI3Kdelta inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model

Low, P. C., Manzanero, S., Mohannak, N., Narayana, V. K., Nguyen, T. H., Kvaskoff, D., Brennan, F. H., Ruitenberg, M. J., Gelderblom, M., Magnus, T., Kim, H. H. A., Broughton, B. R. S., Sobey, C. G., Vanhaesebroeck, B., Stow, J. L., Arumugam, T. & Meunier, F. A., 2014, In : Nature Communications. 5, 3450, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Potential efficacy of amnion epithelial cells to treat post-stroke inflammation

Broughton, B. R. S., Lim, R. S. W., Evans, M. A., Drummond, G. R., Wallace, E. M. & Sobey, C. G., 2014, Perinatal Stem Cells. Atala, A. & Murphy, S. V. (eds.). 1st ed. USA: Springer, p. 219 - 229 11 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Sex-dependent effects of G protein-coupled estrogen receptor activity on outcome after ischemic stroke

Broughton, B. R. S., Brait, V. H., Kim, H. H. A., Lee, S. S., Chu, H. X., Gardiner-Mann, C. V., Guida, E., Evans, M. A., Miller, A. A., Arumugam, T., Drummond, G. R. & Sobey, C. G., 2014, In : Stroke. 45, 3, p. 835 - 841 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Enhanced depolarization-induced pulmonary vasoconstriction following chronic hypoxia requires EGFR-dependent activation of NAD(P)H oxidase 2

Norton, C. E., Broughton, B. RS., Jernigan, N. L., Walker, B. R. & Resta, T. C., 2013, In : Antioxidants and Redox Signaling. 18, 14, p. 1777 - 1788 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Nox1 oxidase suppresses influenza a virus-induced lung inflammation and oxidative stress

Selemidis, S., Seow, H. J., Broughton, B. R. S., Vinh, A., Bozinovski, S., Sobey, C. G., Drummond, G. R. & Vlahos, R., 2013, In : PLoS ONE. 8, 4, 12 p., e60792.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Open Access

Stroke increases g protein-coupled estrogen receptor expression in the brain of male but not female mice

Broughton, B. RS., Brait, V. H., Guida, E., Lee, S., Arumugam, T. V., Gardiner-Mann, C. V., Miller, A. A., Tang, S-C., Drummond, G. R. & Sobey, C. G., 2013, In : Neurosignals. 21, 3-4, p. 229 - 239 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2012

Angiotensin II Type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats

McCarthy, C. A., Vinh, A., Broughton, B. RS., Sobey, C. G., Callaway, J. K. & Widdop, R. E., 2012, In : Hypertension. 60, 6, p. 1531 - 1537 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease

Ding, A., Kalaignanasundaram, P., Ricardo, S. D., Abdelkader, A., Witting, P. K., Broughton, B. RS., Kim, H. B., Wyse, B. F., Phillips, J. K. & Evans, R. G., 2012, In : Clinical and Experimental Pharmacology and Physiology. 39, 11, p. 917 - 929 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Diffusive oxygen shunting between vessels in the preglomerular renal vasculature: anatomic observations and computational modeling

Gardiner, B. S., Thompson, S. L., Ngo, J. P., Smith, D. W., Abdelkader, A., Broughton, B. RS., Bertram, J. F. & Evans, R. G., 2012, In : American Journal of Physiology - Renal Physiology. 303, 5, p. F605 - F618 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Over-expression of DSCR1 protects against post-ischemic neuronal injury

Brait, V. H., Martin, K. R., Corlett, A. R. I., Broughton, B. RS., Kim, H., Thundyil, J., Drummond, G. R., Arumugam, T. V., Pritchard, M. A. & Sobey, C. G., 2012, In : PLoS ONE. 7, 10, 8 p., e47841.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2011

Chemokine-related gene expression in the brain following ischemic stroke: No role for CXCR2 in outcome

Brait, V. H., Rivera, J., Broughton, B. RS., Lee, S. S., Drummond, G. R. & Sobey, C. G., 2011, In : Brain Research. 1372, p. 169 - 179 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Inhibition of nox2 oxidase activity ameliorates influenza a virus-induced lung inflammation

Vlahos, R., Stambas, J., Bozinovski, S., Broughton, B. RS., Drummond, G. R. & Selemidis, S., 2011, In : PLoS Pathogens. 7, 2, p. 1 - 12 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2010

Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA

Broughton, B. R. S., Jernigan, N. L., Norton, C. E., Walker, B. R. & Resta, T. C., 2010, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 298, 2, p. 232 - 242 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries

Broughton, B. R. S., Miller, A. A. & Sobey, C. G., 2010, In : American Journal of Physiology - Heart and Circulatory Physiology. 298, 3, p. H1055 - H1061 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide

Brait, V. H., Jackman, K. A., Walduck, A., Selemidis, S., Diep, H., Mast, A., Guida, E., Broughton, B. RS., Drummond, G. R. & Sobey, C. G., 2010, In : Journal of Cerebral Blood Flow and Metabolism. 30, 7, p. 1306 - 1317 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Reactive oxygen species and RhoA signaling in vascular smooth muscle: role in chronic hypoxia-induced pulmonary hypertension

Resta, T. C., Broughton, B. R. S. & Jernigan, N. L., 2010, Advances in Experimental Medicine and Biology. Yuan, J. X-J. & Ward, J. P. T. (eds.). 661 ed. USA: Humana Press, p. 355 - 374 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2009

Apoptotic mechanisms after cerebral ischemia

Broughton, B. R. S., Reutens, D. C. & Sobey, C. G., 2009, In : Stroke. 40, 5, p. 331 - 339 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Gender influences cerebral vascular responses to angiotensin II through Nox2-derived reactive oxygen species

De Silva, T. M., Broughton, B. R. S., Drummond, G. R., Sobey, C. G. & Miller, A. A., 2009, In : Stroke. 40, 4, p. 1091 - 1097 7 p.

Research output: Contribution to journalArticleResearchpeer-review

NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: Role of Nox2

Miller, A. A., Drummond, G. R., De Silva, T. M., Mast, A., Hickey, H., Williams, J. P., Broughton, B. R. S. & Sobey, C. G., 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 296, p. H220 - H225 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries

Broughton, B. R. S., Walker, B. R. & Resta, T. C., 2008, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 294, 4, p. 797 - 806 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Dual mechanisms for nitric oxide control of large arteries in the estuarine crocodile Crocodylus porosus

Broughton, B. R. S. & Donald, J. A., 2007, In : Journal of Experimental Biology. 210, Pt 1, p. 129 - 137 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Impaired NO-dependent inhibition of store- and receptor-operated calcium entry in pulmonary vascular smooth muscle after chronic hypoxia

Jernigan, N. L., Broughton, B. R. S., Walker, B. R. & Resta, T. C., 2006, In : American Journal of Physiology - Lung Cellular and Molecular Physiology. 290, 3, p. 517 - 525 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Nitric oxide control of large veins in the toad Bufo marinus

Broughton, B. R. S. & Donald, J. A., 2005, In : Journal of Comparative Physiology B-Biochemical Systemic and Environmental Physiology. 175, 3, p. 157 - 166 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Nitric oxide control of lower vertebrate blood vessels by vasomotor nerves

Donald, J. A. & Broughton, B. R. S., 2005, In : Comparative Biochemistry and Physiology A-Molecular & Integrative Physiology. 142, 2, p. 188 - 197 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Nitric oxide control of the dorsal aorta and the intestinal vein of the Australian short-finned eel Anguilla australis

Jennings, B. L., Broughton, B. R. S. & Donald, J. A., Mar 2004, In : Journal of Experimental Biology. 207, 8, p. 1295-1303 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Vasodilator mechanisms in the dorsal aorta of the giant shovelnose ray, Rhinobatus typus (Rajiformes; Rhinobatidae)

Donald, J. A., Broughton, B. R. S. & Bennett, M. B., 2004, In : Comparative Biochemistry and Physiology - A Molecular and Integrative Physiology. 137, 1, p. 21-31 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Nitric oxide regulation of the central aortae of the toad Bufo marinus occurs independently of the endothelium

Broughton, B. R. S. & Donald, J. A., Oct 2002, In : Journal of Experimental Biology. 205, 19, p. 3093-3100 8 p.

Research output: Contribution to journalArticleResearchpeer-review