Projects per year
Personal profile
Biography
Dr Brad Broughton has an emerging profile in both the national and international cardiovascular community. Brad is currently a Foundation for High Blood Pressure Research Fellow and is a senior member of the Vascular Biology and Immunopharmacology Group in the Department of Pharmacology. He is a member of two Editorial Boards (ISRN Stroke and Physiology Journal) and is a Chief Investigator on a NHMRC Project Grant and Grant-in-aid from the National Heart Foundation.
Over the past 12 years, Brad's research has contributed to our knowledge of reactive oxygen species, calcium, apoptosis, oestrogen, Rho kinase and nitric oxide signalling in the systemic, pulmonary and cerebral circulations. His studies have elucidated physiological mechanisms in vivo and in vitro, identified gender differences, as well as abnormalities in diseases including stroke, pulmonary hypertension and atherosclerosis. The primary focus of his current research is to advance our understanding of mechanisms that contribute to brain damage after stroke, develop safe and effective stroke therapies and identify novel imaging agents that detect cell loss in the brain following stroke.
Research area keywords
- Stroke
- Pulmonary Hypertension
- Stem cells
- Exosomes
Network
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Delivering a novel cell free therapy to improve stroke outcomes
Broughton, B., Lim, R. & Sobey, C. G.
1/01/21 → 31/12/22
Project: Research
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Development of a first-in-class neuroprotective drug for protecting the brain after stroke
King, G. F., Widdop, R., Broughton, B., Rash, L. D. & Smith, M. T.
1/01/19 → 31/12/21
Project: Research
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Where have all the stem cells gone? Preliminary in vivo MRI study to track iron-oxide nanoparticle-labelled stem cells
Lim, R., Jenkin, G., McDonald, C., Bhakoo, K., Sobey, C., Broughton, B., Sievert, W., Vreys, R. & Hodge, A.
Agilent Technologies (Australia), Monash University – Internal University Contribution
1/12/14 → 31/12/14
Project: Research
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Aldosterone-induced hypertension is sex-dependent, mediated by T cells and sensitive to GPER activation
Dinh, Q. N., Vinh, A., Kim, H. A., Saini, N., Broughton, B. R. S., Chrissobolis, S., Diep, H., Judkins, C. P., Drummond, G. R. & Sobey, C. G., 1 Mar 2021, In: Cardiovascular Research. 117, 3, p. 960-970 11 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Combining mesenchymal stem cells with serelaxin provides enhanced renoprotection against 1K/DOCA/salt-induced hypertension
Li, Y., Shen, M., Ferens, D., Broughton, B. R. S., Murthi, P., Saini, S., Widdop, R. E., Ricardo, S. D., Pinar, A. A. & Samuel, C. S., Mar 2021, In: British Journal of Pharmacology. 178, 5, p. 1164-1181 18 p.Research output: Contribution to journal › Article › Research › peer-review
5 Citations (Scopus) -
Comparing the renoprotective effects of BM-MSCs versus BM-MSC-exosomes, when combined with an anti-fibrotic drug, in hypertensive mice
Li, Y., Chakraborty, A., Broughton, B. R. S., Ferens, D., Widdop, R. E., Ricardo, S. D. & Samuel, C. S., Dec 2021, In: Biomedicine & Pharmacotherapy. 144, 12 p., 112256.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Self-assembling injectable peptide hydrogels for emerging treatment of ischemic stroke
Hong, A., Aguilar, M-I., Del Borgo, M. P., Sobey, C. G., Broughton, B. R. S. & Forsythe, J. S., 2019, In: Journal of Materials Chemistry B. 7, 25, p. 3927-3943 17 p.Research output: Contribution to journal › Review Article › Research › peer-review
10 Citations (Scopus) -
Actin polymerization contributes to enhanced pulmonary vasoconstrictor reactivity following chronic hypoxia
Weise-Cross, L., Sands, M. A., Sheak, J. R., Broughton, B. R. S., Snow, J. B., Gonzalez Bosc, L. V., Jernigan, N. L., Walker, B. R. & Resta, T. C., May 2018, In: American Journal of Physiology - Heart and Circulatory Physiology. 314, 5, p. H1011-H1021 11 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile12 Citations (Scopus)