Brad Edwards

Assoc Professor

  • 264 Ferntree Gully Road, Ground floor

    3164 Notting Hill

    Australia

  • 264 Ferntree Gully Road, Building 1

    3164 Notting Hill

    Australia

Accepting PhD Students

PhD projects

Understanding the causes of sleep apnoea and using this information to personalise treatment to the individual

20062020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Article
2020

Assessing ventilatory control stability in children with and without an elevated central apnoea index

Harman, K., Weichard, A. J., Davey, M. J., Horne, R. S. C., Nixon, G. M. & Edwards, B. A., Feb 2020, In : Respirology. 25, 2, p. 214-220 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Effect of Hypopnea Scoring Criteria on Noninvasive Assessment of Loop Gain and Surgical Outcome Prediction

Landry, S. A., Joosten, S. A., Thomson, L. D. J., Turton, A., Wong, A-M., Leong, P., Terrill, P. I., Mann, D., Sands, S. A., Hamilton, G. S. & Edwards, B. A., Apr 2020, In : Annals of the American Thoracic Society. 17, 4, p. 484-491 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of ventilatory control instability in children with sleep-disordered breathing

Siriwardhana, L. S., Weichard, A., Nixon, G. M., Davey, M. J., Walter, L. M., Edwards, B. A. & Horne, R. S. C., 2 Apr 2020, (Accepted/In press) In : Respirology. 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2019

Exposure to mild intermittent hypoxia increases loop gain and the arousal threshold in participants with obstructive sleep apnoea

Alex, R. M., Panza, G. S., Hakim, H., Badr, M. S., Edwards, B. A., Sands, S. A. & Mateika, J. H., 15 Jul 2019, In : Journal of Physiology. 597, 14, p. 3697-3711 15 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Is there a threshold that triggers cortical arousals in obstructive sleep apnea

Li, Y., Orr, J., Jen, R., Sands, S. A., DeYoung, P., Smales, E., Edwards, B., Owens, R. L. & Malhotra, A., Jun 2019, In : Sleep. 42, 6, 8 p., zsz047.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Polysomnographic endotyping to select patients with obstructive sleep apnea for oral appliances

Bamagoos, A. A., Cistulli, P. A., Sutherland, K., Madronio, M., Eckert, D. J., Hess, L., Edwards, B. A., Wellman, A. & Sands, S. A., Nov 2019, In : Annals of the American Thoracic Society. 16, 11, p. 1422-1431 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The combination of atomoxetine and oxybutynin greatly reduces obstructive sleep apnea severity a randomized, placebo-controlled, double-blind crossover trial

Taranto-Montemurro, L., Messineo, L., Sands, S. A., Azarbarzin, A., Marques, M., Edwards, B. A., Eckert, D. J., White, D. P. & Wellman, A., 15 May 2019, In : American Journal of Respiratory and Critical Care Medicine. 199, 10, p. 1267-1276 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

The physiological phenotype of obstructive sleep apnea differs between Caucasian and Chinese patients

O'Driscoll, D. M., Landry, S. A., Pham, J., Young, A., Sands, S. A., Hamilton, G. S. & Edwards, B. A., Nov 2019, In : Sleep. 42, 11, 9 p., zsz186.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)
2018

A graphical method for comparing nocturnal oxygen saturation profiles in individuals and populations: Application to healthy infants and preterm neonates

Terrill, P. I., Dakin, C., Edwards, B. A., Wilson, S. J. & Maclean, J. E., May 2018, In : Pediatric Pulmonology. 53, 5, p. 645-655 11 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Assessing ventilatory instability using the response to spontaneous sighs during sleep in preterm infants

Edwards, B. A., Nava-Guerra, L., Kemp, J. S., Carroll, J. L., Khoo, M. C., Sands, S. A., Terrill, P. I., Landry, S. A. & Amin, R. S., 1 Nov 2018, In : Sleep. 41, 11, 8 p., zsy161.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Identifying obstructive sleep apnoea patients responsive to supplemental oxygen therapy

Sands, S. A., Edwards, B. A., Terrill, P. I., Butler, J. P., Owens, R. L., Taranto-Montemurro, L., Azarbarzin, A., Marques, M., Hess, L. B., Smales, E. T., De Melo, C. M., White, D. P., Malhotra, A. & Wellman, A., 1 Sep 2018, In : European Respiratory Journal. 52, 3, 12 p., 1800674.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Phenotyping pharyngeal pathophysiology using polysomnography in patients with obstructive sleep apnea

Sands, S. A., Edwards, B. A., Terrill, P. I., Taranto-Montemurro, L., Azarbarzin, A., Marques, M., Hess, L. B., White, D. P. & Wellman, A., 1 May 2018, In : American Journal of Respiratory and Critical Care Medicine. 197, 9, p. 1187-1197 11 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Prevalence, associated clinical features, and impact on continuous positive airway pressure use of a low respiratory arousal threshold among male United States veterans with obstructive sleep apnea

Zinchuk, A., Edwards, B. A., Jeon, S., Koo, B. B., Concato, J., Sands, S., Wellman, A. & Yaggi, H. K., 15 May 2018, In : Journal of Clinical Sleep Medicine. 14, 5, p. 809-817 9 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Quantifying the arousal threshold using polysomnography in obstructive sleep apnea

Sands, S. A., Terrill, P. I., Edwards, B. A., Montemurro, L. T., Azarbarzin, A., Marques, M., De Melo, C. M., Loring, S. H., Butler, J. P., White, D. P. & Wellman, A., 1 Jan 2018, In : Sleep. 41, 1, 9 p., zsx183.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Quantifying ventilatory control stability from spontaneous sigh responses during sleep: a comparison of two approaches

Nava-Guerra, L., Edwards, B. A., Terrill, P. I., Sands, S. A., Amin, R. S., Kemp, J. S. & Khoo, M. CK., 13 Nov 2018, In : Physiological Measurement. 39, 11, 14 p., 114005.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Ventilatory control sensitivity in patients with obstructive sleep apnea is sleep stage dependent

Landry, S. A., Andara, C., Terrill, P. I., Joosten, S. A., Leong, P., Mann, D. L., Sands, S. A., Hamilton, G. S. & Edwards, B. A., 1 May 2018, In : Sleep. 41, 5, 10 p., 040.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
13 Citations (Scopus)
2017

Differences in respiratory arousal threshold in Caucasian and Chinese patients with obstructive sleep apnoea

Lee, R. W. W., Sutherland, K., Sands, S. A., Edwards, B. A., Chan, T. O., S.S. Ng, S., Hui, D. S. C. & Cistulli, P. A., 1 Jul 2017, In : Respirology. 22, 5, p. 1015-1021 7 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Dynamic loop gain increases upon adopting the supine body position during sleep in patients with obstructive sleep apnoea

Joosten, S. A., Landry, S. A., Sands, S. A., Terrill, P. I., Mann, D., Andara, C., Skuza, E., Turton, A., Berger, P., Hamilton, G. S. & Edwards, B. A., 1 Nov 2017, In : Respirology. 22, 8, p. 1662-1669 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
9 Citations (Scopus)

Effect of 4-aminopyridine on genioglossus muscle activity during sleep in healthy adults

Taranto-Montemurro, L., Sands, S. A., Azarbarzin, A., Marques, M., De Melo, C. M., Edwards, B. A., Eckert, D. J., Messineo, L., White, D. P. & Wellman, A., 1 Jul 2017, In : Annals of the American Thoracic Society. 14, 7, p. 1177-1183 7 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Effects of tiagabine on slow wave sleep and arousal threshold in patients with obstructive sleep apnea

Taranto-Montemurro, L., Sands, S. A., Edwards, B. A., Azarbarzin, A., Marques, M., De Melo, C., Eckert, D. J., White, D. P. & Wellman, A., 1 Feb 2017, In : Sleep. 40, 2, 7 p., zsw047.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Estimation of pharyngeal collapsibility during sleep by peak inspiratory airflow

Azarbarzin, A., Sands, S. A., Taranto-Montemurro, L., Oliveira Marques, M. D., Genta, P. R., Edwards, B. A., Butler, J. P., White, D. P. & Wellman, A., 1 Jan 2017, In : Sleep. 40, 1, 11 p., zsw005.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Improvement in obstructive sleep apnea with weight loss is dependent on body position during sleep

Joosten, S. A., Khoo, J. K., Edwards, B. A., Landry, S. A., Naughton, M. T., Dixon, J. B. & Hamilton, G. S., 1 May 2017, In : Sleep. 40, 5, 6 p., zsx047.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
11 Citations (Scopus)

Loop gain predicts the response to upper airway surgery in patients with obstructive sleep apnea

Joosten, S. A., Leong, P., Landry, S. A., Sands, S. A., Terrill, P. I., Mann, D. L., Turton, A., Rangaswamy, J., Andara, C., Burgess, G., Mansfield, D., Hamilton, G. S. & Edwards, B. A., 1 Jul 2017, In : Sleep. 40, 7, 10 p., zsx094.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
28 Citations (Scopus)

Oxygen desaturation index differs significantly between types of sleep software

Ng, Y., Joosten, S. A., Edwards, B. A., Turton, A., Romios, H., Samarasinghe, T., Landry, S., Mansfield, D. R. & Hamilton, G. S., 2017, In : Journal of Clinical Sleep Medicine. 13, 4, p. 599-605 7 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Resonance as the mechanism of daytime periodic breathing in patients with heart failure

Sands, S. A., Mebrate, Y., Edwards, B. A., Nemati, S., Manisty, C. H., Desai, A. S., Wellman, A., Willson, K., Francis, D. P., Butler, J. P. & Malhotra, A., 15 Jan 2017, In : American Journal of Respiratory and Critical Care Medicine. 195, 2, p. 237-246 10 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Response to a combination of oxygen and a hypnotic as treatment for obstructive sleep apnoea is predicted by a patient's therapeutic CPAP requirement

Landry, S. A., Joosten, S. A., Sands, S. A., White, D. P., Malhotra, A., Wellman, A., Hamilton, G. S. & Edwards, B. A., Aug 2017, In : Respirology. 22, 6, p. 1219-1224 6 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Therapeutic CPAP level predicts upper airway collapsibility in patients with obstructive sleep apnea

Landry, S. A., Joosten, S. A., Eckert, D. J., Jordan, A. S., Sands, S. A., White, D. P., Malhotra, A., Wellman, A., Hamilton, G. S. & Edwards, B. A., 1 Jun 2017, In : Sleep. 40, 6, 8 p., zsx056.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
22 Citations (Scopus)

The relationship between partial upper-airway obstruction and inter-breath transition period during sleep

Mann, D. L., Edwards, B. A., Joosten, S. A., Hamilton, G. S., Landry, S., Sands, S. A., Wilson, S. J. & Terrill, P. I., 1 Oct 2017, In : Respiratory Physiology and Neurobiology. 244, p. 32-40 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Control theory prediction of resolved Cheyne-Stokes respiration in heart failure

Sands, S. A., Edwards, B. A., Kee, K., Stuart-Andrews, C., Skuza, E. M., Roebuck, T., Turton, A., Hamilton, G. S., Naughton, M. T. & Berger, P. J., 1 Nov 2016, In : European Respiratory Journal. 48, 5, p. 1351-1359 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation

Taranto-Montemurro, L., Sands, S. A., Edwards, B. A., Azarbarzin, A., Marques, M., De Melo, C., Eckert, D. J., White, D. P. & Wellman, A., 1 Nov 2016, In : European Respiratory Journal. 48, 5, p. 1340-1350 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
38 Citations (Scopus)

Desipramine increases genioglossus activity and reduces upper airway collapsibility during non-REM sleep in healthy subjects

Taranto-Montemurro, L., Edwards, B. A., Sands, S. A., Marques, M., Eckert, D. J., White, D. P. & Wellman, A., 1 Oct 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 7, p. 878-885 8 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Oronasal masks require a higher pressure than nasal and nasal pillow masks for the treatment of obstructive sleep apnea

Deshpande, S., Joosten, S., Turton, A., Edwards, B. A., Landry, S., Mansfield, D. R. & Hamilton, G. S., 2016, In : Journal of Clinical Sleep Medicine. 12, 9, p. 1263-1268 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
20 Citations (Scopus)

The combination of supplemental oxygen and a hypnotic markedly improves obstructive sleep apnea in patients with a mild to moderate upper airway collapsibility

Edwards, B. A., Sands, S. A., Owens, R. L., Eckert, D. J., Landry, S., White, D. P., Malhotra, A. & Wellman, A., 1 Nov 2016, In : Sleep. 39, 11, p. 1973-1983 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
38 Citations (Scopus)

Tube law of the pharyngeal airway in sleeping patients with obstructive sleep apnea

Genta, P. R., Edwards, B. A., Sands, S. A., Owens, R. L., Butler, J. P., Loring, S. H., White, D. P. & Wellman, A., 1 Feb 2016, In : Sleep. 39, 2, p. 337-343 7 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Upper-airway collapsibility and loop gain predict the response to oral appliance therapy in patients with obstructive sleep apnea

Edwards, B. A., Andara, C., Landry, S., Sands, S. A., Joosten, S. A., Owens, R. L., White, D. P., Hamilton, G. S. & Wellman, A., 1 Dec 2016, In : American Journal of Respiratory and Critical Care Medicine. 194, 11, p. 1413-1422 10 p.

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)
2015

An integrative model of physiological traits can be used to predict obstructive sleep apnea and response to non positive airway pressure therapy

Owens, R. L., Edwards, B. A., Eckert, D. J., Jordan, A. S., Sands, S. A., Malhotra, A., White, D. P., Loring, S. H., Butler, J. P. & Wellman, A., 1 Jun 2015, In : Sleep. 38, 6, p. 961-970 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
72 Citations (Scopus)

Evaluation of the role of lung volume and airway size and shape in supine-predominant obstructive sleep apnoea patients

Joosten, S. A., Sands, S., Edwards, B. A., Hamza, K., Turton, A. R., Lau, K. K-P., Crossett, M., Berger, P. J. & Hamilton, G. S., 2015, In : Respirology. 20, 5, p. 819 - 827 9 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Quantifying the ventilatory control contribution to sleep apnoea using polysomnography

Terrill, P. I., Edwards, B. A., Nemati, S., Butler, J. P., Owens, R. L., Eckert, D. J., White, D. P., Malhotra, A., Wellman, A. & Sands, S. A., 1 Feb 2015, In : European Respiratory Journal. 45, 2, p. 408-418 11 p.

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)

The effect of body position on physiological factors that contribute to obstructive sleep apnea

Joosten, S. A., Edwards, B. A., Wellman, A., Turton, A. R., Skuza, E. M., Berger, P. J. & Hamilton, G. S., 2015, In : Sleep. 38, 9, p. 1469 - 1478 10 p.

Research output: Contribution to journalArticleResearchpeer-review

34 Citations (Scopus)

Trazodone effects on obstructive sleep apnea and non-REM arousal threshold

Smales, E. T., Edwards, B. A., Deyoung, P. N., McSharry, D. G., Wellman, A., Velasquez, A., Owens, R., Orr, J. E. & Malhotra, A., 1 May 2015, In : Annals of the American Thoracic Society. 12, 5, p. 758-764 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
44 Citations (Scopus)
2014

Acetazolamide attenuates hunter-cheyne-stokes breathing but augments the hypercapnic ventilatory response in patients with heart failure

Javaheri, S., Sands, S. A. & Edwards, B. A., 1 Jan 2014, In : Annals of the American Thoracic Society. 11, 1, p. 80-86 7 p.

Research output: Contribution to journalArticleResearchpeer-review

30 Citations (Scopus)

Blood pressure improvement with continuous positive airway pressure is independent of obstructive sleep apnea severity

Bakker, J. P., Edwards, B. A., Gautam, S. P., Montesi, S. B., Durán-Cantolla, J., Barandiarán, F. A., Barbé, F., Sańchez-De-La-Torre, M. & Malhotra, A., 2014, In : Journal of Clinical Sleep Medicine. 10, 4, p. 365-369 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
37 Citations (Scopus)

Clinical predictors of the respiratory arousal threshold in patients with obstructive sleep apnea

Edwards, B. A., Eckert, D. J., McSharry, D. G., Sands, S., Desai, A., Kehlmann, G., Bakker, J. P., Genta, P. R., Owens, R. L., White, D. P., Wellman, A. & Malhotra, A., 2014, In : American Journal of Respiratory and Critical Care Medicine. 190, 11, p. 1293 - 1300 8 p.

Research output: Contribution to journalArticleResearchpeer-review

96 Citations (Scopus)

CrossTalk opposing view: Loop gain is not a consequence of obstructive sleep apnoea

Orr, J. E., Edwards, B. A. & Malhotra, A., 15 Jul 2014, In : The Journal of Physiology. 592, 14, p. 2903-2905 3 p.

Research output: Contribution to journalArticleOtherpeer-review

15 Citations (Scopus)

Effects of hyperoxia and hypoxia on the physiological traits responsible for obstructive sleep apnoea

Edwards, B. A., Sands, S. A., Owens, R. L., White, D. P., Genta, P. R., Butler, J. P., Malhotra, A. & Wellman, A., 15 Oct 2014, In : Journal of Physiology. 592, 20, p. 4523-4535 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
31 Citations (Scopus)

Enhanced upper-airway muscle responsiveness is a distinct feature of overweight/obese individuals without sleep apnea

Sands, S. A., Eckert, D. J., Jordan, A. S., Edwards, B. A., Owens, R. L., Butler, J. P., Schwab, R. J., Loring, S. H., Malhotra, A., White, D. P. & Wellman, A., 15 Oct 2014, In : American Journal of Respiratory and Critical Care Medicine. 190, 8, p. 930-937 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
56 Citations (Scopus)

Influence of pharyngeal muscle activity on inspiratory negative effort dependence in the human upper airway

Genta, P. R., Owens, R. L., Edwards, B. A., Sands, S. A., Eckert, D. J., Butler, J. P., Loring, S. H., Malhotra, A., Jackson, A. C., White, D. P. & Wellman, A., 15 Sep 2014, In : Respiratory Physiology and Neurobiology. 201, p. 55-59 5 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Model-based estimation of loop gain using spontaneous breathing: A validation study

Gederi, E., Nemati, S., Edwards, B. A., Clifford, G. D., Malhotra, A. & Wellman, A., 15 Sep 2014, In : Respiratory Physiology and Neurobiology. 201, p. 84-92 9 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)