Bimbil Graham

Assoc Professor

19972019
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Research Output 1997 2019

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2019

Interaction of Nucleotides with a Trinuclear Terbium(III)-Dizinc(II) Complex: Efficient Sensitization of Terbium Luminescence by Guanosine Monophosphate and Application to Real-Time Monitoring of Phosphodiesterase Activity

Aulsebrook, M. L., Starck, M., Grace, M. R., Graham, B., Thordarson, P., Pal, R. & Tuck, K. L., 7 Jan 2019, In : Inorganic Chemistry. 58, 1, p. 495-505 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Visible light-triggered cargo release from donor acceptor Stenhouse adduct (DASA)-doped lyotropic liquid crystalline nanoparticles

Jia, S., Tan, A., Hawley, A., Graham, B. & Boyd, B. J., 15 Jul 2019, In : Journal of Colloid and Interface Science. 548, p. 151-159 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase

Dennis, M. L., Lee, M. D., Harjani, J. R., Ahmed, M., Debono, A. J., Pitcher, N. P., Wang, Z-C., Chhabra, S., Barlow, N., Rahmani, R., Cleary, B., Dolezal, O., Hattarki, M., Aurelio, L., Shonberg, J., Graham, B., Peat, T. S., Baell, J. B. & Swarbrick, J. D., 6 Feb 2018, In : Chemistry - A European Journal. 24, 8, p. 1922-1930 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Fluorescently Labeled Morphine Derivatives for Bioimaging Studies

Lam, R., Gondin, A. B., Canals, M., Kellam, B., Briddon, S. J., Graham, B. & Scammells, P. J., 8 Feb 2018, In : Journal of Medicinal Chemistry. 61, 3, p. 1316-1329 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Genetically encoded amino acids with tert-butyl and trimethylsilyl groups for site-selective studies of proteins by NMR spectroscopy

Loh, C. T., Adams, L. A., Graham, B. & Otting, G., 1 Aug 2018, In : Journal of Biomolecular NMR. 71, 4, p. 287-293 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Lanthanide complexes for luminescence-based sensing of low molecular weight analytes

Aulsebrook, M. L., Graham, B., Grace, M. R. & Tuck, K. L., 2018, (Accepted/In press) In : Coordination Chemistry Reviews. 30 p.

Research output: Contribution to journalArticleResearchpeer-review

Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

Yu, S. H., Patra, M., Ferrari, S., Ramirez Garcia, P., Veldhuis, N. A., Kaminskas, L. M., Graham, B., Quinn, J. F., Whittaker, M. R., Gasser, G. & Davis, T. P., 29 Oct 2018, In : Journal of Materials Chemistry B. 6, 47, p. 7805-7810 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Modified Gold Nanoparticles for the Temperature-Dependent Colorimetric Detection of Mercury and Methylmercury

Aulsebrook, M. L., Watkins, E., Grace, M. R., Graham, B. & Tuck, K. L., 21 Feb 2018, In : ChemistrySelect. 3, 7, p. 2088-2091 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel agrochemical conjugates with self-assembling behaviour

Liu, Q., Graham, B., Hawley, A., Dong, Y. D. & Boyd, B. J., 15 Feb 2018, In : Journal of Colloid and Interface Science. 512, p. 369-378 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Quantifying Cellular Internalization with a Fluorescent Click Sensor

Selby, L. I., Aurelio, L., Yuen, D., Graham, B. & Johnston, A. P. R., 2018, In : ACS Sensors. 3, 6, p. 1182-1189 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Site-Specific Incorporation of Selenocysteine by Genetic Encoding as a Photocaged Unnatural Amino Acid

Welegedara, A. P., Adams, L. A., Huber, T., Graham, B. & Otting, G., 18 Jul 2018, In : Bioconjugate Chemistry. 29, 7, p. 2257-2264 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Small neutral Gd(iii) tags for distance measurements in proteins by double electron-electron resonance experiments

Mahawaththa, M. C., Lee, M. D., Giannoulis, A., Adams, L. A., Feintuch, A., Swarbrick, J. D., Graham, B., Nitsche, C., Goldfarb, D. & Otting, G., 1 Jan 2018, In : Physical Chemistry Chemical Physics. 20, 36, p. 23535-23545 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Spectroscopic Studies on Photoinduced Reactions of the Anticancer Prodrug, trans,trans,trans-[Pt(N3)2(OH)2(py)2]

Vernooij, R. R., Joshi, T., Horbury, M. D., Graham, B., Izgorodina, E. I., Stavros, V. G., Sadler, P. J., Spiccia, L. & Wood, B. R., 17 Apr 2018, In : Chemistry - A European Journal. 24, 22, p. 5790-5803 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Trimethylsilyl tag for probing protein–ligand interactions by NMR

Becker, W., Adams, L. A., Graham, B., Wagner, G. E., Zangger, K., Otting, G. & Nitsche, C., 1 Apr 2018, In : Journal of Biomolecular NMR. 70, 4, p. 211-218 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2017

A luminogenic lanthanide-based probe for the highly selective detection of nanomolar sulfide levels in aqueous samples

Aulsebrook, M., Biswas, S., Leaver, F. M., Grace, M. R., Graham, B., Barrios, A. M. & Tuck, K. L., 2017, In : Chemical Communications. 53, 36, p. 4911-4914 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Chemical Tagging with tert-Butyl and Trimethylsilyl Groups for Measuring Intermolecular Nuclear Overhauser Effects in a Large Protein–Ligand Complex

Jabar, S., Adams, L. A., Wang, Y., Aurelio, L., Graham, B. & Otting, G., 21 Sep 2017, In : Chemistry - A European Journal. 23, 53, p. 13033-13036 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Double-Arm Lanthanide Tags Deliver Narrow Gd3+–Gd3+ Distance Distributions in Double Electron–Electron Resonance (DEER) Measurements

Welegedara, A. P., Yang, Y., Lee, M. D., Swarbrick, J. D., Huber, T., Graham, B., Goldfarb, D. & Otting, G., 25 Aug 2017, In : Chemistry - A European Journal. 23, 48, p. 11694-11702 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of guanidino modified aminoglycosides on mammalian membranes studied using a quartz crystal microbalance

John, T., Voo, Z. X., Kubeil, C., Abel, B., Graham, B., Spiccia, L. & Martin, L. L., 2017, In : MedChemComm. 8, 5, p. 1112-1120 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Extending the Excitation Wavelength of Potential Photosensitizers via Appendage of a Kinetically Stable Terbium(III) Macrocyclic Complex for Applications in Photodynamic Therapy

Ung, P., Clerc, M., Huang, H., Qiu, K., Chao, H., Seitz, M., Boyd, B. J., Graham, B. & Gasser, G., 17 Jul 2017, In : Inorganic Chemistry. 56, 14, p. 7960-7974 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation

Edgington-Mitchell, L. E., Barlow, N., Aurelio, L., Samha, A., Szabo, M., Graham, B. & Bunnett, N., 15 Jan 2017, In : Bioorganic and Medicinal Chemistry Letters. 27, 2, p. 254-260 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Investigation of donor-acceptor Stenhouse adducts as new visible wavelength-responsive switching elements for lipid-based liquid crystalline systems

Jia, S., Du, J. D., Hawley, A., Fong, W-K., Graham, B. & Boyd, B. J., 7 Mar 2017, In : Langmuir: the ACS journal of surfaces and colloids. 33, 9, p. 2215-2221 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulating the activity of membrane-active peptides through Zn(II) complexation

Paquet-Côté, P. A., Tuck, K. L., Paradis, J. P., Graham, B. & Voyer, N., 13 Dec 2017, In : Tetrahedron Letters. 58, 50, p. 4672-4676 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Jensen, D. D., Lieu, T., Halls, M. L., Veldhuis, N. A., Imlach, W. L., Mai, Q. N., Poole, D. P., Quach, T., Aurelio, L., Conner, J., Klein Herenbrink, C., Barlow, N., Simpson, J. S., Scanlon, M. J., Graham, B., McCluskey, A., Robinson, P. J., Escriou, V., Nassini, R., Materazzi, S. & 6 othersGeppetti, P., Hicks, G. A., Christie, M. J., Porter, C. J. H., Canals, M. & Bunnett, N. W., 31 May 2017, In : Science Translational Medicine. 9, 392, 15 p., aal3447.

Research output: Contribution to journalArticleResearchpeer-review

New lanthanide tag for the generation of pseudocontact shifts in DNA by site-specific ligation to a phosphorothioate group

Wu, Z., Lee, M. D., Carruthers, T. J., Szabo, M., Dennis, M. L., Swarbrick, J. D., Graham, B. & Otting, G., 21 Jun 2017, In : Bioconjugate Chemistry. 28, 6, p. 1741−1748 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Selective Distance Measurements Using Triple Spin Labeling with Gd3+, Mn2+, and a Nitroxide

Wu, Z., Feintuch, A., Collauto, A., Adams, L. A., Aurelio, L., Graham, B., Otting, G. & Goldfarb, D., 2 Nov 2017, In : Journal of Physical Chemistry Letters. 8, 21, p. 5277-5282 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Solution conformations of a linked construct of the Zika virus NS2B-NS3 protease

Mahawaththa, M. C., Pearce, B. J. G., Szabo, M., Graham, B., Klein, C. D., Nitsche, C. & Otting, G., 1 Jun 2017, In : Antiviral Research. 142, p. 141-147 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Structure restraints from heteronuclear pseudocontact shifts generated by lanthanide tags at two different sites

Pearce, B. J. G., Jabar, S., Loh, C-T., Szabo, M., Graham, B. & Otting, G., 1 May 2017, In : Journal of Biomolecular NMR. 68, 1, p. 19-32 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Studies of carbon monoxide release from ruthenium(II) bipyridine carbonyl complexes upon UV-light exposure

Kubeil, M., Vernooij, R. R., Kubeil, C., Wood, B. R., Graham, B., Stephan, H. & Spiccia, L., 15 May 2017, In : Inorganic Chemistry. 56, 10, p. 5941-5952 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Utility of iron nanoparticles and a solution-phase iron species for the N-demethylation of alkaloids

Awalt, J. K., Lam, R., Kellam, B., Graham, B., Scammells, P. J. & Singer, R. D., 2017, In : Green Chemistry. 19, 11, p. 2587-2594 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Zwitterionic modification of ultrasmall iron oxide nanoparticles for reduced protein corona formation

Pombo-García, K., Rühl, C. L., Lam, R., Barreto, J. A., Ang, C-S., Scammells, P. J., Comba, P., Spiccia, L., Graham, B., Joshi, T. & Stephan, H., 2017, In : ChemPlusChem. 82, 4, p. 638–646 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Cellular uptake and photo-cytotoxicity of a gadolinium(III)-DOTA-naphthalimide complex "clicked" to a lipidated tat peptide

O'Malley, W., Rubbiani, R., Aulsebrook, M., Grace, M., Spiccia, L., Tuck, K., Gasser, G. & Graham, B., 1 Feb 2016, In : Molecules. 21, 2, p. 1-16 16 p., 194.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Comprehensive vibrational spectroscopic investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) diazido anticancer prodrug candidate

Vernooij, R. R., Joshi, T., Shaili, E., Kubeil, M., Appadoo, D. R. T., Izgorodina, E. I., Graham, B., Sadler, P. J., Wood, B. & Spiccia, L., 20 Jun 2016, In : Inorganic Chemistry. 55, 12, p. 5983-5992 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Enantiomeric two-armed lanthanide-binding tags for complementary effects in paramagnetic NMR spectroscopy

Lee, M. D., Dennis, M. L., Swarbrick, J. D. & Graham, B., 2016, In : Chemical Communications. 52, 51, p. 7954-7957 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Installation of a rigid EDTA-like motif into a protein α-helix for paramagnetic NMR spectroscopy with cobalt(II) ions

Swarbrick, J. D., Ung, P., Dennis, M. L., Lee, M. D., Chhabra, S. & Graham, B., 22 Jan 2016, In : Chemistry - A European Journal. 22, 4, p. 1228-1232 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Legumain is activated in macrophages during pancreatitis

Edgington-Mitchell, L. E., Wartmann, T., Fleming, A. K., Gocheva, V., van der Linden, W. A., Withana, N. P., Verdoes, M., Aurelio, L., Edgington-Mitchell, D., Lieu, T., Parker, B. S., Graham, B., Reinheckel, T., Furness, J. B., Joyce, J. A., Storz, P., Halangk, W., Bogyo, M. & Bunnett, N. W., Sep 2016, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 311, 3, p. G548-G560 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Luminescent alkyne-bearing terbium(III) complexes and their application to bioorthogonal protein labeling

O'Malley, W., Abdelkader, E. H., Aulsebrook, M., Rubbiani, R., Loh, C. T., Grace, M., Spiccia, L., Gasser, G., Otting, G., Tuck, K. & Graham, B., 15 Feb 2016, In : Inorganic Chemistry. 55, 4, p. 1674-1682 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Neomycin B-cyclen conjugates and their Zn(II) complexes as RNA-binding agents

Kong, B., Joshi, T., Belousoff, M. J., Tor, Y., Graham, B. & Spiccia, L., 2016, In : Journal of Inorganic Biochemistry. 162, p. 334-342 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Overcoming artificial broadening in Gd3+-Gd3+ distance distributions arising from dipolar pseudo-secular terms in DEER experiments

Cohen, M. F. R., Frydman, V., Milko, P., Iron, M. A., Abdelkader, E. H., Lee, M. D., Swarbrick, J. D., Raitsimring, A., Otting, G., Graham, B., Feintuch, A. & Goldfarb, D., 2016, In : Physical Chemistry Chemical Physics. 18, 18, p. 12847-12859 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Pulse EPR-enabled interpretation of scarce pseudocontact shifts induced by lanthanide binding tags

Abdelkader, E. H., Yao, X., Feintuch, A., Adams, L. A., Aurelio, L., Graham, B., Goldfarb, D. & Otting, G., 2016, In : Journal of Biomolecular NMR. 64, 1, p. 39-51 13 p.

Research output: Contribution to journalArticleResearchpeer-review

RIDME distance measurements using Gd(III) tags with a narrow central transition

Collauto, A., Frydman, V., Lee, M. D., Abdelkader, E. H., Feintuch, A., Swarbrick, J. D., Graham, B., Otting, G. & Goldfarb, D., 2016, In : Physical Chemistry Chemical Physics. 18, 28, p. 19037-19049 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Sensitive NMR approach for determining the binding mode of tightly binding ligand molecules to protein targets

Chen, W-N., Nitsche, C., Pilla, K. B., Graham, B., Huber, T., Klein, C. D. & Otting, G., 2016, In : Journal of the American Chemical Society. 138, 13, p. 4539-4546 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Sequence-specific assignment of methyl groups from the neuronal SNARE complex using lanthanide-induced pseudocontact shifts

Pan, Y-Z., Quade, B., Brewer, K. D., Szabo, M., Swarbrick, J. D., Graham, B. & Rizo, J., 1 Dec 2016, In : Journal of Biomolecular NMR. 66, 4, p. 281-293 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and phosphate ester cleavage properties of copper(II) complexes of guanidinium-bridged bis(1,4,7-triazacyclononane) ligands

Tjioe, L., Joshi, T., Graham, B. & Spiccia, L., 2016, In : Polyhedron. 120, p. 11-17 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Zwitterionic polymer-coated ultrasmall superparamagnetic iron oxide nanoparticles with low protein interaction and high biocompatibility

Pombo-García, K., Weiss, S., Zarschler, K., Ang, C-S., Hübner, R., Pufe, J., Meister, S., Seidel, J., Pietzsch, J., Spiccia, L., Stephan, H. & Graham, B., 2016, In : ChemNanoMat. 2, 10, p. 959-971 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

A new Gd3+ spin label for Gd3+-Gd3+ distance measurements in proteins produces narrow distance distributions

Abdelkader, E. H., Lee, M. D., Feintuch, A., Cohen, M. R., Swarbrick, J. D., Otting, G., Graham, B. & Goldfarb, D., 2015, In : Journal of Physical Chemistry Letters. 6, 24, p. 5016-5021 6 p.

Research output: Contribution to journalArticleResearchpeer-review

An SECM study on the influence of cationic, membrane-active peptides on a gold-supported self-assembled monolayer

Abdelhamid, M., Piantavigna, S., Bond, A. M., Graham, B., Spiccia, L., Martin, L. L. & O'Mullane, A. P., 2015, In : Electrochemistry Communications. 51, p. 11-14 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Compact, hydrophilic, lanthanide-binding tags for paramagnetic NMR spectroscopy

Lee, M. D., Loh, C. T., Shin, J., Chhabra, S., Dennis, M. L., Otting, G., Swarbrick, J. D. & Graham, B., 2015, In : Chemical Science. 6, 4, p. 2614-2624 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Coordination chemistry of a mono-dibenzofuran derivative of 1,4,7,10-tetraazacyclododecane

Barreto Solano, J. A., Joshi, T., Venkatachalam, T., Reutens, D. C., Graham, B. & Spiccia, L., 2015, In : Journal of Coordination Chemistry. 68, 2, p. 335-349 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Coumarin-based fluorescent sensors for zinc(II) and hypochlorite

Aulsebrook, M., Graham, B., Grace, M. R. & Tuck, K. L., 2015, In : Supramolecular Chemistry. 27, 11-12, p. 798-806 9 p.

Research output: Contribution to journalArticleResearchpeer-review