Bernard Flynn

Assoc Professor

1990 …2020
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Research Output 1990 2019

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2019

Formation of Highly Substituted Indenes through Acid Promoted Cyclodehydration with Nucleophile Incorporation

Dillon, A. S., Kerr, D. J. & Flynn, B. L., 1 Mar 2019, In : Journal of Organic Chemistry. 84, 5, p. 2756-2767 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Asymmetric synthesis of multiple quaternary stereocentre-containing cyclopentyls by oxazolidinone-promoted Nazarov cyclizations

Volpe, R., Lepage, R. J., White, J. M., Krenske, E. H. & Flynn, B. L., 20 Apr 2018, In : Chemical Science. 9, 20, p. 4644-4649 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Jimenez-Vargas, N. N., Pattison, L. A., Zhao, P., Lieu, T., Latorre, R., Jensen, D. D., Castro, J., Aurelio, L., Le, G. T., Flynn, B., Herenbrink, C. K., Yeatman, H. R., Edgington-Mitchell, L., Porter, C. J. H., Halls, M. L., Canals, M., Veldhuis, N. A., Poole, D. P., McLean, P., Hicks, G. A. & 7 othersScheff, N., Chen, E., Bhattacharya, A., Schmidt, B. L., Brierley, S. M., Vanner, S. J. & Bunnett, N. W., 31 Jul 2018, In : Proceedings of the National Academy of Sciences of the United States of America. 115, 31, p. E7438-E7447 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
2017

Linear and Angular Heteroacenes from Double-Electrophilic Cyclization (DEC) and DEC-Reductive Elimination of Diynes

Gupta, A. & Flynn, B. L., 21 Apr 2017, In : Organic Letters. 19, 8, p. 1939-1941 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanisms of Carbonyl Activation by BINOL N-Triflylphosphoramides: Enantioselective Nazarov Cyclizations

Lovie-Toon, J. P., Tram, C. M., Flynn, B. L. & Krenske, E. H., 5 May 2017, In : ACS Catalysis. 7, 5, p. 3466-3476 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Multistereocenter-Containing Cyclopentanoids from Ynamides via Oxazolidinone-Controlled Nazarov Cyclization

Manchala, N., Law, H. Y. L., Kerr, D. J., Volpe, R., Lepage, R. J., White, J. M., Krenske, E. H. & Flynn, B. L., 7 Jul 2017, In : Journal of Organic Chemistry. 82, 13, p. 6511-6527 17 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

Electrophilic Activation of P-Alkynes in the Synthesis of P-Substituted and P-Centered Heterocycles

Gupta, A. & Flynn, B. L., 20 May 2016, In : Journal of Organic Chemistry. 81, 10, p. 4012-4019 8 p.

Research output: Contribution to journalArticleResearchpeer-review

From sphingosine kinase to dihydroceramide desaturase: a structure-activity relationship (SAR) study of the enzyme inhibitory and anticancer activity of 4-((4-(4-chlorophenyl)thiazol-2-yl)amino)phenol (SKI-II)

Aurelio, L., Scullino, C. V., Pitman, M. R., Sexton, A. E., Oliver, V., Davies, L., Rebello, R. J., Furic, L., Creek, D. J., Pitson, S. M. & Flynn, B. L., 11 Feb 2016, In : Journal of Medicinal Chemistry. 59, 3, p. 965-984 20 p.

Research output: Contribution to journalArticleResearchpeer-review

2015

Mapping the interactions of I2, I; I-, and I+ with alkynes and their roles in iodocyclizations

Volpe, R., Aurelio, L., Gillin, M., Krenske, E. H. & Flynn, B. L., 2015, In : Chemistry - A European Journal. 21, 28, p. 10191 - 10199 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Studies towards a concise enantioselective synthesis of roseophilins

Kerr, D. J. & Flynn, B. L., 2015, In : Australian Journal of Chemistry. 68, 12, p. 1821-1828 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Convergent access to polycyclic cyclopentanoids from a,b-unsaturated acid chlorides and alkynes through a reductive coupling, Nazarov cyclization sequence

Chaplin, J. H., Jackson, K. E., White, J. & Flynn, B. L., 2014, In : Journal of Organic Chemistry. 79, 8, p. 3659 - 3664 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of thieno-fused heterocycles through reiterative iodocyclization

Aurelio, L., Volpe, R., Halim, R., Scammells, P. J. & Flynn, B. L., 2014, In : Advanced Synthesis and Catalysis. 356, 9, p. 1974 - 1978 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2013

Asymmetric synthesis of (+)- and (-)-pauciflorol F: Confirmation of absolute stereochemistry

Kerr, D. J., Miletic, M., Manchala, N., White, J. & Flynn, B. L., 2013, In : Organic Letters. 15, 16, p. 4118 - 4121 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Opposing auxiliary conformations produce the same torquoselectivity in an oxazolidinone-directed Nazarov cyclization

Flynn, B. L., Manchala, N. & Krenske, E. H., 2013, In : Journal of the American Chemical Society. 135, 24, p. 9156 - 9163 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Scaffold-divergent synthesis of ring-fused indoles, quinolines, and quinolones via iodonium-induced reaction cascades

Halim, R., Aurelio, L., Scammells, P. J. & Flynn, B. L., 2013, In : Journal of Organic Chemistry. 78, 10, p. 4708 - 4718 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

A new approach to highly substituted cyclopentanoids from a concise formal synthesis of (+)-roseophilin

Kerr, D. J. & Flynn, B. L., 2012, In : Organic Letters. 14, 7, p. 1740 - 1743 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Convergent total syntheses of the pentacyclic lamellarins K, T, U and W via the addition of azomethine ylides to tethered tolans

Flynn, B. L. & Banwell, M., 2012, In : Heterocycles. 84, 2, p. 1141 - 1170 30 p.

Research output: Contribution to journalArticleResearchpeer-review

Oxazolidinone-promoted, torquoselective Nazarov cyclizations

Kerr, D. J., Miletic, M., Chaplin, J. H., White, J. M. & Flynn, B. L., 2012, In : Organic Letters. 14, 7, p. 1732 - 1735 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Tumour targeting of Auger emitters using DNA ligands conjugated to octreotate

Lobachevsky, P. N., Smith, J., Denoyer, D., Skene, C. E., White, J. M., Flynn, B. L., Kerr, D. J., Hicks, R. & Martin, R. F., 2012, In : International Journal of Radiation Biology. 88, 12, p. 1009 - 1018 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2011

Discovery of 7-hydroxy-6-methoxy-2-methyl-3-(3,4,5-trimethoxybenzoyl)benzo[b]furan (BNC105), a tubulin polymerization inhibitor with potent antiproliferative and tumor vascular disrupting properties

Flynn, B., Gurmit, G., Grobelny, D., Chaplin, J., Paul, D., Leske, A., Lavranos, T., Chalmers, D., Charman, S., Kostewicz, E., Shackleford, D., Morizzi, J., Hamel, E., Jung, K. & Kremmidiotis, G., 2011, In : Journal of Medicinal Chemistry. 54, 17, p. 6014 - 6027 14 p.

Research output: Contribution to journalArticleResearchpeer-review

New methodology for the N-alkylation of 2-amino-3-acylthiophenes

Scammells, P., Flynn, B. & Aurelio, L., 2011, In : Organic and Biomolecular Chemistry. 9, 13, p. 4886 - 4902 17 p.

Research output: Contribution to journalArticleResearchpeer-review

The evaluation of solution-and solid-phase approaches to the divergent synthesis cinnoline and phenanthrene ring systems

Bui, C. & Flynn, B., 2011, In : Molecular Diversity. 15, p. 83 - 89 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

An efficient synthesis of (+-)-frondosin B using a Stille-Heck reaction sequence

Masters, K-S. & Flynn, B. L., 2010, In : Organic and Biomolecular Chemistry. 8, 6, p. 1290 - 1292 3 p.

Research output: Contribution to journalArticleResearchpeer-review

A reductive-coupling plus Nazarov cyclization sequence in the asymmetric synthesis of five-membered carbocycles

Kerr, D., White, J. & Flynn, B., 2010, In : Journal of Organic Chemistry. 75, 21, p. 7073 - 7084 12 p.

Research output: Contribution to journalArticleResearchpeer-review

BNC105: A novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy

Kremmidiotis, G., Leske, A., Lavranos, T., Beaumont, D., Gasic, J., Hall, A., O'Callaghan, M., Matthews, C. & Flynn, B., 2010, In : Molecular Cancer Therapeutics. 9, 6, p. 1562 - 1573 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A1 adenosine receptor modulation

Aurelio, L., Valant, C., Flynn, B., Sexton, P., White, J., Christopoulos, A. & Scammells, P., 2010, In : Journal of Medicinal Chemistry. 53, p. 6550 - 6559 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Richter cyclization and co-cyclization reactions of triazene-masked diazonium ions

Goeminne, A., Scammells, P., Devine, S. & Flynn, B., 2010, In : Tetrahedron Letters. 51, 52, p. 6882 - 6885 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

3- and 6-substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists

Aurelio, L., Valant, C., Figler, H., Flynn, B. L., Linden, J., Sexton, P., Christopoulos, A. & Scammells, P. J., 2009, In : Bioorganic & Medicinal Chemistry. 17, 20, p. 7353 - 7361 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Alternation of Chemoselective Control in Stille-Heck and Heck-Stille Reaction Sequences

Masters, K-S. & Flynn, B. L., 2009, In : Advanced Synthesis and Catalysis. 351, 4, p. 530 - 536 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Reaction pathways to 2-aminothiophenes and thiophene-3-carbonitriles

Aurelio, L., Flynn, B. L. & Scammells, P. J., 2009, In : Australian Journal of Chemistry. 62, 5, p. 402 - 406 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

2-Aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists

Ferguson, G. N., Valant, C., Horne, H. J., Figler, H., Flynn, B. L., Linden, J., Chalmers, D. K., Sexton, P., Christopoulos, A. & Scammells, P. J., 2008, In : Journal of Medicinal Chemistry. 51, 19, p. 6165 - 6172 8 p.

Research output: Contribution to journalArticleResearchpeer-review

5-Substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers

Aurelio, L., Figler, H., Flynn, B. L., Linden, J. & Scammells, P. J., 2008, In : Bioorganic & Medicinal Chemistry. 16, 3, p. 1319 - 1327 9 p.

Research output: Contribution to journalArticleResearchpeer-review

A concise approach to the polycyclic scaffold of frondosin D

Masters, K-S. & Flynn, B. L., 2008, In : Journal of Organic Chemistry. 73, 20, p. 8081 - 8084 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Alternating lodonium-mediated reaction cascades giving indole- And quinoline-containing polycycles

Halim, R., Scammells, P. J. & Flynn, B. L., 2008, In : Organic Letters. 10, 10, p. 1967 - 1970 4 p.

Research output: Contribution to journalArticleResearchpeer-review

An Efficient Synthesis and Substitution of 3-Aroyl-2-bromobenzo[b]furans

Gurmit, G. S., Grobelny, D., Chaplin, J. H. & Flynn, B. L., 2008, In : Journal of Organic Chemistry. 73, 3, p. 1131 - 1134 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and Biological Evaluation of Chalcones as Inhibitors of the Voltage-Gated Potassium Channel Kv1.3

Cianci, J., Baell, J. B., Flynn, B. L., Gable, R. W., Mould, J., Paul, D. & Harvey, A. J., 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 6, p. 2055 - 2061 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

The concise synthesis of chalcone, indanone and indenone analogues of combretastatin A4

Kerr, D. J., Hamel, E., Jung, K. & Flynn, B. L., 2007, In : Bioorganic & Medicinal Chemistry. 15, 9, p. 3290 - 3298 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

A practical method for phosphorylation of combretastatin A-4 with phosphorus oxychloride

Gurmit, G. S., Grobelny, D. & Flynn, B. L., 2006, In : Organic Preparations and Procedures International. 38, 6, p. 604 - 608 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Selective endo and exo iodocyclizations in the synthesis of Quinolines and Indoles

Hessian, K. O. & Flynn, B. L., 2006, In : Organic Letters. 8, 2, p. 243 - 246 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Solid-Phase Synthesis of 2,3-Disubstituted Benzo[b]thiophenes and Benzo[b]selenophenes

Bui, C. T. & Flynn, B. L., 2006, In : Journal of Combinatorial Chemistry. 8, 2, p. 163 - 167 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

From α,β-unsaturated Fischer carbene complexes to highly substituted 3-ethoxycyclopentadienes, masked cyclopentenones

Wu, Y. T., Flynn, B., Schirmer, H., Funke, F., Müller, S., Labahn, T., Nötzel, M. & De Meijere, A., 13 Feb 2004, In : European Journal of Organic Chemistry. 4, p. 724-748 25 p.

Research output: Contribution to journalArticleResearchpeer-review

Multicomponent Coupling Approach to (±)-Frondosin B and a Ring-Expanded Analogue

Kerr, D. J., Willis, A. C. & Flynn, B. L., 19 Feb 2004, In : Organic Letters. 6, 4, p. 457-460 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

A convenient two step protocol for the synthesis of cyclopentenones and indanones, including an asymmetric variant

Kerr, D. J., Metje, C. & Flynn, B. L., 21 Jun 2003, In : Chemical Communications. 9, 12, p. 1380-1381 2 p.

Research output: Contribution to journalArticleResearchpeer-review

An enantioselective double Diels-Alder approach to the tetracyclic framework of colombiasin A

Chaplin, J. H., Edwards, A. J. & Flynn, B. L., 21 Jul 2003, In : Organic and Biomolecular Chemistry. 1, 11, p. 1842-1844 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Iodine -induced reaction cascades for the rapid construction of variously substituted benzothiophenes

Hessian, K. O. & Flynn, B. L., 2003, In : Organic Letters. 5, 23, p. 4377 - 4380 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Efficient syntheses of angularly fused triquinanes via β-amino-substituted α,β-unsaturated fischer-carbene complexes

Milic, J., Schirmer, H., Flynn, B. L., Noltemeyer, M. & De Meijere, A., 22 Jun 2002, In : Synlett. 6, p. 875-878 4 p.

Research output: Contribution to journalArticleResearchpeer-review

One-pot synthesis of benzo[b]furan and indole inhibitors of tubulin polymerization

Flynn, B. L., Hamel, E. & Jung, M. K., 6 Jun 2002, In : Journal of Medicinal Chemistry. 45, 12, p. 2670-2673 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

A multi-component coupling approach to benzo[b]furans and indoles

Chaplin, J. H. & Flynn, B. L., 1 Jan 2001, In : Chemical Communications. 1, 17, p. 1594-1595 2 p.

Research output: Contribution to journalArticleResearchpeer-review