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Research Output 1998 2019

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2013

Low adhesion receptor levels on circulating platelets in patients with lymphoproliferative diseases before receiving Navitoclax (ABT-263)

Qiao, J. L., Schoenwaelder, S. M., Mason, K. D., Tran, H. A., Davis, A., Kaplan, Z., Jackson, S., Kile, B., Andrews, R. K., Roberts, A. W. & Gardiner, E. E., 2013, In : Blood. 121, 8, p. 1479 - 1481 3 p.

Research output: Contribution to journalArticleResearchpeer-review

MCMV-mediated inhibition of the pro-apoptotic Bak protein is Required for optimal in vivo replication

Fleming, P., Kvansakul, M., Voigt, V., Kile, B. T., Kluck, R. M., Huang, D. C. S., Degli-Esposti, M. A. & Andoniou, C. E., 28 Feb 2013, In : PLoS Pathogens. 9, 2, 12 p., e1003192.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke

Downes, C. E., Wong, C. H. Y., Henley, K. J., Guio-Aguilar, P. L., Zhang, M., Ates, R., Mansell, A. S., Kile, B. T. & Crack, P. J., 2013, In : PLoS ONE. 8, 3, 8 p., e57948.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Proapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune disease

Mason, K. D., Lin, A., Robb, L., Josefsson, E. C., Henley, K. J., Gray, D. H. D., Kile, B. T., Roberts, A. W., Strasser, A., Huang, D. C. S., Waring, P. & O'Reilly, L. A., 12 Feb 2013, In : Proceedings of the National Academy of Sciences. 110, 7, p. 2599-2604 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia

Tang, J. Z., Carmichael, C. L., Shi, W., Metcalf, D., Ng, A. P., Hyland, C. D., Jenkins, N. A., Copeland, N. G., Howell, V. M., Zhao, Z. J., Smyth, G. K., Kile, B. T. & Alexander, W. S., 9 Apr 2013, In : Proceedings of the National Academy of Sciences. 110, 15, p. 6091-6096 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Two ENU-induced alleles of Atp2b2 cause deafness in mice

Carpinelli, M., Manning, M. G., Kile, B. & Burt, R. A., Jun 2013, In : PLoS ONE. 8, 6 , 8 p., e67479.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Variability of Inducible Expression across the Hematopoietic System of Tetracycline Transactivator Transgenic Mice

Takiguchi, M., Dow, L. E., Prier, J. E., Carmichael, C., Kile, B., Turner, S. J., Lowe, S. W., Huang, D. C. S. & Dickins, R. A., Jan 2013, In : PLoS ONE. 8, 1, 10 p., e54009.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2012

Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets

Kraemer, B. F., Campbell, R. A., Schwertz, H., Franks, Z. G., Vieira de Abreu, A., Grundler, K., Kile, B. T., Dhakal, B. K., Rondina, M. T., Kahr, W. H. A., A. Mulvey, M., Blaylock, R. C., A. Zimmerman, G. & Weyrich, A. S., 13 Dec 2012, In : Blood. 120, 25, p. 5014-5020 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function

White, M. J., Schoenwaelder, S. M., Josefsson, E. C., Jarman, K. E., Henley, K. J., James, C., Debrincat, M. A., Jackson, S. P., Huang, D. C. S. & Kile, B. T., 3 May 2012, In : Blood. 119, 18, p. 4283-4290 8 p., 18.

Research output: Contribution to journalArticleResearchpeer-review

Genetic modifier screens in mice

Carpinelli, M., Burt, R. A. & Kile, B. T., 2012, In : Current Protocols in Mouse Biology. 2, p. 75 - 87 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia

Carmichael, C. L., Metcalf, D., Henley, K. J., Kruse, E. A., Di Ragoa, L., Mifsud, S., Alexander, W. S. & Kile, B. T., 18 Sep 2012, In : Proceedings of the National Academy of Sciences. 109, 38, p. 15437-15442 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Mcl-1 and Bcl-x L coordinately regulate megakaryocyte survival

Debrincat, M. A., Josefsson, E. C., James, C., Henley, K. J., Ellis, S., Lebois, M., Betterman, K. L., Lane, R. M., Rogers, K. L., White, M. J., Roberts, A. W., Harvey, N. L., Metcalf, D. & Kile, B. T., 14 Jun 2012, In : Blood. 119, 24, p. 5850-5858 9 p.

Research output: Contribution to journalArticleResearchpeer-review

NLRP1 inflammasome activation induces pyroptosis of hematopoietic progenitor cells

Masters, S. L., Gerlic, M., Metcalf, D., Preston, S., Pellegrini, M., O'Donnell, J. A., McArthur, K., Baldwin, T. M., Chevrier, S., Nowell, C. J., Cengia, L. H., Henley, K. J., Collinge, J. E., Kastner, D. L., Feigenbaum, L., Hilton, D. J., Alexander, W. S., Kile, B. T. & Croker, B. A., 14 Dec 2012, In : Immunity. 37, 6, p. 1009-1023 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Reduced lymphocyte longevity and homeostatic proliferation in lamin B receptor-deficient mice results in profound and progressive lymphopenia

Verhagen, A. M., de Graaf, C. A., Baldwin, T. M., Goradia, A., Collinge, J. E., Kile, B. T., Metcalf, D., Starr, R. & Hilton, D. J., 1 Jan 2012, In : Journal of Immunology. 188, 1, p. 122-134 13 p.

Research output: Contribution to journalArticleResearchpeer-review

The dendritic cell receptor Clec9A binds damaged cells via exposed actin filaments

Zhang, J-G., Czabotar, P. E., Policheni, A. N., Caminschi, I., Wan, S. S., Kitsoulis, S., Tullett, K. M., Robin, A. Y., Brammananth, R., van Delft, M. F., Lu, J., O'Reilly, L. A., Josefsson, E. C., Kile, B. T., Chin, W. J., Mintern, J. D., Olshina, M. A., Wong, W., Baum, J., Wright, M. D. & 7 othersHuang, D. C. S., Mohandas, N., Coppel, R. L., Colman, P. M., Nicola, N. A., Shortman, K. & Lahoud, M. H., 2012, In : Immunity. 36, 4, p. 646-657 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Thrombocytopenia and erythrocytosis in mice with a mutation in the gene encoding the hemoglobin β minor chain

Kauppi, M., Hilton, A. A., Metcalf, D., Ng, A. P., Hyland, C. D., Collinge, J. E., Kile, B. T., Hilton, D. J. & Alexander, W. S., 10 Jan 2012, In : Proceedings of the National Academy of Sciences. 109, 2, p. 576-581 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor

Lindqvist, LM., Vikstrom, I., Chambers, JM., McArthur, K., Anderson, M. A., Henley, KJ., Happo, L., Cluse, L., Johnstone, RW., Roberts, AW., Kile, BT., Croker, BA., Burns, CJ., Rizzacasa, MA., Strasser, A. & Huang, DCS., Oct 2012, In : Cell Death and Disease. 3, 10, 9 p., e409.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2011

An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation

Nguyen, N-Y. N., Maxwell, M. J., Ooms, L., Davies, E. M., Hilton, A. A., Collinge, J. E., Hilton, D. J., Kile, B. T., Mitchell, C. A., Hibbs, M. L., Jane, S. M. & Curtis, D. J., 2011, In : Blood. 117, 20, p. 5362-5371 10 p., 20.

Research output: Contribution to journalArticleResearchpeer-review

Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets

Schoenwaelder, S. M., Jarman, K. E., Gardiner, E. E., Hua, M., Qiao, J., White, M. J., Josefsson, E. C., Alwis, I., Ono, A., Willcox, A., Andrews, R. K., Mason, K. D., Salem, H. H., Huang, D. C. S., Kile, B. T., Roberts, A. W. & Jackson, S. P., 2011, In : Blood. 118, 6, p. 1663-1674 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia

Bishton, M. J., Harrison, S. J., Martin, B. P., McLaughlin, N., James, C., Josefsson, E. C., Henley, K. J., Kile, B. T., Prince, H. M. & Johnstone, R. W., 31 Mar 2011, In : Blood. 117, 13, p. 3658-3668 11 p.

Research output: Contribution to journalArticleResearchpeer-review

ERG dependence distinguishes developmental control of hematopoietic stem cell maintenance from hematopoietic specification

Taoudi, S., Bee, T., Hilton, A., Knezevic, K., Scott, J., Willson, T. A., Collin, C., Thomas, T., Voss, A. K., Kile, B. T., Alexander, W. S., Pimanda, J. E. & Hilton, D. J., Feb 2011, In : Genes and Development. 25, 3, p. 251-262 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Erg is required for self-renewal of hematopoietic stem cells during stress hematopoiesis in mice

Ng, A. P., Loughran, S. J., Metcalf, D., Hyland, C. D., de Graaf, C. A., Hu, Y., Smyth, G. K., Hilton, D. J., Kile, B. T. & Alexander, W. S., 1 Sep 2011, In : Blood. 118, 9, p. 2454-2461 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets

Josefsson, E. C., James, C., Henley, K. J., Debrincat, M. A., Rogers, K. L., Dowling, M. R., White, M. J., Kruse, E. A., Lane, R. M., Ellis, S., Nurden, P., Mason, K. D., O'Reilly, L. A., Roberts, A. W., Metcalf, D., Huang, D. C. S. & Kile, B. T., 26 Sep 2011, In : Journal of Experimental Medicine. 208, 10, p. 2017-2031 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Mutation discovery in mice by whole exome sequencing

Fairfield, H., Gilbert, G. J., Barter, M., Corrigan, R. R., Curtain, M., Ding, Y., D'Ascenzo, M., Gerhardt, D. J., He, C., Huang, W., Richmond, T., Rowe, L., Probst, F. J., Bergstrom, D. E., Murray, S. A., Bult, C., Richardson, J., Kile, B. T., Gut, I., Hager, J. & 14 othersSigurdsson, S., Mauceli, E., Di Palma, F., Lindblad-Toh, K., Cunningham, M. L., Cox, T. C., Justice, M. J., Spector, M. S., Lowe, S. W., Albert, T., Donahue, L. R., Jeddeloh, J., Shendure, J. & Reinholt, L. G., 14 Sep 2011, In : Genome Biology. 12, 12 p., 12:R86.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2010

Apoptotic Processes in Megakaryocytes and Platelets

White, M. J. & Kile, B. T., Jul 2010, In : Seminars in Hematology. 47, 3, p. 227-234 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: Implications for subcellular trafficking and secretion

Cordell, P. A., Kile, B. T., Standeven, K. F., Josefsson, E. C., Pease, R. J. & Grant, P. J., 1 Apr 2010, In : Blood. 115, 13, p. 2674-2681 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Critical roles for c-Myb in lymphoid priming and early B-cell development

Greig, K. T., de Graaf, C. A., Murphy, J. M., Carpinelli, M. R., Pang, S. H. M., Frampton, J., Kile, B. T., Hilton, D. J. & Nutt, S. L., 8 Apr 2010, In : Blood. 115, 14, p. 2796 - 2805 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Individual and overlapping roles of BH3-only proteins Bim and Bad in apoptosis of lymphocytes and platelets and in suppression of thymic lymphoma development

Kelly, PN., White, MJ., Goschnick, M., Fairfax, K., Tarlinton, D., Kinkel, S., Bouillet, P., Adams, J., Kile, B. T. & Strasser, A., 2010, In : Cell Death and Differentiation. 17, 10, p. 1655 - 1664 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Platelet senescence is regulated by an internal timer, not damage inflicted by hits

Dowling, M. R., Josefsson, E. C., Henley, K. J., Hodgkin, P. D. & Kile, B. T., 9 Sep 2010, In : Blood. 116, 10, p. 1776-1778 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Transgenic, inducible RNAi in megakaryocytes and platelets in mice

Takiguchi, M., James, C., Josefsson, E. C., Carmichael, C. L., Premsrirut, P. K., Lowe, S. W., Hamilton, J. R., Huang, D. CS., Kile, B. & Dickins, R. A., 2010, In : Journal of Thrombosis and Haemostasis. 8, 1538-7933, p. 2751 - 2756 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome

Ng, A. Q. P., Hyland, C. D., Metcalf, D., Carmichael, C. L., Loughran, S. J., Di Rago, L., Kile, B. T. & Alexander, W. S., 13 May 2010, In : Blood. 115, 19, p. 3966-3969 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

A kinase-dead allele of lyn attenuates autoimmune disease normally associated with lyn deficiency

Verhagen, A., Wallace, M., Goradia, A., Jones, S. A., Croom, H., Metcalf, D., Collinge, J., Maxwell, M., Hibbs, M., Alexander, W., Hilton, D., Kile, B. & Starr, R., 2009, In : Journal of Immunology. 182, p. 2020 - 2029 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Dual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage

Kruse, E. A., Loughran, S. J., Baldwin, T. M., Josefsson, E. C., Ellis, S. L., Watson, D. K., Nurden, P., Metcalf, D., Hilton, D. J., Alexander, W. S. & Kile, B. T., 18 Aug 2009, In : Proceedings of the National Academy of Sciences. 106, 33, p. 13814-13819 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Mutational inhibition of c-Myb or p300 ameliorates treatment-induced thrombocytopenia

Hilton, D. J., Kile, B. T. & Alexander, W. S., 2009, In : Blood. 113, 22, p. 5599-5604 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel roles for erythroid Ankyrin-1 revealed through an ENU-induced null mouse mutant

Rank, G., Sutton, R., Marshall, V., Lundie, R. J., Caddy, J., Romeo, T., Fernandez, K. M., McCormack, M. P., Cooke, B. M., Foote, S. J., Crabb, B. S., Curtis, D. J., Hilton, D. J., Kile, B. T. & Jane, S. M., 2009, In : Blood. 113, 14, p. 3352 - 3362 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The role of the ETS factor erg in zebrafish vasculogenesis

Ellett, F., Kile, B. & Lieschke, G., 2009, In : Mechanisms of Development. 126, 3-4, p. 220 - 229 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function

Schoenwaelder, S. M., Yuan, Y-P., Josefsson, E. C., White, M. J., Yao, Y., Mason, K. D., O'Reilly, L. A., Henley, K. J., Ono, A., Hsiao, S. T-F., Willcox, A. E. H., Roberts, A. W., Huang, D. C. S., Salem, H. H., Kile, B. & Jackson, S., 2009, In : Blood. 114, 3, p. 663 - 666 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2008

A mouse model of harlequin ichthyosis delineates a key role for Abca12 in lipid homeostasis

Smyth, I. M., Hacking, D. F., Hilton, A. A., Mukhamedova, N., Meikle, P. J., Ellis, S. L., Slattery, K., Collinge, J. E., de Graaf, C. A., Bahlo, M., Sviridov, D., Kile, B. & Hilton, D., 2008, In : PLoS Genetics. 4, 9 (e1000192), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl/mice

Kauppi, M., Murphy, J. M., De Graaf, C. A., Hyland, C. D., Greig, K. T., Metcalf, D., Hilton, A. A., Nicola, N. A., Kile, B. T., Hilton, D. J. & Alexander, W. S., 15 Oct 2008, In : Blood. 112, 8, p. 3148-3153 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells

Loughran, S. J., Kruse, E. A., Hacking, D. F., de Graaf, C. A., Hyland, C. D., Willson, T. A., Henley, K. J., Ellis, S., Voss, A. K., Metcalf, D., Hilton, D. J., Alexander, W. S. & Kile, B. T., Jul 2008, In : Nature Immunology. 9, 7, p. 810-819 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2007

Agm1/Pgm3-mediated sugar nucleotide synthesis is essential for hematopoiesis and development

Greig, K. T., Antonchuk, J., Metcalf, D., Morgan, P. O., Krebs, D. L., Zhang, J. G., Hacking, D. F., Bode, L., Robb, L., Kranz, C., De Graaf, C., Bahlo, M., Nicola, N. A., Nutt, S. L., Freeze, H. H., Alexander, W. S., Hilton, D. J. & Kile, B. T., Aug 2007, In : Molecular and Cellular Biology. 27, 16, p. 5849-5859 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Ankyrin repeat and suppressors of cytokine signaling box protein Asb-9 targets creatine kinase B for degradation

Debrincat, M. A., Zhang, J. G., Willson, T. A., Silke, J., Connolly, L. M., Simpson, R. J., Alexander, W. S., Nicola, N. A., Kile, B. T. & Hilton, D. J., 16 Feb 2007, In : Journal of Biological Chemistry. 282, 7, p. 4728-4737 10 p.

Research output: Contribution to journalArticleResearchpeer-review

A novel mutation in the Nfkb2 gene generates an NF-κB2 "super repressor"

Tucker, E., O'Donnell, K., Fuchsberger, M., Hilton, A. A., Metcalf, D., Greig, K., Sims, N. A., Quinn, J. M., Alexander, W. S., Hilton, D. J., Kile, B. T., Tarlinton, D. M. & Starr, R., 1 Dec 2007, In : Journal of Immunology. 179, 11, p. 7514-7522 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Mutations in the cofilin partner Aip1/Wdr1 cause autoinflammatory disease and macrothrombocytopenia

Kile, B. T., Panopoulos, A. D., Stirzaker, R. A., Hacking, D. F., Tahtamouni, L. H., Willson, T. A., Mielke, L. A., Henley, K. J., Zhang, J. G., Wicks, I. P., Stevenson, W. S., Nurden, P., Watowich, S. S. & Justice, M. J., 1 Oct 2007, In : Blood. 110, 7, p. 2371-2380 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Probabilistic analysis of recessive mutagenesis screen strategies

Silver, J. D., Hilton, D. J., Bahlo, M. & Kile, B. T., Jan 2007, In : Mammalian Genome. 18, 1, p. 5-22 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Programmed anuclear cell death delimits platelet life span

Mason, K. D., Carpinelli, M., Fletcher, J. I., Collinge, J. E., Hilton, A. A., Ellis, S. L., Kelly, P., Ekert, P. G., Metcalf, D., Roberts, A. W., Huang, D. CS. & Kile, B. T., 2007, In : Cell. 128, 6, p. 1173 - 1186 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2006

Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene

Alexander, W., Viney, E. M., Zhang, J., Metcalf, D., Kauppi, M., Hyland, C. D., Carpinelli, M., Stevenson, W., Croker, B., Hilton, A. A., Ellis, S. L., Selan, C., Nandurkar, H., Goodnow, C., Kile, B. T., Nicola, N. A., Roberts, A. W. & Hilton, D., 2006, In : Proceedings of the National Academy of Sciences. 103, 44, p. 16442 - 16447 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Functional genetic analysis of mouse chromosome 11

Kile, B. T., Hentges, K. E., Clark, A. T., Nakamura, H., Salinger, A. P., Liu, B., Box, N., Stockton, D. W., Johnson, R. L., Behringer, R. R., Bradley, A. & Justice, M. J., 4 Sep 2003, In : Nature. 425, 6953, p. 81-86 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains

Kile, B. T., Mason-Garrison, C. L. & Justice, M. J., 1 Jan 2003, In : Mammalian Genome. 14, 1, p. 81-85 5 p.

Research output: Contribution to journalArticleResearchpeer-review