Projects per year
Personal profile
Biography
I am a research scientist who studies the DNA of bacteria using computational biology, then tests hypotheses in the laboratory using micro and molecular biology.
I am currently working as a postdoctoral research fellow with Dr. Kelly Wyres within the Infectious Diseases Genomics @ Alfed, within the Department of Infectious Diseases, School of Translational Medicine at Monash University (2020 - current). I use genomic and bioinformatic techniques to look at the evolutionary history of Klebsiella pneumoniae, a notable infectious pathogen. I study the metabolism of these pathogens via metabolic modelling and comparative genomics.
Prior to this, I completed a 1.5 year postdoctoral position at the Griffith Institute of Drug Discovery, Griffith University (2018 - 2019). I used structural biology and computational approaches to inform wet-lab experiments to study the circular bacteriocin, plantacyclin B21AG.
I have also worked as a research scientist at RMIT university doing diagnostics, RNA sequencing analysis and genomics of chicken pathogen Campylobacter hepaticus, the cause of spotty liver disease (2018).
I completed a PhD in molecular and microbiology at the Biomedicine Discovery Institute, Monash University (2014 - 2018), where I worked on constructing a live vaccine for chickens, using the commensal bacteria Ligilactobacillus agilis. I discovered new constitutive promoters which I then used as genetic tools and novel expression systems.
I completed Honours at Deakin University (2013) where I constructed novel shuttle plasmids for commensal bacteria Ligilactobacillus agilis using native plasmids as a backbone.
Research interests
I am concerned about antibiotic resistance and am focused on alternative approaches to combat this serious issue, such as developing vaccines, antimicrobial proteins, diagnostics and surveillance, all of which are informed by genetics-based approaches. Also, bacteria are just cool, so that makes them interesting and worthy of study in their own right.
Feel free to check out my Scholar and ORCID pages to see my written contributions to science
I am offering the following research projects for potential Honours and Masters students:
Consulting
Outside of direct academic collaborations, I do bioinformatics consulting for biotech companies and research groups. Please feel free to get in touch if you have sequencing data and would like analysis performed.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Education/Academic qualification
Molecular and Microbiology, PhD, Development of Lactobacillus agilis La3 as a live vector for the delivery of vaccine antigens to the gastrointestinal tract of chickens
1 Feb 2014 → 1 May 2018
Award Date: 1 Aug 2018
External positions
Freelance Computational Biology
1 Apr 2020 → 1 Oct 2020
Postdoctoral Research Fellow, Griffith University
11 Jan 2019 → 15 Apr 2020
Research Scientist, RMIT University
1 Jan 2018 → 1 Sept 2018
Research area keywords
- Computational Biology
- Bioinformatics
- Molecular Biology
- Microbiology
- Antimicrobial Resistance
- Antimicrobial agent
- Vaccine design
- Genomics
- Genetics, microbial
Collaborations and top research areas from the last five years
Projects
- 1 Active
-
Ben Barres Spotlight Award
Vezina, B. (Primary Chief Investigator (PCI))
1/09/23 → 1/07/26
Project: Research
-
A validated pangenome-scale metabolic model for the Klebsiella pneumoniae species complex
Cooper, H. B., Vezina, B., Hawkey, J., Passet, V., López-Fernández, S., Monk, J. M., Brisse, S., Holt, K. E. & Wyres, K. L., 20 Feb 2024, In: Microbial Genomics. 10, 2, 16 p., 001206.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Ethanolamine metabolism through two genetically distinct loci enables Klebsiella pneumoniae to bypass nutritional competition in the gut
Barnes, A. J., Bennett, E. F., Vezina, B., Hudson, A. W., Hernandez, G. E., Nutter, N. A., Bray, A. S., Nagpal, R., Wyres, K. L. & Zafar, M. A., May 2024, In: PLoS Pathogens. 20, 5, 28 p., e1012189.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Genomic investigation of multispecies and multivariant bla NDM outbreak reveals key role of horizontal plasmid transmission
Macesic, N. (Leading Author), Dennis, A., Hawkey, J., Vezina, B., Wisniewski, J. A., Cottingham, H., Blakeway, L. V., Harshegyi, T., Pragastis, K., Badoordeen, G. Z., Bass, P., Stewardson, A. J., Dennison, A., Spelman, D. W., Jenney, A. W. J. & Peleg, A. Y. (Leading Author), Jun 2024, In: Infection Control & Hospital Epidemiology. 45, 6, p. 709-716 8 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Bactabolize is a tool for high-throughput generation of bacterial strain-specific metabolic models
Vezina, B., Watts, S. C., Hawkey, J., Cooper, H. B., Judd, L. M., Jenney, A. W. J., Monk, J. M., Holt, K. E. & Wyres, K. L., Oct 2023, In: eLife. 12, 22 p., e87406.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus) -
Genomic dissection of endemic carbapenem resistance reveals metallo-beta-lactamase dissemination through clonal, plasmid and integron transfer
Macesic, N., Hawkey, J., Vezina, B., Wisniewski, J. A., Cottingham, H., Blakeway, L. V., Harshegyi, T., Pragastis, K., Badoordeen, G. Z., Dennison, A., Spelman, D. W., Jenney, A. W. J. & Peleg, A. Y., 8 Aug 2023, In: Nature Communications. 14, 1, p. 4764 1 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access22 Citations (Scopus)
Prizes
-
ATA Scientific Encouragement Award ($1,500)
Vezina, B. (Recipient), 31 Dec 2020
Prize: Prize (including medals and awards)
File -
Ben Barres Spotlight Award ($2680 USD)
Vezina, B. (Recipient), 31 Aug 2023
Prize: Prize (including medals and awards)
-
Central Clinical School EMCR Virtual Conference Support Grant ($300)
Vezina, B. (Recipient), 1 Dec 2021
Prize: Prize (including medals and awards)
-
FMNHS ECR Travel Grant 2022 ($2000)
Vezina, B. (Recipient), 10 Jun 2022
Prize: Prize (including medals and awards)
-
People's Choice for Best Talk - MicroSeq 2023 (£100)
Vezina, B. (Recipient), 7 Sept 2023
Prize: Prize (including medals and awards)
File
-
Invited speaker at Informal Online Bioinformatics Seminar
Vezina, B. (Contributor)
9 Mar 2022Activity: Community Talks, Presentations, Exhibitions and Events › Public lecture/debate/seminar
-
Monash Young MedTech Innovators Medhack Elevate (hackathon) Co-designer/expert
Vezina, B. (Advisor)
6 May 2022 → 8 May 2022Activity: Community Talks, Presentations, Exhibitions and Events › Public outreach
-
MicroSeq2022
Vezina, B. (Session chair)
8 Sept 2022Activity: Participating in or organising an event types › Contribution to conference
-
Invited speaker at ASM Victoria - One Health Microbial Genomics seminar
Vezina, B. (Contributor)
31 May 2022Activity: Community Talks, Presentations, Exhibitions and Events › Public lecture/debate/seminar
-
MicroSeq2022
Vezina, B. (Speaker)
7 Sept 2022Activity: Participating in or organising an event types › Contribution to conference