Projects per year
Personal profile
Research interests
In the stem cell laboratory, our focus is on finding new treatments for patients with epilepsy that cannot be treated with currently available anti-epileptic drugs. To do this, we take patient cells and turn them into stem cells – cells which can then be directed to become any cell in the body. To study epilepsy, we then instruct these cells to become brain cells or neurons – the cells which are affected in epilepsy. This allows us create a personalised ‘epilepsy-in-a-dish’ model for each patient, on which we can then test a variety of existing or new anti-epileptic drugs. Importantly, this personalised model allows testing without any risk to the patient and can be scaled up to allow high-throughput screening of thousands of potential life-changing drugs.
Research area keywords
- Epilepsy
- Personalised medicine
- Stem Cells
- Disease model development
Network
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Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy
May, L., Webb, G., Carlsson, J., Baltos, J., Nguyen, A., Christopoulos, A., Miao, Y., O'Brien, T., Rollo, B., Casillas-Espinosa, P., Gregory, K., Scammells, P. & Nguyen, T.
1/01/22 → 31/12/25
Project: Research
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Insights into CDKL5 neuronal regulation: pathways to improving neurological outcomes for CDKL5 Deficiency Disorder
Van Bergen, N., Rollo, B., Christodoulou, J., Quigley, A., Kapsa, R. M. I. & Harris, A.
1/06/21 → 31/05/24
Project: Research
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Transforming the paradigm of epilepsy care with precision medicine
Wolvetang, E. J., Kwan, P., Vadlamudi, L., O'Brien, T., Ge, Z., Anderson, A., Shaker, M., Antonic-Baker, A., Leeson, H. & Rollo, B.
Department of Health (Australia)
1/06/21 → 31/05/24
Project: Research
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Discovering new drugs for epilepsy using personalised medicine
Kwan, P., Rollo, B., Langmead, C., Ayers, K. L. & Harris, A.
1/06/20 → 31/05/22
Project: Research
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Human high-throughput in-vitro phenotypic screening for new epilepsy drugs
Rollo, B., Kwan, P., O'Brien, T., Langmead, C., Baell, J., Casillas-Espinosa, P., May, L., Ayers, K. L. & Sumer, H.
1/06/22 → 1/01/23
Project: Research
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Therapeutic Inhibition of Acid-Sensing Ion Channel 1a Recovers Heart Function after Ischemia-Reperfusion Injury
Redd, M. A., Scheuer, S. E., Saez, N. J., Yoshikawa, Y., Chiu, H. S., Gao, L., Hicks, M., Villanueva, J. E., Joshi, Y., Chow, C. Y., Cuellar-Partida, G., Peart, J. N., See Hoe, L. E., Chen, X., Sun, Y., Suen, J. Y., Hatch, R. J., Rollo, B., Xia, D., Alzubaidi, M. A. H. & 13 others, , Sep 2021, In: Circulation. 144, 12, p. 947-960 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
New era of personalised epilepsy management
Chen, Z., Rollo, B., Antonic-Baker, A., Anderson, A., Ma, Y., O'Brien, T. J., Ge, Z., Wang, X. & Kwan, P., 9 Oct 2020, In: The BMJ. 371, 5 p., m3658.Research output: Contribution to journal › Review Article › Other › peer-review
Open Access6 Citations (Scopus) -
The enteric neural crest progressively loses capacity to form enteric nervous system
Zhang, D., Rollo, B. N., Nagy, N., Stamp, L. & Newgreen, D. F., 1 Feb 2019, In: Developmental Biology. 446, 1, p. 34-42 9 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus) -
Can mutation-mediated effects occurring early in development cause long-term seizure susceptibility in genetic generalized epilepsies?
Reid, C. A., Rollo, B., Petrou, S. & Berkovic, S. F., 1 May 2018, In: Epilepsia. 59, 5, p. 915-922 8 p.Research output: Contribution to journal › Article › Other › peer-review
Open Access7 Citations (Scopus) -
Method of derivation and differentiation of mouse embryonic stem cells generating synchronous neuronal networks
Gazina, E. V., Morrisroe, E., Mendis, G. D. C., Michalska, A. E., Chen, J., Nefzger, C. M., Rollo, B. N., Reid, C. A., Pera, M. F. & Petrou, S., 1 Jan 2018, In: Journal of Neuroscience Methods. 293, p. 53-58 6 p.Research output: Contribution to journal › Article › Research › peer-review
9 Citations (Scopus)