Ben Markman

Dr

20082024
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Research Output 2008 2018

Phase IB Trial of the Anti-Cancer Stem Cell DLL4-Binding Agent Demcizumab with Pemetrexed and Carboplatin as First-Line Treatment of Metastatic Non-Squamous NSCLC

McKeage, M. J., Kotasek, D., Markman, B., Hidalgo, M., Millward, M. J., Jameson, M. B., Harris, D. L., Stagg, R. J., Kapoun, A. M., Xu, L. & Hughes, B. G. M., 1 Feb 2018, In : Targeted Oncology. 13, 1, p. 89-98 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2016

mTOR inhibition beyond rapalogs

Markman, B., Serra, V. & Tabernero, J., 2016, mTOR Inhibition for Cancer Therapy: Past, Present and Future. Mita, M., Mita, A. & Rowinsky, E. K. (eds.). Paris France: Springer, p. 251 - 27 25 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

2014

Phase I safety, pharmacokinetic, and pharmacodynamic study of SAR245409 (XL765), a novel, orally administered PI3K/mTOR inhibitor in patients with advanced solid tumors

Papadopoulos, K. P., Tabernero, J., Markman, B., Patnaik, A., Tolcher, A. W., Baselga, J., Shi, W., Egile, C., Ruiz-Soto, R., Laird, A. D., Miles, D. & LoRusso, P. M., 2014, In : Clinical Cancer Research. 20, 9, p. 2445 - 2456 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2013

PI3K pathway inhibitors: better not left alone

Markman, B., Tao, J. J. & Scaltriti, M., 2013, In : Current Pharmaceutical Design. 19, 5, p. 895 - 906 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Application of monoclonal antibodies as cancer therapy in solid tumors

Dienstmann, R., Markman, B. & Tabernero, J., 2012, In : Current Clinical Pharmacology. 7, 2, p. 137 - 145 9 p.

Research output: Contribution to journalArticleOther

2011

Phase I pharmacokinetic and pharmacodynamic dose-escalation study of RG7160 (GA201), the first glycoengineered monoclonal antibody against the epidermal growth factor receptor, in patients with advanced solid tumors

Paz-Ares, L., Gomez-Roca, C., Delord, J-P., Cervantes, A., Markman, B., Corral, J., Soria, J-C., Berge, Y., Roda, D., Russell-Yarde, F., Hollingsworth, S., Baselga, J., Umana, P., Manenti, L. & Tabernero, J., 2011, In : Journal of Clinical Oncology. 29, 28, p. 3783 - 3790 8 p.

Research output: Contribution to journalArticleResearchpeer-review

PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

Serra, V., Scaltriti, M., Prudkin, L., Eichhorn, P., Ibrahim, Y., Chandarlapaty, S., Markman, B., Rodriguez, O., Guzman, M., Rodriguez, S., Gili, M., Rusillo, M., Parra, J., Singh, S., Arribas, J., Rosen, N. & Baselga, J., 2011, In : Oncogene. 30, 22, p. 2547 - 2557 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Recent developments in anti-cancer agents targeting PI3K, Akt and mTORC1/2

Dienstmann, R., Rodon, J., Markman, B. & Tabernero, J., 2011, In : Recent Patents on Anti-Cancer Drug Discovery. 6, 2, p. 210 - 236 27 p.

Research output: Contribution to journalArticleResearchpeer-review

2010

Biomarkers in colorectal cancer

Markman, B., Rodriguez-Freixinos, V. & Tabernero, J., 2010, In : Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.. 12, 4, p. 261 - 270 10 p.

Research output: Contribution to journalArticleResearchpeer-review

EGFR and KRAS in colorectal cancer

Markman, B., Ramos, F., Capdevila, J. & Tabernero, J., 2010, Advances in Clinical Chemistry. Inc, E. (ed.). United States: Academic Press, p. 71 - 119 49 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Integration of anti-epidermal growth factor receptor therapies with cytotoxic chemotherapy

Serrano, C., Markman, B. & Tabernero, J., 2010, In : Cancer Journal. 16, 3, p. 226 - 234 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Membrane receptors as targets for therapeutic approaches in colorectal cancer

Macarulla, T., Markman, B. & Tabernero, J., 2010, 2010 Educational Book. United States: American Society of Clinical Oncology, p. e52 - e55 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other

Monoclonal antibodies in solid tumours

Markman, B. & Tabernero, J., 2010, In : Current Clinical Pharmacology. 5, 3, p. 160 - 165 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Status of PI3K inhibition and biomarker development in cancer therapeutics

Markman, B., Atzori, F., Perez-Garcia, J., Tabernero, J. & Baselga, J., 2010, In : Annals of Oncology. 21, 4, p. 683 - 691 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Targeting the PI3K/Akt/mTOR pathway - Beyond rapalogs

Markman, B., Dienstmann, R. & Tabernero, J., 2010, In : Oncotarget. 1, 7, p. 530 - 543 14 p.

Research output: Contribution to journalArticleResearchpeer-review

2009

New approaches and targets in advanced colorectal cancer

Macarulla, T., Capdevila, J., Perez-Garcia, J., Ramos, F. J., Elez, M. E., Markman, B., Ruiz-Echarri, M. & Tabernero, J., 2009, In : European Journal of Cancer. 45, Supp 1, p. 79 - 88 10 p.

Research output: Contribution to journalArticleResearchpeer-review

New trends in epidermal growth factor receptor-directed monoclonal antibodies

Markman, B., Capdevila, J., Elez, M. & Tabernero, J., 2009, In : Immunotherapy. 1, 6, p. 965 - 982 18 p.

Research output: Contribution to journalArticleResearchpeer-review

Therapeutic armamentarium in metastatic colorectal cancer

Macarulla, T., Markman, B. & Tabernero, J., 2009, In : European Gastroenterology & Hepatology Review. 5, p. 64 - 68 5 p.

Research output: Contribution to journalArticleOther

2008

NVP-BEZ235, a dual PI3K/mTOR inhibitor, prevents PI3K signaling and inhibits the growth of cancer cells with activating PI3K mutations

Serra, V., Markman, B., Scaltriti, M., Eichhorn, P. J. A., Valero, V., Guzman, M., Botero, M. L., Llonch, E., Atzori, F., Di Cosimo, S., Maira, M., Garcia-Echeverria, C., Parra, J. L., Arribas, J. & Baselga, J., 2008, In : Cancer Research. 68, 19, p. 8022 - 8030 9 p.

Research output: Contribution to journalArticleResearchpeer-review