Ben Gully

Dr

Accepting PhD Students

20122019

Research output per year

If you made any changes in Pure these will be visible here soon.

Personal profile

Biography

Dr Benjamin Gully gained his PhD in 2016 in the group of Professor Charlie Bond and Professor Swaminathan Iyer at the University of Western Australia, investigating the structural characterisation of a previously ill-defined RNA binding protein family. 

He then moved to Monash University and joined Professor Jamie Rossjohn’s laboratory to investigate the molecular determinants of T cell recognition. Here he utilised a multitude of structural and biochemical techniques to study poorly understood - yet numerous - T cell subsets and other immune cell receptors. He expanded into using single-particle cryoEM and now runs a group studying unconventional T cell subsets 

We investigate the ability of adaptive immune cells to respond to  infections or disease. This specialised cellular system relies on the molecular determination of self, from non-self, via cell surface proteins. Thus understanding these protein complexes in high detail is of great interest and holds vast implications for therapeutic development. We study all three lineages of lymphocytes; B cells, ɑβ T cells and most prominently γδ T cells. 

Research interests

We use world leading resources and techniques including use of the Monash Ramaciotti Centre for Cryo-Electron Microscopy. Most notably use of Australia’s first Titan KRIOS fitted with a Falcon III Direct Electron Detector, a Gatan Energy Filter with a K2 Summit Direct Electron Detector, and Volta Phase Plate. In addition we have fortnightly access to the world leading facilities at the Australian Synchrotron after generating protein crystals with the Monash Molecular Crystallisation Facility. Using these resources we have charctersied novel and meritoroius immune complexes publishing in journals such as Science and Nature communications.

Education/Academic qualification

Structural biology, PhD, University of Western Australia

External positions

Local Ambassador for the Biochemical Society in the Asia-Pacific, Biochemical Society

2012 → …

International Ambassador for the University of Huddersfield, UK , University of Huddersfield

2011 → …

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Research Output

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

Le Nours, J., Gherardin, N. A., Ramarathinam, S. H., Awad, W., Wiede, F., Gully, B. S., Khandokar, Y., Praveena, T., Wubben, J. M., Sandow, J. J., Webb, A. I., von Borstel, A., Rice, M. T., Redmond, S. J., Seneviratna, R., Sandoval-Romero, M. L., Li, S., Souter, M. N. T., Eckle, S. B. G., Corbett, A. J. & 15 others, Reid, H. H., Liu, L., Fairlie, D. P., Giles, E. M., Westall, G. P., Tothill, R. W., Davey, M. S., Berry, R., Tiganis, T., McCluskey, J., Pellicci, D. G., Purcell, A. W., Uldrich, A. P., Godfrey, D. I. & Rossjohn, J., 20 Dec 2019, In : Science. 366, 6472, p. 1522-1527 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Divergent T-cell receptor recognition modes of a HLA-I restricted extended tumour-associated peptide

Chan, K. F., Gully, B. S., Gras, S., Beringer, D. X., Kjer-Nielsen, L., Cebon, J., McCluskey, J., Chen, W. & Rossjohn, J., 1 Dec 2018, In : Nature Communications. 9, 1, 13 p., 1026.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
6 Citations (Scopus)

Recognition of host Clr-b by the inhibitory NKR-P1B receptor provides a basis for missing-self recognition

Balaji, G. R., Aguilar, O. A., Tanaka, M., Shingu-Vazquez, M. A., Fu, Z., Gully, B. S., Lanier, L. L., Carlyle, J. R., Rossjohn, J. & Berry, R., 5 Nov 2018, In : Nature Communications. 9, 1, 12 p., 4623.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
5 Citations (Scopus)

Recognition of nectin-2 by the natural killer cell receptor T cell immunoglobulin and ITIM domain (TIGIT)

Deuss, F. A., Gully, B. S., Rossjohn, J. & Berry, R., 7 Jul 2017, In : Journal of Biological Chemistry. 292, 27, p. 11413-11422 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
18 Citations (Scopus)

The design and structural characterization of a synthetic pentatricopeptide repeat protein

Gully, B. S., Shah, K. R., Lee, M., Shearston, K., Smith, N. M., Sadowska, A., Blythe, A. J., Bernath-Levin, K., Stanley, W. A., Small, I. D. & Bond, C. S., 1 Jan 2015, In : Acta Crystallographica Section D: Biological Crystallography. 71, p. 196-208 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
20 Citations (Scopus)

Prizes

Australian Research council, Australian postgraduate award (industry)

Ben Gully (Recipient), 2010

Prize: Prize (including medals and awards)

Monash Biomedicine Discovery Institute, travel award

Ben Gully (Recipient), 2018

Prize: Prize (including medals and awards)

Monash Biomedicine Discovery Institute, travel award

Ben Gully (Recipient), 2016

Prize: Prize (including medals and awards)

Activities

  • 1 Contribution to conference
  • 1 Contribution to workshop, seminar, course

2nd CRYOZ conference

Ben Gully (Member of programme committee)
2019 → …

Activity: Participating in or organising an event typesContribution to workshop, seminar, course

2nd CRYOZ conference

Ben Gully (Session chair)
2019 → …

Activity: Participating in or organising an event typesContribution to conference

Press / Media

Using X-rays to shed light on the murky world of T cell communication

Ben Gully

1/06/18

1 Media contribution

Press/Media: Public Engagement Activities