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Research Output 1990 2019

1 Citation (Scopus)

2,2,7-Trichloro-3,4-dihydronaphthalen-1(2H)-one

Capuano, B., Crosby, I. T., Forsyth, C. M. & Shin, J. K., 2009, In : Acta Crystallographica Section E: Structure Reports Online. 65, Part 9, p. 02254 - 02254 1 p.

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-6][1,5]benzodiazepine methanol solvate monohydrate

Capuano, B., Crosby, I. T., Fallon, G. D., Lloyd, E. J., Yuriev, E. & Egan, S., 1 Sep 2003, In : Acta Crystallographica Section E: Structure Reports Online. 59, 9, p. 1367-1369 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

4-chloro-N-[4-(8-chloro-5H-dibenzo[6,e][1,4]-diazepin-11-yl) -1-methylpiperazinio]benzamidate dichloromethane solvate

Capuano, B., Crosby, I. T., Egan, S., Fallon, G. D., Lloyd, E. J. & Neve, J. E., 2005, In : Acta Crystallographica Section E: Structure Reports Online. 61, Part 1, p. o20 - o22 3 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

4-phenylpyridin-2-one derivatives: a novel class of positive allosteric modulator of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Jorg, M., Lim, H., Vinh, N. B., Sexton, P. M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 388-409 22 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

5,5'-(Piperazine-1,4-diyl)bis(8-chloropyrido-[2,3-b][1,5]benzoxazepine)

Capuano, B., Crosby, I. T., Forsyth, C. M., Lloyd, E. J., Vom, A. & Yuriev, E., 2006, In : Acta Crystallographica Section E: Structure Reports Online. 62, 12, p. O5434 - O5436 3 p.

Research output: Contribution to journalArticleResearchpeer-review

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

8-Chloro-11-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazino]-5H- dibenzo[b,e][1,4]diazepine

Capuano, B., 1999, In : Molecules. 4, 11, p. 329-332 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

8-Chloro-5-(4-phenethylpiperazin-1 - Yl)pyrido[2,3-b][1,5]benzoxazepine

Capuano, B., Crosby, I. T., Forsyth, C. M., Lloyd, E. J., Vom, A. & Yuriev, E., 2008, In : Acta Crystallographica Section E: Structure Reports Online. 64, Part 10, p. O1865 - O1866 1 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Aminimides as potential CNS acting agents. I. Design, synthesis, and receptor binding of 4'-aryl aminimide analogues of clozapine as prospective novel antipsychotics

Capuano, B., Crosby, I. T., Lloyd, T., Neve, J. E. & Taylor, D., 2007, In : Australian Journal of Chemistry. 60, 9, p. 673 - 684 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Aminimides as potential CNS acting agents. II design, synthesis, and receptor binding of 4'-arylalkyl aminimide analogues of clozapine as prospective novel antipsychotics

Capuano, B., Crosby, I. T., Lloyd, E. J., Neve, J. E. & Taylor, D., 2008, In : Australian Journal of Chemistry. 61, 1, p. 5 - 10 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Aminimides as potential CNS-acting agents. III. Design, synthesis, and receptor binding of aminimide analogues of dopamine, serotonin, morphine, and nicotine

Capuano, B., Crosby, I. T., Lloyd, E. J., Neve, J. E. & Taylor, D., 2008, In : Australian Journal of Chemistry. 61, 6, p. 422 - 431 10 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

A new mechanism of allostery in a G protein-coupled receptor dimer

Lane, J. R. D., Donthamsetti, P., Shonberg, J., Draper-Joyce, C. J., Dentry, S., Michino, M., Shi, L., Lopez Munoz, L., Scammells, P. J., Capuano, B., Sexton, P., Javitch, J. A. & Christopoulos, A., 2014, In : Nature Chemical Biology. 10, 9, p. 745 - 752 8 p.

Research output: Contribution to journalArticleResearchpeer-review

A Novel Class of N-Sulfonyl and N-Sulfamoyl Noscapine Derivatives that Promote Mitotic Arrest in Cancer Cells

Yong, C., Devine, S. M., Gao, X., Yan, A., Callaghan, R., Capuano, B. & Scammells, P. J., 1 Jan 2019, (Accepted/In press) In : ChemMedChem.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

A protocol for the combined sub-fractionation and delipidation of lipid binding proteins using hydrophobic interaction chromatography

Velkov, T., Lim, M. L. R., Capuano, B. & Prankerd, R. J., 2008, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 867, 2, p. 238 - 246 9 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

A structure-activity analysis of biased agonism at the dopamine D2 receptor

Shonberg, J., Klein Herenbrink, C., Lopez, L., Christopoulos, A., Scammells, P. J., Capuano, B. & Lane, J. R. D., 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9199 - 9221 23 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

A structure-activity relationship study of the positive allosteric modulator LY2033298 at the M4 muscarinic acetylcholine receptor

Szabo, M., Huynh, T., Valant, C., Lane, J. R., Sexton, P. M., Christopoulos, A. & Capuano, B., 2015, In : MedChemComm. 6, 11, p. 1998-2003 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Oct 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 174-206 33 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Bacterial fatty acid synthesis: Effect of Tween 80 on antibiotic potency against Streptococcus agalactiae and methicillin-resistant Staphylococcus aureus

Krsta, D., Ku, K. U. C., Crosby, I. T., Capuano, B. & Manallack, D. T., 2014, In : Anti-Infective Agents. 12, 1, p. 80 - 84 5 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Biased agonism at G protein-coupled receptors: The promise and the challenges - A medicinal chemistry perspective

Shonberg, J., Lopez Munoz, L., Scammells, P. J., Christopoulos, A., Capuano, B. & Lane, J. R. D., 2014, In : Medicinal Research Reviews. 34, 6, p. 1286 - 1330 45 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Characterization of the N-methyltransferase activities of the multifunctional polypeptide cyclosporin synthetase

Velkov, T., Horne, J., Scanlon, M., Capuano, B., Yuriev, E. & Lawen, A., 2011, In : Chemistry and Biology. 18, 4, p. 464 - 475 12 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Clozapine

McLeish, M. J., Capuano, B. & Lloyd, E. J., 1 Jan 1993, In : Analytical Profiles of Drug Substances and Excipients. 22, C, p. 145-184 40 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Conformational Analysis of Drug Molecules: A Practical Exercise in the Medicinal Chemistry Course

Yuriev, E., Chalmers, D. K. & Capuano, B., 2009, In : Journal of Chemical Education. 86, 4, p. 477 - 478 2 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Crossword puzzles for chemistry education: Learning goals beyond vocabulary

Yuriev, E., Capuano, B. & Short, J. L., 2016, In : Chemistry Education Research and Practice. 17, 3, p. 532-554 23 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Design strategies for bivalent ligands targeting GPCRs

Shonberg, J., Scammells, P. & Capuano, B., 2011, In : ChemMedChem. 6, 6, p. 963 - 974 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Detection and prevention of aggregation-based false positives in STD-NMR-based fragment screening

Vom, A., Headey, S. J., Wang, G., Capuano, B., Yuriev, E., Scanlon, M. & Simpson, J. S., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1518 - 1524 7 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Development of a photoactivatable allosteric ligand for the M1 muscarinic acetylcholine receptor

Davie, B. J., Sexton, P., Capuano, B., Christopoulos, A. & Scammells, P. J., 2014, In : ACS Chemical Neuroscience. 5, 10, p. 902 - 907 6 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Discovery of a novel class of negative allosteric modulator of the dopamine D2 receptor through fragmentation of a bitopic ligand

Mistry, S. N., Shonberg, J., Draper-Joyce, C. J., Klein Herenbrink, C., Michino, M., Shi, L., Christopoulos, A., Capuano, B., Scammells, P. J. & Lane, J. R. D., 2015, In : Journal of Medicinal Chemistry. 58, 17, p. 6819-6843 25 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Di-tert-butyl N-[2,6-bis(methoxymethoxy)phenyl]iminodiacetate

Capuano, B., Crosby, I. T., Forsyth, C. M., Khakham, Y. & Manallack, D. T., 2009, In : Acta Crystallographica Section E: Structure Reports Online. 65, 819, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Dual Action Calcium-Sensing Receptor Modulator Unmasks Novel Mode-Switching Mechanism

Gregory, K., Kufareva, I., Keller, A. N., Khajehali, E., Mun, H., Goolam, M. A., Mason, R. S., Capuano, B., Conigrave, A., Christopoulos, A. & Leach, K., 12 Sep 2018, In : ACS Pharmacology and Translational Sciences. 1, 2, p. 96-109 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Geometric forms of 8-chloro-11-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin- 11-yl)piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine-acetone-pentane (2/1/1)

Capuano, B., Crosby, I. T., Fallon, G. D., Forsyth, C. M., Lloyd, E. J., Podloucka, A. & Yuriev, E., 2007, In : Acta Crystallographica Section E: Structure Reports Online. 63, 10, p. O4034 - U2899 10 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Homobivalent ligands of the atypical antipsychotic clozapine: Design, synthesis, and pharmacological evaluation

McRobb, F. M., Crosby, I. T., Yuriev, E., Lane, J. R. D. & Capuano, B., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1622 - 1634 13 p.

Research output: Contribution to journalArticleResearchpeer-review

83 Citations (Scopus)

Homology modeling and docking evaluation of aminergic G protein-coupled receptors

McRobb, F., Capuano, B., Crosby, I., Chalmers, D. & Yuriev, E., 2010, In : Journal of Chemical Information and Modeling. 50, 4, p. 626 - 637 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Investigation of novel ropinirole analogues: Synthesis, pharmacological evaluation and computational analysis of dopamine D2 receptor functionalized congeners and homobivalent ligands

Jorg, M. T., Kaczor, A. A., Mak, F. S., Lee, K. C. K., Poso, A., Miller, N. D., Scammells, P. J. & Capuano, B., 2014, In : MedChemComm. 5, 7, p. 891 - 898 8 p.

Research output: Contribution to journalArticleResearchpeer-review

JL13, a clozapine-like potential antipsychotic agent, reduces sympathetic cutaneous vasomotor alerting responses (SCVARs) in rats, but the drug is less potent than clozapine

Blessing, W. W., Capuano, B., Crosby, I. T. & Taylor, D. A., 1 Mar 2008, In : FASEB Journal. 22, 1 supplement

Research output: Contribution to journalMeeting AbstractOther

7 Citations (Scopus)

JL13 has clozapine-like actions on thermoregulatory cutaneous blood flow in rats: Involvement of serotonin 5-HT1A and 5-HT2A receptor mechanisms

Capuano, B., Crosby, I., McRobb, F., Taylor, D., Vom, A. & Blessing, W., 2010, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 34, 1, p. 136 - 142 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole

Klein Herenbrink, C., Verma, R., Lim, H. D., Kopinathan, A., Keen, A., Shonberg, J., Draper-Joyce, C. J., Scammells, P. J., Christopoulos, A., Javitch, J. A., Capuano, B., Shi, L. & Lane, J. R., 16 Aug 2019, In : ACS Chemical Biology. 14, 8, p. 1780-1792 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Multivalent approaches and beyond: novel tools for the investigation of dopamine D2 receptor pharmacology

Kopinathan, A., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Jul 2016, In : Future Medicinal Chemistry. 8, 11, p. 1349-1372 24 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

New hybrids of clozapine and haloperidol and their isosteric analogues: Synthesis, X-ray crystallography, conformational analysis and preliminary pharmacological evaluation

Capuano, B., Crosby, I., Forsyth, C. M., McRobb, F. M., Moudretski, V. V., Taylor, D. A., Vom, A. & Yuriev, E., 2010, In : Structural Chemistry. 21, 3, p. 613 - 628 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

NMR case study of ropinirole: Concentration-dependent effects of nonexchangeable proton resonances

Jorg, M. T., Headey, S. J., Scammells, P. J. & Capuano, B., 2014, In : Magnetic Resonance in Chemistry. 52, 11, p. 715-718 4 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
8 Citations (Scopus)

Novel fused arylpyrimidinone based allosteric modulators of the M1 muscarinic acetylcholine receptor

Mistry, S. N., Lim, H., Jorg, M., Capuano, B., Christopoulos, A., Lane, J. R. & Scammells, P. J., 18 May 2016, In : ACS Chemical Neuroscience. 7, 5, p. 647-661 15 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

N-Piperonyl analogue of the atypical antipsychotic clozapine

Capuano, B., Crosby, I. T., Gable, R. W. & Lloyd, E. J., 1 Jan 2000, In : Acta Crystallographica Section C: Crystal Structure Communications. 56, 3, p. 339-340 2 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Overcoming P-Glycoprotein-Mediated Drug Resistance with Noscapine Derivatives

Muthiah, D., Henshaw, G. K., DeBono, A. J., Capuano, B., Scammells, P. J. & Callaghan, R., 1 Feb 2019, In : Drug Metabolism and Disposition. 47, 2, p. 164-172 9 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Plantensimycin: A promising antimicrobial targeting fatty acid synthesis

Manallack, D. T., Crosby, I. T., Khakham, Y. & Capuano, B., 2008, In : Current Medicinal Chemistry. 15, 7, p. 705 - 710 6 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor

Huynh, T., Valant, C., Crosby, I. T., Sexton, P., Christopoulos, A. & Capuano, B., 2013, In : Journal of Medicinal Chemistry. 56, 20, p. 8196 - 8200 5 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Progress toward the development of noscapine and derivatives as anticancer agents

DeBono, A., Capuano, B. & Scammells, P. J., 2015, In : Journal of Medicinal Chemistry. 58, 15, p. 5699-5727 29 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Proof of concept study for designed multiple ligands targeting the dopamine D2, serotonin 5-HT2A, and muscarinic M1 acetylcholine receptors

Szabo, M., Lim, H. D., Klein Herenbrink, C., Christopoulos, A., Lane, J. R. D. & Capuano, B., 2015, In : Journal of Medicinal Chemistry. 58, 3, p. 1550 - 1555 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Reply to ‘Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects’

Sykes, D. A., Lane, J. R., Szabo, M., Capuano, B., Javitch, J. A. & Charlton, S. J., 1 Dec 2018, In : Nature Communications. 9, 1, 5 p., 3568.

Research output: Contribution to journalLetterResearchpeer-review

Open Access
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19 Citations (Scopus)

Schizophrenia: a systematic review of the disease state, current therapeutics and their molecular mechanisms of action

Shin, J., Malone, D., Crosby, I. & Capuano, B., 2011, In : Current Medicinal Chemistry. 18, 9, p. 1380 - 1404 25 p.

Research output: Contribution to journalArticleResearchpeer-review