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Research Output 1990 2019

1990
9 Citations (Scopus)
1993
8 Citations (Scopus)

Clozapine

McLeish, M. J., Capuano, B. & Lloyd, E. J., 1 Jan 1993, In : Analytical Profiles of Drug Substances and Excipients. 22, C, p. 145-184 40 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

The synthesis and biological evaluation of a series of novel antipsychotics

Capuano, B., Crosby, I. T. & Lloyd, E. J., 1998, p. P58 - P58. 1 p.

Research output: Contribution to conferenceAbstractOther

1999
4 Citations (Scopus)

8-Chloro-11-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazino]-5H- dibenzo[b,e][1,4]diazepine

Capuano, B., 1999, In : Molecules. 4, 11, p. 329-332 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2000
7 Citations (Scopus)

N-Piperonyl analogue of the atypical antipsychotic clozapine

Capuano, B., Crosby, I. T., Gable, R. W. & Lloyd, E. J., 1 Jan 2000, In : Acta Crystallographica Section C: Crystal Structure Communications. 56, 3, p. 339-340 2 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
64 Citations (Scopus)

Schizophrenia: genesis, receptorology and current therapeutics

Capuano, B., Crosby, I. T. & Lloyd, E. J., 2002, In : Current Medicinal Chemistry. 9, 5, p. 521 - 548 28 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Synthesis and preliminary pharmacological evaluation of 4'-arylmethyl analogues of clozapine. I. The effect of aromatic substituents

Capuano, B., Crosby, I. T., Lloyd, E. J. & Taylor, D. A., 2002, In : Australian Journal of Chemistry. 55, 9, p. 565 - 576 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2003
17 Citations (Scopus)

2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3-6][1,5]benzodiazepine methanol solvate monohydrate

Capuano, B., Crosby, I. T., Fallon, G. D., Lloyd, E. J., Yuriev, E. & Egan, S., 1 Sep 2003, In : Acta Crystallographica Section E: Structure Reports Online. 59, 9, p. 1367-1369 3 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Synthesis and preliminary pharmacological evaluation of 4'-arylalkyl analogues of clozapine. II. *Effect of the nature and length of the linker

Capuano, B., Crosby, I. T., Lloyd, E. J., Podloucka, A. & Taylor, D. A., 2003, In : Australian Journal of Chemistry. 56, p. 875 - 886 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
2 Citations (Scopus)

4-chloro-N-[4-(8-chloro-5H-dibenzo[6,e][1,4]-diazepin-11-yl) -1-methylpiperazinio]benzamidate dichloromethane solvate

Capuano, B., Crosby, I. T., Egan, S., Fallon, G. D., Lloyd, E. J. & Neve, J. E., 2005, In : Acta Crystallographica Section E: Structure Reports Online. 61, Part 1, p. o20 - o22 3 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis of 8-chloro-11-(4-(3-(p-tolyloxy)propyl)piperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine

Capuano, B., Crosby, I. T., Lim, S. E. K., Lloyd, E. J. & Yuriev, E., 2005, In : Molbank. 12, December, p. M454/1 - M454/2 1 p.

Research output: Contribution to journalArticleOther

Synthesis of Benzyl 2-(4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin-11-yl)piperazin-1-yl)acetate

Camerino, M., Capuano, B., Crosby, I. T. & Lloyd, E. J., 2005, In : Molbank. 12, December, p. M453/1 - M453/2 1 p.

Research output: Contribution to journalArticleOther

2006
3 Citations (Scopus)

5,5'-(Piperazine-1,4-diyl)bis(8-chloropyrido-[2,3-b][1,5]benzoxazepine)

Capuano, B., Crosby, I. T., Forsyth, C. M., Lloyd, E. J., Vom, A. & Yuriev, E., 2006, In : Acta Crystallographica Section E: Structure Reports Online. 62, 12, p. O5434 - O5436 3 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
7 Citations (Scopus)

Aminimides as potential CNS acting agents. I. Design, synthesis, and receptor binding of 4'-aryl aminimide analogues of clozapine as prospective novel antipsychotics

Capuano, B., Crosby, I. T., Lloyd, T., Neve, J. E. & Taylor, D., 2007, In : Australian Journal of Chemistry. 60, 9, p. 673 - 684 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Geometric forms of 8-chloro-11-[4-(8-chloro-5H-dibenzo[b,e][1,4]diazepin- 11-yl)piperazin-1-yl]-5H-dibenzo[b,e][1,4]diazepine-acetone-pentane (2/1/1)

Capuano, B., Crosby, I. T., Fallon, G. D., Forsyth, C. M., Lloyd, E. J., Podloucka, A. & Yuriev, E., 2007, In : Acta Crystallographica Section E: Structure Reports Online. 63, 10, p. O4034 - U2899 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Synthesis and preliminary pharmacological evaluation of 4'-arylalkyl analogues of clozapine. III. Replacement of the tricyclic nucleus with a bicyclic template

Capuano, B., Crosby, I. T., Lloyd, E. J. & Taylor, D., 2007, In : Australian Journal of Chemistry. 60, 12, p. 928 - 933 6 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

The first aminimide synthesis from benzoyl azide and pyridine

Capuano, B., Crosby, I. T., Lloyd, E. J. & Neve, J. E., 2007, In : Australian Journal of Chemistry. 60, 3, p. 214 - 217 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
1 Citation (Scopus)

8-Chloro-5-(4-phenethylpiperazin-1 - Yl)pyrido[2,3-b][1,5]benzoxazepine

Capuano, B., Crosby, I. T., Forsyth, C. M., Lloyd, E. J., Vom, A. & Yuriev, E., 2008, In : Acta Crystallographica Section E: Structure Reports Online. 64, Part 10, p. O1865 - O1866 1 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Aminimides as potential CNS acting agents. II design, synthesis, and receptor binding of 4'-arylalkyl aminimide analogues of clozapine as prospective novel antipsychotics

Capuano, B., Crosby, I. T., Lloyd, E. J., Neve, J. E. & Taylor, D., 2008, In : Australian Journal of Chemistry. 61, 1, p. 5 - 10 6 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

Aminimides as potential CNS-acting agents. III. Design, synthesis, and receptor binding of aminimide analogues of dopamine, serotonin, morphine, and nicotine

Capuano, B., Crosby, I. T., Lloyd, E. J., Neve, J. E. & Taylor, D., 2008, In : Australian Journal of Chemistry. 61, 6, p. 422 - 431 10 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

A protocol for the combined sub-fractionation and delipidation of lipid binding proteins using hydrophobic interaction chromatography

Velkov, T., Lim, M. L. R., Capuano, B. & Prankerd, R. J., 2008, In : Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences. 867, 2, p. 238 - 246 9 p.

Research output: Contribution to journalArticleResearchpeer-review

JL13, a clozapine-like potential antipsychotic agent, reduces sympathetic cutaneous vasomotor alerting responses (SCVARs) in rats, but the drug is less potent than clozapine

Blessing, W. W., Capuano, B., Crosby, I. T. & Taylor, D. A., 1 Mar 2008, In : FASEB Journal. 22, 1 supplement

Research output: Contribution to journalMeeting AbstractOther

36 Citations (Scopus)

Plantensimycin: A promising antimicrobial targeting fatty acid synthesis

Manallack, D. T., Crosby, I. T., Khakham, Y. & Capuano, B., 2008, In : Current Medicinal Chemistry. 15, 7, p. 705 - 710 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Synthesis and preliminary pharmacological evaluation of 4'-arylalkyl analogues of clozapine. IV. the effects of aromaticity and isosteric replacement

Capuano, B., Crosby, I. T., Lloyd, E. J., Podloucka, A. & Taylor, D., 2008, In : Australian Journal of Chemistry. 61, 12, p. 930 - 940 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
1 Citation (Scopus)

2,2,7-Trichloro-3,4-dihydronaphthalen-1(2H)-one

Capuano, B., Crosby, I. T., Forsyth, C. M. & Shin, J. K., 2009, In : Acta Crystallographica Section E: Structure Reports Online. 65, Part 9, p. 02254 - 02254 1 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Conformational Analysis of Drug Molecules: A Practical Exercise in the Medicinal Chemistry Course

Yuriev, E., Chalmers, D. K. & Capuano, B., 2009, In : Journal of Chemical Education. 86, 4, p. 477 - 478 2 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Di-tert-butyl N-[2,6-bis(methoxymethoxy)phenyl]iminodiacetate

Capuano, B., Crosby, I. T., Forsyth, C. M., Khakham, Y. & Manallack, D. T., 2009, In : Acta Crystallographica Section E: Structure Reports Online. 65, 819, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2010
83 Citations (Scopus)

Homology modeling and docking evaluation of aminergic G protein-coupled receptors

McRobb, F., Capuano, B., Crosby, I., Chalmers, D. & Yuriev, E., 2010, In : Journal of Chemical Information and Modeling. 50, 4, p. 626 - 637 12 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

JL13 has clozapine-like actions on thermoregulatory cutaneous blood flow in rats: Involvement of serotonin 5-HT1A and 5-HT2A receptor mechanisms

Capuano, B., Crosby, I., McRobb, F., Taylor, D., Vom, A. & Blessing, W., 2010, In : Progress in Neuro-Psychopharmacology and Biological Psychiatry. 34, 1, p. 136 - 142 7 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

New hybrids of clozapine and haloperidol and their isosteric analogues: Synthesis, X-ray crystallography, conformational analysis and preliminary pharmacological evaluation

Capuano, B., Crosby, I., Forsyth, C. M., McRobb, F. M., Moudretski, V. V., Taylor, D. A., Vom, A. & Yuriev, E., 2010, In : Structural Chemistry. 21, 3, p. 613 - 628 16 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The application of the Schmidt reaction and Beckmann rearrangement to the synthesis of bicyclic lactams: some mechanistic considerations

Crosby, I., Shin, J. & Capuano, B., 2010, In : Australian Journal of Chemistry. 63, 2, p. 211 - 226 16 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)

The synthesis and preliminary pharmacological evaluation of a series of substituted 4-phenoxypropyl analogues of the atypical antipsychotic clozapine

Capuano, B., Crosby, I. T., McRobb, F. M., Podloucka, A., Taylor, D. A., Vom, A. & Yuriev, E., 2010, In : Australian Journal of Chemistry. 63, 1, p. 116 - 124 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2011
8 Citations (Scopus)

Characterization of the N-methyltransferase activities of the multifunctional polypeptide cyclosporin synthetase

Velkov, T., Horne, J., Scanlon, M., Capuano, B., Yuriev, E. & Lawen, A., 2011, In : Chemistry and Biology. 18, 4, p. 464 - 475 12 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

Design strategies for bivalent ligands targeting GPCRs

Shonberg, J., Scammells, P. & Capuano, B., 2011, In : ChemMedChem. 6, 6, p. 963 - 974 12 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Schizophrenia: a systematic review of the disease state, current therapeutics and their molecular mechanisms of action

Shin, J., Malone, D., Crosby, I. & Capuano, B., 2011, In : Current Medicinal Chemistry. 18, 9, p. 1380 - 1404 25 p.

Research output: Contribution to journalArticleResearchpeer-review

225 Citations (Scopus)

Status of GPCR modeling and docking as reflected by community-wide GPCR Dock 2010 assessment

Kufareva, I., Rueda, M., Katritch, V., Stevens, R. C., Abagyan, R., McRobb, F. M., Capuano, B., Crosby, I. T., Chalmers, D. K., Yuriev, E., Simms, J. W., Sexton, P., Wootten, D. L. & Hall, N. E., 2011, In : Structure. 19, 8, p. 1108 - 1126 19 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors

Szabo, M., Agostino, M., Malone, D., Yuriev, E. & Capuano, B., 2011, In : Bioorganic and Medicinal Chemistry Letters. 21, 22, p. 6782 - 6787 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2012
33 Citations (Scopus)

Homobivalent ligands of the atypical antipsychotic clozapine: Design, synthesis, and pharmacological evaluation

McRobb, F. M., Crosby, I. T., Yuriev, E., Lane, J. R. D. & Capuano, B., 2012, In : Journal of Medicinal Chemistry. 55, 4, p. 1622 - 1634 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Simplified platensimycin analogues as antibacterial agents

Krsta, D., Ku, K. U. C., Crosby, I. T., Capuano, B. & Manallack, D. T., 2012, In : MedChemComm. 3, 2, p. 244 - 249 6 p.

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Synthesis and biological evaluation of N-substituted noscapine analogues

Debono, A. J., Xie, J. H., Ventura, S., Pouton, C. W., Capuano, B. & Scammells, P. J., 2012, In : ChemMedChem. 7, 12, p. 2122 - 2133 12 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists

Conway, R., Valant, C., Christopoulos, A., Robertson, A. D., Capuano, B. & Crosby, I. T., 2012, In : Bioorganic and Medicinal Chemistry Letters. 22, 7, p. 2560 - 2564 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
61 Citations (Scopus)

A structure-activity analysis of biased agonism at the dopamine D2 receptor

Shonberg, J., Klein Herenbrink, C., Lopez, L., Christopoulos, A., Scammells, P. J., Capuano, B. & Lane, J. R. D., 2013, In : Journal of Medicinal Chemistry. 56, 22, p. 9199 - 9221 23 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Detection and prevention of aggregation-based false positives in STD-NMR-based fragment screening

Vom, A., Headey, S. J., Wang, G., Capuano, B., Yuriev, E., Scanlon, M. & Simpson, J. S., 2013, In : Australian Journal of Chemistry. 66, 12, p. 1518 - 1524 7 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)
13 Citations (Scopus)

Probing structural requirements of positive allosteric modulators of the M4 muscarinic receptor

Huynh, T., Valant, C., Crosby, I. T., Sexton, P., Christopoulos, A. & Capuano, B., 2013, In : Journal of Medicinal Chemistry. 56, 20, p. 8196 - 8200 5 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Synthesis, functional and binding profile of (R)-apomorphine based homobivalent ligands targeting the dopamine D2 receptor

Shonberg, J., Lane, J. R. D., Scammells, P. J. & Capuano, B., 2013, In : MedChemComm. 4, 9, p. 1290 - 1296 7 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Synthesis, molecular structure, NMR spectroscopic and computational analysis of a selective adenosine A2A antagonist, ZM 241385

Jorg, M., Agostino, M. J., Yuriev, E., Mak, F. S., Miller, N. D., White, J., Scammells, P. J. & Capuano, B., 2013, In : Structural Chemistry. 24, 4, p. 1241 - 1251 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2014
78 Citations (Scopus)

A new mechanism of allostery in a G protein-coupled receptor dimer

Lane, J. R. D., Donthamsetti, P., Shonberg, J., Draper-Joyce, C. J., Dentry, S., Michino, M., Shi, L., Lopez Munoz, L., Scammells, P. J., Capuano, B., Sexton, P., Javitch, J. A. & Christopoulos, A., 2014, In : Nature Chemical Biology. 10, 9, p. 745 - 752 8 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Bacterial fatty acid synthesis: Effect of Tween 80 on antibiotic potency against Streptococcus agalactiae and methicillin-resistant Staphylococcus aureus

Krsta, D., Ku, K. U. C., Crosby, I. T., Capuano, B. & Manallack, D. T., 2014, In : Anti-Infective Agents. 12, 1, p. 80 - 84 5 p.

Research output: Contribution to journalArticleResearchpeer-review