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Personal profile



Senior Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences

Monash teaching commitment

Bachelor of Pharmaceutical Science teaching:
- Introduction to pharmaceutical sciences
- Analytical methods
- Molecular basis of drug action
- Research project

Bachelor of Pharmacy teaching:
- Basis of drug action I
- Integrated therapeutics: Psychiatry


Dr Capuano is an experienced synthetic medicinal chemist specialising in the design, synthesis and biological evaluation of: (1) small biomolecules targeting G protein-coupled receptors implicated in schizophrenia and Parkinson's disease, (2) analogues of the opium poppy-derived alkaloid noscapine as novel anticancer agents and (3) allosteric modulators of the central muscarinic receptor as a potential treatment for Alzheimer's disease, and (4) fragment-based drug discovery towards novel inhibitors of the enzymes DsbA and HIV-integrase as potential antibacterial agents and anti-HIV agents, respectively. The specific expertise include (i) solution and solid phase organic synthesis, (ii) comprehensive chemical purification and characterisation (iii) knowledge of molecular modeling techniques including virtual screening and molecular docking and (iv) training in in vitro/functional & behavioural assays.


  • G protein-coupled receptors
  • schizophrenia
  • Parkinson's disease
  • Dopamine D2 Receptor
  • allosteric modulation
  • Fragment Based Drug Design
  • Serotonin Receptors
  • structure-based drug design
  • ligand-based drug design
  • orthosteric ligands

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Projects 2000 2020

Research Output 1990 2019

6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity

Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.

Research output: Contribution to journalArticleResearchpeer-review

A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor

Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 2018, (Accepted/In press) In : Journal of Medicinal Chemistry. 82 p.

Research output: Contribution to journalArticleResearchpeer-review

Reply to ‘Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects’

Sykes, D. A., Lane, J. R., Szabo, M., Capuano, B., Javitch, J. A. & Charlton, S. J., 1 Dec 2018, In : Nature Communications. 9, 1, 5 p., 3568.

Research output: Contribution to journalLetterOtherpeer-review

Open Access

Activities 2013 2013

  • 1 Submissions to industry or govt committees, commissions and inquiries

Medicinal Chemistry

Ben Capuano (Member)
13 Aug 2013

Activity: External Academic EngagementSubmissions to industry or govt committees, commissions and inquiries