Ben Capuano

Assoc Professor

1990 …2020

Research output per year

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Personal profile

Biography

Position

Senior Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences

Monash teaching commitment

Bachelor of Pharmaceutical Science teaching:
- Introduction to pharmaceutical sciences
- Analytical methods
- Molecular basis of drug action
- Research project

Bachelor of Pharmacy teaching:
- Basis of drug action I
- Integrated therapeutics: Psychiatry

Biography

Dr Capuano is an experienced synthetic medicinal chemist specialising in the design, synthesis and biological evaluation of: (1) small biomolecules targeting G protein-coupled receptors implicated in schizophrenia and Parkinson's disease, (2) analogues of the opium poppy-derived alkaloid noscapine as novel anticancer agents and (3) allosteric modulators of the central muscarinic receptor as a potential treatment for Alzheimer's disease, and (4) fragment-based drug discovery towards novel inhibitors of the enzymes DsbA and HIV-integrase as potential antibacterial agents and anti-HIV agents, respectively. The specific expertise include (i) solution and solid phase organic synthesis, (ii) comprehensive chemical purification and characterisation (iii) knowledge of molecular modeling techniques including virtual screening and molecular docking and (iv) training in in vitro/functional & behavioural assays.

Research area keywords

  • G protein-coupled receptors
  • schizophrenia
  • Parkinson's disease
  • Dopamine D2 Receptor
  • allosteric modulation
  • Fragment Based Drug Design
  • Serotonin Receptors
  • structure-based drug design
  • ligand-based drug design
  • orthosteric ligands

Network

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  • Medicinal Chemistry

    Ben Capuano (Member)

    13 Aug 2013

    Activity: External Academic EngagementSubmissions to industry or govt committees, commissions and inquiries

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