Projects per year
Personal profile
Biography
Position
Senior Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences
Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences
Monash teaching commitment
Bachelor of Pharmaceutical Science teaching:
- Introduction to pharmaceutical sciences
- Analytical methods
- Molecular basis of drug action
- Research project
Bachelor of Pharmacy teaching:
- Basis of drug action I
- Integrated therapeutics: Psychiatry
Biography
Dr Capuano is an experienced synthetic medicinal chemist specialising in the design, synthesis and biological evaluation of: (1) small biomolecules targeting G protein-coupled receptors implicated in schizophrenia and Parkinson's disease, (2) analogues of the opium poppy-derived alkaloid noscapine as novel anticancer agents and (3) allosteric modulators of the central muscarinic receptor as a potential treatment for Alzheimer's disease, and (4) fragment-based drug discovery towards novel inhibitors of the enzymes DsbA and HIV-integrase as potential antibacterial agents and anti-HIV agents, respectively. The specific expertise include (i) solution and solid phase organic synthesis, (ii) comprehensive chemical purification and characterisation (iii) knowledge of molecular modeling techniques including virtual screening and molecular docking and (iv) training in in vitro/functional & behavioural assays.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- G protein-coupled receptors
- schizophrenia
- Parkinson's disease
- Dopamine D2 Receptor
- allosteric modulation
- Fragment Based Drug Design
- Serotonin Receptors
- structure-based drug design
- ligand-based drug design
- orthosteric ligands
Network
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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IC18.4 Enabling fragment-based lead discovery for challenging targets
Mackay, J. P., Kassiou, M., Scanlon, M. & Capuano, B.
19/12/19 → 21/07/24
Project: Research
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A computer based approach to drug discovery: Identifying New Treatments for Osteoporosis and Asthma
Keller, A., Leach, K., Gregory, K. & Capuano, B.
Project: Research
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IC18.8 Characterisation of soluble and membrane proteins for fragment-based screening using mass spectrometry
Poulsen, S., Scanlon, M., Hallili, M. & Capuano, B.
22/07/19 → 21/07/21
Project: Research
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How do BET bromodomain proteins regulate gene expression?
Mackay, J. P., Blobel, G. & Capuano, B.
1/01/18 → 31/12/20
Project: Research
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1,3-Benzodioxole-Modified Noscapine Analogues: Synthesis, Antiproliferative Activity, and Tubulin-Bound Structure
Yong, C., Devine, S. M., Abel, A. C., Tomlins, S. D., Muthiah, D., Gao, X., Callaghan, R., Steinmetz, M. O., Prota, A. E., Capuano, B. & Scammells, P. J., 16 Sep 2021, In: ChemMedChem. 16, 18, p. 2882-2894 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Development of AC265347-Inspired Calcium-Sensing Receptor Ago-Positive Allosteric Modulators
Dinh, L. V., DeBono, A., Keller, A. N., Josephs, T. M., Gregory, K. J., Leach, K. & Capuano, B., 19 Nov 2021, In: ChemMedChem. 16, 22, p. 3451-3462 12 p.Research output: Contribution to journal › Article › Research › peer-review
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Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor
Jörg, M., Khajehali, E., van der Westhuizen, E. T., C. Choy, K. H., Shackleford, D. M., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 8 Jan 2021, In: ChemMedChem. 16, 1, p. 216-233 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Enantioenriched positive allosteric modulators display distinct pharmacology at the dopamine d1 receptor
Fyfe, T. J., Scammells, P. J., Lane, J. R. & Capuano, B., 1 Jul 2021, In: Molecules. 26, 13, 19 p., 3799.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access1 Citation (Scopus) -
Therapeutic Opportunities of Targeting Allosteric Binding Sites on the Calcium-Sensing Receptor
Diao, J., Debono, A., Josephs, T. M., Bourke, J. E., Capuano, B., Gregory, K. J. & Leach, K., 9 Apr 2021, In: ACS Pharmacology & Translational Science. 4, 2, p. 666–679 14 p.Research output: Contribution to journal › Review Article › Research › peer-review