Projects per year
Personal profile
Biography
Position
Senior Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences
Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences
Monash teaching commitment
Bachelor of Pharmaceutical Science teaching:
- Introduction to pharmaceutical sciences
- Analytical methods
- Molecular basis of drug action
- Research project
Bachelor of Pharmacy teaching:
- Basis of drug action I
- Integrated therapeutics: Psychiatry
Biography
Dr Capuano is an experienced synthetic medicinal chemist specialising in the design, synthesis and biological evaluation of: (1) small biomolecules targeting G protein-coupled receptors implicated in schizophrenia and Parkinson's disease, (2) analogues of the opium poppy-derived alkaloid noscapine as novel anticancer agents and (3) allosteric modulators of the central muscarinic receptor as a potential treatment for Alzheimer's disease, and (4) fragment-based drug discovery towards novel inhibitors of the enzymes DsbA and HIV-integrase as potential antibacterial agents and anti-HIV agents, respectively. The specific expertise include (i) solution and solid phase organic synthesis, (ii) comprehensive chemical purification and characterisation (iii) knowledge of molecular modeling techniques including virtual screening and molecular docking and (iv) training in in vitro/functional & behavioural assays.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- G protein-coupled receptors
- schizophrenia
- Parkinson's disease
- Dopamine D2 Receptor
- allosteric modulation
- Fragment Based Drug Design
- Serotonin Receptors
- structure-based drug design
- ligand-based drug design
- orthosteric ligands
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Modulation of the M4 muscarinic receptor for the treatment of schizophrenia
Valant, C. (Primary Chief Investigator (PCI)), Capuano, B. (Chief Investigator (CI)), Choy, C. (Chief Investigator (CI)), Thal, D. (Associate Investigator (AI)), Miao, Y. (Associate Investigator (AI)), Christopoulos, A. (Associate Investigator (AI)), Felder, C. (Associate Investigator (AI)) & Pantellis, C. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
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A computer based approach to drug discovery: Identifying New Treatments for Osteoporosis and Asthma
Keller, A. (Primary Chief Investigator (PCI)), Leach, K. (Chief Investigator (CI)), Gregory, K. (Chief Investigator (CI)) & Capuano, B. (Chief Investigator (CI))
Project: Research
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IC18.4 Enabling fragment-based lead discovery for challenging targets
Mackay, J. P. (Primary Chief Investigator (PCI)), Kassiou, M. (Chief Investigator (CI)), Scanlon, M. (Chief Investigator (CI)) & Capuano, B. (Chief Investigator (CI))
19/12/19 → 21/07/24
Project: Research
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IC18.8 Characterisation of soluble and membrane proteins for fragment-based screening using mass spectrometry
Poulsen, S.-A. (Primary Chief Investigator (PCI)), Scanlon, M. (Chief Investigator (CI)), Hallili, M. (Chief Investigator (CI)) & Capuano, B. (Chief Investigator (CI))
22/07/19 → 21/07/21
Project: Research
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Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders
Liu, B., Thompson, G., Jörg, M., Barnes, N., Thal, D. M., Christopoulos, A., Capuano, B., Valant, C. & Scammells, P. J., 18 Jul 2024, In: Journal of Medicinal Chemistry. 67, 15, p. 13286–13304 19 p.Research output: Contribution to journal › Article › Research › peer-review
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Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR
Jörg, M., van der Westhuizen, E. T., Lu, Y., Christopher Choy, K. H., Shackleford, D. M., Khajehali, E., Tobin, A. B., Thal, D. M., Capuano, B., Christopoulos, A., Valant, C. & Scammells, P. J., 5 Oct 2023, In: European Journal of Medicinal Chemistry. 258, 20 p., 115588.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Rapid Elaboration of Fragments into Leads Applied to Bromodomain-3 Extra-Terminal Domain
Adams, L. A., Wilkinson-White, L. E., Gunzburg, M. J., Headey, S. J., Mohanty, B., Scanlon, M. J., Capuano, B., Mackay, J. P. & Doak, B. C., 18 Apr 2023, In: Journal of Medicinal Chemistry. 66, 8, p. 5859–5872 14 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Personalised medicines for familial hypercalcemia and hyperparathyroidism
Josephs, T. M., Zhang, F., Dinh, L. V., Keller, A. N., Conigrave, A. D., Capuano, B., Gregory, K. J. & Leach, K., 9 May 2022, In: Journal of Molecular Endocrinology. 69, 1, p. 243-257 15 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile3 Citations (Scopus) -
Structural Features of Iperoxo-BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy
Wakeham, M. C. L., Davie, B. J., Chalmers, D. K., Christopoulos, A., Capuano, B., Valant, C. & Scammells, P. J., 5 Jan 2022, In: ACS Chemical Neuroscience. 13, 1, p. 97-111 15 p.Research output: Contribution to journal › Article › Research › peer-review
4 Citations (Scopus)