Projects per year
Personal profile
Biography
Position
Senior Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences
Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences
Monash teaching commitment
Bachelor of Pharmaceutical Science teaching:
- Introduction to pharmaceutical sciences
- Analytical methods
- Molecular basis of drug action
- Research project
Bachelor of Pharmacy teaching:
- Basis of drug action I
- Integrated therapeutics: Psychiatry
Biography
Dr Capuano is an experienced synthetic medicinal chemist specialising in the design, synthesis and biological evaluation of: (1) small biomolecules targeting G protein-coupled receptors implicated in schizophrenia and Parkinson's disease, (2) analogues of the opium poppy-derived alkaloid noscapine as novel anticancer agents and (3) allosteric modulators of the central muscarinic receptor as a potential treatment for Alzheimer's disease, and (4) fragment-based drug discovery towards novel inhibitors of the enzymes DsbA and HIV-integrase as potential antibacterial agents and anti-HIV agents, respectively. The specific expertise include (i) solution and solid phase organic synthesis, (ii) comprehensive chemical purification and characterisation (iii) knowledge of molecular modeling techniques including virtual screening and molecular docking and (iv) training in in vitro/functional & behavioural assays.
Keywords
- G protein-coupled receptors
- schizophrenia
- Parkinson's disease
- Dopamine D2 Receptor
- allosteric modulation
- Fragment Based Drug Design
- Serotonin Receptors
- structure-based drug design
- ligand-based drug design
- orthosteric ligands
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2000 2020
How do BET bromodomain proteins regulate gene expression?
Mackay, J. P., Blobel, G. & Capuano, B.
1/01/18 → 31/12/20
Project: Research
Towards the rational design of calcium sensing receptor allosteric modulators for the treatment of osteoporosis and calcium handling disorders
Leach, K., Gregory, K., Conigrave, A., Capuano, B., Kufareva, I., Thakker, R. & Hannan, F.
National Health & Medical Research Council (NHMRC)
1/01/18 → 31/12/20
Project: Research
Stabilising biased allosteric G protein-coupled receptor conformations
Leach, K., Gregory, K., Capuano, B. & Kufareva, I.
Australian Research Council (ARC), Monash University, University of California
1/01/17 → 31/12/19
Project: Research
Research Output 1990 2019
6-Phenylpyrimidin-4-ones as Positive Allosteric Modulators at the M1 mAChR: The Determinants of Allosteric Activity
Jorg, M. T., van der Westhuizen, E. T., Khajehali, E., Burger, W. A. C., White, J., Choy, K. H. C., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 20 Mar 2019, In : ACS Chemical Neuroscience. 10, 3, p. 1099-1114 16 p.Research output: Contribution to journal › Article › Research › peer-review
Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors
Van Der Westhuizen, E. T., Spathis, A., Khajehali, E., Jorg, M., Mistry, S. N., Capuano, B., Tobin, A. B., Sexton, P. M., Scammells, P. J., Valant, C. & Christopoulos, A., 1 May 2018, In : Molecular Pharmacology. 94, 1, p. 770-783 14 p.Research output: Contribution to journal › Article › Research › peer-review
A Thieno[2,3-d]pyrimidine Scaffold is a Novel Negative Allosteric Modulator of the Dopamine D2 Receptor
Fyfe, T. J., Zarzycka, B., Lim, H. D., Kellam, B., Mistry, S. N., Katrich, V., Scammells, P. J., Lane, J. R. & Capuano, B., 2018, (Accepted/In press) In : Journal of Medicinal Chemistry. 82 p.Research output: Contribution to journal › Article › Research › peer-review
Reply to ‘Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects’
Sykes, D. A., Lane, J. R., Szabo, M., Capuano, B., Javitch, J. A. & Charlton, S. J., 1 Dec 2018, In : Nature Communications. 9, 1, 5 p., 3568.Research output: Contribution to journal › Letter › Other › peer-review
Open Access
File
Synthesis and Pharmacological Evaluation of Heterocyclic Carboxamides: Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor with Weak Agonist Activity and Diverse Modulatory Profiles
Dallagnol, J. C. C., Khajehali, E., Van Der Westhuizen, E. T., Jörg, M., Valant, C., Gonçalves, A. G., Capuano, B., Christopoulos, A. & Scammells, P. J., 12 Apr 2018, In : Journal of Medicinal Chemistry. 61, 7, p. 2875-2894 20 p.Research output: Contribution to journal › Article › Research › peer-review
Activities 2013 2013
- 1 Submissions to industry or govt committees, commissions and inquiries
Medicinal Chemistry
Ben Capuano (Member)13 Aug 2013
Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries