Ben Adler

Emeritus Prof

1989 …2018
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Research Output 1989 2018

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2018

Heterologous protection elicited by a live, attenuated, Leptospira vaccine

Murray, G. L., Simawaranon, T., Kaewraemruaen, C., Adler, B. & Sermswan, R. W., 1 Sep 2018, In : Veterinary Microbiology. 223, p. 47-50 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Lvr, a signaling system that controls global gene regulation and virulence in pathogenic Leptospira

Adhikarla, H., Wunder, E. A., Mechaly, A. E., Mehta, S., Wang, Z., Santos, L., Bisht, V., Diggle, P., Murray, G., Adler, B., Lopez, F., Townsend, J. P., Groisman, E., Picardeau, M., Buschiazzo, A. & Ko, A. I., 23 Feb 2018, In : Frontiers in Cellular and Infection Microbiology. 8, 13 p., 45.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2017

Adipose tissue is the first colonization site of Leptospira interrogans in subcutaneously infected hamsters

Ozuru, R., Saito, M., Kanemaru, T., Miyahara, S., Villanueva, S. Y. A. M., Murray, G. L., Adler, B., Fujii, J. & Yoshida, S. I., 28 Feb 2017, In : PLoS ONE. 12, 2, 13 p., e0172973.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Characterization of two novel lipopolysaccharide phosphoethanolamine transferases in Pasteurella multocida and their role in resistance to cathelicidin-2

Harper, M., Wright, A., Michael, F. S., Li, J., Lucas, D. D., Ford, M., Adler, B., Cox, A. D. & Boyce, J. D., Nov 2017, In : Infection and Immunity. 85, 11, 16 p., e00557-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2016

Perturbation of the two-component signal transduction system, BprRS, results in attenuated virulence and motility defects in Burkholderia pseudomallei

Lazar Adler, N. R., Allwood, E. M., Deveson Lucas, D., Harrison, P., Watts, S., Dimitropoulos, A., Treerat, P., Alwis, P., Devenish, R. J., Prescott, M., Govan, B., Adler, B., Harper, M. & Boyce, J. D., 4 May 2016, In : BMC Genomics. 17, 17 p., 331.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Protective efficacy afforded by live Pasteurella multocida vaccines in chickens is independent of lipopolysaccharide outer core structure

Harper, M., John, M., Edmunds, M., Wright, A. A., Ford, M. E., Turni, C., Blackall, P. J., Cox, A. D., Adler, B. & Boyce, J. D., 2016, In : Vaccine. 34, 14, p. 1696 - 1703 8 p.

Research output: Contribution to journalArticleResearchpeer-review

What makes a bacterial species pathogenic? Comparative genomic analysis of the genus Leptospira

Fouts, D. E., Matthias, M. A., Adhikarla, H., Adler, B., Amorim-Santos, L., Berg, D. E., Bulach, D., Buschiazzo, A., Chang, Y-F., Galloway, R. L., Haake, D. A., Haft, D. H., Hartskeerl, R., Ko, A. I., Levett, P. N., Matsunaga, J., Mechaly, A. E., Monk, J. M., Nascimento, A. L. T., Nelson, K. E. & 9 others, Palsson, B., Peacock, S. J., Picardeau, M., Ricaldi, J. N., Thaipandungpanit, J., Wunder Jr., E. A., Yang, X. F., Zhang, J-J. & Vinetz, J. M., 18 Feb 2016, In : PLoS Neglected Tropical Diseases. 10, 2, 57 p., 0004403.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Burkholderia pseudomallei type III secretion system cluster 3 ATPase BsaS, a chemotherapeutic target for small-molecule ATPase inhibitors

Gong, L., Lai, S., Treerat, P., Prescott, M., Adler, B., Boyce, J. D. & Devenish, R. J., 2015, In : Infection and Immunity. 83, 4, p. 1276 - 1285 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Characterization of the lipopolysaccharide produced by Pasteurella multocida serovars 6, 7 and 16: identification of lipopolysaccharide genotypes L4 and L8

Harper, M., St Michael, F., Steen, J. A., John, M., Wright, A. L., van Dorsten, L., Vinogradov, E., Adler, B., Cox, A. D. & Boyce, J. D., 2015, In : Glycobiology. 25, 3, p. 294 - 302 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Comparative genomic analysis of asian haemorrhagic septicaemia-associated strains of pasteurella multocida identifies more than 90 haemorrhagic septicaemia-specific genes

Moustafa, A. M., Seemann, T., Gladman, S. L., Adler, B., Harper, M., Boyce, J. D. & Bennett, M. D., 2015, In : PLoS ONE. 10, 7, 16 p., e0130296.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Complete genome sequence of leptospira interrogans serovar bratislava, strain PigK151

Alt, D. P., Wilson-Welder, J. H., Bayles, D. O., Cameron, C. E., Adler, B., Bulach, D. M., Seemann, T., Lehane, M. J., Haines, L. R., Darby, A. C., Hall, N., Radford, A. D. & Zuerner, R. L., 2015, In : Genomic Announcements. 3, 3, 2 p., e00678-15.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Determinants of proteolysis and cell-binding for the shigella flexneri cytotoxin, SigA

Chua, E. G., Al-Hasani, K., Scanlon, M. J., Adler, B. & Sakellaris, H. H., 2015, In : Current Microbiology. 71, 5, p. 613 - 617 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Development of a rapid multiplex PCR assay to genotype pasteurella multocida strains by use of the lipopolysaccharide outer core biosynthesis locus

Harper, M., John, M., Turni, C., Edmunds, M. L., St Michael, F., Adler, B., Blackall, P. J., Cox, A. D. & Boyce, J. D., 2015, In : Journal of Clinical Microbiology. 53, 2, p. 477 - 485 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and evaluation of antibacterial activity of (R)-2-methylheptyl isonicotinate, a putative naturally occurring bioactive agent

Cao, J., Adler, B. & Perlmutter, P., 2015, In : Bioorganic and Medicinal Chemistry Letters. 25, 22, p. 5025-5027 3 p.

Research output: Contribution to journalArticleResearchpeer-review

The Burkholderia pseudomallei proteins BapA and BapC are secreted TTSS3 effectors and BapB levels modulate expression of BopE

Treerat, P., Alwis, P. A., D'Cruze, T. M., Cullinane, M., Vadivelu, J., Devenish, R. J., Prescott, M., Adler, B. & Boyce, J. D., 2015, In : PLoS ONE. 10, 12, 19 p., e0143916.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The transcriptomic response of Acinetobacter baumannii to colistin and doripenem alone and in combination in an in vitro pharmacokinetics/pharmacodynamics model

Henry, R. M., Crane, B. A., Powell, D. R., Deveson-Lucas, D. S., Li, Z., Aranda, J., Harrison, P. F., Nation, R. L., Adler, B., Harper, M., Boyce, J. D. & Li, J., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 5, p. 1303 - 1313 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2014

Biological cost of different mechanisms of colistin resistance and their impact on virulence in Acinetobacter baumannii

Beceiro, A., Moreno, A., Fernandez, N., Vallejo, J. A., Aranda, J., Adler, B., Harper, M., Boyce, J. D. & Bou, G., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 1, p. 518 - 526 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

High-temperature protein G is an essential virulence factor of Leptospira interrogans

King, A. M., Pretre, G., Bartpho, T., Sermswan, R., Toma, C., Suzuki, T., Eshghi, A., Picardeau, M., Adler, B. & Murray, G. L., 2014, In : Infection and Immunity. 82, 3, p. 1123 - 1131 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

In silico prediction of Gallibacterium anatis pan-immunogens

Bager, R. J., Kudirkiene, E., de Piedade, I., Seemann, T., Nielsen, T. K., Pors, S. E., Mattsson, A. H., Boyce, J. D., Adler, B. & Bojesen, A. M., 2014, In : Veterinary Research. 45, 1, p. 1 - 12 12 p., 80.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Leptospiral outer membrane protein LMB216 is involved in enhancement of phagocytic uptake by macrophages

Toma, C., Murray, G. L., Nohara, T., Mizuyama, M., Koizumi, N., Adler, B. & Suzuki, T., 2014, In : Cellular Microbiology. 16, 9, p. 1366 - 1377 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Pathogenesis of leptospirosis: cellular and molecular aspects

Adler, B., 2014, In : Veterinary Microbiology. 172, 3-4, p. 353 - 358 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Recombinant LipL32 stimulates interferon-gamma production in cattle vaccinated with a monovalent Leptospira borgpetersenii serovar Hardjo subtype Hardjobovis vaccine

Deveson, D. S., Lo, M., Bulach, D. M., Quinsey, N. S., Murray, G. L., Allen, A. & Adler, B., 2014, In : Veterinary Microbiology. 169, 3-4, p. 163 - 170 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Role of Acinetobacter baumannii UmuD homologs in antibiotic resistance acquired through DNA damage-induced mutagenesis

Aranda, J., Lopez, M., Leiva, E., Magan, A., Adler, B., Bou, G. & Barbe, J., 2014, In : Antimicrobial Agents and Chemotherapy. 58, 3, p. 1771 - 1773 3 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access

Structural analysis of lipopolysaccharide produced by Heddleston serovars 10, 11, 12 and 15 and the identification of a new Pasteurella multocida lipopolysaccharide outer core biosynthesis locus, L6

Harper, M., St Michael, F., John, M., Steen, J. A., van Dorsten, L., Parnas, H., Vinogradov, E., Adler, B., Cox, A. D. & Boyce, J. D., 2014, In : Glycobiology. 24, 7, p. 649 - 659 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2013
Open Access

Classification of Leptospira genomospecies 1, 3, 4 and 5 as Leptospira alstonii sp. nov., Leptospira vanthielii sp. nov., Leptospira terpstrae sp. nov. and Leptospira yanagawae sp. nov., respectively

Smythe, L. D., Adler, B., Hartskeerl, R., Galloway, R. L., Turenne, C. Y. & Levett, P. N., 2013, In : International Journal of Systematic and Evolutionary Microbiology. 63, Pt 5, p. 1859 - 1862 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Evaluation of 238 antigens of Leptospira borgpetersenii serovar Hardjo for protection against kidney colonisation

Murray, G. L., Lo, M., Bulach, D. M., Srikram, A., Seemann, T., Quinsey, N. S., Sermswan, R., Allen, A. & Adler, B., 2013, In : Vaccine. 31, 3, p. 495 - 499 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Evolutionary analysis of Burkholderia pseudomallei identifies putative novel virulence genes, including a microbial regulator of host cell autophagy

Singh, A. P., Lai, S., Nandi, T., Chua, H. H., Ooi, W. F., Ong, C., Boyce, J. D., Adler, B., Devenish, R. J. & Tan, P., 2013, In : Journal of Bacteriology. 195, 24, p. 5487 - 5498 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Identification of a DNA-damage-inducible regulon in Acinetobacter baumannii

Aranda, J., Poza, M., Shingu-Vazquez, M. A., Cortes, P., Boyce, J. D., Adler, B., Barbe, J. & Bou, G., 2013, In : Journal of Bacteriology. 195, 24, p. 5577 - 5582 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Leptospiral LruA is required for virulence and modulates an interaction with mammalian apolipoprotein AI

Zhang, K., Murray, G. L., Seemann, T., Srikram, A., Bartpho, T., Sermswan, R., Adler, B. & Hoke, D. E., 2013, In : Infection and Immunity. 81, 10, p. 3872 - 3879 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Leptospiral outer membrane protein LipL41 is not essential for acute leptospirosis but requires a small chaperone protein, lep, for stable expression

King, A. M., Bartpho, T., Sermswan, R., Bulach, D. M., Eshghi, A., Picardeau, M., Adler, B. & Murray, G. L., 2013, In : Infection and Immunity. 81, 8, p. 2768 - 2776 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Leptospirosis in horses

Verma, A., Stevenson, B. & Adler, B., 2013, In : Veterinary Microbiology. 167, 1-2, p. 61 - 66 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Pasteurella multocida Heddleston serovar 3 and 4 strains share a common lipopolysaccharide biosynthesis locus but display both inter- and intrastrain lipopolysaccharide heterogeneity

Harper, M., St Michael, F., John, M., Vinogradov, E., Steen, J. A., van Dorsten, L., Steen, J. A., Turni, C., Blackall, P. J., Adler, B., Cox, A. D. & Boyce, J. D., 2013, In : Journal of Bacteriology. 195, 21, p. 4854 - 4864 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Precipitation of Iron on the Surface of Leptospira interrogans Is Associated with Mutation of the Stress Response Metalloprotease HtpX

Henry, R. M., Lo, M., Khoo, C. A., Zhang, H., Boysen, R. I., Picardeau, M., Murray, G. L., Bulach, D. M. & Adler, B., 2013, In : Applied and Environmental Microbiology. 79, 15, p. 4653 - 4660 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structural and functional characterization of an orphan ATP-binding cassette ATPase involved in manganese utilization and tolerance in Leptospira spp

Benaroudj, N., Saul, F., Bellalou, J., Miras, I., Weber, P., Bondet, V., Murray, G. L., Adler, B., Bristow, P., Louvel, H., Haouz, A. & Picardeau, M., 2013, In : Journal of Bacteriology. 195, 24, p. 5583 - 5591 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Structure and biosynthetic locus of the lipopolysaccharide outer core produced by Pasteurella multocida serovars 8 and 13 and the identification of a novel phospho-glycero moiety

Harper, M., St Michael, F., Vinogradov, E., John, M., Steen, J. A., van Dorsten, L., Boyce, J. D., Adler, B. & Cox, A. D., 2013, In : Glycobiology. 23, 3, p. 286 - 294 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The fimbrial protein FlfA from Gallibacterium anatis is a virulence factor and vaccine candidate

Bager, R., Nesta, B., Pors, S. E., Soriani, M., Serino, L., Boyce, J. D., Adler, B. & Bojesen, A. M., 2013, In : Infection and Immunity. 81, 6, p. 1964 - 1973 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Use of a high-throughput screen to identify Leptospira mutants unable to colonize the carrier host or cause disease in the acute model of infection

Marcsisin-Rogers, R. A., Bartpho, T., Bulach, D. M., Srikram, A., Sermswan, R., Adler, B. & Murray, G. L., 2013, In : Journal of Medical Microbiology. 62, Pt 10, p. 1601 - 1608 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2012

Application of protein purification methods for the enrichment of a cytotoxin from Campylobacter jejuni

Gatsos, X., Steer, D. L., Junaid, T. A., Smith, A. I., Adler, B. & Albert, M. J., 2012, In : BMC Microbiology. 12, Art No.:303, p. 1 - 10 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Characterization of the lipopolysaccharide from Pasteurella multocida Heddleston serovar 9: identification of a proposed bi-functional dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis enzyme

Harper, M., St Michael, F., Vinogradov, E., John, M., Boyce, J. D., Adler, B. & Cox, A. D., 2012, In : Glycobiology. 22, 3, p. 332 - 344 13 p.

Research output: Contribution to journalArticleResearchpeer-review

FlaA proteins in Leptospira interrogans are essential for motility and virulence but are not required for formation of the flagellum sheath

Lambert, A., Picardeau, M., Haake, D. A., Sermswan, R., Srikram, A., Adler, B. & Murray, G., 2012, In : Infection and Immunity. 80, 6, p. 2019 - 2025 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Leptospira interrogans catalase is required for resistance to H2O2 and for virulence

Eshghi, A., Lourdault, K., Murray, G. L., Bartpho, T., Sermswan, R., Picardeau, M., Adler, B., Snarr, B., Zuerner, R. L. & Cameron, C. E., 2012, In : Infection and Immunity. 80, 11, p. 3892 - 3899 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Pasteurella multocida: diseases and pathogenesis

Wilkie, I. W., Harper, M., Boyce, J. D. & Adler, B., 2012, In : Current topics in microbiology and immunology. 361, p. 1 - 22 22 p.

Research output: Contribution to journalArticleResearchpeer-review

Pathogenomics of pasteurella multocida

Boyce, J. D., Seemann, T., Adler, B. & Harper, M., 2012, In : Current topics in microbiology and immunology. 361, p. 23 - 38 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Screening of 71 P. multocida proteins for protective efficacy in a fowl cholera infection model and characterization of the protective antigen PlpE

Hatfaludi, T. Z., Al-Hasani, K., Gong, L., Boyce, J. D., Ford, M., Wilkie, I. W., Quinsey, N. S., Dunstone, M. A., Hoke, D. E. & Adler, B., 2012, In : PLoS ONE. 7, 7, 11 p., e39973.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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The key surface components of pasteurella multocida: capsule and lipopolysaccharide

Harper, M., Boyce, J. D. & Adler, B., 2012, In : Current topics in microbiology and immunology. 361, p. 39 - 51 13 p.

Research output: Contribution to journalArticleResearchpeer-review