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Research Output

Abstract

Development of a novel peptide tracer for detection of cardiac fibrosis and atrial fibrillation using mouse models of cardiomyopathies

Niego, B., Alt, K., Noor, A., How, O. J., Du, X-J., Donnelly, P. S., McMullen, J. & Hagemeyer, C., 9 Jul 2019.

Research output: Contribution to conferenceAbstract

Intravenous administration of t-PA dampens the immune response in a murine model of ischaemic stroke

Draxler, D. F., Lee, F., Ho, H., Medcalf, R. & Niego, B., 3 Sep 2018.

Research output: Contribution to conferenceAbstract

TNFalpha stimulation desensitises a human in vitro BBB model to t-PA-mediated permeabilisation.

Niego, B., Sashindranath, M., Galle, A., Freeman, R. & Medcalf, R., 11 Dec 2014.

Research output: Contribution to conferenceAbstract

Article

A nonfibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury

Samson, A. L., Borg, R. J., Niego, B., Wong, C. H. Y., Crack, P. J., Yongqing, T. & Medcalf, R. L., 2009, In : Blood. 114, 9, p. 1937 - 1946 10 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Desmoteplase-mediated plasminogen activation and clot lysis are inhibited by the lysine analogue tranexamic acid

Niego, B., Horvath, A. J., Coughlin, P. B., Pugsley, M. K. & Medcalf, R. L., 2008, In : Blood Coagulation and Fibrinolysis. 19, 4, p. 322 - 324 3 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Effective treatment of house metastatic prostate cancer by low electric field enhanced chemotherapy

Plotnikov, A., Niego, B., Ophir, R., Korenstein, R. & Keisari, Y., 2006, In : Prostate. 66, 15, p. 1620 - 1630 11 p.

Research output: Contribution to journalArticleResearchpeer-review

19 Citations (Scopus)

Fabrication of complex PDMS microfluidic structures and embedded functional substrates by one-step injection moulding

Szydzik, C., Niego, B., Dalzell, G., Knoerzer, M., Ball, F., Nesbitt, W. S., Medcalf, R. L., Khoshmanesh, K. & Mitchell, A., 2016, In : RSC Advances. 6, 91, p. 87988-87994 7 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Improved method for the preparation of a human cell-based, contact model of the blood-brain barrier

Niego, B. & Medcalf, R. L., 2013, In : Journal of Visualized Experiments. 2013, 81, p. 1 - 1 1 p.

Research output: Contribution to journalArticleOtherpeer-review

7 Citations (Scopus)

Limiting neuronal nogo receptor 1 signaling during experimental autoimmune encephalomyelitis preserves axonal transport and abrogates inflammatory demyelination

Lee, J. Y., Kim, M. J., Thomas, S., Oorschot, V., Ramm, G., Aui, P. M., Sekine, Y., Deliyanti, D., Wilkinson-Berka, J., Niego, B., Harvey, A. R., Theotokis, P., McLean, C., Strittmatter, S. M. & Petratos, S., 10 Jul 2019, In : Journal of Neuroscience. 39, 28, p. 5562-5580 19 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Novel Thrombolytic Drug Based on Thrombin Cleavable Microplasminogen Coupled to a Single-Chain Antibody Specific for Activated GPIIb/IIIa

Bonnard, T., Tennant, Z., Niego, B., Kanojia, R., Alt, K., Jagdale, S., Law, L. S., Rigby, S., Medcalf, R. L., Peter, K. & Hagemeyer, C. E., 3 Feb 2017, In : American Heart Association. Journal. Cardiovascular and Cerebrovascular Disease. 6, 2, e004535.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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9 Citations (Scopus)

Oncostatin M is a neuroprotective cytokine that inhibits excitotoxic injury in vitro and in vivo

Weiss, T. W., Samson, A. L., Niego, B., Daniel, P. B. & Medcalf, R. L., 2006, In : The FASEB Journal. 20, 13, p. 2369 - 2371 3 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Selective inhibition of brain endothelial Rho-kinase-2 provides optimal protection of an in vitro blood-brain barrier from tissue-type plasminogen activator and plasmin

Niego, B., Lee, N., Larsson, P., De Silva, T. M., Au, A. E. L., McCutcheon, F. & Medcalf, R. L., 1 May 2017, In : PLoS ONE. 12, 5, 21 p., e0177332.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

The influence of differentially expressed tissue-type plasminogen activator in experimental autoimmune encephalomyelitis: Implications for multiple sclerosis

Dahl, L. C. M., Nasa, Z., Chung, J., Niego, B., Tarlac, V., Ho, K. C. H., Galle, A. A., Petratos, S., Alderuccio, F. P. & Medcalf, R. L., 18 Jul 2016, In : PLoS ONE. 11, 7, 22 p., e0158653.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)

Thrombin-induced activation of astrocytes in mixed rat hippocampal cultures is inhibited by soluble thrombomodulin

Niego, B., Samson, A., Petersen, K-U. & Medcalf, R., 2011, In : Brain Research. 1381, p. 38 - 51 14 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function

Samson, A. L., Nevin, S. T., Croucher, D., Niego, B., Daniel, P. B., Weiss, T. W., Moreno, E., Monard, D., Lawrence, D. A. & Medcalf, R. L., 2008, In : Journal of Neurochemistry. 107, 4, p. 1091 - 1101 11 p.

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)

t-PA, but not desmoteplase, induces plasmin-dependent opening of a blood-brain barrier model under normoxic and ischaemic conditions

Freeman, R., Niego, B., Croucher, D. R., Pederson, L. O. & Medcalf, R. L., 2014, In : Brain Research. 1565, p. 63 - 73 11 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

t-PA-specific modulation of a human blood-brain barrier model involves plasmin-mediated activation of the Rho kinase pathway in astrocytes

Niego, B., Freeman, R., Puschmann, T., Turnley, A. & Medcalf, R. L., 2012, In : Blood. 119, 20, p. 4752 - 4761 10 p.

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

T-PA suppresses the immune response and aggravates neurological deficit in a murine model of ischemic stroke

Draxler, D. F., Lee, F., Ho, H., Keragala, C. B., Medcalf, R. L. & Niego, B., 27 Mar 2019, In : Frontiers in Immunology. 10, MAR, 12 p., 591.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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3 Citations (Scopus)

Tranexamic acid modulates the cellular immune profile after traumatic brain injury in mice without hyperfibrinolysis

Draxler, D. F., Daglas, M., Fernando, A., Hanafi, G., McCutcheon, F., Ho, H., Galle, A., Gregory, J., Larsson, P., Keragala, C., Wright, D. K., Tavancheh, E., Au, A. E., Niego, B., Wilson, K., Plebanski, M., Sashindranath, M. & Medcalf, R. L., Dec 2019, In : Journal of Thrombosis and Haemostasis. 17, 12, p. 2174-2187 14 p.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)

Two conserved regions within the tissue-type plasminogen activator gene promoter mediate regulation by brain-derived neurotrophic factor

Daniel, P. B., Lux, W., Samson, A. L., Schleuning, W-D., Niego, B., Weiss, T. W., Tjarnlung-Wolf, A. & Medcalf, R. L., 2007, In : FEBS Journal. 274, 9, p. 2411 - 2423 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Valproic acid selectively increases vascular endothelial tissue-type plasminogen activator production and reduces thrombus formation in the mouse

Larsson, P., Alwis, I., Niego, B., Sashindranath, M., Fogelstrand, P., Wu, M. C. L., Glise, L., Magnusson, M., Daglas, M., Bergh, N., Jackson, S. P., Medcalf, R. L. & Jern, S., 23 Nov 2016, In : Journal of Thrombosis and Haemostasis. 14, 12, p. 2496-2508 13 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)
Review Article

Applications of nanotechnology in the diagnosis and therapy of stroke

Landowski, L. M., Niego, B., Sutherland, B. A., Hagemeyer, C. & Howells, D. W., Jun 2020, In : Seminars in Thrombosis and Hemostasis. 46, 5, p. 592-605 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Plasmin-dependent modulation of the blood-brain barrier: a major consideration during tPA-induced thrombolysis?

Niego, B. & Medcalf, R. L., 2014, In : Journal of Cerebral Blood Flow and Metabolism. 34, 8, p. 1283 - 1296 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
57 Citations (Scopus)

Shear-Dependent Platelet Aggregation: Mechanisms and Therapeutic Opportunities

Rana, A., Westein, E., Niego, B. & Hagemeyer, C. E., 20 Sep 2019, In : Frontiers in Cardiovascular Medicine. 6, 21 p., 141.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
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10 Citations (Scopus)