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Personal profile

Biography

Dr Barbara Kemp-Harper is a vascular pharmacologist whose research focuses on improving blood vessel function in hypertension, high cholesterol and diabetes. She is a Senior Lecturer in the Department of Pharmacology, Monash University and a group leader within the Vascular Biology and Immunopharmacology Group. Barbara leads the Vascular Signalling Group and currently holds a NHMRC Project Grant.

Barbara has a long standing interest in the mechanisms underlying blood vessel dysfunction in cardiovascular disease. She is particularly interested in nitric oxide, a biologically active gas, which is produced in blood vessels to help maintain adequate blood flow and blood pressure. In disease states, nitric oxide signalling is compromised and Barbara's work seeks to identify new therapeutic strategies to overcome nitric oxide dysfunction. She has become internationally recognised for her work on nitroxyl, a novel sibling of nitric oxide, which has many advantages over nitric oxide. Barbara's work has identified a potential for nitroxyl-like drugs to be used in the treatment of angina, high blood pressure and high cholesterol.

Research area keywords

  • Vascular Disease
  • nitric oxide
  • inflammation

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Projects 2001 2019

Research Output 1993 2019

D. Russelii venom mediates vasodilatation of resistance like arteries via activation of k v and k ca channels

Kakumanu, R., Kuruppu, S., Rash, L. D., Isbister, G. K., Hodgson, W. C. & Kemp-Harper, B. K., 1 Apr 2019, In : Toxins. 11, 4, 10 p., 197.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

Krishnan, S. M., Ling, Y. H., Huuskes, B. M., Ferens, D. M., Saini, N., Chan, C. T., Diep, H., Kett, M. M., Samuel, C. S., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Peter, K., Latz, E., Mansell, A. S., Sobey, C. G., Drummond, G. R. & Vinh, A., 15 Mar 2019, In : Cardiovascular Research. 115, 4, p. 776-787 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Vampire venom: Vasodilatory mechanisms of vampire bat (desmodus rotundus) blood feeding

Kakumanu, R., Hodgson, W. C., Ravi, R., Alagon, A., Harris, R. J., Brust, A., Alewood, P. F., Kemp-Harper, B. K. & Fry, B. G., 8 Jan 2019, In : Toxins. 11, 1, 10 p., 26.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Proteomic Identification of Interferon-Induced Proteins with Tetratricopeptide Repeats as Markers of M1 Macrophage Polarization

Huang, C., Lewis, C., Borg, N. A., Canals, M., Diep, H., Drummond, G. R., Goode, R. J., Schittenhelm, R. B., Vinh, A., Zhu, M., Kemp-Harper, B., Kleifeld, O. & Stone, M. J., 6 Apr 2018, In : Journal of Proteome Research. 17, 4, p. 1485-1499 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

Ling, Y. H., Krishnan, S. M., Chan, C. T., Diep, H., Ferens, D., Chin-Dusting, J., Kemp-Harper, B. K., Samuel, C. S., Hewitson, T. D., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., Feb 2017, In : Pharmacological Research. 116, p. 77-86 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Prizes

Monash University Exceptional Acheivement Award

Barbara Harper (Recipient), Dec 2005

Prize: Prize (including medals and awards)

Monash University Exceptional Achievement Award

Barbara Harper (Recipient), Dec 2017

Prize: Prize (including medals and awards)