Projects per year
Personal profile
Biography
Dr Barbara Kemp-Harper is a vascular pharmacologist whose research focuses on improving blood vessel function in hypertension, high cholesterol and diabetes. She is a Senior Lecturer in the Department of Pharmacology, Monash University and a group leader within the Vascular Biology and Immunopharmacology Group. Barbara leads the Vascular Signalling Group and currently holds a NHMRC Project Grant.
Barbara has a long standing interest in the mechanisms underlying blood vessel dysfunction in cardiovascular disease. She is particularly interested in nitric oxide, a biologically active gas, which is produced in blood vessels to help maintain adequate blood flow and blood pressure. In disease states, nitric oxide signalling is compromised and Barbara's work seeks to identify new therapeutic strategies to overcome nitric oxide dysfunction. She has become internationally recognised for her work on nitroxyl, a novel sibling of nitric oxide, which has many advantages over nitric oxide. Barbara's work has identified a potential for nitroxyl-like drugs to be used in the treatment of angina, high blood pressure and high cholesterol.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Vascular Disease
- nitric oxide
- inflammation
Network
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Defining Chemotactic Signalling Networks to Identify New Anti-inflammatory Targets
Stone, M., Foster, S. R., Kufareva, I., Schittenhelm, R., Handel, T. M., Harper, B., Simpson, K. J. & Payne, R.
1/01/22 → 31/12/25
Project: Research
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Knocking down the resistance: a new strategy for the treatment of high blood pressure
Harper, B., Zhu, M., Stone, M. & Schlaich, M. P.
1/01/21 → 28/02/22
Project: Research
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Decoding monocyte signalling networks
Foster, S., Stone, M., Harper, B. & Schittenhelm, R.
1/07/20 → 30/06/21
Project: Research
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Sphingosine Kinase-1 Inhibitors for the Treatment of Pulmonary Hypertension
1/02/20 → 1/02/21
Project: Research
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Nitroxyl donors: novel pharmacotherapy for management of heart failure induced by type 2 diabetes
1/01/17 → 31/12/17
Project: Research
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A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy
Velagic, A., Li, M., Deo, M., Li, J. C., Kiriazis, H., Donner, D. G., Anderson, D., De Blasio, M. J., Woodman, O. L., Kemp-Harper, B. K., Qin, C. X. & Ritchie, R. H., Feb 2023, In: American Journal of Physiology - Heart and Circulatory Physiology. 324, 2, p. H241-H257 17 p.Research output: Contribution to journal › Article › Research › peer-review
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Post-stroke administration of H2 relaxin reduces functional deficits, neuronal apoptosis and immune cell infiltration into the mouse brain
Truong, S. H. T., Bonnici, B., Rupasinghe, S., Kemp-Harper, B. K., Samuel, C. S. & Broughton, B. R. S., Jan 2023, In: Pharmacological Research. 187, 11 p., 106611.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
The single-chain relaxin mimetic, B7-33, maintains the cardioprotective effects of relaxin and more rapidly reduces left ventricular fibrosis compared to perindopril in an experimental model of cardiomyopathy
Alam, F., Gaspari, T. A., Kemp-Harper, B. K., Low, E., Aw, A., Ferens, D., Spizzo, I., Jefferis, A-M., Praveen, P., Widdop, R. E., Bathgate, R. A. D., Hossain, M. A. & Samuel, C. S., Apr 2023, In: Biomedicine and Pharmacotherapy. 160, 12 p., 114370.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Cardioprotective actions of nitroxyl donor Angeli's salt are preserved in the diabetic heart and vasculature in the face of nitric oxide resistance
Velagic, A., Li, J. C., Qin, C. X., Li, M., Deo, M., Marshall, S. A., Anderson, D., Woodman, O. L., Horowitz, J. D., Kemp-Harper, B. K. & Ritchie, R. H., Aug 2022, In: British Journal of Pharmacology. 179, 16, p. 4117-4135 19 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation
Kemp-Harper, B. K., Velagic, A., Paolocci, N., Horowitz, J. D. & Ritchie, R. H., 2021, Reactive Oxygen Species: Network Pharmacology and Therapeutic Applications. Schmidt, H. H. H. W., Ghezzi, P. & Cuadrado, A. (eds.). Cham Switzerland: Springer, Vol. 264. p. 311-337 27 p. (Handbook of Experimental Pharmacology).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review
6 Citations (Scopus)
Prizes
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ASCEPT (Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists) Service Award
Harper, Barbara (Recipient), 3 Dec 2013
Prize: National/international honour
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Monash Biomedicine Discovery Institute 2017 Award for Outstandind Achievement: Innovation in Learning & Teaching
Harper, Barbara (Recipient) & Davis, E. A. (Recipient), 21 Nov 2017
Prize: Prize (including medals and awards)
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Monash University Exceptional Acheivement Award
Harper, Barbara (Recipient), Dec 2005
Prize: Prize (including medals and awards)
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Monash University Exceptional Achievement Award
Harper, Barbara (Recipient), Dec 2017
Prize: Prize (including medals and awards)