Projects per year
Personal profile
Biography
Dr Barbara Kemp-Harper is a vascular pharmacologist whose research focuses on improving blood vessel function in hypertension, high cholesterol and diabetes. She is a Senior Lecturer in the Department of Pharmacology, Monash University and a group leader within the Vascular Biology and Immunopharmacology Group. Barbara leads the Vascular Signalling Group and currently holds a NHMRC Project Grant.
Barbara has a long standing interest in the mechanisms underlying blood vessel dysfunction in cardiovascular disease. She is particularly interested in nitric oxide, a biologically active gas, which is produced in blood vessels to help maintain adequate blood flow and blood pressure. In disease states, nitric oxide signalling is compromised and Barbara's work seeks to identify new therapeutic strategies to overcome nitric oxide dysfunction. She has become internationally recognised for her work on nitroxyl, a novel sibling of nitric oxide, which has many advantages over nitric oxide. Barbara's work has identified a potential for nitroxyl-like drugs to be used in the treatment of angina, high blood pressure and high cholesterol.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Vascular Disease
- nitric oxide
- inflammation
Network
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Defining Chemotactic Signalling Networks to Identify New Anti-inflammatory Targets
Stone, M., Foster, S., Kufareva, I., Schittenhelm, R., Handel, T. M., Harper, B., Simpson, K. J. & Payne, R.
1/01/22 → 31/12/25
Project: Research
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Knocking down the resistance: a new strategy for the treatment of high blood pressure
Harper, B., Zhu, M., Stone, M. & Schlaich, M. P.
1/01/21 → 28/02/22
Project: Research
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Decoding monocyte signalling networks
Foster, S., Stone, M., Harper, B. & Schittenhelm, R.
1/07/20 → 30/06/21
Project: Research
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Sphingosine Kinase-1 Inhibitors for the Treatment of Pulmonary Hypertension
1/02/20 → 1/02/21
Project: Research
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Nitroxyl donors: novel pharmacotherapy for management of heart failure induced by type 2 diabetes
1/01/17 → 31/12/17
Project: Research
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Cardiovascular Therapeutic Potential of the Redox Siblings, Nitric Oxide (NO•) and Nitroxyl (HNO), in the Setting of Reactive Oxygen Species Dysregulation
Kemp-Harper, B. K., Velagic, A., Paolocci, N., Horowitz, J. D. & Ritchie, R. H., 2021, Reactive Oxygen Species: Network Pharmacology and Therapeutic Applications. Schmidt, H. H. H. W., Ghezzi, P. & Cuadrado, A. (eds.). Cham Switzerland: Springer, Vol. 264. p. 311-337 27 p. (Handbook of Experimental Pharmacology).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Research › peer-review
3 Citations (Scopus) -
Diabetes Attenuates the Contribution of Endogenous Nitric Oxide but Not Nitroxyl to Endothelium Dependent Relaxation of Rat Carotid Arteries
Li, J. C., Velagic, A., Qin, C. X., Li, M., Leo, C. H., Kemp-Harper, B. K., Ritchie, R. H. & Woodman, O. L., 21 Jan 2021, In: Frontiers in Pharmacology. 11, 16 p., 585740.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
IL-18 (Interleukin-18) Produced by Renal Tubular Epithelial Cells Promotes Renal Inflammation and Injury during Deoxycorticosterone/Salt-Induced Hypertension in Mice
Thomas, J. M., Ling, Y. H., Huuskes, B., Jelinic, M., Sharma, P., Saini, N., Ferens, D. M., Diep, H., Krishnan, S. M., Kemp-Harper, B. K., O'Connor, P. M., Latz, E., Arumugam, T. V., Guzik, T. J., Hickey, M. J., Mansell, A., Sobey, C. G., Vinh, A. & Drummond, G. R., Nov 2021, In: Hypertension. 78, 5, p. 1296-1309 14 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Simultaneous targeting of oxidative stress and fibrosis reverses cardiomyopathy-induced ventricular remodelling and dysfunction
Wang, C., Gaspari, T. A., Ferens, D., Spizzo, I., Kemp-Harper, B. K. & Samuel, C. S., Jun 2021, In: British Journal of Pharmacology. 178, 12, p. 2424-2442 19 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Nitric Oxide Resistance, Induced in the Myocardium by Diabetes, Is Circumvented by the Nitric Oxide Redox Sibling, Nitroxyl
Qin, C. X., Anthonisz, J., Leo, C. H., Kahlberg, N., Velagic, A., Li, M., Jap, E., Woodman, O. L., Parry, L. J., Horowitz, J. D., Kemp-Harper, B. K. & Ritchie, R. H., 1 Jan 2020, In: Antioxidants and Redox Signaling. 32, 1, p. 60-78 19 p.Research output: Contribution to journal › Article › Research › peer-review
11 Citations (Scopus)
Prizes
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ASCEPT (Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists) Service Award
Harper, Barbara (Recipient), 3 Dec 2013
Prize: National/international honour
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Monash Biomedicine Discovery Institute 2017 Award for Outstandind Achievement: Innovation in Learning & Teaching
Harper, Barbara (Recipient) & Davis, E. A. (Recipient), 21 Nov 2017
Prize: Prize (including medals and awards)
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Monash University Exceptional Acheivement Award
Harper, Barbara (Recipient), Dec 2005
Prize: Prize (including medals and awards)
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Monash University Exceptional Achievement Award
Harper, Barbara (Recipient), Dec 2017
Prize: Prize (including medals and awards)