Accepting PhD Students

PhD projects

Biomarkers and interventions in pregnancy and gestational diabetes Description Gestational diabetes mellitus (GDM) is a common metabolic disorder affecting 15-20% of pregnancies, and its incidence is rising in line with maternal obesity and advanced childbearing age. GDM is characterised by insulin resistance and is a known risk factor for adverse pregnancy outcomes including preeclampsia, macrosomia, and fetal abnormalities. It is also the strongest population predictor of type 2 diabetes (T2D), where up to 63% of women with GDM will develop T2D within 5 years of pregnancy. New research has yielded the concept that ‘diabetes begets diabetes’, suggesting that GDM not only predisposes the mother, but also the infant, to obesity and metabolic disorders later in life. An improved understanding of the mechanisms underpinning GDM development and the efficacy of current interventions are therefore of paramount importance to facilitate early detection and prevention of GDM and its sequelae. This project encompasses multiple aims as follows: - to advance understanding of the pathophysiology of hypergylcaemia in pregnancy and GDM; - to identify novel GDM biomarkers to facilitate early identification and prevention; - to evaluate the efficacy of nutritional, lifestyle, and pharmaceutical interventions for preventing or treating GDM and its complications; and - ultimately, to translate research findings into clinical practice to improve pregnancy outcomes and long-term maternal and child health. To achieve these aims, the project will encompass a multidisciplinary approach with ample opportunities for students to obtain key research knowledge and skills. Multiple methodologies will be utilized to achieve the research aims, spanning across the research continuum from mechanistic and epidemiological research, to clinical trials, large-scale meta-analyses, and translational activities. Ideally, this project would be suited for students with an interest in nutrition, metabolism and maternal health and with a passion for delivering research with impact.

20152024

Research output per year

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Research Output

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Article

Adipsin concentrations are associated with back pain independently of adiposity in overweight or obese adults

Brady, S. R. E., Mousa, A., Naderpoor, N., de Courten, M. P. J., Cicuttini, F. & de Courten, B., 12 Feb 2018, In : Frontiers in Physiology. 9, FEB, 93.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
4 Citations (Scopus)

Bioavailable and free 25-hydroxyvitamin D and vitamin D binding protein in polycystic ovary syndrome: Relationships with obesity and insulin resistance

Naderpoor, N., Shorakae, S., Abell, S. K., Mousa, A., Joham, A. E., Moran, L. J., Stepto, N. K., Spritzer, P. M., Teede, H. J. & de Courten, B., Mar 2018, In : Journal of Steroid Biochemistry and Molecular Biology. 177, p. 209-215 7 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Carnosine supplementation improves serum resistin concentrations in overweight or obese otherwise healthy adults: A pilot randomized trial

Baye, E., Ukropec, J., de Courten, M. P. J., Mousa, A., Kurdiova, T., Johnson, J., Wilson, K., Plebanski, M., Aldini, G., Ukropcova, B. & de Courten, B., 7 Sep 2018, In : Nutrients. 10, 9, 10 p., 1258.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
3 Citations (Scopus)

Effect of 16-weeks vitamin D replacement on calcium-phosphate homeostasis in overweight and obese adults

Mesinovic, J., Mousa, A., Wilson, K., Scragg, R., Plebanski, M., de Courten, M., Scott, D., Naderpoor, N. & de Courten, B., Feb 2019, In : Journal of Steroid Biochemistry and Molecular Biology. 186, p. 169-175 7 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Effect of vitamin D supplementation on inflammation: Protocol for a systematic review

Mousa, A., Misso, M., Teede, H., Scragg, R. & de Courten, B., 5 Apr 2016, In : BMJ Open. 6, 4, e100804.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File
23 Citations (Scopus)

Effect of Vitamin D supplementation on inflammation and nuclear factor kappa-B activity in overweight/obese adults: A randomized placebo-controlled trial

Mousa, A., Naderpoor, N., Johnson, J., Sourris, K., De Courten, M. P. J., Wilson, K., Scragg, R., Plebanski, M. & De Courten, B., 1 Dec 2017, In : Scientific Reports. 7, 1, 11 p., 15154.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
10 Citations (Scopus)
15 Citations (Scopus)

Faecal microbiota is related to insulin sensitivity and secretion

Naderpoor, N., Mousa, A., Gomez-Arango, L. F., Barrett, H. L., Nitert, M. D. & de Courten, B., 4 Apr 2019, In : Journal of Clinical Medicine. 8, 4, 12 p., 452.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Higher glomerular filtration rate is related to insulin resistance but not to obesity in a predominantly obese non-diabetic cohort

Naderpoor, N., Lyons, J. G., Mousa, A., Ranasinha, S., de Courten, M. P. J., Soldatos, G. & De Courten, B., 3 Apr 2017, In : Scientific Reports. 7, 8 p., 45522.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
7 Citations (Scopus)

Increased inflammation and cardiometabolic risk in individuals with low AMY1 copy numbers

Marquina, C., Mousa, A., Belski, R., Banaharis, H., Naderpoor, N. & Vozarova de Courten, B., 19 Mar 2019, In : Journal of Clinical Medicine. 8, 3, 11 p., 382.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
Open Access
File

Interventions and practice models for improving health and psychosocial outcomes of children and young people in out-of-home care: protocol for a systematic review

Galvin, E., O'donnell, R., Skouteris, H., Halfpenny, N. & Mousa, A., 11 Sep 2019, In : BMJ Open. 9, 9, 6 p., e031362.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
File

Lipidomic profiling reveals early-stage metabolic dysfunction in overweight or obese humans

Mousa, A., Naderpoor, N., Mellett, N., Wilson, K. L., Plebanski, M., Meikle, P. J. & de Courten, B., 1 Mar 2019, In : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 3, p. 335-343 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Plasma 25-hydroxyvitamin D is related to protein signaling involved in glucose homeostasis in a tissue-specific manner

Parker, L., Levinger, I., Mousa, A., Howlett, K. F. & De Courten, B., 1 Oct 2016, In : Nutrients. 8, 10, 631.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
8 Citations (Scopus)

Relationship between vitamin D and gestational diabetes in overweight or obese pregnant women may be mediated by adiponectin

Mousa, A., Abell, S. K., Shorakae, S., Harrison, C. L., Naderpoor, N., Hiam, D., Moreno-Asso, A., Stepto, N. K., Teede, H. J. & de Courten, B., Nov 2017, In : Molecular Nutrition and Food Research. 61, 11, 1700488.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Vitamin D and cardiometabolic disorders: a review of current evidence, genetic determinants and pathomechanisms

Marquina, C., Mousa, A., Scragg, R. & de Courten, B., Feb 2019, In : Obesity Reviews. 20, 2, p. 262-277 16 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Vitamin D supplementation increases adipokine concentrations in overweight or obese adults

Mousa, A., Naderpoor, N., Wilson, K., Plebanski, M., de Courten, M. P. J., Scragg, R. & de Courten, B., Feb 2020, In : European Journal of Nutrition. 59, 1, p. 195-204 10 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Vitamin D supplementation may improve back pain disability in vitamin D deficient and overweight or obese adults

Brady, S. R. E., Naderpoor, N., de Courten, M. P. J., Scragg, R., Cicuttini, F., Mousa, A. & de Courten, B., Jan 2019, In : Journal of Steroid Biochemistry and Molecular Biology. 185, p. 212-217 6 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)