Accepting PhD Students

PhD projects

Innate Immune immunometabolism: the intersection between metabolism and immunology Suitability: Honours, PhD Project leader: A/Prof Ashley Mansell e: ashley.mansell@hudson.org.au Project description: Recent discoveries have positioned mitochondrial reprogramming by Toll-like receptors (TLRs), at the centre of innate immune inflammation. Immunometabolism describes the interplay between immunological and metabolic processes which are not only critical to the immediate innate immune response to infection, but also the new paradigm of innate memory or training, the concept that myeloid lineage cells can respond more strongly to future challenge via epigenetic reprogramming. We have discovered a role for STAT3 in immunometabolism and how this regulates inflammatory gene induction, mitochondrial health, and metabolism. This project offers the opportunity to explore the molecular dynamics and mechanisms of TLR-induced mitochondrial metabolism, and the temporal influence on transcriptional and epigenetic remodelling using advanced genetic sequencing and metabolomic approaches, in conjunction with novel mouse models of dysfunctional STAT3 signalling and inflammatory disease. Keywords: Innate immunity, inflammation Toll-like receptors, Pattern Recognition Receptors, cell biology, mitochondria, metabolism Inflammasomes and how to drug them to treat emerging pandemic viruses Suitability: Honours, PhD Project leader: A/Prof Ashley Mansell e: ashley.mansell@hudson.org.au Project description: The recent and deadly emergence of SARS CoV 2 (COVID-19) has illustrated how unprepared we are for an emerging infectious disease.There is a desperate need to identify and target how these pathogens induce severe and lethal inflammation during infection. We recently identified and characterised aggregated viral proteins as a novel class of inflammasome activators that induce hyperinflammation characteristic of infections such as avian influenza. We have now identified several proteins that show aggregating potential and inflammasome activation in viruses characterised by excessive inflammation, such as Ebola virus, SARS-coronavirus, dengue virus and picornaviruses. Using novel cell biology methodologies, cell lines, microimaging and gene-deficient mouse models, we will explore the capacity of peptides based on these viral proteins to examine inflammasome activation. This project offers the opportunity to interact with virologists and our collaborators in Bonn, Germany. Keywords: innate immunity, inflammation, emerging infectious diseases, inflammasome, infectious disease

1993 …2020

Research output per year

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Research Output

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Review Article
2018

An update on the NLRP3 inflammasome and influenza: the road to redemption or perdition?

Tate, M. D. & Mansell, A., 1 Jul 2018, In : Current Opinion in Immunology. 54, p. 80-85 6 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

9 Citations (Scopus)
2017

Hero turned villain: NLRP3 inflammasome-induced inflammation during influenza A virus infection

Ong, J. D. H., Mansell, A. & Tate, M. D., Jun 2017, In : Journal of leukocyte biology. 101, 4, p. 863-874 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

19 Citations (Scopus)
2016

Toll-like receptors: the swiss army knife of immunity and vaccine development

Dowling, J. K. & Mansell, A., 2016, In : Clinical & Translational Immunology. 5, 10 p., e85.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File

TRIF-dependent TLR signaling, its functions in host defense and inflammation, and its potential as a therapeutic target

Ullah, M. O., Sweet, M. J., Mansell, A., Kellie, S. & Kobe, B., 1 Jul 2016, In : Journal of leukocyte biology. 100, 1, p. 27-45 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

42 Citations (Scopus)