Accepting PhD Students

PhD projects

Innate Immune immunometabolism: the intersection between metabolism and immunology Suitability: Honours, PhD Project leader: A/Prof Ashley Mansell e: ashley.mansell@hudson.org.au Project description: Recent discoveries have positioned mitochondrial reprogramming by Toll-like receptors (TLRs), at the centre of innate immune inflammation. Immunometabolism describes the interplay between immunological and metabolic processes which are not only critical to the immediate innate immune response to infection, but also the new paradigm of innate memory or training, the concept that myeloid lineage cells can respond more strongly to future challenge via epigenetic reprogramming. We have discovered a role for STAT3 in immunometabolism and how this regulates inflammatory gene induction, mitochondrial health, and metabolism. This project offers the opportunity to explore the molecular dynamics and mechanisms of TLR-induced mitochondrial metabolism, and the temporal influence on transcriptional and epigenetic remodelling using advanced genetic sequencing and metabolomic approaches, in conjunction with novel mouse models of dysfunctional STAT3 signalling and inflammatory disease. Keywords: Innate immunity, inflammation Toll-like receptors, Pattern Recognition Receptors, cell biology, mitochondria, metabolism Inflammasomes and how to drug them to treat emerging pandemic viruses Suitability: Honours, PhD Project leader: A/Prof Ashley Mansell e: ashley.mansell@hudson.org.au Project description: The recent and deadly emergence of SARS CoV 2 (COVID-19) has illustrated how unprepared we are for an emerging infectious disease.There is a desperate need to identify and target how these pathogens induce severe and lethal inflammation during infection. We recently identified and characterised aggregated viral proteins as a novel class of inflammasome activators that induce hyperinflammation characteristic of infections such as avian influenza. We have now identified several proteins that show aggregating potential and inflammasome activation in viruses characterised by excessive inflammation, such as Ebola virus, SARS-coronavirus, dengue virus and picornaviruses. Using novel cell biology methodologies, cell lines, microimaging and gene-deficient mouse models, we will explore the capacity of peptides based on these viral proteins to examine inflammasome activation. This project offers the opportunity to interact with virologists and our collaborators in Bonn, Germany. Keywords: innate immunity, inflammation, emerging infectious diseases, inflammasome, infectious disease

1993 …2020

Research output per year

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Article
2020

Parsing the IL-37-mediated suppression of inflammasome function

Rudloff, I., Ung, H. K., Dowling, J. K., Mansell, A., D'Andrea, L., Ellisdon, A. M., Whisstock, J., Berger, P., Nold, C. & Nold, M., Jan 2020, In : Cells. 9, 1, 19 p., 178.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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STAT3 serine phosphorylation is required for TLR4 metabolic reprogramming and IL-1B expression

Balic, J. J., Albargy, H., Luu, K., Kirby, F. J., Jayasekara, W. S. N., Mansell, F., Garama, D. J., De Nardo, D., Baschuk, N., Louis, C., Humphries, F., Fitzgerald, K., Latz, E., Gough, D. J. & Mansell, A., 30 Jul 2020, In : Nature Communications. 11, 11 p., 3816.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2019

Pharmacological inhibition of the NLRP3 inflammasome reduces blood pressure, renal damage, and dysfunction in salt-sensitive hypertension

Krishnan, S. M., Ling, Y. H., Huuskes, B. M., Ferens, D. M., Saini, N., Chan, C. T., Diep, H., Kett, M. M., Samuel, C. S., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Peter, K., Latz, E., Mansell, A. S., Sobey, C. G., Drummond, G. R. & Vinh, A., 15 Mar 2019, In : Cardiovascular Research. 115, 4, p. 776-787 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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31 Citations (Scopus)

Repurposing drugs targeting the P2X7 receptor to limit hyperinflammation and disease during influenza virus infection

Rosli, S., Kirby, F. J., Lawlor, K. E., Rainczuk, K., Drummond, G. R., Mansell, A. & Tate, M. D., Oct 2019, In : British Journal of Pharmacology. 176, 19, p. 3834-3844 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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7 Citations (Scopus)

The Single Nucleotide Polymorphism Mal-D96N Mice Provide New Insights into Functionality of Mal in TLR Immune Responses

Dowling, J. K., Tate, M. D., Rosli, S., Bourke, N. M., Bitto, N., Lauterbach, M. A., Cheung, S., Ve, T., Kobe, B., Golenbock, D. & Mansell, A., 15 Apr 2019, In : Journal of Immunology. 202, 8, p. 2384-2396 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)
2018

Macrophage migration inhibitory factor is required for NLRP3 inflammasome activation

Lang, T., Lee, J. P. W., Elgass, K., Pinar, A. A., Tate, M. D., Aitken, E. H., Fan, H., Creed, S. J., Deen, N. S., Traore, D. A. K., Mueller, I., Stanisic, D., Baiwog, F. S., Skene, C., Wilce, M. C. J., Mansell, A., Morand, E. F. & Harris, J., 1 Dec 2018, In : Nature Communications. 9, 1, 15 p., 2223.

Research output: Contribution to journalArticleResearchpeer-review

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32 Citations (Scopus)

Membrane vesicles from Pseudomonas aeruginosa activate the noncanonical inflammasome through caspase-5 in human monocytes

Bitto, N. J., Baker, P. J., Dowling, J. K., Wray-McCann, G., De Paoli, A., Tran, L. S., Leung, P. L., Stacey, K. J., Mansell, A., Masters, S. L. & Ferrero, R. L., Nov 2018, In : Immunology and Cell Biology. 96, 10, p. 1120-1130 11 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2017

Anakinra reduces blood pressure and renal fibrosis in one kidney/DOCA/salt-induced hypertension

Ling, Y. H., Krishnan, S. M., Chan, C. T., Diep, H., Ferens, D., Chin-Dusting, J., Kemp-Harper, B. K., Samuel, C. S., Hewitson, T. D., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., Feb 2017, In : Pharmacological Research. 116, p. 77-86 10 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Disruption of Serinc1, which facilitates serine-derived lipid synthesis, fails to alter macrophage function, lymphocyte proliferation or autoimmune disease susceptibility

Chu, E. P. F., Elso, C. M., Pollock, A. H., Alsayb, M. A., Mackin, L., Thomas, H. E., Kay, T. W. H., Silveira, P. A., Mansell, A. S., Gaus, K. & Brodnicki, T. C., 1 Feb 2017, In : Molecular Immunology. 82, p. 19-33 15 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Outer membrane vesicles prime and activate macrophage inflammasomes and cytokine secretion in vitro and in vivo

Cecil, J. D., O'Brien-Simpson, N. M., Lenzo, J. C., Holden, J. A., Singleton, W. C. J., Perez-Gonzalez, A., Mansell, A. & Reynolds, E. C., 25 Aug 2017, In : Frontiers in Immunology. 8, AUG, 22 p., 1017.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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21 Citations (Scopus)

PB1-F2 peptide derived from avian influenza A virus H7N9 induces inflammation via activation of the NLRP3 inflammasome

Pinar, A., Dowling, J. K., Bitto, N. J., Robertson, A. A. B., Latz, E., Stewart, C. R., Drummond, G. R., Cooper, M. A., McAuley, J. L., Tate, M. D. & Mansell, A., 20 Jan 2017, In : The Journal of Biological Chemistry. 292, 3, p. 826-836 11 p.

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Porphyromonas gulae activates unprimed and gamma interferon-primed macrophages via the pattern recognition receptors Toll-like receptor 2 (TLR2), TLR4, and NOD2

Holden, J. A., O'Brien-Simpson, N. M., Lenzo, J. C., Orth, R. K. H., Mansell, A. & Reynolds, E. C., 1 Sep 2017, In : Infection and Immunity. 85, 9, 15 p., e00282-17.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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5 Citations (Scopus)

Pressor response to angiotensin II is enhanced in aged mice and associated with inflammation, vasoconstriction and oxidative stress

Dinh, Q. N., Drummond, G. R., Kemp-Harper, B. K., Diep, H., De Silva, T. M., Kim, H. A., Vinh, A., Robertson, A. A. B., Cooper, M. A., Mansell, A., Chrissobolis, S. & Sobey, C. G., 28 Jun 2017, In : Aging. 9, 6, p. 1595-1605 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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18 Citations (Scopus)

Solution structure of the TLR adaptor MAL/TIRAP reveals an intact BB loop and supports MAL Cys91 glutathionylation for signaling

Hughes, M. M., Lavrencic, P., Coll, R. C., Ve, T., Ryan, D. G., Williams, N. C., Menon, D., Mansell, A., Board, P. G., Mobli, M., Kobe, B. & O’Neill, L. A. J., 8 Aug 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 32, p. E6480-E6489 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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16 Citations (Scopus)

Structural basis of TIR-domain-assembly formation in MAL- and MyD88-dependent TLR4 signaling

Ve, T., Vajjhala, P. R., Hedger, A., Croll, T., Dimaio, F., Horsefield, S., Yu, X., Lavrencic, P., Hassan, Z., Morgan, G. P., Mansell, A., Mobli, M., O'Carroll, A., Chauvin, B., Gambin, Y., Sierecki, E., Landsberg, M. J., Stacey, K. J., Egelman, E. H. & Kobe, B., 7 Sep 2017, In : Nature Structural & Molecular Biology. 24, 9, p. 743-751 9 p.

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages

Alvarado, R., To, J., Lund, M. E., Pinar, A., Mansell, A., Robinson, M. W., O'Brien, B. A., Dalton, J. P. & Donnelly, S. M., 1 Jan 2017, In : The FASEB Journal. 31, 1, p. 85-95 11 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)
2016

Induction of memory cytotoxic T cells to influenza A virus and subsequent viral clearance is not modulated by PB1-F2-dependent inflammasome activation

Lee, P. Y., Bird, N. L., MacKenzie-Kludas, C., Mansell, A., Kedzierska, K., Brown, L. & McAuley, J., 1 May 2016, In : Immunology and Cell Biology. 94, 5, p. 439-446 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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4 Citations (Scopus)

Inflammasome activity is essential for one kidney/deoxycorticosterone acetate/salt-induced hypertension in mice

Krishnan, S. M., Dowling, J. K., Ling, Y. H., Diep, H., Chan, C. T., Ferens, D., Kett, M. M., Pinar, A., Samuel, C. S., Vinh, A., Arumugam, T. V., Hewitson, T. D., Kemp-Harper, B. K., Robertson, A. A. B., Cooper, M. A., Latz, E., Mansell, A., Sobey, C. G. & Drummond, G. R., 1 Feb 2016, In : British Journal of Pharmacology. 173, 4, p. 752-765 14 p.

Research output: Contribution to journalArticleResearchpeer-review

66 Citations (Scopus)

Reassessing the role of the NLRP3 inflammasome during pathogenic influenza A virus infection via temporal inhibition

Tate, M. D., Ong, J. DH., Dowling, J. K., McAuley, J. L., Robertson, A. B., Latz, E., Drummond, G. R., Cooper, M. A., Hertzog, P. J. & Mansell, A., 10 Jun 2016, In : Scientific Reports. 6, 8 p., 27912.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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59 Citations (Scopus)

Toll-IL1 receptor-mediated innate immune responses vary across HBV genotype and predict treatment response to pegylated-IFN in HBeAg-positive CHB patients

Visvanathan, K., Lang, T., Ryan, K., Wilson, R., Skinner, N. A., Thompson, A. J. V., Ahn, S. H., Weilert, F., Abbott, W., Gane, E., Colledge, D., Li, K., Locarnini, S., Mansell, A. & Revill, P. A., 1 Mar 2016, In : Journal of Viral Hepatitis. 23, 3, p. 170-179 10 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2015

BTB-ZF transcriptional regulator PLZF modifies chromatin to restrain inflammatory signaling programs

Sadler, A. J., Rossello, F. J., Yu, L., Deane, J. A., Yuan, X-L., Wang, D., Irving, A. T., Liaskos, M., Gantier, M. P. M., Ying, H., Yim, H. C. H., Hartland, E. L., Notini, A. J., De Boer, C. M., White, S., Mansell, A. S., Liu, J-P., Watkins, D. N., Gerondakis, S. D., Williams, B. R. G. & 1 others, Xu, D., 2015, In : Proceedings of the National Academy of Sciences of the United States of America. 112, 5, p. 1535 - 1540 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
34 Citations (Scopus)

HIV blocks interferon induction in human dendritic cells and macrophages by dysregulation of TBK1

Harman, A. N., Nasr, N., Feetham, A., Galoyan, A., Alshehri, A. A., Rambukwelle, D., Botting, R. A., Hiener, B. M., Diefenbach, E., Diefenbach, R. J., Kim, M., Mansell, A. S. & Cunningham, A. L., 2015, In : Journal of Virology. 89, 13, p. 6575 - 6584 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
47 Citations (Scopus)

Recombinant production of functional full-length and truncated human TRAM/TICAM-2 adaptor protein involved in Toll-like receptor and interferon signaling

Ullah, M. O., Valkov, E., Ve, T., Williams, S., Mas, C., Mansell, A. S. & Kobe, B., 2015, In : Protein Expression and Purification. 106, p. 31 - 40 10 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The acetyltransferase HAT1 moderates the NF-?B response by regulating the transcription factor PLZF

Sadler, A. J., Suliman, B. A., Yu, L., Yuan, X-L., Wang, D., Irving, A. T., Sarvestani, S., Banerjee, A., Mansell, A. S., Liu, J-P., Gerondakis, S. D., Williams, B. R. G. & Xu, D., 2015, In : Nature Communications. 6, 13 (Art. ID: 6795), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
30 Citations (Scopus)
2014

IL-1beta and IL-18: inflammatory markers or mediators of hypertension?

Murali Krishnan, S., Sobey, C. G., Latz, E., Mansell, A. S. & Drummond, G. R., 2014, In : British Journal of Pharmacology. 171, 24, p. 5589 - 5602 14 p.

Research output: Contribution to journalArticleResearchpeer-review

72 Citations (Scopus)

Innate IL-17A-producing leukocytes promote acute kidney injury via inflammasome and Toll-like receptor activation

Chan, A., Alikhan, M., Odobasic, D., Gan, P. Y., Khouri, M., Steinmetz, O., Mansell, A. S., Kitching, A. R., Holdsworth, S. R. & Summers, S. A., 2014, In : American Journal of Pathology. 184, 5, p. 1411 - 1418 8 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

IRF7 in the Australian black flying fox, Pteropus alecto: evidence for a unique expression pattern and functional conservation

Zhou, P. C., Cowled, C., Mansell, A. S., Monaghan, P., Green, D., Wu, L., Shi, Z., Wang, L. & Baker, M. L., 2014, In : PLoS ONE. 9, 8 (Art. ID: e103875), p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
23 Citations (Scopus)

Mechanism of bacterial interference with TLR4 signaling by Brucella Toll/interleukin-1 receptor domain-containing protein TcpB

Alaidarous, M., Ve, T., Casey, L. W., Valkov, E., Ericsson, D. J., Ullah, M. O., Schembri, M. A., Mansell, A. S., Sweet, M. J. & Kobe, B., 2014, In : The Journal of Biological Chemistry. 289, 2, p. 654 - 668 15 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Porphyromonas gingivalis lipopolysaccharide weakly activates M1 and M2 polarized mouse macrophages but induces inflammatory cytokines

Holden, J. A., Attard, T. J., Laughton, K. M., Mansell, A. S., O'Brien-Simpson, N. M. & Reynolds, E. C., 2014, In : Infection and Immunity. 82, 10, p. 4190 - 4203 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
46 Citations (Scopus)

Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation

Dowling, J. K., Becker, C., Bourke, N., Corr, S. C., Connolly, D. J., Quinn, S. R., Pandolfi, P. P., Mansell, A. S. & O'Neill, L. A. J., 2014, In : The Journal of Biological Chemistry. 289, 10, p. 6429 - 6437 9 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Role of caspase-1 in nuclear translocation of IL-37, release of the cytokine, and IL-37 inhibition of innate immune responses

Bulau, A-M., Nold, M. F., Li, S., Nold, C. A., Fink, M., Mansell, A. S., Schwerd, T., Hong, J-W., Rubartelli, A., Dinarello, C. A. & Bufler, P., 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 7, p. 2650 - 2655 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
119 Citations (Scopus)

STAT1 plays a role in TLR signal transduction and inflammatory responses

Luu, K., Greenhill, C. J., Majoros, A., Decker, T., Jenkins, B. J. & Mansell, A. S., 2014, In : Immunology and Cell Biology. 92, 9, p. 761 - 769 9 p.

Research output: Contribution to journalArticleResearchpeer-review

64 Citations (Scopus)

The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4

Verstak, B., Stack, J., Ve, T., Mangan, M., Hjerrild, K., Jeon, J., Stahl, R., Latz, E., Gay, N., Kobe, B., Bowie, A. G. & Mansell, A. S., 2014, In : Journal of leukocyte biology. 96, 3, p. 427 - 436 10 p.

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)
2013

Activation of the NLRP3 inflammasome by IAV virulence protein PB1-F2 contributes to severe pathophysiology and disease

McAuley, J., Tate, M., Mackenzie-kludas, C., Pinar, A., Zeng, W., Stutz, A., Latz, E., Brown, L. E. & Mansell, A. S., 2013, In : PLoS Pathogens. 9, 5 (art. no. e1003392 ), p. 1 - 14 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
114 Citations (Scopus)

A type III effector antagonizes death receptor signalling during bacterial gut infection

Pearson, J. S., Giogha, C., Ong, S. Y., Kennedy, C. L., Kelly, M., Robinson, K. S., Lung, T. W. F., Mansell, A. S., Riedmaier, P., Oates, C. VL., Zaid, A., Muhlen, S., Crepin, V. F., Marches, O., Ang, C-S., Williamson, N. A., O'Reilly, L. A., Bankovacki, A., Nachbur, U., Infusini, G. & 5 others, Webb, A. I., Silke, J., Strasser, A., Frankel, G. M. & Hartland, E. L., 2013, In : Nature. 501, 7466, p. 247-251 5 p.

Research output: Contribution to journalArticleResearchpeer-review

142 Citations (Scopus)

Cloning, expression, purification, crystallization and preliminary X-ray crystallographic analysis of the TIR domain from the Brucella melitensis TIR-domain-containing protein TcpB

Alaidarous, M., Ve, T., Ullah, M. O., Valkov, E., Mansell, A. S., Schembri, M. A., Sweet, M. J. & Kobe, B., 2013, In : Acta Crystallographica. Section F: Structural Biology Communications. 69, 10, p. 1167 - 1170 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Crystallization and X-ray diffraction analysis of the N-terminal domain of the Toll-like receptor signalling adaptor protein TRIF/TICAM-1

Ullah, M. O., Ve, T., Dkhar, J., Alaidarous, M., Ericsson, D. J., Sweet, M. J., Mansell, A. S. & Kobe, B., 2013, In : Acta Crystallographica. Section F: Structural Biology Communications. 69, 7, p. 766 - 770 5 p.

Research output: Contribution to journalArticleResearchpeer-review

2 Citations (Scopus)
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21 Citations (Scopus)
38 Citations (Scopus)

Mitochondria: an unexpected force in innate immunity

Khoo, J., Nagley, P. & Mansell, A. S., 2013, In : Australian Biochemist. 44, 1, p. 17 - 20 4 p.

Research output: Contribution to journalArticleOther

Mitochondrially localised MUL1 is a novel modulator of antiviral signaling

Jenkins, K. A., Khoo, J. J., Sadler, A. J., Piganis, R. A. R., Wang, D., Borg, N., Hjerrild, K., Gould, J. A., Thomas, B., Nagley, P., Hertzog, P. J. & Mansell, A. S., 2013, In : Immunology and Cell Biology. 91, 4, p. 321 - 330 10 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

MyD88 is a critical regulator of hematopoietic cell-mediated neuroprotection seen after stroke

Downes, C. E., Wong, C. H. Y., Henley, K. J., Guio-Aguilar, P. L., Zhang, M., Ates, R., Mansell, A. S., Kile, B. T. & Crack, P. J., 2013, In : PLoS ONE. 8, 3, 8 p., e57948.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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17 Citations (Scopus)

Rotavirus NSP4 triggers secretion of proinflammatory cytokines from macrophages via Toll-Like Receptor 2

Ge, Y., Mansell, A. S., Ussher, J. E., Brooks, A. E. S., Manning, K., Wang, C. J. H. & Taylor, J. A., 2013, In : Journal of Virology. 87, 20, p. 11160 - 11167 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
32 Citations (Scopus)

The TLR signalling adaptor TRIF/TICAM-1 has an N-terminal helical domain with structural similarity to IFIT proteins

Ullah, M. O., Ve, T., Mangan, M., Alaidarous, M., Sweet, M. J., Mansell, A. S. & Kobe, B., 2013, In : Acta Crystallographica Section D: Biological Crystallography. 69, 12, p. 2420 - 2430 11 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

TLR ligands of ryegrass pollen microbial contaminants enhance Th1 and Th2 responses and decrease induction of Foxp3(hi) regulatory T cells

Mittag, D., Varese, N. P., Scholzen, A., Mansell, A. S., Barker, G., Rice, G., Rolland, J. M. & O'Hehir, R. E., 2013, In : European Journal of Immunology. 43, 3, p. 723 - 733 11 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)
2012

Adaptors in toll-like receptor signaling and their potential as therapeutic targets

Ve, T., Gay, N., Mansell, A. S., Kobe, B. & Kellie, S., 2012, In : Current Drug Targets. 13, 11, p. 1360 - 1374 15 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

LPS hypersensitivity of gp130 mutant mice is independent of elevated haemopoietic TLR4 signaling

Greenhill, C. J., Gould, J. A., Ernst, M. R., Jarnicki, A. G., Hertzog, P. J., Mansell, A. S. & Jenkins, B. J., 2012, In : Immunology and Cell Biology. 90, 5, p. 559 - 563 5 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)
2011

Carbonylation caused by cigarette smoke extract is associated with defective macrophage immunity

Bozinovski, S., Vlahos, R., Zhang, Y., Lah, L., Seow, H., Mansell, A. & Anderson, G., 2011, In : American Journal of Respiratory Cell and Molecular Biology. 45, 2, p. 229 - 236 8 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

Valkov, E., Stamp, A., DiMaio, F., Baker, D., Verstak, B., Roversi, P., Kellie, S., Sweet, M., Mansell, A., Gay, N., Martin, J. & Kobe, B., 2011, In : Proceedings of the National Academy of Sciences of the United States of America. 108, 36, p. 14879 - 14884 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
97 Citations (Scopus)

IL-6 trans-signaling modulates TLR4-dependent inflammatory responses via STAT3

Greenhill, C. J., Rose-John, S., Lissilaa, R., Ferlin, W., Ernst, M., Hertzog, P. J., Mansell, A. S. & Jenkins, B. J., 2011, In : Journal of Immunology. 186, 2, p. 1199 - 1208 10 p.

Research output: Contribution to journalArticleResearchpeer-review

141 Citations (Scopus)