Ashley Mansell

Emailashley.mansellhudson.orgau

Accepting PhD Students

PhD projects

Innate Immune immunometabolism: the intersection between metabolism and immunology
Suitability: Honours, PhD
Project leader: A/Prof Ashley Mansell
e: [email protected]
Project description: Recent discoveries have positioned mitochondrial reprogramming by Toll-like receptors (TLRs), at the centre of innate immune inflammation. Immunometabolism describes the interplay between immunological and metabolic processes which are not only critical to the immediate innate immune response to infection, but also the new paradigm of innate memory or training, the concept that myeloid lineage cells can respond more strongly to future challenge via epigenetic reprogramming. We have discovered a role for STAT3 in immunometabolism and how this regulates inflammatory gene induction, mitochondrial health, and metabolism. This project offers the opportunity to explore the molecular dynamics and mechanisms of TLR-induced mitochondrial metabolism, and the temporal influence on transcriptional and epigenetic remodelling using advanced genetic sequencing and metabolomic approaches, in conjunction with novel mouse models of dysfunctional STAT3 signalling and inflammatory disease.
Keywords: Innate immunity, inflammation Toll-like receptors, Pattern Recognition Receptors, cell biology, mitochondria, metabolism

Inflammasomes and how to drug them to treat emerging pandemic viruses
Suitability: Honours, PhD
Project leader: A/Prof Ashley Mansell
e: [email protected]
Project description: The recent and deadly emergence of SARS CoV 2 (COVID-19) has illustrated how unprepared we are for an emerging infectious disease.There is a desperate need to identify and target how these pathogens induce severe and lethal inflammation during infection.
We recently identified and characterised aggregated viral proteins as a novel class of inflammasome activators that induce hyperinflammation characteristic of infections such as avian influenza. We have now identified several proteins that show aggregating potential and inflammasome activation in viruses characterised by excessive inflammation, such as Ebola virus, SARS-coronavirus, dengue virus and picornaviruses. Using novel cell biology methodologies, cell lines, microimaging and gene-deficient mouse models, we will explore the capacity of peptides based on these viral proteins to examine inflammasome activation. This project offers the opportunity to interact with virologists and our collaborators in Bonn, Germany.
Keywords: innate immunity, inflammation, emerging infectious diseases, inflammasome, infectious disease

Research activity per year

1 Active
19 Finished

19 results

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Finished

Potential of the NLRP3 inflammasome as a biomarker and therapeutic target in silicosis
Tate, M. (Primary Chief Investigator (PCI)) & Mansell, A. (Chief Investigator (CI))
Department of Health and Aged Care (Australia)
1/08/21 → 31/07/24
Project: Research
Finding the balance – Reducing inflammation during severe influenza infections
Tate, M. (Primary Chief Investigator (PCI)) & Mansell, A. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/20 → 31/12/22
Project: Research
Targeting the inflammasome; the key to curing Cerebral Palsy?
McDonald, C. (Primary Chief Investigator (PCI)), Dowling, J. (Chief Investigator (CI)), Miller, S. (Chief Investigator (CI)), Mansell, A. (Chief Investigator (CI)), Fahey, M. (Chief Investigator (CI)) & Hodges, R. (Chief Investigator (CI))
Cerebral Palsy Alliance
1/03/18 → 28/02/20
Project: Research
INFLAMMASOMES AND INTERLEUKIN-18 SIGNALLING: NOVEL BIOMARKERS AND THERAPEUTIC TARGETS FOR KIDNEY DISEASE
Drummond, G. (Primary Chief Investigator (PCI)), Hickey, M. (Chief Investigator (CI)), Mansell, A. (Chief Investigator (CI)), Sobey, C. G. (Chief Investigator (CI)) & Vinh, A. (Chief Investigator (CI))
1/01/18 → 31/12/21
Project: Research
Regulation of immune responses in the adult testis and male reproductive health
Hedger, M. (Primary Chief Investigator (PCI)), Loveland, K. (Chief Investigator (CI)), Mansell, A. (Chief Investigator (CI)) & Meinhardt, A. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/17 → 31/12/19
Project: Research
Acquisition of a state-of-the-art confocal microscope for imaging of live and fixed samples
Nold, M. (Primary Chief Investigator (PCI)), Elgass, K. (Chief Investigator (CI)), Hickey, M. (Chief Investigator (CI)), Kitching, R. (Chief Investigator (CI)), Wallace, E. (Chief Investigator (CI)), Nikolic-Paterson, D. (Chief Investigator (CI)), Wong, C. (Chief Investigator (CI)), Loveland, K. (Chief Investigator (CI)), Gargett, C. (Chief Investigator (CI)), Hooper, S. (Chief Investigator (CI)), Ferrero, R. (Chief Investigator (CI)), Lim, R. (Chief Investigator (CI)), Mansell, A. (Chief Investigator (CI)) & Harper, I. (Chief Investigator (CI))
1/12/16 → 31/12/17
Project: Research
Characterization and inhibition of higher-order assembly signalling in Toll-like receptor pathways
Mansell, A. (Primary Chief Investigator (PCI)), Mangan, N. (Chief Investigator (CI)) & Kobe, B. (Partner Investigator (PI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/16 → 31/12/18
Project: Research
PB1-F2 is critical to Influenza A virus pathogenicity through activation of the inflammasome
Mansell, A. (Primary Chief Investigator (PCI)) & McAuley, J. L. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/15 → 30/06/18
Project: Research
Targeting renal and vascular inflammation in hypertension
Drummond, G. (Primary Chief Investigator (PCI)), Latz, E. (Chief Investigator (CI)), Mansell, A. (Chief Investigator (CI)) & Sobey, C. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/14 → 31/12/16
Project: Research
Defining the role of the novel gene MUL1 in antiviral innate immunity
Mansell, A. (Primary Chief Investigator (PCI)) & Hertzog, P. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/14 → 31/12/16
Project: Research
Toll-like receptor and MyD88 signalling in the testis
Hedger, M. (Primary Chief Investigator (PCI)), Mansell, A. (Chief Investigator (CI)) & Meinhardt, A. (Partner Investigator (PI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/11 → 30/04/14
Project: Research
Molecular and structural basis of signalling by TIR domain-containing adaptors in TLR pathways
Mansell, A. (Primary Chief Investigator (PCI)), Gay, N. (Partner Investigator (PI)) & Kobe, B. (Partner Investigator (PI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/11 → 31/12/13
Project: Research
Cross-talk between cytokines and pathogen rcognition receptor networks in the pathogenesis of gastric cancer.
Jenkins, B. (Primary Chief Investigator (PCI)), Ferrero, R. (Chief Investigator (CI)) & Mansell, A. (Chief Investigator (CI))
Worldwide Cancer Research
1/10/08 → 30/09/11
Project: Research
Suppression of Immune Toll-like receptor signaling by Hepatitis B e Antigen (HBeASg)
Mansell, A. (Primary Chief Investigator (PCI)), Locarnini, S. (Chief Investigator (CI)) & Visvanathan, K. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
2/01/08 → 31/12/10
Project: Research
Cross-talk between cytokine and pathogen recognition receptor networks in the pathogenesis of gastric cancer
Jenkins, B. (Primary Chief Investigator (PCI)), Ferrero, R. (Chief Investigator (CI)) & Mansell, A. (Chief Investigator (CI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/08 → 30/06/09
Project: Research
Cross-talk between cytokine and pathogen recognition receptor networks in the pathogenesis of gastric cancer
Jenkins, B. (Primary Chief Investigator (PCI)), Ferrero, R. (Chief Investigator (CI)) & Mansell, A. (Chief Investigator (CI))
Cancer Council Victoria
1/01/08 → 10/12/10
Project: Research
Sanyo Cell Co2 Incubator.
Mansell, A. (Primary Chief Investigator (PCI))
Trust Company (Australia) Limited
2/10/07 → 31/12/07
Project: Research
Negative regulation and immune subversion of Toll-like receptor signaling pathways
Mansell, A. (Primary Chief Investigator (PCI))
NHMRC - National Health and Medical Research Council (Australia)
2/01/07 → 31/12/11
Project: Research
The role of Mal in Toll-like receptor signal transduction of the pro-inflammatory response ID: 334023
Mansell, A. (Primary Chief Investigator (PCI))
NHMRC - National Health and Medical Research Council (Australia)
1/01/05 → 31/12/07
Project: Research

Ashley Mansell

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