Projects per year
Personal profile
Research interests
We combine x-ray crystallography and biophysics with molecular simulation to study the structure, folding and dynamics of proteins, with a particular focus on the design and engineering of proteins for medical and biotechnological application. Our team is a unique and exciting mix of experimentalists and computational biologists using modeling and simulation to make predictions that can be tested in the lab.
Bioinformatics databases we have developed:
Department page | All publications on PubMed | Lab Facebook page | ORCID | Google Scholar
Biography
I completed my PhD in 1994 in the laboratory of Prof Sir Alan Fersht at the University of Cambridge, on the structure determination of protein-DNA and protein-protein complexes. As a postdoc then staff scientist at the MRC Centre Cambridge, I made contributions to the understanding of protein stability, molecular recognition and the action of molecular chaperones. I relocated to Monash University, Australia in 2003 and am currently a group leader in the Department of Biochemistry and Molecular Biology.
A longer bio is here.
Keywords
- Protein design
- Protein Biophysics
- Protein folding
- Protein engineering
- Molecular Dynamics
- Directed evolution
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects 2004 2019
Design and engineering of adnectins for diagnosis and therapy
Buckle, A. M. & Jackson, C.
National Health & Medical Research Council (NHMRC)
1/01/17 → 31/12/19
Project: Research
Investigating the dynamic nature of antibody stability
Australian Research Council (ARC)
1/01/16 → 30/12/18
Project: Research
Design and engineering of proteins for biotechnology and biomedicine
Australian Research Council (ARC), Monash University
1/01/15 → 24/12/18
Project: Research
Beckman Coulter Optima Analytical Ultracentrifuge (AUC)
Dunstone, M. A., Whisstock, J., Daly, R. J., Atkinson, S. C., Turner, S. J., Lithgow, T. J., Gras, S., Stone, M. J., Davidovich, C., Rood, J. I., Coulibaly, F. J., Wilce, J. A., Paxman, N., McGowan, S., Buckle, A. M., Elmlund, D. A., Elmlund, H. O., Belousoff, M. J., Ellisdon, A. M., Law, R. H. P., Purcell, A. W., Cryle, M., Nold, M. F., Nold, C. A., Warr, C., Johnson, T. K., Henstridge, M. A., Aguilar, M. I., Stroud, D. & Ryan, M. T.
1/12/16 → 31/12/17
Project: Research
Research Output 1993 2018
Genetic variation affecting DNA methylation and the human imprinting disorder, Beckwith-Wiedemann syndrome
Dagar, V. , Hutchison, W. , Muscat, A. , Krishnan, A. , Hoke, D. , Buckle, A. , Siswara, P. , Amor, D. J. , Mann, J. , Pinner, J. , Colley, A. , Wilson, M. , Sachdev, R. , McGillivray, G. , Edwards, M. , Kirk, E. , Collins, F. , Jones, K. , Taylor, J. , Hayes, I. & 14 others 30 Aug 2018 In : Clinical Epigenetics. 10, 1, 13 p., 114Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Laboratory evolution of protein conformational dynamics
Campbell, E. C., Correy, G. J., Mabbitt, P. D., Buckle, A. M., Tokiriki, N. & Jackson, C. J. 1 Jun 2018 In : Current Opinion in Structural Biology. 50, p. 49-57 9 p.Research output: Contribution to journal › Review Article › Research › peer-review
Previously hidden dynamics at the TCR-peptide-MHC interface revealed
Fodor, J., Riley, B. T., Borg, N. A. & Buckle, A. M. 15 Jun 2018 In : Journal of Immunology. 200, 12, p. 4134-4145 12 p.Research output: Contribution to journal › Article › Research › peer-review
Recognition by host nuclear transport proteins drives disorder-to-order transition in Hendra virus v
Atkinson, S. C., Audsley, M. D., Lieu, K. G., Marsh, G. A., Thomas, D. R., Heaton, S. M., Paxman, J. J., Wagstaff, K. M., Buckle, A. M., Moseley, G. W., Jans, D. A. & Borg, N. A. 10 Jan 2018 In : Scientific Reports. 8, 1, 17 p., 358Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Structural Capacitance in Protein Evolution and Human Diseases
Li, C., Clark, L. V. T., Zhang, R., Porebski, B. T., McCoey, J. M., Borg, N. A., Webb, G. I., Kass, I., Buckle, M., Song, J., Woolfson, A. & Buckle, A. M. 14 Sep 2018 In : Journal of Molecular Biology. 430, 18, p. 3200-3217 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
Press / Media
The inaugural Monash Biomedicine Discovery Institute (BDI) Industry Showcase event
Ashley Maurice Buckle & Peter Geoffrey Chandler
15/11/17
1 item of media coverage
Press/Media: Research
'Jekyll and Hyde' protein linked to type 1 diabetes
10/06/14
1 item of media coverage
Press/Media: Research
Sewer to saviour, PlyC is back
Ashley Maurice Buckle & Sheena McGowan
1/02/13
1 item of media coverage
Press/Media: Research
Monash scientists score breakthrough on non-antibiotic bug killer
Ashley Maurice Buckle & Sheena McGowan
29/07/12
1 item of media coverage
Press/Media: Research