1993 …2019
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Personal profile

Research interests

We combine x-ray crystallography and biophysics with molecular simulation to study the structure, folding and dynamics of proteins, with a particular focus on the design and engineering of proteins for medical and biotechnological application. Our team is a unique and exciting mix of experimentalists and computational biologists using modeling and simulation to make predictions that can be tested in the lab.

Bioinformatics databases we have developed:

REFOLD

Mustang-MR

PolyQ

KinetochoreDB

MyTardis

Store.Synchrotron

 

Department pageAll publications on PubMed | Lab Facebook page | ORCID | Google Scholar

Biography

I completed my PhD in 1994 in the laboratory of Prof Sir Alan Fersht at the University of Cambridge, on the structure determination of protein-DNA and protein-protein complexes. As a postdoc then staff scientist at the MRC Centre Cambridge, I made contributions to the understanding of protein stability, molecular recognition and the action of molecular chaperones. I relocated to Monash University, Australia in 2003 and am currently a group leader in the Department of Biochemistry and Molecular Biology

 A longer bio is here.

 

Keywords

  • Protein design
  • Protein Biophysics
  • Protein folding
  • Protein engineering
  • Molecular Dynamics
  • Directed evolution

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Projects 2004 2019

Research Output 1993 2019

KLK4 Inhibition by Cyclic and Acyclic Peptides: Structural and Dynamical Insights into Standard-Mechanism Protease Inhibitors

Riley, B. T., Ilyichova, O., De Veer, S. J., Swedberg, J. E., Wilson, E., Hoke, D. E., Harris, J. M. & Buckle, A. M., 28 May 2019, In : Biochemistry. 58, 21, p. 2524-2533 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif

Chen, X., Riley, B. T., De Veer, S. J., Hoke, D. E., Van Haeften, J., Leahy, D., Swedberg, J. E., Brattsand, M., Hartfield, P. J., Buckle, A. M. & Harris, J. M., 22 Jan 2019, In : PLoS ONE. 14, 1, 15 p., e0210842.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Prostate cancer risk-associated single-nucleotide polymorphism affects prostate-specific antigen glycosylation and its function

Srinivasan, S., Stephens, C., Wilson, E., Panchadsaram, J., DeVoss, K., Koistinen, H., Stenman, U. H., Brook, M. N., on behalf of the PRACTICAL consortium, Buckle, A. M., Klein, R. J., Lilja, H., Clements, J. & Batra, J., 1 Jan 2019, In : Clinical Chemistry. 65, 1, p. E1-E9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Protein engineering: the potential of remote mutations

Wilding, M., Hong, N., Spence, M., Buckle, A. M. & Jackson, C. J., Apr 2019, In : Biochemical Society Transactions. 47, 2, p. 701-711 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Reactive centre loop dynamics and serpin specificity

Marijanovic, E. M., Fodor, J., Riley, B. T., Porebski, B. T., Costa, M. G. S., Kass, I., Hoke, D. E., McGowan, S. & Buckle, A. M., 7 Mar 2019, In : Scientific Reports. 9, 1, 15 p., 3870.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File

Press / Media

The spark that created life

Ashley Buckle

12/09/18

1 item of media coverage

Press/Media: Blogs, Podcasts and Social MediaSocial Media Article

The spark that created life

Ashley Buckle

12/09/18

1 item of media coverage

Press/Media: Article/Feature

The spark that created life

Ashley Buckle

12/09/18

1 item of media coverage

Press/Media: Blogs, Podcasts and Social MediaSocial Media Article

The inaugural Monash Biomedicine Discovery Institute (BDI) Industry Showcase event

Ashley Buckle & Peter Geoffrey Chandler

15/11/17

1 item of media coverage

Press/Media: Research