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Personal profile

Biography

Dr. Ashish Banerjee is an Immunologist interested in autoimmune and inflammatory diseases. He received his PhD from the world renowned Indian Institute of Science in Bangalore, India. Subsequently, he moved to Melbourne for his post-doctoral studies which involved understanding the cross talk between NF-kB and MAP kinase signalling pathways in immune cells. His work unravelled a novel link between NF-kB and ERK signalling that controls inflammation and cell survival in macrophages and B cells respectively.

Regulatory T cells: "Dr. Jekyll and Mr. Hyde" of the Immune system

Dr. Banerjee is currently studying Regulatory T cells (Tregs), which are a specialised subset of blood cells essential for the maintenance of immune homeostasis. Mice and humans that lack Tregs suffer from an early-onset, multi-organ fatal inflammatory disease. Although Tregs play a pivotal role in preventing autoimmune disease and limiting chronic inflammation, they also impair beneficial responses by impairing sterilising immunity to certain pathogens and by limiting anti-tumour immunity. Given their key function in the immune system, it is imperative to understand how Treg numbers and function are controlled. The NF-kB family of transcription factors have been identified as major players in Treg development and function. In close collaboration with Dr. George Grigoriadis we are trying to understand the precise role of NF-kB in Tregs.

As therapeutic agents that impact upon the NF-kB pathway are increasingly being utilised in the treatment of a diverse spectrum of diseases, research into how these drugs may impact on Treg differentiation, function or stability is urgently needed. We anticipate that our findings will be beneficial to clinical practice and will help formulate novel therapeutic strategies to usefully manipulate Tregs in human disease.

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Projects 2013 2018

Research Output 2006 2016

NFκB1 is essential to prevent the development of multiorgan autoimmunity by limiting IL-6 production in follicular B cells

de Valle, E., Grigoriadis, G., O'Rielly, L. A., Willis, S. N., Maxwell, M. J., Corcoran, L. M., Tsantikos, E., Cornish, J. K. S., Fairfax, K. A., Vasanthakumar, A., Febbraio, M. A., Hibbs, M. L., Pellegrini, M., Banerjee, A., Hodgkin, P. D., Kallies, A., Mackay, F., Strasser, A., Gerondakis, S. & Gugasyan, R., 4 Apr 2016, In : Journal of Experimental Medicine. 213, 4, p. 621-641 21 p., PMC4821646.

Research output: Contribution to journalArticleResearchpeer-review

The SMAC mimetic, LCL-161, reduces survival in aggressive MYC-driven lymphoma while promoting susceptibility to endotoxic shock

West, A. C., Martin, B. P., Andrews, D. A., Hogg, S. J., Banerjee, A., Grigoriadis, G., Johnstone, R. W. & Shortt, J., 4 Apr 2016, In : Oncogenesis. 5, 6 p., e216.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Controlling the fire--tissue-specific mechanisms of effector regulatory T-cell homing

Chow, Z., Banerjee, A. & Hickey, M. J., 2015, In : Immunology and Cell Biology. 93, 4, p. 355 - 363 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The acetyltransferase HAT1 moderates the NF-?B response by regulating the transcription factor PLZF

Sadler, A. J., Suliman, B. A., Yu, L., Yuan, X-L., Wang, D., Irving, A. T., Sarvestani, S., Banerjee, A., Mansell, A. S., Liu, J-P., Gerondakis, S. D., Williams, B. R. G. & Xu, D., 2015, In : Nature Communications. 6, 13 (Art. ID: 6795), p. 1 - 11 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access