1993 …2020

Research output per year

If you made any changes in Pure these will be visible here soon.

Research Output

Filter
Review Article
2018

Mechanisms of signalling and biased agonism in G protein-coupled receptors

Wootten, D. L., Christopoulos, A., Marti-Solano, M., Babu, M. M. & Sexton, P. M., Oct 2018, In : Nature Reviews Molecular Cell Biology. 19, 10, p. 638-653 16 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
79 Citations (Scopus)

New paradigms in adenosine receptor pharmacology: allostery, oligomerization and biased agonism

Vecchio, E. A., Baltos, J. A., Nguyen, A. T. N., Christopoulos, A., White, P. J. & May, L. T., 1 Nov 2018, In : British Journal of Pharmacology. 175, 21, p. 4036-4046 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

15 Citations (Scopus)

Rules of Engagement: GPCRs and G Proteins

Glukhova, A., Draper-Joyce, C. J., Sunahara, R. K., Christopoulos, A., Wootten, D. L. & Sexton, P. M., 7 Sep 2018, In : ACS Pharmacology & Translational Science. 1, 2, p. 73-83 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Strength in numbers - An arrestin interaction code

Draper-Joyce, C. J. & Christopoulos, A., 1 Jun 2018, In : Nature Structural & Molecular Biology. 25, 6, p. 437-439 3 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Structural insights into G-protein-coupled receptor allostery

Thal, D. M., Glukhova, A., Sexton, P. M. & Christopoulos, A., 5 Jul 2018, In : Nature. 559, 7712, p. 45-53 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

76 Citations (Scopus)
2017

A kinetic view of GPCR allostery and biased agonism

Lane, J. R., May, L. T., Parton, R. G., Sexton, P. M. & Christopoulos, A., 18 Aug 2017, In : Nature Chemical Biology. 13, 9, p. 929-937 9 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
53 Citations (Scopus)

Allosteric modulation as a unifying mechanism for receptor function and regulation

Changeux, J-P. & Christopoulos, A., 1 Sep 2017, In : Diabetes, Obesity and Metabolism. 19, p. 4-21 18 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Open Access
File
17 Citations (Scopus)

Allostery and Biased Agonism at Class B G Protein-Coupled Receptors

Wootten, D., Miller, L. J., Koole, C., Christopoulos, A. & Sexton, P. M., 11 Jan 2017, In : Chemical Reviews. 117, 1, p. 111-138 28 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

40 Citations (Scopus)
2016

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation

Changeux, J. P. & Christopoulos, A., 25 Aug 2016, In : Cell. 166, 5, p. 1084-1102 19 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

98 Citations (Scopus)
2015

The Concise Guide to PHARMACOLOGY 2015/16: Overview

CGTP Collaborators, 1 Dec 2015, In : British Journal of Pharmacology. 172, 24, p. 5729-5743 15 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

Open Access
File
152 Citations (Scopus)
2009

Orthosteric/allosteric bitopic ligands going hybrid with GPCRs

Valant, C., Sexton, P. M. & Christopoulos, A., 1 Jun 2009, In : Molecular Interventions. 9, 3, p. 125-135 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

69 Citations (Scopus)
2004

Allosteric modulation of G protein-coupled receptors

May, L. T., Avlani, V. A., Sexton, P. M. & Christopoulos, A., 2004, In : Current Pharmaceutical Design. 10, 17, p. 2003-2013 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

72 Citations (Scopus)
2003

Allosteric modulators of G-protein-coupled receptors

May, L. T. & Christopoulos, A., Oct 2003, In : Current Opinion in Pharmacology. 3, 5, p. 551-556 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

65 Citations (Scopus)

Cellular signaling mechanisms for muscarinic acetylcholine receptors

Lanzafame, A. A., Christopoulos, A. & Mitchelson, F., 15 Sep 2003, In : Receptors and Channels. 9, 4, p. 241-260 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

105 Citations (Scopus)

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology

Neubig, R. R., Spedding, M., Kenakin, T. & Christopoulos, A., 1 Dec 2003, In : Pharmacological Reviews. 55, 4, p. 597-606 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

355 Citations (Scopus)
2002

Allosteric binding sites on cell-surface receptors: Novel targets for drug discovery

Christopoulos, A., 1 Mar 2002, In : Nature Reviews Drug Discovery. 1, 3, p. 198-210 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

502 Citations (Scopus)
2000

Beyond eyeballing: Fitting models to experimental data

Christopoulos, A. & Lew, M. J., 1 Jan 2000, In : Critical Reviews in Biochemistry and Molecular Biology. 35, 5, p. 359-391 33 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

27 Citations (Scopus)

Dynamic mechanisms of non-classical antagonism by competitive AT1 receptor antagonists

Lew, M. J., Ziogas, J. & Christopoulos, A., 1 Oct 2000, In : Trends in Pharmacological Sciences. 21, 10, p. 376-381 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

43 Citations (Scopus)
1999

Qualitative and quantitative assessment of relative agonist efficacy

Christopoulos, A. & El-Fakahany, E. E., 1 Sep 1999, In : Biochemical Pharmacology. 58, 5, p. 735-748 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

43 Citations (Scopus)
1998

Minireview: The generation of nitric oxide by G protein-coupled receptors

Christopoulos, A. & El-Fakahany, E. E., 27 Nov 1998, In : Life Sciences. 64, 1, p. 1-15 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

42 Citations (Scopus)