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Research Output 1993 2019

Effects of anandamide on the binding and signaling properties of M 1 muscarinic acetylcholine receptors

Lanzafame, A. A., Guida, E. & Christopoulos, A., 1 Dec 2004, In : Biochemical Pharmacology. 68, 11, p. 2207-2219 13 p.

Research output: Contribution to journalArticleResearchpeer-review

G-protein-coupled receptor allosterism: the promise and the problem(s)

Christopoulos, A., May, L. T., Avlani, V. A. & Sexton, P. M., 2004, In : Biochemical Society Transactions. 32, Pt 5, p. 873 - 877 5 p.

Research output: Contribution to journalArticleOther

Preface

Sexton, P. M. & Christopoulos, A., 12 Jul 2004, In : Current Pharmaceutical Design. 10, 17, p. xxx 1 p.

Research output: Contribution to journalEditorialOtherpeer-review

Regulation of serotonin 5-HT{2C} receptors by chronic ligand exposure

Devlin, M. G., Smith, N. J., Ryan, O. M., Guida, E., Sexton, P. M. & Christopoulos, A., 2004, In : European Journal of Pharmacology. 498, 1-3, p. 59 - 69 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Allosteric modulators of G-protein-coupled receptors

May, L. T. & Christopoulos, A., Oct 2003, In : Current Opinion in Pharmacology. 3, 5, p. 551-556 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Cellular signaling mechanisms for muscarinic acetylcholine receptors

Lanzafame, A. A., Christopoulos, A. & Mitchelson, F., 15 Sep 2003, In : Receptors and Channels. 9, 4, p. 241-260 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Guest editor's introduction

Christopoulos, A., 15 Sep 2003, In : Receptors and Channels. 9, 4, p. 213-214 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology

Neubig, R. R., Spedding, M., Kenakin, T. & Christopoulos, A., 1 Dec 2003, In : Pharmacological Reviews. 55, 4, p. 597-606 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Novel receptor partners and function of receptor activity-modifying proteins

Christopoulos, A., Christopoulos, G., Morfis, M., Udawela, M., Laburthe, M., Couvineau, A., Kuwasako, K., Tilakaratne, N. & Sexton, P. M., 2003, In : Journal of Biological Chemistry. 278, 5, p. 3293 - 3297 5 p.

Research output: Contribution to journalArticleResearchpeer-review

RAMPs: 5 years on, where to now?

Morfis, M., Christopoulos, A. & Sexton, P., 2003, In : Trends in Pharmacological Sciences. 24, 11, p. 596 - 601 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Allosteric binding sites on cell-surface receptors: Novel targets for drug discovery

Christopoulos, A., 1 Mar 2002, In : Nature Reviews Drug Discovery. 1, 3, p. 198-210 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Darifenacin reveals a functional role for M4 muscarinic acetylcholine receptors in guinea pig gallbladder

Akici, A., Nacak, M., Christopoulos, A. & Oktay, Ş., 1 Oct 2002, In : Marmara Medical Journal. 15, 4, p. 248-252 5 p.

Research output: Contribution to journalArticleResearchpeer-review

G protein-coupled receptor allosterism and complexing

Christopoulos, A. & Kenakin, T., 2002, In : Pharmacological Reviews. 54, 2, p. 323 - 374 52 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulation of cannabinoid agonist binding by 5-HT in the rat cerebellum

Devlin, M. G. & Christopoulos, A., 5 Aug 2002, In : Journal of Neurochemistry. 80, 6, p. 1095-1102 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Reversible and specific extracellular antagonism of receptor-histidine kinase signaling

Lyon, G. J., Wright, J. S., Christopoulos, A., Novick, R. P. & Muir, T. W., 2002, In : Journal of Biological Chemistry. 277, 8, p. 6247 - 6253 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

From "captive" agonism to insurmountable antagonism: Demonstrating the power of analytical pharmacology

Christopoulos, A., 15 Mar 2001, In : Clinical and Experimental Pharmacology and Physiology. 28, 3, p. 223-229 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Insurmountable AT1 receptor antagonism: Message in a model? [2]

Lew, M., Christopoulos, A. & Ziogas, J., 1 Nov 2001, In : Trends in Pharmacological Sciences. 22, 11, p. 555-557 3 p.

Research output: Contribution to journalLetterOtherpeer-review

Interaction of anandamide with the M 1 and M 4 muscarinic acetylcholine receptors

Christopoulos, A. & Wilson, K., 5 Oct 2001, In : Brain Research. 915, 1, p. 70-78 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Non-surmountable antagonism: Transcending steady state [3]

Lew, M. J., Christopoulos, A. & Ziogas, J., 1 Feb 2001, In : Trends in Pharmacological Sciences. 22, 2, p. 65-66 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens

Christopoulos, A., Coles, P., Lay, L., Lew, M. J. & Angus, J. A., 1 Jan 2001, In : British Journal of Pharmacology. 132, 6, p. 1281-1291 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists

Christopoulos, A., Grant, M. K. O., Ayoubzadeh, N., Kim, O. N., Sauerberg, P., Jeppesen, L. & El-Fakahany, E. E., 29 Aug 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 3, p. 1260-1268 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea-pig atria

Lanzafame, A., Christopoulos, A. & Mitchelson, F. J., 2001, In : European Journal of Pharmacology. 416, p. 235 - 244 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Beyond eyeballing: Fitting models to experimental data

Christopoulos, A. & Lew, M. J., 1 Jan 2000, In : Critical Reviews in Biochemistry and Molecular Biology. 35, 5, p. 359-391 33 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Beyond eyeballing: Fitting models to experimental data

Christopoulos, A. & Lew, M. J., 1 Jan 2000, Biomedical Applications of Computer Modeling. CRC Press, p. 195-232 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Biomedical applications of computer modeling

Christopoulos, A. (ed.), 1 Jan 2000, 1st ed. Boca Raton: CRC Press. 240 p.

Research output: Book/ReportEdited BookOtherpeer-review

Dynamic mechanisms of non-classical antagonism by competitive AT1 receptor antagonists

Lew, M. J., Ziogas, J. & Christopoulos, A., 1 Oct 2000, In : Trends in Pharmacological Sciences. 21, 10, p. 376-381 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Further evidence for the heterogeneity of functional muscarinic receptors in guinea pig gallbladder

Akici, A., Karaalp, A., Iskender, E., Christopoulos, A., El-Fakahany, E. E. & Oktay, Ş., 24 Jan 2000, In : European Journal of Pharmacology. 388, 1, p. 115-123 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Preface

Christopoulos, A., 1 Jan 2000, Biomedical Applications of Computer Modeling. 1st ed. Boca Raton: CRC Press, p. vii 1 p.

Research output: Chapter in Book/Report/Conference proceedingForeword / PostscriptOtherpeer-review

Transducer abstraction - A novel approach to the detection of partial agonist efficacy in radioligand binding studies

Christopoulos, A., Grant, M. K. O. & El-Fakahany, E. E., 4 Dec 2000, In : Journal of Pharmacological and Toxicological Methods. 43, 1, p. 55-67 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

Characterization of the subtype selectivity of the all osteric modulator heptan-1,7-bis-(dimethyl-3'- phthalimidopropl)ammonium bromide(C7/3-phth)at cloned muscarine acetycholine receptors

Christopoulos, A., Sorman, J. L., Mitchelson, F. J. & El-Fakahany, E. E., 1999, In : Biochemical Pharmacology. p. 171 - 179 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the subtype selectivity of the allosteric modulator heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl) ammonium bromide (c7/3-phth) at cloned muscarinic acetylcholine receptors

Christopoulos, A., Sorman, J. L., Mitchelson, F. & El-Fakahany, E. E., 15 Jan 1999, In : Biochemical Pharmacology. 57, 2, p. 171-179 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor

Christopoulos, A., Parsons, A. M. & El-Fakahany, E. E., 1 Jun 1999, In : Journal of Pharmacology and Experimental Therapeutics. 289, 3, p. 1220-1228 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Qualitative and quantitative assessment of relative agonist efficacy

Christopoulos, A. & El-Fakahany, E. E., 1 Sep 1999, In : Biochemical Pharmacology. 58, 5, p. 735-748 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Regulation of acetylcholine binding by ATP at the muscarinic M1 receptor in intact CHO cells

Grant, M. K. O., Christopoulos, A. & El-Fakahany, E. E., 21 Aug 1999, In : Brain Research. 839, 1, p. 94-99 6 p.

Research output: Contribution to journalArticleResearchpeer-review

The assessment of antagonist potency under conditions of transient response kinetics

Christopoulos, A., Parsons, A. M., Lew, M. J. & El-Fakahany, E. E., 15 Oct 1999, In : European Journal of Pharmacology. 382, 3, p. 217-227 11 p.

Research output: Contribution to journalArticleResearchpeer-review

1998

Allosteric interactions at muscarinic cholinoceptors

Christopoulos, A., Lanzafame, A. & Mitchelson, F. J., 1998, In : Clinical and Experimental Pharmacology and Physiology. p. 185 - 194 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Assessing the distribution of parameters in models of ligand-receptor interaction: To log or not to log

Christopoulos, A., 1 Sep 1998, In : Trends in Pharmacological Sciences. 19, 9, p. 351-357 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the subtype selectivity of the allosteric modulator, C7/ 3 - PHTH, at cloned muscarinic acetylcholine receptors

El-Fakahany, E. E., Christopoulos, A., Sorman, J. L. & Mitchelson, F. J., 1998, p. 14 - 14. 1 p.

Research output: Contribution to conferenceAbstractOther

Minireview: The generation of nitric oxide by G protein-coupled receptors

Christopoulos, A. & El-Fakahany, E. E., 27 Nov 1998, In : Life Sciences. 64, 1, p. 1-15 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor

Christopoulos, A., Pierce, T. L., Sorman, J. L. & El-Fakahany, E. E., 1 Jun 1998, In : Molecular Pharmacology. 53, 6, p. 1120-1130 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The interaction of otenzepad (AF- DX 116) with allosteric modulators and competitive antagonists at a muscarinic M2 receptor

Mitchelson, F. J., Lanzafame, A. & Christopoulos, A., 1998, p. 9 - 9. 1 p.

Research output: Contribution to conferenceAbstractOther

Use of a spreadsheet to quantitate the equilibrium binding of an allosteric modulator

Christopoulos, A. & Mitchelson, F. J., 1998, In : European Journal of Pharmacology. p. 103 - 111 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1997

A common site of action for two allosteric antagonists

Christopoulos, A., Lanzafame, A. & Mitchelson, F. J., 1997, p. 1173 - 1173. 1 p.

Research output: Contribution to conferenceAbstractOther

Application of an allosteric ternary complex model to the technique of pharmacological resultant analysis

Christopoulos, A. & Mitchelson, F., 1997, In : Journal of Pharmacy and Pharmacology. p. 781 - 786 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction of ebeinone, an alkaloid from Fritellaria imperialis, at two muscarinic acetylcholine receptor subtypes

Gilani, A. H., Shaheen, F., Christopoulos, A. & Mitchelson, F., 17 Jan 1997, In : Life Sciences. 60, 8, p. 535-544 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction of ebeinone, an alkaloid from Fritillaria imperialis, at two muscrinic acetylcholine receptor subtypes

Gilani, A. H., Shaheen, F., Christopoulos, A. & Mitchelson, F. J., 1997, In : Life Sciences. p. 535 - 544 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Kinetic studies of co-operativity at atrial muscarinic M2 receptors with an 'infinite dilution' procedure

Christopoulos, A., Lanzafame, A., Ziegler, A. & Mitchelson, F., 21 Mar 1997, In : Biochemical Pharmacology. 53, 6, p. 795-800 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Novel persistent activation of muscarinic M1 receptors by xanomeline

Christopoulos, A. & El-Fakahany, E. E., 3 Sep 1997, In : European Journal of Pharmacology. 334, 1, p. R3-R4 2 p.

Research output: Contribution to journalArticleOtherpeer-review