1993 …2023
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Research Output 1993 2019

2006

Interaction studies of multiple binding sites on M4 muscarinic acetylcholine receptors

Lanzafame, A. A., Sexton, P. M. & Christopoulos, A., 2006, In : Molecular Pharmacology. 70, 2, p. 736 - 746 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Mechanisms of ERK1/2 regulation by seven-transmembrane-domain receptors

Werry, T. D., Christopoulos, A. & Sexton, P. M., 2006, In : Current Pharmaceutical Design. 12, 14, p. 1683 - 1702 20 p.

Research output: Contribution to journalArticleResearchpeer-review

Non-classical modes of signaling by 5HT(2C) receptors

Christopoulos, A., 2006, p. 55 - 55. 1 p.

Research output: Contribution to conferenceAbstractOther

On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2

Mathiesen, J. M., Christopoulos, A., Ulven, T., Royer, J. F., Campillo, M., Heinemann, A., Pardo, L. & Kostenis, E., 2006, In : Molecular Pharmacology. 69, 4, p. 1441 - 1453 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2- methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M1 receptor: Direct pharmacological evidence that AC-42 is an allosteric agonist

Langmead, C. J., Fry, V. A., Forbes, I. T., Branch, C. L., Christopoulos, A., Wood, M. D. & Herdon, H. J., 2006, In : Molecular Pharmacology. 69, 1, p. 236 - 246 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2005

Allosteric modulation of the cannabinoid CB1 receptor

Price, M. R., Baillie, G. L., Thomas, A., Stevenson, L. A., Easson, M., Goodwin, R., McLean, A., McIntosh, L., Goodwin, G., Walker, G., Westwood, P., Marrs, J., Thomson, F., Cowley, P., Christopoulos, A., Pertwee, R. G. & Ross, R. A., 2005, In : Molecular Pharmacology. 68, 5, p. 1484 - 1495 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2

Werry, T. D., Gregory, K. J., Sexton, P. M. & Christopoulos, A., 2005, In : Journal of Neurochemistry. 93, p. 1603 - 1615 13 p.

Research output: Contribution to journalArticleResearchpeer-review

Editorial

Christopoulos, A., 1 Jun 2005, In : Mini-Reviews in Medicinal Chemistry. 5, 6, p. 521-521 1 p.

Research output: Contribution to journalEditorialOtherpeer-review

Effects of urea pretreatment on the binding properties of adenosine A 1 receptors

May, L. T., Sexton, P. M. & Christopoulos, A., 2005, In : British Journal of Pharmacology. 146, 8, p. 1119 - 1129 11 p.

Research output: Contribution to journalArticleResearchpeer-review

G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor

Kostenis, E., Milligan, G., Christopoulos, A., Sanchez-Ferrer, C. F., Heringer-Walther, S., Sexton, P. M., Gembardt, F., Kellett, E., Martini, L., Vanderheyden, P., Schultheiss, H-P. & Walther, T., 2005, In : Circulation. 111, p. 1806 - 1813 8 p.

Research output: Contribution to journalArticleResearchpeer-review

'Ins and outs' of seven-transmembrane receptor signalling to ERK

Werry, T. D., Sexton, P. M. & Christopoulos, A., 2005, In : Trends in Endocrinology and Metabolism. 16, 1, p. 26 - 33 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes

Hay, D. L., Christopoulos, G., Christopoulos, A., Poyner, D. R. & Sexton, P. M., 2005, In : Molecular Pharmacology. 67, 5, p. 1655 - 1665 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2004

Allosteric modulation of G protein-coupled receptors

May, L. T., Avlani, V. A., Sexton, P. & Christopoulos, A., 2004, In : Current Pharmaceutical Design. 10, 17, p. 2003 - 2013 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Allosteric modulation of G protein-coupled receptors

May, L. T., Avlani, V. A., Sexton, P. M. & Christopoulos, A., 2004, In : Current Pharmaceutical Design. 10, 17, p. 2003-2013 11 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Amylin receptors: Molecular composition and pharmacology

Hay, D. L., Christopoulos, G., Christopoulos, A. & Sexton, P., 2004, In : Biochemical Society Transactions. 32, Pt 5, p. 865 - 867 3 p.

Research output: Contribution to journalArticleOther

Effects of anandamide on the binding and signaling properties of M 1 muscarinic acetylcholine receptors

Lanzafame, A. A., Guida, E. & Christopoulos, A., 1 Dec 2004, In : Biochemical Pharmacology. 68, 11, p. 2207-2219 13 p.

Research output: Contribution to journalArticleResearchpeer-review

G-protein-coupled receptor allosterism: the promise and the problem(s)

Christopoulos, A., May, L. T., Avlani, V. A. & Sexton, P. M., 2004, In : Biochemical Society Transactions. 32, Pt 5, p. 873 - 877 5 p.

Research output: Contribution to journalArticleOther

Preface

Sexton, P. M. & Christopoulos, A., 12 Jul 2004, In : Current Pharmaceutical Design. 10, 17, p. xxx 1 p.

Research output: Contribution to journalEditorialOtherpeer-review

Regulation of serotonin 5-HT{2C} receptors by chronic ligand exposure

Devlin, M. G., Smith, N. J., Ryan, O. M., Guida, E., Sexton, P. M. & Christopoulos, A., 2004, In : European Journal of Pharmacology. 498, 1-3, p. 59 - 69 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2003

Allosteric modulators of G-protein-coupled receptors

May, L. T. & Christopoulos, A., Oct 2003, In : Current Opinion in Pharmacology. 3, 5, p. 551-556 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Cellular signaling mechanisms for muscarinic acetylcholine receptors

Lanzafame, A. A., Christopoulos, A. & Mitchelson, F., 15 Sep 2003, In : Receptors and Channels. 9, 4, p. 241-260 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Guest editor's introduction

Christopoulos, A., 15 Sep 2003, In : Receptors and Channels. 9, 4, p. 213-214 2 p.

Research output: Contribution to journalEditorialOtherpeer-review

International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification. XXXVIII. Update on Terms and Symbols in Quantitative Pharmacology

Neubig, R. R., Spedding, M., Kenakin, T. & Christopoulos, A., 1 Dec 2003, In : Pharmacological Reviews. 55, 4, p. 597-606 10 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Novel receptor partners and function of receptor activity-modifying proteins

Christopoulos, A., Christopoulos, G., Morfis, M., Udawela, M., Laburthe, M., Couvineau, A., Kuwasako, K., Tilakaratne, N. & Sexton, P. M., 2003, In : Journal of Biological Chemistry. 278, 5, p. 3293 - 3297 5 p.

Research output: Contribution to journalArticleResearchpeer-review

RAMPs: 5 years on, where to now?

Morfis, M., Christopoulos, A. & Sexton, P., 2003, In : Trends in Pharmacological Sciences. 24, 11, p. 596 - 601 6 p.

Research output: Contribution to journalArticleResearchpeer-review

2002

Allosteric binding sites on cell-surface receptors: Novel targets for drug discovery

Christopoulos, A., 1 Mar 2002, In : Nature Reviews Drug Discovery. 1, 3, p. 198-210 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Darifenacin reveals a functional role for M4 muscarinic acetylcholine receptors in guinea pig gallbladder

Akici, A., Nacak, M., Christopoulos, A. & Oktay, Ş., 1 Oct 2002, In : Marmara Medical Journal. 15, 4, p. 248-252 5 p.

Research output: Contribution to journalArticleResearchpeer-review

G protein-coupled receptor allosterism and complexing

Christopoulos, A. & Kenakin, T., 2002, In : Pharmacological Reviews. 54, 2, p. 323 - 374 52 p.

Research output: Contribution to journalArticleResearchpeer-review

Modulation of cannabinoid agonist binding by 5-HT in the rat cerebellum

Devlin, M. G. & Christopoulos, A., 5 Aug 2002, In : Journal of Neurochemistry. 80, 6, p. 1095-1102 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Reversible and specific extracellular antagonism of receptor-histidine kinase signaling

Lyon, G. J., Wright, J. S., Christopoulos, A., Novick, R. P. & Muir, T. W., 2002, In : Journal of Biological Chemistry. 277, 8, p. 6247 - 6253 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2001

From "captive" agonism to insurmountable antagonism: Demonstrating the power of analytical pharmacology

Christopoulos, A., 15 Mar 2001, In : Clinical and Experimental Pharmacology and Physiology. 28, 3, p. 223-229 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Insurmountable AT1 receptor antagonism: Message in a model? [2]

Lew, M., Christopoulos, A. & Ziogas, J., 1 Nov 2001, In : Trends in Pharmacological Sciences. 22, 11, p. 555-557 3 p.

Research output: Contribution to journalLetterOtherpeer-review

Interaction of anandamide with the M 1 and M 4 muscarinic acetylcholine receptors

Christopoulos, A. & Wilson, K., 5 Oct 2001, In : Brain Research. 915, 1, p. 70-78 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Non-surmountable antagonism: Transcending steady state [3]

Lew, M. J., Christopoulos, A. & Ziogas, J., 1 Feb 2001, In : Trends in Pharmacological Sciences. 22, 2, p. 65-66 2 p.

Research output: Contribution to journalLetterOtherpeer-review

Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens

Christopoulos, A., Coles, P., Lay, L., Lew, M. J. & Angus, J. A., 1 Jan 2001, In : British Journal of Pharmacology. 132, 6, p. 1281-1291 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists

Christopoulos, A., Grant, M. K. O., Ayoubzadeh, N., Kim, O. N., Sauerberg, P., Jeppesen, L. & El-Fakahany, E. E., 29 Aug 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 3, p. 1260-1268 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea-pig atria

Lanzafame, A., Christopoulos, A. & Mitchelson, F. J., 2001, In : European Journal of Pharmacology. 416, p. 235 - 244 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2000

Beyond eyeballing: Fitting models to experimental data

Christopoulos, A. & Lew, M. J., 1 Jan 2000, In : Critical Reviews in Biochemistry and Molecular Biology. 35, 5, p. 359-391 33 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Beyond eyeballing: Fitting models to experimental data

Christopoulos, A. & Lew, M. J., 1 Jan 2000, Biomedical Applications of Computer Modeling. CRC Press, p. 195-232 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Biomedical applications of computer modeling

Christopoulos, A. (ed.), 1 Jan 2000, 1st ed. Boca Raton: CRC Press. 240 p.

Research output: Book/ReportEdited BookOtherpeer-review

Dynamic mechanisms of non-classical antagonism by competitive AT1 receptor antagonists

Lew, M. J., Ziogas, J. & Christopoulos, A., 1 Oct 2000, In : Trends in Pharmacological Sciences. 21, 10, p. 376-381 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Further evidence for the heterogeneity of functional muscarinic receptors in guinea pig gallbladder

Akici, A., Karaalp, A., Iskender, E., Christopoulos, A., El-Fakahany, E. E. & Oktay, Ş., 24 Jan 2000, In : European Journal of Pharmacology. 388, 1, p. 115-123 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Preface

Christopoulos, A., 1 Jan 2000, Biomedical Applications of Computer Modeling. 1st ed. Boca Raton: CRC Press, p. vii 1 p.

Research output: Chapter in Book/Report/Conference proceedingForeword / PostscriptOtherpeer-review

Transducer abstraction - A novel approach to the detection of partial agonist efficacy in radioligand binding studies

Christopoulos, A., Grant, M. K. O. & El-Fakahany, E. E., 4 Dec 2000, In : Journal of Pharmacological and Toxicological Methods. 43, 1, p. 55-67 13 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

Characterization of the subtype selectivity of the all osteric modulator heptan-1,7-bis-(dimethyl-3'- phthalimidopropl)ammonium bromide(C7/3-phth)at cloned muscarine acetycholine receptors

Christopoulos, A., Sorman, J. L., Mitchelson, F. J. & El-Fakahany, E. E., 1999, In : Biochemical Pharmacology. p. 171 - 179 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the subtype selectivity of the allosteric modulator heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl) ammonium bromide (c7/3-phth) at cloned muscarinic acetylcholine receptors

Christopoulos, A., Sorman, J. L., Mitchelson, F. & El-Fakahany, E. E., 15 Jan 1999, In : Biochemical Pharmacology. 57, 2, p. 171-179 9 p.

Research output: Contribution to journalArticleResearchpeer-review