1993 …2023
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Research Output 1993 2019

1993
15 Citations (Scopus)
1994
38 Citations (Scopus)

Assessment of the allosteric interactions of the bisquaternary heptane- 1,7-bis(dimethyl-3'-phthalimidopropyl)ammonium bromide at M1 and M2 muscarine receptors

Christopoulos, A. & Mitchelson, F., 1 Jan 1994, In : Molecular Pharmacology. 46, 1, p. 105-114 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1995
4 Citations (Scopus)

[3H]N-methylscopolamine dissociation from muscarine receptors affected by low concentrations of allosteric modulators

Christopoulos, A. & Mitchelson, F., 15 Aug 1995, In : European Journal of Pharmacology: Molecular Pharmacology. 290, 3, p. 259-262 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1996
26 Citations (Scopus)

Interactions of agonists with an allosteric antagonist at muscarinic acetylcholine M2 receptors

Lanzafame, A., Christopoulos, A. & Mitchelson, F., 28 Nov 1996, In : European Journal of Pharmacology. 316, 1, p. 27-32 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Inverse agonism: A developing concept of drug action

Christopoulos, A. & Mitchelson, F., 1 Aug 1996, In : Australian Journal of Pharmacy. 77, 917, p. 868-871 4 p.

Research output: Contribution to journalArticleResearchpeer-review

1997

A common site of action for two allosteric antagonists

Christopoulos, A., Lanzafame, A. & Mitchelson, F. J., 1997, p. 1173 - 1173. 1 p.

Research output: Contribution to conferenceAbstractOther

15 Citations (Scopus)

Application of an allosteric ternary complex model to the technique of pharmacological resultant analysis

Christopoulos, A. & Mitchelson, F., 1997, In : Journal of Pharmacy and Pharmacology. p. 781 - 786 6 p.

Research output: Contribution to journalArticleResearchpeer-review

62 Citations (Scopus)

Interaction of ebeinone, an alkaloid from Fritellaria imperialis, at two muscarinic acetylcholine receptor subtypes

Gilani, A. H., Shaheen, F., Christopoulos, A. & Mitchelson, F., 17 Jan 1997, In : Life Sciences. 60, 8, p. 535-544 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Interaction of ebeinone, an alkaloid from Fritillaria imperialis, at two muscrinic acetylcholine receptor subtypes

Gilani, A. H., Shaheen, F., Christopoulos, A. & Mitchelson, F. J., 1997, In : Life Sciences. p. 535 - 544 10 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Kinetic studies of co-operativity at atrial muscarinic M2 receptors with an 'infinite dilution' procedure

Christopoulos, A., Lanzafame, A., Ziegler, A. & Mitchelson, F., 21 Mar 1997, In : Biochemical Pharmacology. 53, 6, p. 795-800 6 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Novel persistent activation of muscarinic M1 receptors by xanomeline

Christopoulos, A. & El-Fakahany, E. E., 3 Sep 1997, In : European Journal of Pharmacology. 334, 1, p. R3-R4 2 p.

Research output: Contribution to journalArticleOtherpeer-review

17 Citations (Scopus)

Pharmacological analysis of the mode of interaction of McN-A-343 at atrial muscarinic M2 receptors

Christopoulos, A. & Mitchelson, F., 1997, In : European Journal of Pharmacology. p. 153 - 156 4 p.

Research output: Contribution to journalArticleResearchpeer-review

The allosteric interaction of otenzepad at muscarinic acetylcholine M2 receptors in cardiac tissue

Lanzafame, A., Christopoulos, A. & Mitchelson, F. J., 1997, p. 47 - 47. 1 p.

Research output: Contribution to conferenceAbstractOther

33 Citations (Scopus)

Three allosteric modulators act at a common site, distinct from that of competitive antagonists, at muscarinic acetylcholine M2 receptors

Lanzafame, A., Christopoulos, A. & Mitchelson, F., 1 Jul 1997, In : Journal of Pharmacology and Experimental Therapeutics. 282, 1, p. 278-285 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Three all osteric modulators act at a common site, distinct from that of competitive antahonists, at muscarinic acetylcholine M2 receptors

Lanzafame, A., Christopoulos, A. & Mitchelson, F., 1997, In : Journal of Pharmacology and Experimental Therapeutics. p. 278 - 285 8 p.

Research output: Contribution to journalArticleResearchpeer-review

1998
92 Citations (Scopus)

Allosteric interactions at muscarinic cholinoceptors

Christopoulos, A., Lanzafame, A. & Mitchelson, F. J., 1998, In : Clinical and Experimental Pharmacology and Physiology. p. 185 - 194 10 p.

Research output: Contribution to journalArticleResearchpeer-review

145 Citations (Scopus)

Assessing the distribution of parameters in models of ligand-receptor interaction: To log or not to log

Christopoulos, A., 1 Sep 1998, In : Trends in Pharmacological Sciences. 19, 9, p. 351-357 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Characterization of the subtype selectivity of the allosteric modulator, C7/ 3 - PHTH, at cloned muscarinic acetylcholine receptors

El-Fakahany, E. E., Christopoulos, A., Sorman, J. L. & Mitchelson, F. J., 1998, p. 14 - 14. 1 p.

Research output: Contribution to conferenceAbstractOther

39 Citations (Scopus)

Minireview: The generation of nitric oxide by G protein-coupled receptors

Christopoulos, A. & El-Fakahany, E. E., 27 Nov 1998, In : Life Sciences. 64, 1, p. 1-15 15 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

50 Citations (Scopus)

On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor

Christopoulos, A., Pierce, T. L., Sorman, J. L. & El-Fakahany, E. E., 1 Jun 1998, In : Molecular Pharmacology. 53, 6, p. 1120-1130 11 p.

Research output: Contribution to journalArticleResearchpeer-review

The interaction of otenzepad (AF- DX 116) with allosteric modulators and competitive antagonists at a muscarinic M2 receptor

Mitchelson, F. J., Lanzafame, A. & Christopoulos, A., 1998, p. 9 - 9. 1 p.

Research output: Contribution to conferenceAbstractOther

5 Citations (Scopus)

Use of a spreadsheet to quantitate the equilibrium binding of an allosteric modulator

Christopoulos, A. & Mitchelson, F. J., 1998, In : European Journal of Pharmacology. p. 103 - 111 9 p.

Research output: Contribution to journalArticleResearchpeer-review

1999

Characterization of the subtype selectivity of the all osteric modulator heptan-1,7-bis-(dimethyl-3'- phthalimidopropl)ammonium bromide(C7/3-phth)at cloned muscarine acetycholine receptors

Christopoulos, A., Sorman, J. L., Mitchelson, F. J. & El-Fakahany, E. E., 1999, In : Biochemical Pharmacology. p. 171 - 179 9 p.

Research output: Contribution to journalArticleResearchpeer-review

32 Citations (Scopus)

Characterization of the subtype selectivity of the allosteric modulator heptane-1,7-bis-(dimethyl-3'-phthalimidopropyl) ammonium bromide (c7/3-phth) at cloned muscarinic acetylcholine receptors

Christopoulos, A., Sorman, J. L., Mitchelson, F. & El-Fakahany, E. E., 15 Jan 1999, In : Biochemical Pharmacology. 57, 2, p. 171-179 9 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor

Christopoulos, A., Parsons, A. M. & El-Fakahany, E. E., 1 Jun 1999, In : Journal of Pharmacology and Experimental Therapeutics. 289, 3, p. 1220-1228 9 p.

Research output: Contribution to journalArticleResearchpeer-review

43 Citations (Scopus)

Qualitative and quantitative assessment of relative agonist efficacy

Christopoulos, A. & El-Fakahany, E. E., 1 Sep 1999, In : Biochemical Pharmacology. 58, 5, p. 735-748 14 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)

Regulation of acetylcholine binding by ATP at the muscarinic M1 receptor in intact CHO cells

Grant, M. K. O., Christopoulos, A. & El-Fakahany, E. E., 21 Aug 1999, In : Brain Research. 839, 1, p. 94-99 6 p.

Research output: Contribution to journalArticleResearchpeer-review

56 Citations (Scopus)

The assessment of antagonist potency under conditions of transient response kinetics

Christopoulos, A., Parsons, A. M., Lew, M. J. & El-Fakahany, E. E., 15 Oct 1999, In : European Journal of Pharmacology. 382, 3, p. 217-227 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2000
27 Citations (Scopus)

Beyond eyeballing: Fitting models to experimental data

Christopoulos, A. & Lew, M. J., 1 Jan 2000, In : Critical Reviews in Biochemistry and Molecular Biology. 35, 5, p. 359-391 33 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

5 Citations (Scopus)

Beyond eyeballing: Fitting models to experimental data

Christopoulos, A. & Lew, M. J., 1 Jan 2000, Biomedical Applications of Computer Modeling. CRC Press, p. 195-232 38 p.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

1 Citation (Scopus)

Biomedical applications of computer modeling

Christopoulos, A. (ed.), 1 Jan 2000, 1st ed. Boca Raton: CRC Press. 240 p.

Research output: Book/ReportEdited BookOtherpeer-review

42 Citations (Scopus)

Dynamic mechanisms of non-classical antagonism by competitive AT1 receptor antagonists

Lew, M. J., Ziogas, J. & Christopoulos, A., 1 Oct 2000, In : Trends in Pharmacological Sciences. 21, 10, p. 376-381 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

9 Citations (Scopus)

Further evidence for the heterogeneity of functional muscarinic receptors in guinea pig gallbladder

Akici, A., Karaalp, A., Iskender, E., Christopoulos, A., El-Fakahany, E. E. & Oktay, Ş., 24 Jan 2000, In : European Journal of Pharmacology. 388, 1, p. 115-123 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Preface

Christopoulos, A., 1 Jan 2000, Biomedical Applications of Computer Modeling. 1st ed. Boca Raton: CRC Press, p. vii 1 p.

Research output: Chapter in Book/Report/Conference proceedingForeword / PostscriptOtherpeer-review

3 Citations (Scopus)

Transducer abstraction - A novel approach to the detection of partial agonist efficacy in radioligand binding studies

Christopoulos, A., Grant, M. K. O. & El-Fakahany, E. E., 4 Dec 2000, In : Journal of Pharmacological and Toxicological Methods. 43, 1, p. 55-67 13 p.

Research output: Contribution to journalArticleResearchpeer-review

2001
5 Citations (Scopus)

From "captive" agonism to insurmountable antagonism: Demonstrating the power of analytical pharmacology

Christopoulos, A., 15 Mar 2001, In : Clinical and Experimental Pharmacology and Physiology. 28, 3, p. 223-229 7 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Insurmountable AT1 receptor antagonism: Message in a model? [2]

Lew, M., Christopoulos, A. & Ziogas, J., 1 Nov 2001, In : Trends in Pharmacological Sciences. 22, 11, p. 555-557 3 p.

Research output: Contribution to journalLetterOtherpeer-review

32 Citations (Scopus)

Interaction of anandamide with the M 1 and M 4 muscarinic acetylcholine receptors

Christopoulos, A. & Wilson, K., 5 Oct 2001, In : Brain Research. 915, 1, p. 70-78 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Non-surmountable antagonism: Transcending steady state [3]

Lew, M. J., Christopoulos, A. & Ziogas, J., 1 Feb 2001, In : Trends in Pharmacological Sciences. 22, 2, p. 65-66 2 p.

Research output: Contribution to journalLetterOtherpeer-review

43 Citations (Scopus)

Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens

Christopoulos, A., Coles, P., Lay, L., Lew, M. J. & Angus, J. A., 1 Jan 2001, In : British Journal of Pharmacology. 132, 6, p. 1281-1291 11 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Synthesis and pharmacological evaluation of dimeric muscarinic acetylcholine receptor agonists

Christopoulos, A., Grant, M. K. O., Ayoubzadeh, N., Kim, O. N., Sauerberg, P., Jeppesen, L. & El-Fakahany, E. E., 29 Aug 2001, In : Journal of Pharmacology and Experimental Therapeutics. 298, 3, p. 1260-1268 9 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea-pig atria

Lanzafame, A., Christopoulos, A. & Mitchelson, F. J., 2001, In : European Journal of Pharmacology. 416, p. 235 - 244 10 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
488 Citations (Scopus)

Allosteric binding sites on cell-surface receptors: Novel targets for drug discovery

Christopoulos, A., 1 Mar 2002, In : Nature Reviews Drug Discovery. 1, 3, p. 198-210 13 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

Darifenacin reveals a functional role for M4 muscarinic acetylcholine receptors in guinea pig gallbladder

Akici, A., Nacak, M., Christopoulos, A. & Oktay, Ş., 1 Oct 2002, In : Marmara Medical Journal. 15, 4, p. 248-252 5 p.

Research output: Contribution to journalArticleResearchpeer-review

727 Citations (Scopus)

G protein-coupled receptor allosterism and complexing

Christopoulos, A. & Kenakin, T., 2002, In : Pharmacological Reviews. 54, 2, p. 323 - 374 52 p.

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Modulation of cannabinoid agonist binding by 5-HT in the rat cerebellum

Devlin, M. G. & Christopoulos, A., 5 Aug 2002, In : Journal of Neurochemistry. 80, 6, p. 1095-1102 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
71 Citations (Scopus)

Reversible and specific extracellular antagonism of receptor-histidine kinase signaling

Lyon, G. J., Wright, J. S., Christopoulos, A., Novick, R. P. & Muir, T. W., 2002, In : Journal of Biological Chemistry. 277, 8, p. 6247 - 6253 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2003
65 Citations (Scopus)

Allosteric modulators of G-protein-coupled receptors

May, L. T. & Christopoulos, A., Oct 2003, In : Current Opinion in Pharmacology. 3, 5, p. 551-556 6 p.

Research output: Contribution to journalReview ArticleResearchpeer-review

102 Citations (Scopus)

Cellular signaling mechanisms for muscarinic acetylcholine receptors

Lanzafame, A. A., Christopoulos, A. & Mitchelson, F., 15 Sep 2003, In : Receptors and Channels. 9, 4, p. 241-260 20 p.

Research output: Contribution to journalReview ArticleResearchpeer-review