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Arthur Christopoulos

Professor

 https://orcid.org/0000-0003-4442-3294
1993 …2020

Research output per year

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Personal profile

Monash teaching commitment

  • Lectures to second year BPharm students in the Faculty of Pharmacy and Pharmaceutical Sciences
  • Lectures to third year BPharmSci students in the Faculty of Pharmacy and Pharmaceutical Sciences
  • Supervision of Honours students in Drug Discovery Biology
  • Supervision of PhD students in Drug Discovery Biology

Research area keywords

  • Analytical Pharmacology
  • Allosteric Modulation
  • Receptor Theory
  • Commentary: Drug Discovery
  • Pharmaceutical Research
  • Drug Side-Effects
  • Psychiatric Drugs
  • Supervision: Molecular Pharmacology
  • Drug Discovery
  • Receptors and Signal Transduction

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects

Chemical-Biology Approaches to Pathway Selective Adenosine Receptor Ligands

Scammells, P. & Christopoulos, A.

1/07/19 → 30/06/22

Project: Research

Discovering novel allosteric probes of muscarinic acetylcholine receptors

Valant, C., Scammells, P. & Christopoulos, A.

10/06/19 → 9/06/22

Project: Research

Translating membrane proteins into therapeutics; from bedside to bench

Sexton, P., Christopoulos, A., Pantelis, C. & Parton, R. G.

1/01/19 → 31/12/23

Project: Research

Adenosine A1 receptor modulation: Structure, dynamics & novel pharmacological interventions

Christopoulos, A., May, L., Imlach, W., Hill, S. & Scott, D.

1/01/18 → 31/12/22

Project: Research

Collaborative Network to Define the Molecular Determinants of G Protein Coupled Receptor Clinical Efficacy

Christopoulos, A., Sexton, P. & Tobin, A. B.

1/11/16 → 31/10/21

Project: Research

Research Output

Acetylcholine Muscarinic M4 Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents

Walker, L. C., Berizzi, A. E., Chen, N. A., Rueda, P., Perreau, V. M., Huckstep, K., Srisontiyakul, J., Govitrapong, P., Xiaojian, J., Lindsley, C. W., Jones, C. K., Riddy, D. M., Christopoulos, A., Langmead, C. J. & Lawrence, A. J., 28 Feb 2020, (Accepted/In press) In : Biological Psychiatry. 12 p.

Research output: Contribution to journal › Article › Research › peer-review

Activation of the GLP-1 receptor by a non-peptidic agonist

Zhao, P., Liang, Y. L., Belousoff, M. J., Deganutti, G., Fletcher, M. M., Willard, F. S., Bell, M. G., Christe, M. E., Sloop, K. W., Inoue, A., Truong, T. T., Clydesdale, L., Furness, S. G. B., Christopoulos, A., Wang, M. W., Miller, L. J., Reynolds, C. A., Danev, R., Sexton, P. M. & Wootten, D., 8 Jan 2020, In : Nature. 577, 7790, p. 432-436 5 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
File
5 Citations (Scopus)

Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs

Bradley, S. J., Molloy, C., Valuskova, P., Dwomoh, L., Scarpa, M., Rossi, M., Finlayson, L., Svensson, K. A., Chernet, E., Barth, V. N., Gherbi, K., Sykes, D. A., Wilson, C. A., Mistry, R., Sexton, P. M., Christopoulos, A., Mogg, A. J., Rosethorne, E. M., Sakata, S., John Challiss, R. A. & 2 others, Broad, L. M. & Tobin, A. B., 20 Feb 2020, In : Nature Chemical Biology. 16, 3, p. 240-249 10 p.

Research output: Contribution to journal › Article › Research › peer-review

Open Access
File
1 Citation (Scopus)

Correction to “Evaluation of Operational Models of Agonism and Allosterism at Receptors with Multiple orthosteric Binding Sites” (Mol Pharmacol, (2020) 97, 1, (35-45) DOI: 10.1124/mol.119.118091)

Gregory, K. J., Giraldo, J., Diao, J., Christopoulos, A. & Leach, K., 1 Jan 2020, In : Molecular Pharmacology. 97, 1, p. 48-48 1 p.

Research output: Contribution to journal › Comment / Debate › Other › peer-review

Differential contribution of metabotropic glutamate receptor 5 common allosteric binding site residues to biased allosteric agonism

Sengmany, K., Hellyer, S. D., Christopoulos, A., Lapinsky, D. J., Leach, K. & Gregory, K. J., 5 May 2020, (Accepted/In press) In : Biochemical Pharmacology. 15 p., 114011.

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Activities

  • 1 Submissions to industry or govt committees, commissions and inquiries

Theme Leader

Arthur Christopoulos (Member)

10 Nov 2011

Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries