Projects per year
Personal profile
Biography
Arthur Christopoulos is the Professor of Analytical Pharmacology, Dean of the Faculty of Pharmacy & Pharmaceutical Sciences, and inaugural Director of the Neuromedicines Discovery Centre, Monash University. Prior to his appointment as Dean, he was a Senior Principal Research Fellow of the National Health and Medical Research Council. His research focuses on novel paradigms of drug action at G protein-coupled receptors (GPCRs), the largest drug-target class for current medicines. His work crosses academic and industry boundaries, incorporating computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease. His work has been applied to fundamental and translational studies encompassing neurological and psychiatric disorders, cardiovascular disease, obesity, diabetes and chronic pain, and he has received substantial, long-term support from international and national competitive, charitable and commercial sources.
Professor Christopoulos has served on the Editorial Board of 8 international journals, consults for numerous companies, and is a Councillor of the International Union of Basic and Clinical Pharmacology (IUPHAR). He has also been the recipient of multiple awards, including the John J. Abel Award from the American Society for Pharmacology and Experimental Therapeutics, the Rand Medal from the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, the British Pharmacological Society (BPS) Gaddum Memorial Award, the IUPHAR Analytical Pharmacology Lecturer, the GSK Award for Research Excellence and a Doctor of Laws from the University of Athens. Clarivate Analytics have named him a Highly Cited Researcher in Pharmacology & Toxicology, as well as in Biology & Biochemistry. In 2017, he was elected a Fellow of the Australian Academy of Health and Medical Sciences and of the BPS, and in 2021 was elected a Fellow of the Australian Academy of Science for his contributions to drug discovery.
Research area keywords
- Analytical Pharmacology
- Allosteric Modulation
- Receptor Theory
- Commentary: Drug Discovery
- Pharmaceutical Research
- Drug Side-Effects
- Psychiatric Drugs
- Supervision: Molecular Pharmacology
- Drug Discovery
- Receptors and Signal Transduction
Network
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Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy
May, L., Webb, G., Carlsson, J., Baltos, J., Nguyen, A., Christopoulos, A., Miao, Y., O'Brien, T., Rollo, B., Casillas-Espinosa, P., Gregory, K., Scammells, P. & Nguyen, T.
1/01/22 → 31/12/25
Project: Research
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Chemical-Biology Approaches to Pathway Selective Adenosine Receptor Ligands
Scammells, P. & Christopoulos, A.
1/07/19 → 30/06/22
Project: Research
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Translating membrane proteins into therapeutics; from bedside to bench
Sexton, P., Christopoulos, A., Pantelis, C. & Parton, R. G.
1/01/19 → 31/12/23
Project: Research
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Adenosine A1 receptor modulation: Structure, dynamics & novel pharmacological interventions
Christopoulos, A., May, L., Imlach, W., Hill, S. & Scott, D.
1/01/18 → 31/12/22
Project: Research
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The muscarinic acetylcholine receptor pharmacology of bispyridinium compounds
Department of Defence (Australia)
10/02/20 → 30/06/20
Project: Research
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A robust method for particulate detection of a genetic tag for 3D electron microscopy
Rae, J., Ferguson, C., Ariotti, N., Webb, R. I., Cheng, H. H., Mead, J. L., Riches, J. D., Hunter, D. J. B., Martel, N., Baltos, J., Christopoulos, A., Bryce, N. S., Cagigas, M. L., Fonseka, S., Sayre, M. E., Hardeman, E. C., Gunning, P. W., Gambin, Y., Hall, T. E. & Parton, R. G., 27 Apr 2021, In: eLife. 10, 17 p., e64630.Research output: Contribution to journal › Article › Research › peer-review
Open Access8 Citations (Scopus) -
Development of Novel 4-Arylpyridin-2-one and 6-Arylpyrimidin-4-one Positive Allosteric Modulators of the M1 Muscarinic Acetylcholine Receptor
Jörg, M., Khajehali, E., van der Westhuizen, E. T., C. Choy, K. H., Shackleford, D. M., Tobin, A. B., Sexton, P. M., Valant, C., Capuano, B., Christopoulos, A. & Scammells, P. J., 8 Jan 2021, In: ChemMedChem. 16, 1, p. 216-233 18 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
Fine Tuning Muscarinic Acetylcholine Receptor Signaling Through Allostery and Bias
van der Westhuizen, E. T., Choy, K. H. C., Valant, C., McKenzie-Nickson, S., Bradley, S. J., Tobin, A. B., Sexton, P. M. & Christopoulos, A., 29 Jan 2021, In: Frontiers in Pharmacology. 11, 27 p., 606656.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access6 Citations (Scopus) -
Identification of a Novel Allosteric Site at the M5Muscarinic Acetylcholine Receptor
Burger, W. A. C., Gentry, P. R., Berizzi, A. E., Vuckovic, Z., Van Der Westhuizen, E. T., Thompson, G., Yeasmin, M., Lindsley, C. W., Sexton, P. M., Langmead, C. J., Tobin, A. B., Christopoulos, A., Valant, C. & Thal, D. M., 18 Aug 2021, In: ACS Chemical Neuroscience. 12, 16, p. 3112-3123 12 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus) -
Neurological, neuropsychiatric and neurodevelopmental complications of COVID-19
Pantelis, C., Jayaram, M., Hannan, A. J., Wesselingh, R., Nithianantharajah, J., Wannan, C. M. J., Syeda, W. T., Choy, KH. C., Zantomio, D., Christopoulos, A., Velakoulis, D. & O’Brien, T. J., Aug 2021, In: Australian & New Zealand Journal of Psychiatry. 55, 8, p. 750-762 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access11 Citations (Scopus)
Activities
- 1 Submissions to industry or govt committees, commissions and inquiries
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Theme Leader
Arthur Christopoulos (Member)
10 Nov 2011Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries