Projects per year
Personal profile
Biography
Arthur Christopoulos is the Professor of Analytical Pharmacology, Dean of the Faculty of Pharmacy & Pharmaceutical Sciences, and inaugural Director of the Neuromedicines Discovery Centre, Monash University. Prior to his appointment as Dean, he was a Senior Principal Research Fellow of the National Health and Medical Research Council. His research focuses on novel paradigms of drug action at G protein-coupled receptors (GPCRs), the largest drug-target class for current medicines. His work crosses academic and industry boundaries, incorporating computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease. His work has been applied to fundamental and translational studies encompassing neurological and psychiatric disorders, cardiovascular disease, obesity, diabetes and chronic pain, and he has received substantial, long-term support from international and national competitive, charitable and commercial sources.
Professor Christopoulos has served on the Editorial Board of 8 international journals, consults for numerous companies, and is a Councillor of the International Union of Basic and Clinical Pharmacology (IUPHAR). He has also been the recipient of multiple awards, including the John J. Abel Award from the American Society for Pharmacology and Experimental Therapeutics, the Rand Medal from the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, the British Pharmacological Society (BPS) Gaddum Memorial Award, the IUPHAR Analytical Pharmacology Lecturer, the GSK Award for Research Excellence and a Doctor of Laws from the University of Athens. Clarivate Analytics have named him a Highly Cited Researcher in Pharmacology & Toxicology, as well as in Biology & Biochemistry. In 2017, he was elected a Fellow of the Australian Academy of Health and Medical Sciences and of the BPS, and in 2021 was elected a Fellow of the Australian Academy of Science for his contributions to drug discovery.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Analytical Pharmacology
- Allosteric Modulation
- Receptor Theory
- Commentary: Drug Discovery
- Pharmaceutical Research
- Drug Side-Effects
- Psychiatric Drugs
- Supervision: Molecular Pharmacology
- Drug Discovery
- Receptors and Signal Transduction
Collaborations and top research areas from the last five years
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Modulation of the M4 muscarinic receptor for the treatment of schizophrenia
Valant, C., Capuano, B., Choy, C., Thal, D., Miao, Y., Christopoulos, A., Felder, C. & Pantellis, C.
1/01/23 → 31/12/26
Project: Research
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Pre-clinical evaluation of selective adenosine A1 receptor positive allosteric modulators for the treatment of drug-resistant epilepsy
Kwan, P., May, L., Rollo, B., O'Brien, T., Casillas-Espinosa, P., Howden, S., Christopoulos, A., Gregory, K., Scammells, P., Baltos, J., Elliot, D., TN Nguyen, A., Langmead, C., Antonic-Baker, A., Sumer, H., Javaid, S. & Gu, J.
1/06/22 → 31/05/27
Project: Research
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Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy
May, L., Webb, G., Carlsson, J., Baltos, J., TN Nguyen, A., Christopoulos, A., Miao, Y., O'Brien, T., Rollo, B., Casillas-Espinosa, P., Gregory, K., Scammells, P. & Nguyen, T.
1/01/22 → 31/12/25
Project: Research
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NAMs of Gq-coupled muscarinic acetylcholine receptors
Valant, C. & Christopoulos, A.
Department of Defence (Australia)
20/09/21 → 28/02/23
Project: Research
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The muscarinic acetylcholine receptor pharmacology of bispyridinium compounds
Department of Defence (Australia)
10/02/20 → 30/06/20
Project: Research
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Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor
Jiang, Y., Yeasmin, M., Gondin, A. B., Christopoulos, A., Valant, C., Burger, W. A. C. & Thal, D. M., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2338-2350 13 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus) -
Ligand-directed biased agonism at human histamine H3 receptor isoforms across Gαi/o- and β-arrestin2-mediated pathways
Rahman, S. N., Imhaouran, F., Leurs, R., Christopoulos, A., Valant, C. & Langmead, C. J., 2024, (Accepted/In press) In: Biochemical Pharmacology. 24 p., 115988.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits
Nguyen, H. T. M., van der Westhuizen, E. T., Langmead, C. J., Tobin, A. B., Sexton, P. M., Christopoulos, A. & Valant, C., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2114-2142 29 p.Research output: Contribution to journal › Review Article › Research › peer-review
5 Citations (Scopus) -
Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders
Saito, A., Alvi, S., Valant, C., Christopoulos, A., Carbone, S. E. & Poole, D. P., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2232-2246 15 p.Research output: Contribution to journal › Review Article › Research › peer-review
2 Citations (Scopus) -
The role of the adenosine system in epilepsy and its comorbidities
Baltos, J. A., Casillas-Espinosa, P. M., Rollo, B., Gregory, K. J., White, P. J., Christopoulos, A., Kwan, P., O'Brien, T. J. & May, L. T., Jul 2024, In: British Journal of Pharmacology. 181, 14, p. 2143-2157 15 p.Research output: Contribution to journal › Review Article › Research › peer-review
Open Access7 Citations (Scopus)
Activities
- 1 Submissions to industry or govt committees, commissions and inquiries
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Theme Leader
Arthur Christopoulos (Member)
10 Nov 2011Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries