Projects per year
Personal profile
Biography
Arthur Christopoulos is the Professor of Analytical Pharmacology, Dean of the Faculty of Pharmacy & Pharmaceutical Sciences, and inaugural Director of the Neuromedicines Discovery Centre, Monash University. Prior to his appointment as Dean, he was a Senior Principal Research Fellow of the National Health and Medical Research Council. His research focuses on novel paradigms of drug action at G protein-coupled receptors (GPCRs), the largest drug-target class for current medicines. His work crosses academic and industry boundaries, incorporating computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease. His work has been applied to fundamental and translational studies encompassing neurological and psychiatric disorders, cardiovascular disease, obesity, diabetes and chronic pain, and he has received substantial, long-term support from international and national competitive, charitable and commercial sources.
Professor Christopoulos has served on the Editorial Board of 8 international journals, consults for numerous companies, and is a Councillor of the International Union of Basic and Clinical Pharmacology (IUPHAR). He has also been the recipient of multiple awards, including the John J. Abel Award from the American Society for Pharmacology and Experimental Therapeutics, the Rand Medal from the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, the British Pharmacological Society (BPS) Gaddum Memorial Award, the IUPHAR Analytical Pharmacology Lecturer, the GSK Award for Research Excellence and a Doctor of Laws from the University of Athens. Clarivate Analytics have named him a Highly Cited Researcher in Pharmacology & Toxicology, as well as in Biology & Biochemistry. In 2017, he was elected a Fellow of the Australian Academy of Health and Medical Sciences and of the BPS, and in 2021 was elected a Fellow of the Australian Academy of Science for his contributions to drug discovery.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Analytical Pharmacology
- Allosteric Modulation
- Receptor Theory
- Commentary: Drug Discovery
- Pharmaceutical Research
- Drug Side-Effects
- Psychiatric Drugs
- Supervision: Molecular Pharmacology
- Drug Discovery
- Receptors and Signal Transduction
Collaborations and top research areas from the last five years
-
Understanding how neural circuit activity is controlled by adenosine
Imlach, W. (Primary Chief Investigator (PCI)), Christopoulos, A. (Chief Investigator (CI)), De Koninck, Y. (Partner Investigator (PI)) & Spanswick, D. (Partner Investigator (PI))
Australian Research Council (ARC), Monash University – Internal Department Contribution
25/03/25 → 24/03/28
Project: Research
-
Development of Allosteric and Bitopic Ligands to Tune Receptor Signalling
Scammells, P. (Primary Chief Investigator (PCI)) & Christopoulos, A. (Chief Investigator (CI))
Australian Research Council (ARC)
29/01/25 → 28/01/28
Project: Research
-
Modulation of the M4 muscarinic receptor for the treatment of schizophrenia
Valant, C. (Primary Chief Investigator (PCI)), Capuano, B. (Chief Investigator (CI)), Choy, C. (Chief Investigator (CI)), Thal, D. (Associate Investigator (AI)), Miao, Y. (Associate Investigator (AI)), Christopoulos, A. (Associate Investigator (AI)), Felder, C. (Associate Investigator (AI)) & Pantellis, C. (Associate Investigator (AI))
1/01/23 → 31/12/26
Project: Research
-
Pre-clinical evaluation of selective adenosine A1 receptor positive allosteric modulators for the treatment of drug-resistant epilepsy
Kwan, P. (Primary Chief Investigator (PCI)), May, L. (Chief Investigator (CI)), Rollo, B. (Chief Investigator (CI)), O'Brien, T. (Chief Investigator (CI)), Casillas-Espinosa, P. (Chief Investigator (CI)), Howden, S. (Chief Investigator (CI)), Christopoulos, A. (Chief Investigator (CI)), Gregory, K. (Chief Investigator (CI)), Scammells, P. (Chief Investigator (CI)), Baltos, J.-A. (Chief Investigator (CI)), Elliot, D. (Chief Investigator (CI)), TN Nguyen, A. (Chief Investigator (CI)), Langmead, C. (Chief Investigator (CI)), Antonic-Baker, A. (Chief Investigator (CI)), Sumer, H. (Chief Investigator (CI)), Javaid, S. (Associate Investigator (AI)) & Gu, J. (Chief Investigator (CI))
1/06/22 → 31/05/27
Project: Research
-
Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy
May, L. (Primary Chief Investigator (PCI)), Webb, G. (Chief Investigator (CI)), Carlsson, J. (Chief Investigator (CI)), Baltos, J.-A. (Chief Investigator (CI)), TN Nguyen, A. (Chief Investigator (CI)), Christopoulos, A. (Associate Investigator (AI)), Miao, Y. (Associate Investigator (AI)), O'Brien, T. (Associate Investigator (AI)), Rollo, B. (Associate Investigator (AI)), Casillas-Espinosa, P. (Associate Investigator (AI)), Gregory, K. (Associate Investigator (AI)), Scammells, P. (Associate Investigator (AI)) & Nguyen, T. (Associate Investigator (AI))
1/01/22 → 31/12/25
Project: Research
-
Brain region-specific alterations in gene expression trajectories in the offspring born from influenza A virus infected mice
Liong, S., Choy, K. H. C., De Luca, S. N., Liong, F., Coward-Smith, M., Oseghale, O., Miles, M. A., Vlahos, R., Valant, C., Nithianantharajah, J., Pantelis, C., Christopoulos, A. & Selemidis, S., Aug 2024, In: Brain, Behavior, and Immunity. 120, p. 488-498 11 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling
Harikumar, K. G., Zhao, P., Cary, B. P., Xu, X., Desai, A. J., Dong, M., Mobbs, J. I., Toufaily, C., Furness, S. G. B., Christopoulos, A., Belousoff, M. J., Wootten, D., Sexton, P. M. & Miller, L. J., Jul 2024, In: PLoS Biology. 22, 7, 26 p., e3002673.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein
Cao, J., Belousoff, M. J., Danev, R., Christopoulos, A., Wootten, D. & Sexton, P. M., 7 May 2024, In: Biochemistry. 63, 9, p. 1089-1096 8 p.Research output: Contribution to journal › Article › Research › peer-review
1 Citation (Scopus) -
Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders
Liu, B., Thompson, G., Jörg, M., Barnes, N., Thal, D. M., Christopoulos, A., Capuano, B., Valant, C. & Scammells, P. J., 18 Jul 2024, In: Journal of Medicinal Chemistry. 67, 15, p. 13286–13304 19 p.Research output: Contribution to journal › Article › Research › peer-review
-
Impact of secretin receptor homo-dimerization on natural ligand binding
Harikumar, K. G., Piper, S. J., Christopoulos, A., Wootten, D., Sexton, P. M. & Miller, L. J., Dec 2024, In: Nature Communications. 15, 1, 12 p., 4390.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)
Activities
- 1 Submissions to industry or govt committees, commissions and inquiries
-
Theme Leader
Arthur Christopoulos (Member)
10 Nov 2011Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries