Projects per year
Personal profile
Biography
Arthur Christopoulos is the Professor of Analytical Pharmacology, Dean of the Faculty of Pharmacy & Pharmaceutical Sciences, and inaugural Director of the Neuromedicines Discovery Centre, Monash University. Prior to his appointment as Dean, he was a Senior Principal Research Fellow of the National Health and Medical Research Council. His research focuses on novel paradigms of drug action at G protein-coupled receptors (GPCRs), the largest drug-target class for current medicines. His work crosses academic and industry boundaries, incorporating computational and mathematical modelling, structural and chemical biology, molecular and cellular pharmacology, medicinal chemistry, and preclinical models of behaviour and disease. His work has been applied to fundamental and translational studies encompassing neurological and psychiatric disorders, cardiovascular disease, obesity, diabetes and chronic pain, and he has received substantial, long-term support from international and national competitive, charitable and commercial sources.
Professor Christopoulos has served on the Editorial Board of 8 international journals, consults for numerous companies, and is a Councillor of the International Union of Basic and Clinical Pharmacology (IUPHAR). He has also been the recipient of multiple awards, including the John J. Abel Award from the American Society for Pharmacology and Experimental Therapeutics, the Rand Medal from the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, the British Pharmacological Society (BPS) Gaddum Memorial Award, the IUPHAR Analytical Pharmacology Lecturer, the GSK Award for Research Excellence and a Doctor of Laws from the University of Athens. Clarivate Analytics have named him a Highly Cited Researcher in Pharmacology & Toxicology, as well as in Biology & Biochemistry. In 2017, he was elected a Fellow of the Australian Academy of Health and Medical Sciences and of the BPS, and in 2021 was elected a Fellow of the Australian Academy of Science for his contributions to drug discovery.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Analytical Pharmacology
- Allosteric Modulation
- Receptor Theory
- Commentary: Drug Discovery
- Pharmaceutical Research
- Drug Side-Effects
- Psychiatric Drugs
- Supervision: Molecular Pharmacology
- Drug Discovery
- Receptors and Signal Transduction
Collaborations and top research areas from the last five years
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Modulation of the M4 muscarinic receptor for the treatment of schizophrenia
Valant, C., Capuano, B., Choy, C., Thal, D., Miao, Y., Christopoulos, A., Felder, C. & Pantellis, C.
1/01/23 → 31/12/26
Project: Research
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Positive allosteric modulation of anti-convulsant G protein-coupled receptor signalling to treat drug-resistant epilepsy
May, L., Webb, G., Carlsson, J., Baltos, J., Nguyen, A., Christopoulos, A., Miao, Y., O'Brien, T., Rollo, B., Casillas-Espinosa, P., Gregory, K., Scammells, P. & Nguyen, T.
1/01/22 → 31/12/25
Project: Research
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Translating membrane proteins into therapeutics; from bedside to bench
Sexton, P., Christopoulos, A., Pantelis, C. & Parton, R. G.
1/01/19 → 31/12/23
Project: Research
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NAMs of Gq-coupled muscarinic acetylcholine receptors
Valant, C. & Christopoulos, A.
Department of Defence (Australia)
20/09/21 → 28/02/23
Project: Research
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The muscarinic acetylcholine receptor pharmacology of bispyridinium compounds
Department of Defence (Australia)
10/02/20 → 30/06/20
Project: Research
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Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR
Jörg, M., van der Westhuizen, E. T., Lu, Y., Christopher Choy, K. H., Shackleford, D. M., Khajehali, E., Tobin, A. B., Thal, D. M., Capuano, B., Christopoulos, A., Valant, C. & Scammells, P. J., 5 Oct 2023, In: European Journal of Medicinal Chemistry. 258, 20 p., 115588.Research output: Contribution to journal › Article › Research › peer-review
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Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics
Vuckovic, Z., Wang, J., Pham, V., Mobbs, J. I., Belousoff, M. J., Bhattarai, A., Burger, W. A. C., Thompson, G., Yeasmin, M., Nawaratne, V., Leach, K., van der Westhuizen, E. T., Khajehali, E., Liang, Y. L., Glukhova, A., Wootten, D., Lindsley, C. W., Tobin, A., Sexton, P., Danev, R., & 4 others , 30 May 2023, In: eLife. 12, 52 p., e83477.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor
Pham, V., Habben Jansen, M. C. C., Thompson, G., Heitman, L. H., Christopoulos, A., Thal, D. M. & Valant, C., 1 Sept 2023, In: Molecular Pharmacology. 104, 3, p. 92-104 13 p.Research output: Contribution to journal › Article › Research › peer-review
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Structural and Molecular Determinants for Isoform Bias at Human Histamine H3 Receptor Isoforms
Rahman, S. N., McNaught-Flores, D. A., Huppelschoten, Y., da Costa Pereira, D., Christopoulos, A., Leurs, R. & Langmead, C. J., 26 Jan 2023, In: ACS Chemical Neuroscience. 14, 4, p. 645-656 12 p.Research output: Contribution to journal › Article › Research › peer-review
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Structural basis of efficacy-driven ligand selectivity at GPCRs
Powers, A. S., Pham, V., Burger, W. A. C., Thompson, G., Laloudakis, Y., Barnes, N., Sexton, P. M., Paul, S. M., Christopoulos, A., Thal, D. M., Felder, C. C., Valant, C. & Dror, R. O., 13 Feb 2023, In: Nature Chemical Biology. 19, p. 805–814 22 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access7 Citations (Scopus)
Activities
- 1 Submissions to industry or govt committees, commissions and inquiries
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Theme Leader
Arthur Christopoulos (Member)
10 Nov 2011Activity: External Academic Engagement › Submissions to industry or govt committees, commissions and inquiries