20072020

Research output per year

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Research Output

  • 19 Article
  • 2 Chapter (Book)
  • 2 Review Article
  • 1 Comment / Debate
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Article
2019

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Guarnerio, J., Zhang, Y., Cheloni, G., Panella, R., Mae Katon, J., Simpson, M., Matsumoto, A., Papa, A., Loretelli, C., Petri, A., Kauppinen, S., Garbutt, C., Petur Nielsen, G., Deshpande, V., Castillo-Martin, M., Cordon-Cardo, C., Spentzos, D., Clohessy, J. G., Batish, M. & Paolo Pandolfi, P., 17 Jun 2019, In : Cell Research. 29, p. 628-640 13 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

Lee, Y. R., Chen, M., Lee, J. D., Zhang, J., Lin, S. Y., Fu, T. M., Chen, H., Ishikawa, T., Chiang, S. Y., Katon, J., Zhang, Y., Shulga, Y. V., Bester, A. C., Fung, J., Monteleone, E., Wan, L., Shen, C., Hsu, C. H., Papa, A., Clohessy, J. G. & 7 others, Teruya-Feldstein, J., Jain, S., Wu, H., Matesic, L., Chen, R. H., Wei, W. & Pandolfi, P. P., 17 May 2019, In : Science. 364, 6441, 15 p., eaau0159.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)
2018

GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance

La, H. M., Chan, A-L., Legrand, J. M. D., Rossello, F. J., Gangemi, C. G., Papa, A., Cheng, Q., Morand, E. F. & Hobbs, R. M., 1 Sep 2018, In : Development (Cambridge). 145, 18, dev165324.

Research output: Contribution to journalArticleResearchpeer-review

6 Citations (Scopus)
2015

In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes

Li Chew, C., Lunardi, A., Gulluni, F., Ruan, D. T., Chen, M., Salmena, L., Nishino, M., Papa, A., Ng, C., Fung, J., Clohessy, J. G., Sasaki, J., Sasaki, T., Bronson, R. T., Hirsch, E. & Pandolfi, P. P., 1 Jul 2015, In : Cancer Discovery. 5, 7, p. 740-751 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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53 Citations (Scopus)

Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity

Newton, R. H., Lu, Y., Papa, A., Whitcher, G. H., Kang, Y-J., Yan, C., Pandolfi, P. P. & Turka, L. A., 2015, In : Blood. 125, 5, p. 852 - 855 4 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

The inositol polyphosphate 5-Phosphatase PIPP regulates AKT1-Dependent breast cancer growth and metastasis

Ooms, L. M., Binge, L. C., Davies, E. M., Rahman, P., Conway, J. R. W., Gurung, R., Ferguson, D. T., Papa, A., Fedele, C. G., Vieusseux, J. L., Chai, R. C. C., Koentgen, F., Price, J. T., Tiganis, T., Timpson, P., McLean, C. A. & Mitchell, C. A., 10 Aug 2015, In : Cancer Cell. 28, 2, p. 155-169 15 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
51 Citations (Scopus)

The PTEN tumor suppressor forms homodimers in solution

Heinrich, F., Chakravarthy, S., Nanda, H., Papa, A., Pandolfi, P. P., Ross, A. H., Harishchandra, R. K., Gericke, A. & Losche, M., 2015, In : Structure. 23, 10, p. 1952 - 1957 6 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)
2014

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

Papa, A., Wan, L., Bonora, M., Salmena, L., Song, M., Hobbs, R. M., Lunardi, A., Webster, K., Ng, C., Newton, R. H., Knoblauch, N. W., Guarnerio, J., Ito, K., Turka, L. A., Beck, A. H., Pinton, P., Bronson, R. T., Wei, W. & Pandolfi, P. P., 2014, In : Cell. 157, 3, p. 595 - 610 16 p.

Research output: Contribution to journalArticleResearchpeer-review

140 Citations (Scopus)

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

Liu, P., Begley, M., Michowski, W., Inuzuka, H., Ginzberg, M., Gao, D., Tsou, P., Gan, W., Papa, A., Kim, B. M., Wan, L., Singh, A., Zhai, B., Yuan, M., Wang, Z., Gygi, S. P., Lee, T. H., Lu, K. P., Toker, A., Pandolfi, P. P. & 5 others, Asara, J. M., Kirschner, M. W., Sicinski, P., Cantley, L. C. & Wei, W., 24 Apr 2014, In : Nature. 508, p. 541-545 5 p.

Research output: Contribution to journalArticleResearchpeer-review

170 Citations (Scopus)

Role of aberrant PI3K pathway activation in gallbladder tumorigenesis

Lunardi, A., Webster, K. A., Papa, A., Padmani, B., Clohessy, J. G., Bronson, R. T. & Pandolfi, P. P., 10 Mar 2014, In : Oncotarget. 5, 4, p. 894-900 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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23 Citations (Scopus)

Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition

González-Billalabeitia, E., Seitzer, N., Song, S. J., Song, M. S., Patnaik, A., Liu, X. S., Epping, M. T., Papa, A., Hobbs, R. M., Chen, M., Lunardi, A., Ng, C., Webster, K. A., Signoretti, S., Loda, M., Asara, J. M., Nardella, C., Clohessy, J. G., Cantley, L. C. & Pandolfi, P. P., Aug 2014, In : Cancer Discovery. 4, 8, p. 896-904 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
File
48 Citations (Scopus)
2013

Pills of PTEN? in and out for tumor suppression

Papa, A., Chen, M. & Pandolfi, P. P., Oct 2013, In : Cell Research. 23, 10, p. 1155-1156 2 p.

Research output: Contribution to journalArticleOtherpeer-review

9 Citations (Scopus)
2012

Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer

Juvekar, A., Burga, L. N., Hu, H., Lunsford, E. P., Ibrahim, Y. H., Balmañà, J., Rajendran, A., Papa, A., Spencer, K., Lyssiotis, C. A., Nardella, C., Pandolfi, P. P., Baselga, J., Scully, R., Asara, J. M., Cantley, L. C. & Wulf, G. M., Nov 2012, In : Cancer Discovery. 2, 11, p. 1048-1063 16 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
239 Citations (Scopus)

Compound In Vivo Inactivation of Pml and p53 Uncovers a Functional Interaction in Angiosarcoma Suppression

Papa, A., Cordon-Cardo, C., Bernardi, R. & Pandolfi, P. P., 2012, In : Genes & Cancer. 3, 9-10, p. 599-603 5 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Functional antagonism between Sall4 and Plzf defines germline progenitors

Hobbs, R. M., Fagoonee, S., Papa, A., Webster, K., Altruda, F., Nishinakamura, R., Chai, L. & Pandolfi, P. P., 2012, In : Cell Stem Cell. 10, 3, p. 284 - 298 15 p.

Research output: Contribution to journalArticleResearchpeer-review

110 Citations (Scopus)
2011

A SP1/MIZ1/MYCN repression complex recruits HDAC1 at the TRKA and p75NTR promoters and affects neuroblastoma malignancy by inhibiting the cell response to NGF

Iraci, N., Diolaiti, D., Papa, A., Porro, A., Valli, E., Gherardi, S., Herold, S., Eilers, M., Bernardoni, R., Della Valle, G. & Perini, G., 15 Jan 2011, In : Cancer Research. 71, 2, p. 404-412 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
56 Citations (Scopus)

Pml represses tumour progression through inhibition of mTOR

Bernardi, R., Papa, A., Egia, A., Coltella, N., Teruya-Feldstein, J., Signoretti, S. & Pandolfi, P. P., May 2011, In : EMBO Molecular Medicine. 3, 5, p. 249-257 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
14 Citations (Scopus)
2008

Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer

Carracedo, A., Ma, L., Teruya-Feldstein, J., Rojo, F., Salmena, L., Alimonti, A., Egia, A., Sasaki, A. T., Thomas, G., Kozma, S. C., Papa, A., Nardella, C., Cantley, L. C., Baselga, J. & Pandolfi, P. P., 2 Sep 2008, In : Journal of Clinical Investigation. 118, 9, p. 3065-3074 10 p.

Research output: Contribution to journalArticleResearchpeer-review

1058 Citations (Scopus)
2007

Functional cooperation between TrkA and p75NTR accelerates neuronal differentiation by increased transcription of GAP-43 and p21(CIP/WAF) genes via ERK1/2 and AP-1 activities

Diolaiti, D., Bernardoni, R., Trazzi, S., Papa, A., Porro, A., Bono, F., Herbert, J. M., Perini, G. & Della Valle, G., 15 Aug 2007, In : Experimental Cell Research. 313, 14, p. 2980-2992 13 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)