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Research Output 2004 2019

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2019

Antibiotic resistance and host immune evasion in Staphylococcus aureus mediated by a metabolic adaptation

Jiang, J-H., Bhuiyan, M. S., Shen, H-H., Cameron, D. R., Rupasinghe, T. W. T., Wu, C. M., Le Brun, A. P., Kostoulias, X., Domene, C., Fulcher, A. J., McConville, M. J., Howden, B. P., Lieschke, G. J. & Peleg, A. Y., 26 Feb 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 9, p. 3722-3727 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Characterization of Hypermutator Pseudomonas aeruginosa Isolates from Patients with Cystic Fibrosis in Australia

Rees, V. E., Deveson Lucas, D. S., López-Causapé, C., Huang, Y., Kotsimbos, T., Bulitta, J. B., Rees, M. C., Barugahare, A., Peleg, A. Y., Nation, R. L., Oliver, A., Boyce, J. D. & Landersdorfer, C. B., 1 Apr 2019, In : Antimicrobial Agents and Chemotherapy. 63, 4, 11 p., e02538-18.

Research output: Contribution to journalArticleResearchpeer-review

Evolution of daptomycin resistance in coagulase-negative staphylococci involves mutations of the essential two-component regulator WALKR

Jiang, J-H., Dexter, C., Cameron, D. R., Monk, I. R., Baines, S. L., Abbott, I. J., Spelman, D. W., Kostoulias, X., Nethercott, C., Howden, B. P. & Peleg, A. Y., 1 Mar 2019, In : Antimicrobial Agents and Chemotherapy. 63, 3, 10 p., e01926-18.

Research output: Contribution to journalArticleResearchpeer-review

Identification of Novel Acinetobacter baumannii Host Fatty Acid Stress Adaptation Strategies

Jiang, J. H., Hassan, K. A., Begg, S. L., Rupasinghe, T. W. T., Naidu, V., Pederick, V. G., Khorvash, M., Whittall, J. J., Paton, J. C., Paulsen, I. T., McDevitt, C. A., Peleg, A. Y. & Eijkelkamp, B. A., 5 Feb 2019, In : mBio. 10, 1, 6 p., e02056-18.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Spectrum of illness among returned Australian travellers from Bali, Indonesia: a 5-year retrospective observational study

Sohail, A., McGuinness, S. L., Lightowler, R., Leder, K., Jomon, B., Bain, C. A. & Peleg, A. Y., 1 Jan 2019, In : Internal Medicine Journal. 49, 1, p. 34-40 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2018

Antibiotic exposure and interpersonal variance mask the effect of ivacaftor on respiratory microbiota composition

Peleg, A. Y., Choo, J. M., Langan, K. M., Edgeworth, D., Keating, D., Wilson, J., Rogers, G. B. & Kotsimbos, T., 1 Jan 2018, In : Journal of Cystic Fibrosis. 17, 1, p. 50-56 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Comprehensive antibiotic-linked mutation assessment by resistance mutation sequencing (RM-seq)

Guérillot, R., Li, L., Baines, S., Howden, B., Schultz, M. B., Seemann, T., Monk, I., Pidot, S. J., Gao, W., Giulieri, S., Gonçalves da Silva, A., D'Agata, A., Tomita, T., Peleg, A. Y., Stinear, T. P. & Howden, B. P., 31 Aug 2018, In : Genome Medicine. 10, 1, 15 p., 63.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Convergent evolution driven by rifampin exacerbates the global burden of drug-resistant Staphylococcus aureus

Guérillot, R., da Silva, A. G., Monk, I., Giulieri, S., Tomita, T., Alison, E., Porter, J., Pidot, S., Gao, W., Peleg, A. Y., Seemann, T., Stinear, T. P. & Howden, B. P., 1 Jan 2018, In : mSphere. 3, 1, e00550-17.

Research output: Contribution to journalArticleResearchpeer-review

Effect of piperacillin-tazobactam vs meropenem on 30-day mortality for patients with e coli or Klebsiella pneumoniae bloodstream infection and ceftriaxone resistance

Harris, P. N. A., Tambyah, P. A., Lye, D. C., Mo, Y., Lee, T. H., Yilmaz, M., Alenazi, T. H., Arabi, Y., Falcone, M., Bassetti, M., Righi, E., Rogers, B. A., Kanj, S., Bhally, H., Iredell, J., Mendelson, M., Boyles, T. H., Looke, D., Miyakis, S., Walls, G. & 15 othersAl Khamis, M., Zikri, A., Crowe, A., Ingram, P., Daneman, N., Griffin, P., Athan, E., Lorenc, P., Baker, P., Roberts, L., Beatson, S. A., Peleg, A. Y., Harris-Brown, T., Paterson, D. L. & for the MERINO Trial Investigators and the Australasian Society for Infectious Disease Clinical Research Network (ASID-CRN), 11 Sep 2018, In : JAMA - Journal of the American Medical Association. 320, 10, p. 984-994 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Elucidation of the pharmacokinetic/pharmacodynamic determinants of fosfomycin activity against Pseudomonas aeruginosa using a dynamic in vitro model

Bilal, H., Peleg, A. Y., McIntosh, M. P., Styles, I. K., Hirsch, E. B., Landersdorfer, C. B. & Bergen, P. J., 1 Jun 2018, In : Journal of Antimicrobial Chemotherapy. 73, 6, p. 1570-1578 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Evolution of carbapenem resistance in Acinetobacter baumannii during a prolonged infection

Hawkey, J., Ascher, D. B., Judd, L. M., Wick, R. R., Kostoulias, X., Cleland, H., Spelman, D. W., Padiglione, A., Peleg, A. Y. & Holt, K. E., Mar 2018, In : Microbial genomics. 4, 3, 11 p., 000165.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Fosfomycin efficacy and emergence of resistance among Enterobacteriaceae in an in vitro dynamic bladder infection model

Abbott, I. J., Meletiadis, J., Belghanch, I., Wijma, R. A., Kanioura, L., Roberts, J. A., Peleg, A. Y. & Mouton, J. W., 1 Mar 2018, In : Journal of Antimicrobial Chemotherapy. 73, 3, p. 709-719 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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In vivo atomic force microscopy–infrared spectroscopy of bacteria

Kochan, K., Perez Guaita, D., Pissang, J., Jiang, J-H., Peleg, A. Y., McNaughton, D., Heraud, P. & Wood, B. R., 1 Jan 2018, In : Journal of the Royal Society Interface. 15, 140, 9 p., 20180115.

Research output: Contribution to journalArticleResearchpeer-review

Meropenem Combined with Ciprofloxacin Combats Hypermutable Pseudomonas aeruginosa from Respiratory Infections of Cystic Fibrosis Patients

Rees, V. E., Yadav, R., Rogers, K. E., Bulitta, J. B., Wirth, V., Oliver, A., Boyce, J. D., Peleg, A. Y., Nation, R. L. & Landersdorfer, C. B., 1 Nov 2018, In : Antimicrobial Agents and Chemotherapy. 62, 11, 12 p., e01150-18.

Research output: Contribution to journalArticleResearchpeer-review

Mobile phones and computer keyboards: unlikely reservoirs of multidrug-resistant organisms in the tertiary intensive care unit

Smibert, O. C., Aung, A. K., Woolnough, E., Carter, G. P., Schultz, M. B., Howden, B. P., Seemann, T., Spelman, D., McGloughlin, S. & Peleg, A. Y., 1 Jul 2018, In : Journal of Hospital Infection. 99, 3, p. 295-298 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Optimization of a meropenem-tobramycin combination dosage regimen against hypermutable and nonhypermutable pseudomonas aeruginosa via mechanism-based modeling and the hollow-fiber infection model

Landersdorfer, C. B., Rees, V. E., Yadav, R., Rogers, K. E., Kim, T. H., Bergen, P. J., Cheah, S-E., Boyce, J. D., Peleg, A. Y., Oliver, A., Shin, B. S., Nation, R. L. & Bulitta, J. B., 1 Apr 2018, In : Antimicrobial Agents and Chemotherapy. 62, 4, 13 p., e02055-17.

Research output: Contribution to journalArticleResearchpeer-review

2017

Donor-derived Mycoplasma hominis and an apparent cluster of M. hominis cases in solid organ transplant recipients

Smibert, O. C., Wilson, H. L., Sohail, A., Narayanasamy, S., Schultz, MB., Ballard, S. A., Kwong, J. C., de Boer, J., Morrissey, O., Peleg, AY., Snell, G., Paraskeva, M. & Jenney, A. W. J., 1 Nov 2017, In : Clinical Infectious Diseases. 65, 9, p. 1504-1508 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Global Gene Expression Profile of Acinetobacter baumannii During Bacteremia

Murray, G. L., Tsyganov, K., Kostoulias, X. P., Bulach, D. M., Powell, D., Creek, D. J., Boyce, J. D., Paulsen, I. T. & Peleg, A. Y., 15 Feb 2017, In : Journal of Infectious Diseases. 215, 1, p. S52-S57

Research output: Contribution to journalArticleResearchpeer-review

Proposed primary endpoints for use in clinical trials that compare treatment options for bloodstream infection in adults: A consensus definition

Harris, P. N. A., McNamara, J. F., Lye, D. C., Davis, J. S., Bernard, L., Cheng, A. C., Doi, Y., Fowler, V. G., Kaye, K. S., Leibovici, L., Lipman, J., Llewelyn, M. J., Munoz-Price, S., Paul, M., Peleg, A. Y., Rodríguez-Baño, J., Rogers, B. A., Seifert, H., Thamlikitkul, V., Thwaites, G. & 5 othersTong, S. Y. C., Turnidge, J., Utili, R., Webb, S. A. R. & Paterson, D. L., Aug 2017, In : Clinical Microbiology and Infection. 23, 8, p. 533-541

Research output: Contribution to journalArticleResearchpeer-review

Recommendations for the control of carbapenemase-producing Enterobacteriaceae (CPE): A guide for acute care health facilities: Australian Commission on Safety and Quality in Health Care

The Australian Commission on Safety and Quality in Health Care, 1 Dec 2017, In : Infection, Disease and Health. 22, 4, p. 159-186 28 p.

Research output: Contribution to journalArticleOtherpeer-review

Open Access
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Structural basis for linezolid binding site rearrangement in the Staphylococcus aureus ribosome

Belousoff, M. J., Eyal, Z., Radjainia, M., Ahmed, T., Bamert, R. S., Matzov, D., Bashan, A., Zimmerman, E., Mishra, S., Cameron, D., Elmlund, H., Peleg, A. Y., Bhushan, S., Lithgow, T. & Yonath, A., 9 May 2017, In : mBio. 8, 3, 7 p., e00395-17.

Research output: Contribution to journalArticleResearchpeer-review

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Synthesis of novel 1,2,5-oxadiazoles and evaluation of action against Acinetobacter baumannii

Christoff, R. M., Murray, G. L., Kostoulias, X. P., Peleg, A. Y. & Abbott, B. M., 15 Dec 2017, In : Bioorganic and Medicinal Chemistry. 25, 24, p. 6267-6272 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Vancomycin-intermediate Staphylococcus aureus isolates are attenuated for virulence when compared with susceptible progenitors

Cameron, D. R., Lin, Y-H., Trouillet-Assant, S., Tafani, V., Kostoulias, X., Mouhtouris, E., Skinner, N., Visvanathan, K., Baines, S. L., Howden, B., Monk, I. R., Laurent, F., Stinear, T. P., Howden, B. P. & Peleg, A. Y., Oct 2017, In : Clinical Microbiology and Infection. 23, 10, p. 767-773 7 p.

Research output: Contribution to journalArticleResearchpeer-review

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2016

Acinetobacter baumannii phenylacetic acid metabolism influences infection outcome through a direct effect on neutrophil chemotaxis

Bhuiyan, M. S., Ellett, F., Murray, G. L., Kostoulias, X., Cerqueira, G. M., Schulze, K. E., Mahamad Maifiah, M. H., Li, J., Creek, D. J., Lieschke, G. J. & Peleg, A. Y., 23 Aug 2016, In : Proceedings of the National Academy of Sciences. 113, 34, p. 9599-9604 6 p., 1523116113.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

A comparative analysis between antibiotic- and nonantibiotic-associated delayed cutaneous adverse drug reactions

Trubiano, J. A., Aung, A. K., Mary, N., Fehily, S., Graudins, L., Cleland, H., Padiglione, A. & Peleg, A. Y., 2016, In : Journal of Allergy and Clinical Immunology: In Practice. 4, 6, p. 1187 - 1193 7 p.

Research output: Contribution to journalArticleResearchpeer-review

COL 6-01 - Le compartiment intracellulaire: un réservoir bactérien pour les souches VISA

Trouillet-Assant, S., Tafani, V., Cameron, D., Valour, F., Peleg, A. & Laurent, F., 1 Jun 2016, In : Medecine et Maladies Infectieuses. 46, 4, p. 13 1 p.

Research output: Contribution to journalArticleOtherpeer-review

Impact of a cross-kingdom signaling molecule of Candida albicans on Acinetobacter baumannii physiology

Kostoulias, X., Murray, G. L., Cerqueira, G. C., Kong, J. B., Bantun, F., Mylonakis, E., Khoo, C. A. & Peleg, A. Y., 1 Jan 2016, In : Antimicrobial Agents and Chemotherapy. 60, 1, p. 161-167 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Polymicrobial infections involving clinically relevant Gram-negative bacteria and fungi

Dhamgaye, S., Qu, Y. & Peleg, A. Y., Dec 2016, In : Cellular Microbiology. 18, 12, p. 1716-1722 7 p.

Research output: Contribution to journalArticleOtherpeer-review

Safety, clinical effectiveness and trough plasma concentrations of intravenous posaconazole in patients with haematological malignancies and/or undergoing allogeneic haematopoietic stem cell transplantation: off-trial experience

Jeong, W., Haywood, P., Shanmuganathan, N., Lindsay, J., Urbancic, K., Ananda-Rajah, M., Chen, S. C. A., Bajel, A., Ritchie, D., Grigg, A., Seymour, J. F., Peleg, A. Y., Kong, D. C. M. & Slavin, M., 11 Aug 2016, In : Journal of Antimicrobial Chemotherapy. 71, 12, p. 3540-3547 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Vancomycin susceptibility in methicillin-resistant Staphylococcus aureus is mediated by YycHI activation of the WalRK essential two-component regulatory system

Cameron, D. R., Jiang, J. H., Kostoulias, X., Foxwell, D. J. & Peleg, A. Y., 7 Sep 2016, In : Scientific Reports. 6, 30823.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2015

Acinetobacter baumannii: evolution of antimicrobial resistance-treatment options

Doi, Y., Murray, G. L. & Peleg, A. Y., 2015, In : Seminars in Respiratory and Critical Care Medicine. 36, 1, p. 85 - 98 14 p.

Research output: Contribution to journalArticleResearchpeer-review

Active surveillance for multidrug-resistant Gram-negative bacteria in the intensive care unit

Abbott, I. J., Jenney, A. W., Spelman, D. W., Pilcher, D. V., Sidjabat, H. E., Richardson, L. J., Paterson, D. L. & Peleg, A. Y., 2015, In : Pathology. 47, 6, p. 575 - 579 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Antibiotic regimen based on population analysis of residing persister cells eradicates Staphylococcus epidermidis biofilms

Yang, S., Hay, I. D., Cameron, D. R., Speir, M., Cui, B., Su, F., Peleg, A. Y., Lithgow, T. J., Deighton, M. A. & Qu, Y., 2015, In : Scientific Reports. 5, 11 p., 18578.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Community-acquired Acinetobacter baumannii: clinical characteristics, epidemiology and pathogenesis

Dexter, C., Murray, G. L., Paulsen, I. T. & Peleg, A. Y., 2015, In : Expert Review of Anti-Infective Therapy. 13, 5, p. 567 - 573 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Daptomycin-nonsusceptible Staphylococcus aureus: the role of combination therapy with daptomycin and gentamicin

Jiang, J-H. & Peleg, A. Y., 2015, In : Genes. 6, 4, p. 1256 - 1267 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Distribution of beta-lactamase genes among carbapenem-resistant Klebsiella pneumoniae strains isolated from patients in Turkey

Iraz, M., Duzgun, A. O. Z., Sandalli, C., Doymaz, M. Z., Akkoyunlu, Y., Saral, A., Peleg, A. Y., Ozgumus, O. B., Beris, F. S., Karaoglu, H. & Cicek, A. C., 2015, In : Annals of Laboratory Medicine. 35, 6, p. 595 - 601 7 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Open Access
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Identification of a class of protein ADP-Ribosylating sirtuins in microbial pathogens

Rack, J. G. M., Morra, R., Barkauskaite, E., Kraehenbuehl, R., Ariza, A., Qu, Y., Ortmayer, M., Leidecker, O., Cameron, D. R., Matic, I., Peleg, A. Y., Leys, D., Traven, A. & Ahel, I., 2015, In : Molecular Cell. 59, 2, p. 309 - 320 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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Impact of daptomycin resistance on staphylococcus aureus virulence

Cameron, D. R., Mortin, L. I., Rubio, A., Mylonakis, E., Moellering Jr, R. C., Eliopoulos, G. M. & Peleg, A. Y., 2015, In : Virulence. 6, 2, p. 127 - 131 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Insights on virulence from the complete genome of Staphylococcus capitis

Cameron, D. R., Jiang, J-H., Hassan, K. A., Elbourne, L. D. H., Tuck, K. L., Paulsen, I. T. & Peleg, A. Y., 2015, In : Frontiers in Microbiology. 6, 12 p., 980.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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In vitro pharmacodynamics of fosfomycin against clinical isolates of Pseudomonas aeruginosa

Walsh, C. C., McIntosh, M. P., Peleg, A. Y., Kirkpatrick, C. M. & Bergen, P. J., 2015, In : Journal of Antimicrobial Chemotherapy. 70, 11, p. 3042-3050 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Managing Pseudomonas aeruginosa respiratory infections in cystic fibrosis

Langan, K. M., Kotsimbos, T. C. & Peleg, A. Y., 2015, In : Current Opinion in Infectious Diseases. 28, 6, p. 547 - 556 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Meropenem versus piperacillin-tazobactam for definitive treatment of bloodstream infections due to ceftriaxone non-susceptible Escherichia coli and Klebsiella spp (the MERINO trial): study protocol for a randomised controlled trial.

Harris, P., Peleg, A. Y., Iredell, J. R., Ingram, P. R., Miyakis, S., Stewardson, A. J., Rogers, B., McBryde, E., Roberts, J. A., Lipman, J., Athan, E., Paul, S. K., Baker, P., Harris, T-B. & Paterson, D. L., 2015, In : Trials. 16, 1, p. 1 - 8 8 p.

Research output: Contribution to journalArticleOther

Species identification within Acinetobacter calcoaceticus-baumannii complex using MALDI-TOF MS

Toh, B. E. W., Paterson, D. L., Kamolvit, W., Zowawi, H. M., Kvaskoff, D., Sidjabat, H. E., Wailan, A. M., Peleg, A. Y. & Huber, C. A., 2015, In : Journal of Microbiological Methods. 118, p. 128 - 132 5 p.

Research output: Contribution to journalArticleResearchpeer-review

Stenotrophomonas, achromobacter, and nonmelioid burkholderia species: Antimicrobial resistance and therapeutic strategies

Abbott, I. J. & Peleg, A. Y., 2015, In : Seminars in Respiratory and Critical Care Medicine. 36, 1, p. 99-110 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Stepwise decrease in daptomycin susceptibility in clinical Staphylococcus aureus isolates associated with an initial mutation in rpoB and a compensatory inactivation of the clpX gene

Baek, K. T., Thogersen, L., Mogenssen, R. G., Mellergaard, M., Thomsen, L. E., Petersen, A., Skov, S., Cameron, D. R., Peleg, A. Y. & Frees, D., 2015, In : Antimicrobial Agents and Chemotherapy. 59, 11, p. 6983 - 6991 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access

Surface coatings with covalently attached caspofungin are effective in eliminating fungal pathogens

Coad, B. R., Lamont-Friedrich, S. J., Gwynne, L., Jasieniak, M., Griesser, S., Traven, A., Peleg, A. Y. & Griesser, H. J., 2015, In : Journal of Materials Chemistry B. 3, 43, p. 8469 - 8476 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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2014

A global virulence regulator in Acinetobacter baumannii and its control of the phenylacetic acid catabolic pathway

Cerqueira, G., Kostoulias, X. P., Khoo, C. A., Aibinu, I., Qu, Y., Traven, A. & Peleg, A. Y., 2014, In : Journal of Infectious Diseases. 210, 1, p. 46 - 55 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
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