Projects per year
Personal profile
Biography
Research Group Head, Molecular Immunity
Centre for innate Immunity and Infectious Diseases, Hudson Institute of Medical Research
Dr Anthony Sadler is an expert in innate immunity. After completing his early research training in microbial genetics at the University of Canterbury and virology at the University of Otago (New Zealand), he travelled to the USA where he conducted postdoctoral research into host immune responses to microbial pathogens at the Centre for Cancer Biology within the Learner Research Institute. In 2007, Dr Sadler relocated to Australia, where he took up a position as a Senior Research Fellow within the Centre for Cancer Research at the Hudson Institute of Medical Research. His research group investigates innate immune responses that drive inflammation. Dr Sadler’s research has advanced our knowledge of the regulation of cell signalling pathways that control responses to our environment. His research aims to characterise mechanisms that cause inflammation, in order to identify strategies to curb inflammatory pathologies and ensuing disease.
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Research area keywords
- Cell biology
- Innate immunity
- Viral immunity
- Inflammation
- Cell signalling
- Auto-immunity
Network
Projects
- 4 Finished
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Targeting cytokine signalling in systemic lupus erythematosus
Sadler, A., Williams, B. & Xu, D.
1/01/18 → 31/12/21
Project: Research
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Gelsolin as a novel antiviral target
National Health and Medical Research Council (NHMRC) (Australia)
1/01/13 → 31/12/15
Project: Research
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A novel lipid sensitive kinase and its role in obesity-induced inflammation and insulin resistance
Williams, B., Febbraio, M., Lancaster, G. & Sadler, A.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/10 → 31/12/12
Project: Research
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Purifying and Crystallizing Proteins to design better cancer therapies
30/07/07 → 31/07/08
Project: Research
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Protein kinase R is an innate immune sensor of proteotoxic stress via accumulation of cytoplasmic IL-24
Davidson, S., Yu, C. H., Steiner, A., Ebstein, F., Baker, P. J., Jarur-Chamy, V., Schaale, K. H., Laohamonthonkul, P., Kong, K., Calleja, D. J., Harapas, C. R., Balka, K. R., Mitchell, J., Jackson, J. T., Geoghegan, N. D., Moghaddas, F., Rogers, K. L., Mayer-Barber, K. D., De Jesus, A. A., De Nardo, D., & 6 others , Feb 2022, In: Science Immunology. 7, 68, 14 p., eabi6763.Research output: Contribution to journal › Article › Research › peer-review
8 Citations (Scopus) -
The role of MDA5 in the development of autoimmune disease
Sadler, A. J., 1 Feb 2018, In: Journal of Leukocyte Biology. 103, 2, p. 185-192 8 p.Research output: Contribution to journal › Review Article › Other › peer-review
13 Citations (Scopus) -
The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53
Szczepny, A., Carey, K., McKenzie, L., Jayasekara, W. S. N., Rossello, F., Gonzalez-Rajal, A., McCaw, A. S., Popovski, D., Wang, D., Sadler, A. J., Mahar, A., Russell, P. A., Wright, G., McCloy, R. A., Garama, D. J., Gough, D. J., Baylin, S. B., Burgess, A., Cain, J. E. & Watkins, D. N., 25 Jan 2018, In: Oncogene. 37, p. 1939-1948 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile13 Citations (Scopus) -
Auto-phosphorylation represses protein kinase R activity
Wang, D., De Weerd, N. A., Willard, B., Polekhina, G., Williams, B. R. G. & Sadler, A. J., 10 Mar 2017, In: Scientific Reports. 7, 15 p., 44340.Research output: Contribution to journal › Article › Research › peer-review
Open AccessFile6 Citations (Scopus) -
The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation
Dou, Y., Yim, H. C. H., Kirkwood, C. D., Williams, B. R. G. & Sadler, A. J., 15 Sep 2017, In: The EMBO Journal. 36, 18, p. 2742-2757 16 p.Research output: Contribution to journal › Article › Research › peer-review
19 Citations (Scopus)
Activities
- 1 Consultancy
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Perpetual Trustees Australia (External organisation)
Anthony Sadler (Member)
2017Activity: Industry, Government and Philanthropy Engagement and Partnerships › Consultancy