Projects per year
Personal profile
Biography
Research Group Head, Molecular Immunity
Centre for innate Immunity and Infectious Diseases, Hudson Institute of Medical Research
Dr Anthony Sadler is an expert in innate immunity. After completing his early research training in microbial genetics at the University of Canterbury and virology at the University of Otago (New Zealand), he travelled to the USA where he conducted postdoctoral research into host immune responses to microbial pathogens at the Centre for Cancer Biology within the Learner Research Institute. In 2007, Dr Sadler relocated to Australia, where he took up a position as a Senior Research Fellow within the Centre for Cancer Research at the Hudson Institute of Medical Research. His research group investigates innate immune responses that drive inflammation. Dr Sadler’s research has advanced our knowledge of the regulation of cell signalling pathways that control responses to our environment. His research aims to characterise mechanisms that cause inflammation, in order to identify strategies to curb inflammatory pathologies and ensuing disease.
Research area keywords
- Cell biology
- Innate immunity
- Viral immunity
- Inflammation
- Cell signalling
- Auto-immunity
Network
Recent external collaboration on country level. Dive into details by clicking on the dots.
Projects
Targeting cytokine signalling in systemic lupus erythematosus
Sadler, A., Williams, B. & Xu, D.
1/01/18 → 31/12/21
Project: Research
Gelsolin as a novel antiviral target
National Health & Medical Research Council (NHMRC)
1/01/13 → 31/12/15
Project: Research
A novel lipid sensitive kinase and its role in obesity-induced inflammation and insulin resistance
Williams, B., Febbraio, M., Lancaster, G. & Sadler, A.
National Health & Medical Research Council (NHMRC)
1/01/10 → 31/12/12
Project: Research
Purifying and Crystallizing Proteins to design better cancer therapies
30/07/07 → 31/07/08
Project: Research
Research Output
The role of MDA5 in the development of autoimmune disease
Sadler, A. J., 1 Feb 2018, In : Journal of leukocyte biology. 103, 2, p. 185-192 8 p.Research output: Contribution to journal › Review Article › Other › peer-review
2
Citations
(Scopus)
The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53
Szczepny, A., Carey, K., McKenzie, L., Jayasekara, W. S. N., Rossello, F., Gonzalez-Rajal, A., McCaw, A. S., Popovski, D., Wang, D., Sadler, A. J., Mahar, A., Russell, P. A., Wright, G., McCloy, R. A., Garama, D. J., Gough, D. J., Baylin, S. B., Burgess, A., Cain, J. E. & Watkins, D. N., 25 Jan 2018, In : Oncogene. 37, p. 1939-1948 10 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
4
Citations
(Scopus)
Auto-phosphorylation represses protein kinase R activity
Wang, D., De Weerd, N. A., Willard, B., Polekhina, G., Williams, B. R. G. & Sadler, A. J., 10 Mar 2017, In : Scientific Reports. 7, 15 p., 44340.Research output: Contribution to journal › Article › Research › peer-review
Open Access
File
1
Citation
(Scopus)
The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation
Dou, Y., Yim, H. C. H., Kirkwood, C. D., Williams, B. R. G. & Sadler, A. J., 15 Sep 2017, In : The EMBO Journal. 36, 18, p. 2742-2757 16 p.Research output: Contribution to journal › Article › Research › peer-review
8
Citations
(Scopus)
PKR
Sadler, A. J., 12 Dec 2016, Encyclopedia of Signaling Molecules. Choi, S. (ed.). 2 ed. New York: Springer, 9 p.Research output: Chapter in Book/Report/Conference proceeding › Encyclopaedia / Dictionary Entry › Other › peer-review
Activities
- 1 Consultancy
Perpetual Trustees Australia (External organisation)
Anthony Sadler (Member)
2017
Activity: Industry, Government and Philanthropy Engagement and Partnerships › Consultancy