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Research Group Head, Molecular Immunity

Centre for innate Immunity and Infectious Diseases, Hudson Institute of Medical Research

Dr Anthony Sadler is an expert in innate immunity. After completing his early research training in microbial genetics at the University of Canterbury and virology at the University of Otago (New Zealand), he travelled to the USA where he conducted postdoctoral research into host immune responses to microbial pathogens at the Centre for Cancer Biology within the Learner Research Institute. In 2007, Dr Sadler relocated to Australia, where he took up a position as a Senior Research Fellow within the Centre for Cancer Research at the Hudson Institute of Medical Research. His research group investigates innate immune responses that drive inflammation. Dr Sadler’s research has advanced our knowledge of the regulation of cell signalling pathways that control responses to our environment. His research aims to characterise mechanisms that cause inflammation, in order to identify strategies to curb inflammatory pathologies and ensuing disease.

Research area keywords

  • Cell biology
  • Innate immunity
  • Viral immunity
  • Inflammation
  • Cell signalling
  • Auto-immunity

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Research Output

The role of MDA5 in the development of autoimmune disease

Sadler, A. J., 1 Feb 2018, In : Journal of leukocyte biology. 103, 2, p. 185-192 8 p.

Research output: Contribution to journalReview ArticleOtherpeer-review

2 Citations (Scopus)

The tumor suppressor Hic1 maintains chromosomal stability independent of Tp53

Szczepny, A., Carey, K., McKenzie, L., Jayasekara, W. S. N., Rossello, F., Gonzalez-Rajal, A., McCaw, A. S., Popovski, D., Wang, D., Sadler, A. J., Mahar, A., Russell, P. A., Wright, G., McCloy, R. A., Garama, D. J., Gough, D. J., Baylin, S. B., Burgess, A., Cain, J. E. & Watkins, D. N., 25 Jan 2018, In : Oncogene. 37, p. 1939-1948 10 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
4 Citations (Scopus)

Auto-phosphorylation represses protein kinase R activity

Wang, D., De Weerd, N. A., Willard, B., Polekhina, G., Williams, B. R. G. & Sadler, A. J., 10 Mar 2017, In : Scientific Reports. 7, 15 p., 44340.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
1 Citation (Scopus)

The innate immune receptor MDA5 limits rotavirus infection but promotes cell death and pancreatic inflammation

Dou, Y., Yim, H. C. H., Kirkwood, C. D., Williams, B. R. G. & Sadler, A. J., 15 Sep 2017, In : The EMBO Journal. 36, 18, p. 2742-2757 16 p.

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)


Sadler, A. J., 12 Dec 2016, Encyclopedia of Signaling Molecules. Choi, S. (ed.). 2 ed. New York: Springer, 9 p.

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review


  • 1 Consultancy

Perpetual Trustees Australia (External organisation)

Anthony Sadler (Member)


Activity: Industry, Government and Philanthropy Engagement and PartnershipsConsultancy