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Research Output 1989 2019

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2007

Expression and purification of the minor histocompatibility antigen, HA-1H generated in Escherichia coli

Etto, T., Stewart, L., Nguyen, T. H. O., Williamson, N., Purcell, A. & Schwarer, A., 2007, In : Protein Expression and Purification. 54, 1, p. 176 - 182 7 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Immune responses to abacavir in antigen-presenting cells from hypersensitive patients

Martin, A. M., Almeida, C. A., Cameron, P., Purcell, A. W., Nolan, D., James, I., McCluskey, J., Phillips, E., Landay, A. & Mallal, S., 1 Jun 2007, In : AIDS. 21, 10, p. 1233-1244 12 p.

Research output: Contribution to journalArticleResearchpeer-review

400 Citations (Scopus)

More than one reason to rethink the use of peptides in vaccine design

Purcell, A. W., McCluskey, J. & Rossjohn, J., 2007, In : Nature Reviews Drug Discovery. 6, 5, p. 404 - 414 11 p.

Research output: Contribution to journalArticleResearchpeer-review

Post translationally modified peptides: New targets in autoimmune disease

Lau, K. & Purcell, A. W., 2 Aug 2007, In : Chimica Oggi. 25, p. 6-9 4 p.

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

The molecular basis of cross-reactivity in the Australian Snake Venom Detection Kit (SVDK)

Winkel, K., Carroll, T., Williamson, N. A., Ignjatovic, V., Fung, K., Purcell, A. W. & Fry, B. G., 15 Dec 2007, In : Toxicon. 50, 8, p. 1041-1052 12 p.

Research output: Contribution to journalArticleResearchpeer-review

2006
28 Citations (Scopus)

C-terminal Src kinase-homologous kinase (CHK), a unique inhibitor inactivating multiple active conformations of Src family tyrosine kinases

Chong, Y. P., Chan, A. S., Chan, K. C., Williamson, N. A., Lerner, E. C., Smithgall, T. E., Bjorge, J. D., Fujita, D. J., Purcell, A. W., Scholz, G., Mulhern, T. D. & Cheng, H. C., 3 Nov 2006, In : Journal of Biological Chemistry. 281, 44, p. 32988-32999 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
48 Citations (Scopus)

Disparate thermodynamics governing T cell receptor-MHC-1 interactions implicate extrinsic factors in guiding MHC restriction

Ely, L. K., Beddoe, T. C., Clements, C. S., Matthews, J. M., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J. & Rossjohn, J., 2006, In : Proceedings of the National Academy of Sciences. 103, 17, p. 6641 - 6646 6 p.

Research output: Contribution to journalArticleResearchpeer-review

165 Citations (Scopus)

Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

Krishnamurthy, B., Dudek, N. L., McKenzie, M. D., Purcell, A. W., Brooks, A. G., Gellert, S., Colman, P. G., Harrison, L. C., Lew, A. M., Thomas, H. E. & Kay, T. W. H., 1 Dec 2006, In : Journal of Clinical Investigation. 116, 12, p. 3258-3265 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
11 Citations (Scopus)

Tumors reveal their secrets to cytotoxic T cells

Williamson, N. A., Rossjohn, J. & Purcell, A. W., 2006, In : Proceedings of the National Academy of Sciences. 103, 40, p. 14649 - 14650 2 p.

Research output: Contribution to journalArticleResearchpeer-review

2005
39 Citations (Scopus)

A charged amino acid residue in the transmembrane/cytoplasmic region of tapasin influences MHC class I assembly and maturation

Petersen, J. L., Hickman-Miller, H. D., McIlhaney, M. M., Vargas, S. E., Purcell, A. W., Hildebrand, W. H. & Solheim, J. C., 15 Jan 2005, In : Journal of Immunology. 174, 2, p. 962-969 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
26 Citations (Scopus)

Antagonism of antiviral and allogeneic activity of a human public ctl clonotype by a single altered peptide ligand: Implications for allograft rejection

Ely, L. K., Green, K. J., Beddoe, T. C., Clements, C. S., Miles, J. J., Bottomley, S. P., Zernich, D., Kjer-Nielsen, L., Purcell, A. W., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2005, In : Journal of Immunology. 174, 9, p. 5593 - 5601 9 p.

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

CTL recognition of a bulged viral peptide involves biased TCR selection

Miles, J. J., Elhassen, D., Borg, N. A., Silins, S. L., Tynan, F. E., Burrows, J. M., Purcell, A. W., Kjer-Nielsen, L., Rossjohn, J., Burrows, S. R. & McCluskey, J., 2005, In : Journal of Immunology. 175, 6, p. 3826 - 3834 9 p.

Research output: Contribution to journalArticleResearchpeer-review

123 Citations (Scopus)

High resolution structures of highly bulged viral epitopes bound to major histocompatibility complex class I: implications for T-Cell receptor engagement and T-cell immunodominance

Tynan, F. E., Borg, N., Miles, J. J., Beddoe, T. C., Elhassen, D., Silins, S. L., van Zuylen, W. JM., Purcell, A. W., Kjer-Nielsen, L., McCluskey, J., Burrows, S. R. & Rossjohn, J., 2005, In : Journal of Biological Chemistry. 280, 25, p. 23900 - 23909 10 p.

Research output: Contribution to journalArticleResearchpeer-review

120 Citations (Scopus)

Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations

Turner, S. J., Kedzierska, K., Komodromou, H., La Gruta, N. L., Dunstone, M. A., Webb, A. I., Webby, R., Walden, H., Xie, W., McCluskey, J., Purcell, A. W., Rossjohn, J. & Doherty, P. C., 2005, In : Nature Immunology. 6, 4, p. 382 - 389 8 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Qualitative and quantitative differences in peptides bound to HLA-B27 in the presence of mouse versus human tapasin define a role for tapasin as a size-dependent peptide editor

Sesma, L., Galocha, B., Vázquez, M., Purcell, A. W., Marcilla, M., McCluskey, J. & López De Castro, J. A., 15 Jun 2005, In : Journal of Immunology. 174, 12, p. 7833-7844 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
47 Citations (Scopus)

T cell determinants incorporating beta-amino acid residues are protease resistant and remain immunogenic in vivo

Webb, A. I., Dunstone, M. A., Williamson, N. A., Price, J. D., de Kauwe, A., Chen, W., Oakley, A. J., Perlmutter, P., McCluskey, J., Aguilar, M-I., Rossjohn, J. & Purcell, A. W., 2005, In : Journal of Immunology. 175, 6, p. 3810 - 3818 9 p.

Research output: Contribution to journalArticleResearchpeer-review

209 Citations (Scopus)

T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

Tynan, F. E., Burrows, S. R., Buckle, A. M., Clements, C. S., Borg, N. A., Miles, J. J., Beddoe, T. C., Whisstock, J. C., Wilce, M. C. J., Silins, S. L., Burrows, J. M., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 11, p. 1114 - 1122 9 p.

Research output: Contribution to journalArticleResearchpeer-review

136 Citations (Scopus)

The CDR3 regions of an Immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

Borg, N. A., Ely, L. K., Beddoe, T. C., Macdonald, W. A., Reid, H. H., Clements, C. S., Purcell, A. W., Kjer-Nielsen, L., Miles, J. J., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2005, In : Nature Immunology. 6, 2, p. 171 - 180 10 p.

Research output: Contribution to journalArticleResearchpeer-review

69 Citations (Scopus)

The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

Tynan, F. E., Elhassen, D., Purcell, A. W., Burrows, J. M., Borg, N. A., Miles, J. J., Williamson, N. A., Green, K. J., Tellam, J., Kjer-Nielsen, L., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2005, In : Journal of Experimental Medicine. 202, 9, p. 1249 - 1260 12 p.

Research output: Contribution to journalArticleResearchpeer-review

136 Citations (Scopus)

The insulin A-chain epitope recognized by human T cells is posttranslationally modified

Mannering, S. I., Harrison, L. C., Williamson, N. A., Morris, J. S., Thearle, D. J., Jensen, K. P., Kay, T. W., Rossjohn, J., Falk, B. A., Nepom, G. T. & Purcell, A. W., 2005, In : Journal of Experimental Medicine. 202, 9, p. 1191 - 1197 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2004
98 Citations (Scopus)

Crystal structure of the human T cell receptor CD3 heterodimer complexed to the therapeutic mAb OKT3

Kjer-Nielsen, L., Dunstone, M. A., Kostenko, L., Ely, L. K., Beddoe, T. C., Mifsud, N. A., Purcell, A. W., Brooks, A. G., McCluskey, J. & Rossjohn, J., 2004, In : Proceedings of the National Academy of Sciences. 101, 20, p. 7675 - 7680 6 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogue

Webb, A. I., Dunstone, M. A., Chen, W., Aguilar, M. I., Chen, Q., Jackson, H., Chang, L., Kjer-Nielsen, L., Beddoe, T. C., McCluskey, J., Rossjohn, J. & Purcell, A. W., 2004, In : Journal of Biological Chemistry. 279, 22, p. 23438 - 23446 9 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Isolation and characterization of naturally processed MHC-bound peptides from the surface of antigen-presenting cells.

Purcell, A. W., 1 Jan 2004, In : Methods in molecular biology (Clifton, N.J.). 251, p. 291-306 16 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion

Zernich, D., Purcell, A. W., Macdonald, W. A., Kjer-Nielsen, L., Ely, L. K., Laham, N., Crockford, T., Mifsud, N. A., Bharadwaj, M., Chang, L., Tait, B. D., Holdsworth, R., Brooks, A. G., Bottomley, S. P., Beddoe, T. C., Peh, C. A., Rossjohn, J. & McCluskey, J., 2004, In : Journal of Experimental Medicine. 200, 1, p. 13 - 24 12 p.

Research output: Contribution to journalArticleResearchpeer-review

386 Citations (Scopus)

Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant

Martin, A. M., Nolan, D., Gaudieri, S., Almeida, C. A., Nolan, R., James, I., Carvalho, F., Phillips, E., Christiansen, F. T., Purcell, A. W., McCluskey, J. & Mallal, S., 23 Mar 2004, In : Proceedings of the National Academy of Sciences of the United States of America. 101, 12, p. 4180-4185 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
42 Citations (Scopus)

TAP genes and immunity

McCluskey, J., Rossjohn, J. & Purcell, A. W., 2004, In : Current Opinion in Immunology. 16, 5, p. 651 - 659 9 p.

Research output: Contribution to journalArticleResearchpeer-review

The production and purification of the human T-cell receptors, the CD3and CD3heterodimers: Complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

Dunstone, M. A., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., Brooks, A. G., Rossjohn, J. & McCluskey, J., 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 8, p. 1425 - 1428 4 p.

Research output: Contribution to journalArticleResearchpeer-review

4 Citations (Scopus)

The production and purification of the human T-cell receptors, the CD3εγ and CD3εδ heterodimers: Complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

Dunstone, M. A., Kjer-Nielsen, L., Kostenko, L., Purcell, A. W., Brooks, A. G., Rossjohn, J. & McCluskey, J., 1 Aug 2004, In : Acta Crystallographica Section D: Biological Crystallography. 60, 8, p. 1425-1428 4 p.

Research output: Contribution to journalArticleResearchpeer-review

26 Citations (Scopus)

The structure of H-2Kb and Kbm8 complexed to a herpes simplex virus determinant: Evidence for a conformational switch that governs T cell repertoire selection and viral resistance

Webb, A. I., Borg, N. A., Dunstone, M. A., Kjer-Nielsen, L., Beddoe, T. C., McCluskey, J., Carbone, F. R., Bottomley, S. P., Aguilar, M. I., Purcell, A. W. & Rossjohn, J., 2004, In : Journal of Immunology. 173, 1, p. 402 - 409 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2003
154 Citations (Scopus)

A naturally selected dimorphism within the HLA-B44 supertype alters Class I structure, peptide repertoire, and T cell recognition

Macdonald, W. A., Purcell, A. W., Mifsud, N. A., Ely, L. K., Williams, D. S., Chang, L., Gorman, J. J., Clements, C. S., Kjer-Nielsen, L., Koelle, D. M., Burrows, S. R., Tait, B. D., Holdsworth, R., Brooks, A. G., Lovrecz, G. O., Lu, L., Rossjohn, J. & McCluskey, J., 2003, In : Journal of Experimental Medicine. 198, 5, p. 679 - 691 13 p.

Research output: Contribution to journalArticleResearchpeer-review

119 Citations (Scopus)

A sensitive method for detecting proliferation of rare autoantigen- specific human T cells

Mannering, S. I., Morris, J. S., Jensen, K. P., Purcell, A. W., Honeyman, M. C., Van Endert, P. M. & Harrison, L. C., 1 Jan 2003, In : Journal of Immunological Methods. 283, 1-2, p. 173-183 11 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Association of stress proteins with autoantigens: A possible mechanism for triggering autoimmunity?

Purcell, A. W., Todd, A., Kinoshita, G., Lynch, T. A., Keech, C. L., Gething, M. J. & Gordon, T. P., 1 May 2003, In : Clinical and Experimental Immunology. 132, 2, p. 193-200 8 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
273 Citations (Scopus)

A structural basis for the selection of dominant T cell receptors in antiviral immunity

Kjer-Nielsen, L., Clements, C. S., Purcell, A. W., Brooks, A. G., Whisstock, J. C., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2003, In : Immunity. 18, 1, p. 53 - 64 12 p.

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Human T-cells recognise N-terminally Fmoc-modified peptide

Mannering, S. I., Purcell, A. W., Honeyman, M. C., McCluskey, J. & Harrison, L. C., 1 Jan 2003, In : Vaccine. 21, 25-26, p. 3638-3646 9 p.

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin

Chang, L., Kjer-Nielsen, L., Flynn, S., Brooks, A. G., Mannering, S. I., Honeyman, M. C., Harrison, L. C., McCluskey, J. & Purcell, A. W., 1 Nov 2003, In : Tissue Antigens. 62, 5, p. 408-417 10 p.

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Optimisation of peptide-based cytotoxic T-cell determinants using non-natural amino acids

Webb, A. I., Aguilar, M-I. & Purcell, A. W., 2003, In : Letters in Peptide Science. 10, 5, p. 561 - 569 9 p.

Research output: Contribution to journalArticleResearchpeer-review

2002
31 Citations (Scopus)

Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant form of each complex

Macdonald, W., Williams, D. S., Gorman, J. J., Kjer-Nielsen, L., Brooks, A. G., McCluskey, J., Rossjohn, J. & Purcell, A. W., 2002, In : FEBS Letters. 527, 1-3, p. 27 - 32 6 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Identification of an I-Ad restricted peptide on the 65-kilodalton heat shock protein of Mycobacterium avium

Nagabhushanam, V., Purcell, A. W., Mannering, S., Germano, S., Praszkier, J. & Cheers, C., 26 Nov 2002, In : Immunology and Cell Biology. 80, 6, p. 574-583 10 p.

Research output: Contribution to journalArticleResearchpeer-review

252 Citations (Scopus)

Optimization of the MHC class I peptide cargo is dependent on tapasin

Williams, A. P., Peh, C. A., Purcell, A. W., McCluskey, J. & Elliott, T., 1 Jan 2002, In : Immunity. 16, 4, p. 509-520 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
12 Citations (Scopus)

Restricted specificity of intermolecular spreading to endogenous La (SS-B) and 60 kDA Ro (SS-A) in experimental autoimmunity

Gordon, T. P., Kinoshita, G., Cavill, D., Keech, C., Farris, A. D., Kaufman, K., McCluskey, J. & Purcell, A. W., 27 Jul 2002, In : Scandinavian Journal of Immunology. 56, 2, p. 168-173 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
58 Citations (Scopus)

The 1.5 Å crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 1 Nov 2002, In : Structure. 10, 11, p. 1521-1532 12 p.

Research output: Contribution to journalArticleResearchpeer-review

The 1.5 Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immonodominance

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., McClusky, J. & Rossjohn, J., 2002, In : Structure. 10, 11, p. 1521 - 1532 12 p.

Research output: Contribution to journalArticleResearchpeer-review

36 Citations (Scopus)

The central role played by peptides in the immune response and the design of peptide-based vaccines against infectious diseases and cancer

Jackson, D. C., Purcell, A. W., Fitzmaurice, C. J., Zeng, W. & Hart, D. N. J., 1 Jan 2002, In : Current Drug Targets. 3, 2, p. 175-196 22 p.

Research output: Contribution to journalArticleResearchpeer-review

The production, purification and crystallization of a soluble heterdimeric form of a highly selected T-cell receptor in its unliganded and liganded state

Clements, C. S., Kjer-Nielsen, L., Macdonald, W. A., Brooks, A. G., Purcell, A. W., McClusky, J. & Rossjohn, J., 2002, In : Acta Crystallographica Section D: Biological Crystallography. 58, 12, p. 2131 - 2134 4 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state

Clements, C. S., Kjer-Nielsen, L., MacDonald, W. A., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 1 Dec 2002, In : Acta Crystallographica Section D: Biological Crystallography. 58, 12, p. 2131-2134 4 p.

Research output: Contribution to journalArticleResearchpeer-review

65 Citations (Scopus)

The structure of HLA-B8 complexed to an immunodominant viral determinant: Peptide-induced conformational changes and a mode of MHC class I dimerization

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., Fontes, M. R., McCluskey, J. & Rossjohn, J., 1 Nov 2002, In : Journal of Immunology. 169, 9, p. 5153-5160 8 p.

Research output: Contribution to journalArticleResearchpeer-review

The structure of HLA-B8 complexed to an immunodominant viral determinant: peptide-induced conformational changes and a mode of MHC class 1 dimerisation1

Kjer-Nielsen, L., Clements, C. S., Brooks, A. G., Purcell, A. W., Fontes, M. R., McCluskey, J. & Rossjohn, J., 2002, In : Journal of Immunology. 169, 9, p. 5153 - 5160 8 p.

Research output: Contribution to journalArticleResearchpeer-review

2001
126 Citations (Scopus)

Quantitative and qualitative influences of tapasin on the class I peptide repertoire

Purcell, A. W., Gorman, J. J., Garcia-Peydró, M., Paradela, A., Burrows, S. R., Talbo, G. H., Laham, N., Chen Au Peh, A. P., Reynolds, E. C., López de Castro, J. A. & McCluskey, J., 15 Jan 2001, In : Journal of Immunology. 166, 2, p. 1016-1027 12 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
2000
22 Citations (Scopus)

Endogenous and exogenous factors contributing to the surface expression of HLA B27 on mutant APC

Purcell, A. W., Kelly, A. J., Peh, C. A., Dudek, N. L. & McCluskey, J., 1 Feb 2000, In : Human Immunology. 61, 2, p. 120-130 11 p.

Research output: Contribution to journalArticleResearchpeer-review

82 Citations (Scopus)

Tapasin-mediated retention and optimization of peptide ligands during the assembly of class I molecules

Barnden, M. J., Purcell, A. W., Gorman, J. J. & McCluskey, J., 1 Jul 2000, In : Journal of Immunology. 165, 1, p. 322-330 9 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access