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Research Output 1989 2019

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Article
2012
52 Citations (Scopus)

Tracking protein aggregation and mislocalization in cells with flow cytometry

Ramdzan, Y. M., Polling, S., Chia, C. P. Z., Ng, I. H. W., Ormsby, A. R., Croft, N. P., Purcell, A. W., Bogoyevitch, M. A., Ng, D. CH., Gleeson, P. A. & Hatters, D. M., 2012, In : Nature Methods. 9, 5, p. 467 - 470 4 p.

Research output: Contribution to journalArticleResearchpeer-review

Unravelling conotoxin folding and molecular diversity

Purcell, A. W. & Safavi-Hemami, H., 2012, In : Australian Biochemist. 43, 2, p. 4 - 6 3 p.

Research output: Contribution to journalArticleOther

2011
3 Citations (Scopus)

A novel strategy for the targeted analysis of protein and peptide metabolites

Williamson, N. A., Reilly, C., Tan, C. T., Ramarathinam, S. H., Jones, A., Hunter, C. L., Rooney, F. R. & Purcell, A. W., 2 Jan 2011, In : Proteomics. 11, 2, p. 183-192 10 p.

Research output: Contribution to journalArticleResearchpeer-review

61 Citations (Scopus)

CD4+ T-cell deficiency in HIV patients responding to antiretroviral therapy is associated with increased expression of interferon-stimulated genes in CD4+ T cells

Fernandez, S., Tanaskovic, S., Helbig, K., Rajasuriar, R., Kramski, M., Murray, J. M., Beard, M. R., Purcell, A. W., Lewin, S. R., Price, P. & French, M., 2011, In : Journal of Infectious Diseases. 204, 12, p. 1 - 9 9 p.

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate

Ia, K. K., Jeschke, G. R., Deng, Y., Kamaruddin, M. A., Williamson, N. A., Scanlon, D. B., Culvenor, J. G., Hossain, M. I., Purcell, A. W., Liu, S., Zhu, H-J., Catimel, B., Turk, B. E. & Cheng, H-C., 9 Aug 2011, In : Biochemistry. 50, 31, p. 6667-6677 11 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring

Tan, C. T., Croft, N. P., Dudek, N. L., Williamson, N. A. & Purcell, A. W., 2011, In : Proteomics. 11, 11, p. 2336 - 2340 5 p.

Research output: Contribution to journalArticleResearchpeer-review

20 Citations (Scopus)

Embryonic toxin expression in the cone snail conus victoriae - primed to kill or divergent function?

Safavi-Hemami, H., Siero, W. A., Kuang, Z., Williamson, N. A., Karas, J. A., Page, L. R., MacMillan, D., Kompella, S. N., Adams, D. J., Norton, R. S. & Purcell, A. W., 2011, In : Journal of Biological Chemistry. 286, 25, p. 22546 - 22557 12 p.

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis

Pham, H., Doerrbecker, J., Ramp, A. A., D'Souza, C. S., Gorasia, D. G., Purcell, A. W., Ayers, M. & Orian, J. M., Mar 2011, In : Journal of Neuroimmunology. 232, 1-2, p. 51-62 12 p.

Research output: Contribution to journalArticleOtherpeer-review

488 Citations (Scopus)

Linear ubiquitination prevents inflammation and regulates immune signalling

Gerlach, B., Cordier, S. M., Schmukle, A. C., Emmerich, C. H., Rieser, E., Haas, T. L., Webb, A. I., Rickard, J. A., Anderton, H., Wong, W. W. L., Nachbur, U., Gangoda, L., Warnken, U., Purcell, A. W., Silke, J. & Walczak, H., 31 Mar 2011, In : Nature. 471, 7340, p. 591-596 6 p.

Research output: Contribution to journalArticleOtherpeer-review

24 Citations (Scopus)

Peptidomimetics: modifying peptides in the pursuit of better vaccines

Croft, N. P. & Purcell, A. W., 2011, In : Expert Review of Vaccines. 10, 2, p. 211 - 226 16 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

Specialisation of the venom gland proteome in predatory cone snails reveals functional diversification of the conotoxin biosynthetic pathway

Safavi-Hemami, H., Siero, W. A., Gorasia, D. G., Young, N. D., MacMillan, D., Williamson, N. A. & Purcell, A. W., 2 Sep 2011, In : Journal of Proteome Research. 10, 9, p. 3904-3919 16 p.

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)

Stable isotope shifted matrices enable the use of low mass ion precursor scanning for targeted metabolite identification

Reilly, C. B., Ramarathinam, S. H., Williamson, N. A. & Purcell, A. W., 17 Jan 2011, In : Proteome Science. 9, 7 p., 2.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
26 Citations (Scopus)

Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses

Day, E. B., Guillonneau, C., Gras, S., La Gruta, N. L., Vignali, D., Doherty, P., Purcell, A., Rossjohn, J. & Turner, S., 2011, In : Proceedings of the National Academy of Sciences. 108, 23, p. 9536 - 9541 6 p.

Research output: Contribution to journalArticleResearchpeer-review

Open Access
23 Citations (Scopus)

β2-glycoprotein I and protection from anti-SSA/Ro60- associated cardiac manifestations of neonatal lupus

Reed, J. H., Clancy, R. M., Purcell, A. W., Kim, M. Y., Gordon, T. P. & Buyon, J. P., 1 Jul 2011, In : Journal of Immunology. 187, 1, p. 520-526 7 p.

Research output: Contribution to journalArticleOtherpeer-review

2010
56 Citations (Scopus)

Allelic polymorphism in the T cell receptor and its impact on immune responses

Gras, S., Chen, Z., Miles, J. J., Liu, Y. C., Bell, M. J., Sullivan, L. C., Kjer-Nielsen, L., Brennan, R. M., Burrows, J. M., Neller, M. A., Khanna, R., Purcell, A. W., Brooks, A. G., McCluskey, J., Rossjohn, J. & Burrows, S. R., 2010, In : Journal of Experimental Medicine. 207, 7, p. 1555 - 1567 13 p.

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

A modular BAM complex in the outer membrane of the alpha-proteobacterium caulobacter crescentus

Anwari, K., Poggio, S., Perry, A., Gatsos, X., Ramarathinam, S. H., Williamson, N. A., Noinaj, N., Buchanan, S., Gabriel, K., Purcell, A. W., Jacobs-Wagner, C. & Lithgow, T., 2010, In : PLoS ONE. 5, 1 (e8619), p. 1 - 8 8 p.

Research output: Contribution to journalArticleResearchpeer-review

46 Citations (Scopus)

Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition

Theodossis, A., Guillonneau, C., Welland, A. D., Ely, L. K., Clements, C. S., Williamson, N. A., Webb, A. I., Wilce, J. A., Mulder, R. J., Dunstone, M. A., Doherty, P. C., McCluskey, J., Purcell, A. W., Turner, S. J. & Rossjohn, J., 2010, In : Proceedings of the National Academy of Sciences. 107, 12, p. 5534 - 5539 6 p.

Research output: Contribution to journalArticleResearchpeer-review

53 Citations (Scopus)

Epitope discovery and their use in peptide based vaccines

Dudek, N. L., Perlmutter, P., Aguilar, M. I., Croft, N. & Purcell, A. W., 2010, In : Current Pharmaceutical Design. 16, 28, p. 3149 - 3157 9 p.

Research output: Contribution to journalArticleResearchpeer-review

80 Citations (Scopus)

Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Burrows, S. R., Chen, Z., Archbold, J. K., Tynan, F. E., Beddoe, T. C., Kjer-Nielsen, L., Miles, J. J., Khanna, R., Moss, D. J., Liu, Y. C., Gras, S., Kostenko, L., Brennan, R. M., Clements, C. S., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2010, In : Proceedings of the National Academy of Sciences. 107, 23, p. 10608 - 10613 6 p.

Research output: Contribution to journalArticleResearchpeer-review

23 Citations (Scopus)

Identification of Conus peptidylprolyl cis-trans isomerases (PPIases) and assessment of their role in the oxidative folding of conotoxins

Safavi-Hemami, H., Bulaj, G., Olivera, B. M., Williamson, N. A. & Purcell, A. W., 23 Apr 2010, In : Journal of Biological Chemistry. 285, 17, p. 12735-12746 12 p.

Research output: Contribution to journalArticleOtherpeer-review

31 Citations (Scopus)

Molecular markers of preterm labor in the choriodecidua

Shankar, R., Johnson, M. P., Williamson, N. A., Cullinane, F., Purcell, A. W., Moses, E. K. & Brennecke, S. P., Mar 2010, In : Reproductive Sciences. 17, 3, p. 297-310 14 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold

Valkenburg, S. A., Gras, S., Guillonneau, C., La Gruta, N. L., Thomas, P. G., Purcell, A. W., Rossjohn, J., Doherty, P. C., Turner, S. J. & Kedzierska, K., 2010, In : PLoS Pathogens. 6, 8 (e1001039), p. 1 - 15 15 p.

Research output: Contribution to journalArticleResearchpeer-review

25 Citations (Scopus)

Proteomic interrogation of venom delivery in marine cone snails: Novel insights into the role of the venom bulb

Safavi-Hemami, H., Young, N. D., Williamson, N. A. & Purcell, A. W., 5 Nov 2010, In : Journal of Proteome Research. 9, 11, p. 5610-5619 10 p.

Research output: Contribution to journalArticleOtherpeer-review

13 Citations (Scopus)

Rapid microscale in-gel processing and digestion of proteins using surface acoustic waves

Kulkarni, K., Ramarathinam, S., Friend, J., Yeo, L., Purcell, A. & Perlmutter, P., 2010, In : Lab on a Chip. 10, 12, p. 1518 - 1520 3 p.

Research output: Contribution to journalArticleResearchpeer-review

9 Citations (Scopus)

Reactivity with dichotomous determinants of Ro 60 stratifies autoantibody responses in lupus and primary Sjogren's syndrome

Reed, J. H., Dudek, N. L., Osborne, S. E., Kaufmann, K. M., Jackson, M. W., Purcell, A. W. & Gordon, T. P., 2010, In : Arthritis and Rheumatism. 62, 5, p. 1448 - 1456 9 p.

Research output: Contribution to journalArticleResearchpeer-review

48 Citations (Scopus)

The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

Pang, S. S., Berry, R., Chen, Z., Kjer-Nielsen, L., Perugini, M. A., King, G. F., Wang, C. C., Chew, S. H., La Gruta, N. L., Williams, N. K., Beddoe, T. C., Tiganis, T., Cowieson, N. P., Godfrey, D. I., Purcell, A. W., Wilce, M. CJ., McCluskey, J. & Rossjohn, J., 2010, In : Nature. 467, 7317, p. 844 - 848 7 p.

Research output: Contribution to journalArticleResearchpeer-review

2009
41 Citations (Scopus)

A long, naturally presented immunodominant epitope from NY-ESO-1 tumor antigen: implications for cancer vaccine design

Ebert, L. M., Liu, Y. C., Clements, C. S., Robson, N. C., Jackson, H. M., Markby, J. L., Dimopoulos, N., Tan, B. S., Luescher, I. F., Davis, I. D., Rossjohn, J., Cebon, J., Purcell, A. W. & Chen, W., 2009, In : Cancer Research. 69, 3, p. 1046 - 1054 9 p.

Research output: Contribution to journalArticleResearchpeer-review

77 Citations (Scopus)

Antigen ligation triggers a conformational change within the constant domain of the alphabeta T cell receptor

Beddoe, T. C., Chen, Z., Clements, C. S., Ely, L. K., Bushell, S. R., Vivian, J. P., Kjer-Nielsen, L., Pang, S. S., Dunstone, M. A., Liu, Y. C., Macdonald, W. A., Perugini, M. A., Wilce, M. C. J., Burrows, S. R., Purcell, A. W., Tiganis, T., Bottomley, S. P., McCluskey, J. & Rossjohn, J., 2009, In : Immunity. 30, 6, p. 777 - 788 12 p.

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Mass spectral identification of Vc1.1 and differential distribution of conopeptides in the venom duct of conus victoriae. effect of post-translational modifications and disulfide isomerisation on bioactivity

Townsend, A., Livett, B. G., Bingham, J. P., Truong, H. T., Karas, J. A., O'Donnell, P., Williamson, N. A., Purcell, A. W. & Scanlon, D., Sep 2009, In : International Journal of Peptide Research and Therapeutics. 15, 3, p. 195-203 9 p.

Research output: Contribution to journalArticleOtherpeer-review

73 Citations (Scopus)

Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

Archbold, J. K., Macdonald, W. A., Gras, S., Ely, L. K., Miles, J. J., Bell, M. J., Brennan, R. M., Beddoe, T. C., Wilce, M. C. J., Clements, C. S., Purcell, A. W., McCluskey, J., Burrows, S. R. & Rossjohn, J., 2009, In : Journal of Experimental Medicine. 206, 1, p. 209 - 219 11 p.

Research output: Contribution to journalArticleResearchpeer-review

33 Citations (Scopus)

Phosphorylated self-peptides alter human leukocyte antigen class l-restricted antigen presentation and generate tumor-specific epitopes

Petersen, J., Wurzbacher, S. J., Williamson, N. A., Ramarathinam, S. H., Reid, H. H., Nair, A. K. N., Zhao, A. Y., Nastovska, R., Rudge, G., Rossjohn, J. & Purcell, A. W., 2009, In : Proceedings of the National Academy of Sciences. 106, 8, p. 2776 - 2781 6 p.

Research output: Contribution to journalArticleResearchpeer-review

39 Citations (Scopus)

Post-translationally modified T cell epitopes: Immune recognition and immunotherapy

Petersen, J., Purcell, A. W. & Rossjohn, J., 2009, In : Journal of Molecular Medicine. 87, 11, p. 1045 - 1051 7 p.

Research output: Contribution to journalArticleResearchpeer-review

159 Citations (Scopus)

T cell allorecognition via molecular mimicry

Macdonald, W. A., Chen, Z., Gras, S., Archbold, J. K., Tynan, F. E., Clements, C. S., Bharadwaj, M., Kjer-Nielsen, L., Saunders, P. M., Wilce, M. C. J., Crawford, F., Stadinsky, B., Jackson, D., Brooks, A., Purcell, A. W., Kappler, J., Burrows, S. R., Rossjohn, J. & McCluskey, J., 2009, In : Immunity. 31, 6, p. 897 - 908 12 p.

Research output: Contribution to journalArticleResearchpeer-review

31 Citations (Scopus)

The A-chain of insulin is a hot-spot for CD4 + T cell epitopes in human type 1 diabetes

Mannering, S. I., Pang, S. H., Williamson, N. A., Naselli, G., Reynolds, E. C., O'Brien-Simpson, N. M., Purcell, A. W. & Harrison, L. C., May 2009, In : Clinical and Experimental Immunology. 156, 2, p. 226-231 6 p.

Research output: Contribution to journalArticleOtherpeer-review

42 Citations (Scopus)

The protein import channel in the outer mitosomal membrane of Giardia intestinalis

Dagley, M. J., Dolezal, P., Likic, V. A., Smid, O., Purcell, A. W., Buchanan, S. K., Tachezy, J. & Lithgow, T. J., 2009, In : Molecular Biology and Evolution. 26, 9, p. 1941 - 1947 7 p.

Research output: Contribution to journalArticleResearchpeer-review

71 Citations (Scopus)

The shaping of T cell receptor recognition by self-tolerance

Gras, S., Burrows, S. R., Kjer-Nielsen, L., Clements, C. S., Liu, Y. C., Sullivan, L. C., Bell, M. J., Brooks, A. G., Purcell, A. W., McCluskey, J. & Rossjohn, J., 2009, In : Immunity. 30, 2, p. 193 - 203 11 p.

Research output: Contribution to journalArticleResearchpeer-review

2008
4 Citations (Scopus)

Can α- and β-Alanine Containing Peptides Be Distinguished Based on the CID Spectra of Their Protonated Ions?

Lam, A. K. Y., Ramarathinam, S. H., Purcell, A. W. & O'Hair, R. A. J., Dec 2008, In : Journal of the American Society for Mass Spectrometry. 19, 12, p. 1743-1754 12 p.

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy

Kedzierska, K., Guillonneau, C., Gras, S., Hatton, L. A., Webby, R., Purcell, A. W., Rossjohn, J., Doherty, P. C. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences. 105, 49, p. 19408 - 19413 5 p.

Research output: Contribution to journalArticleResearchpeer-review

42 Citations (Scopus)

Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

La Gruta, N. L., Thomas, P. G., Webb, A. I., Dunstone, M. A., Cukalac, T., Doherty, P. C., Purcell, A. W., Rossjohn, J. & Turner, S. J., 2008, In : Proceedings of the National Academy of Sciences. 105, 6, p. 2034 - 2039 6 p.

Research output: Contribution to journalArticleResearchpeer-review

233 Citations (Scopus)

Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity

Chessman, D., Kostenko, L., Lethborg, T., Purcell, A. W., Williamson, N. A., Chen, Z., Kjer-Nielsen, L., Mifsud, N. A., Tait, B. D., Holdsworth, R., Almeida, C. A., Nolan, D., Macdonald, W. A., Archbold, J. K., Kellerher, A. D., Marriott, D., Mallal, S., Bharadwaj, M., Rossjohn, J. & McCluskey, J., 2008, In : Immunity. 28, 6, p. 822 - 832 11 p.

Research output: Contribution to journalArticleResearchpeer-review

22 Citations (Scopus)

Immunodominance hierarchies and gender bias in direct Tcd8-cell alloreactivity

Mifsud, N. A., Purcell, A. W., Chen, W. W., Holdsworth, R., Tait, B. D. & McCluskey, J., 2008, In : American Journal of Transplantation. 8, 1, p. 121 - 132 12 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant

Butler, N. S., Theodossis, A., Webb, A. I., Nastovska, R., Ramarathinam, S. H., Dunstone, M. A., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : PLoS Pathogens. 4, 10, p. 1 - 13 13 p.

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Refinement in the production and purification of recombinant HCMV IE1-pp65 protein for the generation of epitope-specific T cell immunity

Nguyen, T. H. O., Mifsud, N. A., Stewart, L. A., Rose, M. J., Etto, T. L., Williamson, N. A., Purcell, A. W., Kotsimbos, T. C. & Schwarer, A., 2008, In : Protein Expression and Purification. 61, 1, p. 22 - 30 9 p.

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Structural and biological basis of CTL escape in coronavirus-infected mice

Butler, N. S., Theodossis, A., Webb, A. I., Dunstone, M. A., Nastovska, R., Ramarathinam, S. H., Rossjohn, J., Purcell, A. W. & Perlman, S., 2008, In : Journal of Immunology. 180, 6, p. 3926 - 3937 12 p.

Research output: Contribution to journalArticleResearchpeer-review

27 Citations (Scopus)

T-cells behaving badly: Structural insights into alloreactivity and autoimmunity

Ely, L. K., Burrows, S. R., Purcell, A. W., Rossjohn, J. & McCluskey, J., 2008, In : Current Opinion in Immunology. 20, 5, p. 575 - 580 6 p.

Research output: Contribution to journalArticleResearchpeer-review

10 Citations (Scopus)

The enantioselective total synthesis and unambiguous proof of the absolute stereochemistry of pervilleine C

Kulkarni, K. P., Zhao, A. Y., Purcell, A. W. & Perlmutter, P., 2008, In : Synlett. 2008, 14, p. 2209 - 2212 4 p.

Research output: Contribution to journalArticleResearchpeer-review

2007
77 Citations (Scopus)

?-Amino acid-containing hybrid peptides - New opportunities in peptidomimetics

Aguilar, M. I., Purcell, A. W., Devi, R., Lew, R. A., Rossjohn, J., Smith, A. I. & Perlmutter, P., 2007, In : Organic and Biomolecular Chemistry. 5, 18, p. 2884 - 2890 7 p.

Research output: Contribution to journalArticleResearchpeer-review

113 Citations (Scopus)

A structural and immunological basis for the role of human leukocyte antigen DQ8 in celiac disease

Henderson, K., Tye-Din, J. A., Reid, H. H., Chen, Z., Borg, N., Beissbarth, T., Tatham, A., Mannering, S. I., Purcell, A. W., Dudek, N. L., van Heel, D. A., McCluskey, J., Rossjohn, J. & Anderson, R. P., 2007, In : Immunity. 27, 1, p. 23 - 34 12 p.

Research output: Contribution to journalArticleResearchpeer-review

158 Citations (Scopus)

A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

Tynan, F. E., Reid, H. H., Kjer-Nielsen, L., Miles, J. J., Wilce, M. C. J., Kostenko, L., Borg, N., Williamson, N. A., Beddoe, T. C., Purcell, A. W., Burrows, S. R., McCluskey, J. & Rossjohn, J., 2007, In : Nature Immunology. 8, 3, p. 268 - 276 9 p.

Research output: Contribution to journalArticleResearchpeer-review

58 Citations (Scopus)

Conserved motifs reveal details of ancestry and structure in the small TIM chaperones of the mitochondrial intermembrane space

Gentle, I. E., Perry, A. J., Alcock, F. H., Likic, V. A., Dolezal, P., Ng, E. T., Purcell, A. W., McConnville, M., Naderer, T., Chanez, A-L., Charriere, F., Aschinger, C., Schneider, A., Tokatlidis, K. & Lithgow, T. J., 2007, In : Molecular Biology and Evolution. 24, 5, p. 1149 - 1160 12 p.

Research output: Contribution to journalArticleResearchpeer-review